Boolean Operators Research Articles

The Influence of Myeloid-Derived Suppressor Cell Expansion in Neuroinflammation and Neurodegenerative Diseases.

The neuro-immune axis has a crucial function both during physiological and pathological conditions. Among the immune cells, myeloid-derived suppressor cells (MDSCs) exert a pivotal role in regulating the immune response in many pathological conditions, influencing neuroinflammation and neurodegenerative disease progression. In chronic neuroinflammation, MDSCs could lead to exacerbation of the inflammatory state and eventually participate in the impairment of cognitive functions. To have a complete overview of the role of MDSCs in neurodegenerative diseases, research on PubMed for articles using a combination of terms made with Boolean operators was performed. According to the search strategy, 80 papers were retrieved. Among these, 44 papers met the eligibility criteria. The two subtypes of MDSCs, monocytic and polymorphonuclear MDSCs, behave differently in these diseases. The initial MDSC proliferation is fundamental for attenuating inflammation in Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS), but not in amyotrophic lateral sclerosis (ALS), where MDSC expansion leads to exacerbation of the disease. Moreover, the accumulation of MDSC subtypes in distinct organs changes during the disease. The proliferation of MDSC subtypes occurs at different disease stages and can influence the progression of each neurodegenerative disorder differently.

Analysis Of Information Retrieval System In The Repository Of The State Islamic University (UIN) Raden Intan Lampung

This research discusses the information retrieval system through the UIN Raden Intan Lampung Repository.This research uses a qualitative research design with data collection using literature study, documentation and observation. The information retrieval system in the UIN Raden Intan Lampung repository can be done through searching and browsing. Searching the repository can be done with simple search and advanced search. In simple search, users can search by entering keywords, title, author and subject. Searching via searching can also use Boolean operators, namely AND, OR, and NOT. Browsing at the UIN Raden Intan Lampung Repository can be done by year, subject, division and author. Furthermore, searching for documents via browsing by author's name is also not optimal, this is due to differences in author name metadata input to different repositories, namely there are names that are reversed. and not reversed, so this also requires user accuracy in searching documents
 Keywords: Information retrieval, Repository, Retrieval system

Interpretation of brain health impairment due to sleep disturbances of the glymphatic system

Sleep is an essential biological cycle that regulates the internal rhythms of the human being and contributes to maintaining homeostasis. During sleep, the glymphatic system, responsible for eliminating brain waste, is activated. Sleep deprivation or related disorders can slow down the elimination of beta-amyloid protein, increasing the risk of cognitive impairment, dementia and Alzheimer's disease. This study sought to interpret how alterations in the glymphatic system during sleep affect brain health. A literature review was conducted using document analysis techniques, analyzing scientific articles in the Virtual Health Library, Lilacs, PubMed and various indexed journals. Search strategies based on descriptors and Boolean operators were developed during the period from August to September 2023. As results, a connection between migraine and the glymphatic system is suggested, observing a decrease in the elimination of brain solutes and metabolites during prolonged periods of wakefulness. A bidirectional relationship has also been identified between post-traumatic headache and sleep disturbances following brain injury, possibly due to dysfunction of the glymphatic system, which limits the clearance of headache-related neuropeptides and contributes to its chronicity. Dysfunction of the glymphatic system is present in several neurological disorders, as well as decreased drainage of proinflammatory chemicals and cytokines in different conditions. It is concluded that these findings suggest that the glymphatic system could be considered as a diagnostic and therapeutic avenue for neurological diseases that were previously considered chronic or irreversible

Technology and sexual abuse - The role of technology in facilitating child and adolescent sexual abuse: A systematic review

Child and adolescent sexual abuse is a reality that affects countless children and adolescents, harming and violating the physical, emotional and psychological integrity of the victims. There are numerous factors that cause vulnerability in this public, one of them being the technological means, due to the influences that the media causes, the exposure of children and adolescents and the facilitation of communication between aggressors and victims. To analyze the relationship between the use of technologies and child and adolescent sexual abuse, exploring how these technological tools have been used to facilitate the sexual abuse of children and adolescents. This is a systematic review of the literature. The search for articles was carried out from the Virtual Health Library (VHL); Lilacs; Scientific Electronic Library Online (SciELO); National Library of Medicine (PubMed). The descriptors used to search for the articles were: Child and adolescent sexual abuse, technologies and pedophilia. The Boolean operator AND was used to cross-reference the terms. Regarding the inclusion criteria used: complete articles, available and indexed in the aforementioned databases, free of charge, in the Portuguese language, published in the last five years between 2019 and 2023 related to the theme. Monographs, book chapters, paid articles, duplicate studies, in another language, and published before 2019 were excluded as exclusion criteria. Modern technologies, such as the internet and social networks, are means that facilitate the increase in cases of child and adolescent sexual abuse.

Boolean interpretation, matching, and ranking of natural language queries in product selection systems

E-commerce is a massive sector in the US economy, generating $767.7 billion in revenue in 2021. E-commerce sites maximize their revenue by helping customers find, examine, and purchase products. To help users easily find the most relevant products in the database for their individual needs, e-commerce sites are equipped with a product retrieval system. Many of these modern retrieval systems parse user-specified constraints or keywords embedded in a simple natural language query, which is generally easier and faster for the customer to specify their needs than navigating a product specification form, and does not require the seller to design or develop such a form. These natural language product retrieval systems, however, suffer from low relevance in retrieved products, especially for complex constraints specified on products. The reduced accuracy is in part due to under-utilizing the rich semantics of natural language, specifically queries that include Boolean operators, and lacking of the ranking on partially-matched relevant results that could be of interest to the customers. This undesirable effect costs e-commerce vendors to lose sales on their merchandise. In solving this problem, we propose a novel product retrieval system, called QuePR\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$${\ extit{QuePR}}$$\\end{document}, that parses arbitrarily simple and complex natural language queries with(out) Boolean operators, utilizes combinatorial numeric and content-based matching to extract relevant products from a database, and ranks retrieved resultant products by relevance before presenting them to the end-user. The advantages of QuePR\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$${\ extit{QuePR}}$$\\end{document} are its ability to process explicit and implicit Boolean operators in queries, handle natural language queries using similarity measures on partially-matched records, and perform best guess or match on ambiguous or incomplete queries. QuePR\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$${\ extit{QuePR}}$$\\end{document} is unique, easy to use, and scalable to all product categories. To verify the accuracy of QuePR\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$${\ extit{QuePR}}$$\\end{document} in retrieving relevant products on different product domains, we have conducted different performance analyses and compared QuePR\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$${\ extit{QuePR}}$$\\end{document} with other ranking and retrieval systems. The empirical results verify that QuePR\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$${\ extit{QuePR}}$$\\end{document} outperforms others while maintaining an optimal runtime speed.

Novel clinical phenotypes, drug categorization, and outcome prediction in drug-induced cholestasis: Analysis of a database of 432 patients developed by literature review and machine learning support

BackgroundSerum transaminases, alkaline phosphatase and bilirubin are common parameters used for DILI diagnosis, classification, and prognosis. However, the relevance of clinical examination, histopathology and drug chemical properties have not been fully investigated. As cholestasis is a frequent and complex DILI manifestation, our goal was to investigate the relevance of clinical features and drug properties to stratify drug-induced cholestasis (DIC) patients, and to develop a prognosis model to identify patients at risk and high-concern drugs. MethodsDIC-related articles were searched by keywords and Boolean operators in seven databases. Relevant articles were uploaded onto Sysrev, a machine-learning based platform for article review and data extraction. Demographic, clinical, biochemical, and liver histopathological data were collected. Drug properties were obtained from databases or QSAR modelling. Statistical analyses and logistic regressions were performed. ResultsData from 432 DIC patients associated with 52 drugs were collected. Fibrosis strongly associated with fatality, whereas canalicular paucity and ALP associated with chronicity. Drugs causing cholestasis clustered in three major groups. The pure cholestatic pattern divided into two subphenotypes with differences in prognosis, canalicular paucity, fibrosis, ALP and bilirubin. A predictive model of DIC outcome based on non-invasive parameters and drug properties was developed. Results demonstrate that physicochemical (pKa-a) and pharmacokinetic (bioavailability, CYP2C9) attributes impinged on the DIC phenotype and allowed the identification of high-concern drugs. ConclusionsWe identified novel associations among DIC manifestations and disclosed novel DIC subphenotypes with specific clinical and chemical traits. The developed predictive DIC outcome model could facilitate DIC prognosis in clinical practice and drug categorization.

Stress, Burnout dan Strategi Coping Perawat Frontline pada Waktu Pandemi COVID-19

This research aims to determine the stress, burnout, and coping of nurses during the COVID-19 pandemic in hospitals. The research method used is a literature review by selecting a theme and determining keywords (Keywords) and Boolean operators (AND, OR NOT, or AND NOT) before searching for scientific articles online. The literature search in this literature review used 4 databases, namely, Cochrane Library, Pubmed, Scopus, and ProQuest. The research results show that psychological symptoms that appeared in health workers due to the COVID-19 pandemic, such as depression, anxiety, stress, PTSD, fatigue, insomnia, and somatic symptoms, increased during the beginning of this pandemic. In conclusion, nurses experience a lot of work stress, medical professional burnout (emotional exhaustion, depersonalization, and a low sense of personal accomplishment), and mental health. Stress prevention should be adapted to the characteristics of the workplace, taking into account workplace optimization, social support, and compensation for workers' efforts. Keywords: Burnout, Coping Strategies, COVID-19, Nurses, Stress

Nursing students and disgust emotion

Disgust is an emotional response to a real or perceived disgusting situation. This emotion is present at all levels of human life, both individual and societal. Disgust could be involved in a wide range of psychopathology such as anxiety. Likewise, disgust influence negatively the motivation. It is an emotion commonly experienced by health professionals and nursing students.The synonyms of disgust and nursing students were identified, and then research has been conducted using, Boolean operators such as Disgust or Revulsion AND Nursing Students OR Pupil Nurses. The databases consulted were: Pubmed, Google scholar, Scopus, Science Direct, Web of science. The selected articles were full-text manuscripts written in English and French, and each contained keywords related to the study in their title or abstract.Nursing students experienced disgust during their training. Some students said that it is inappropriate to express this emotion to keep the patient’s trust. Disgust sensitivity can influence the choice of professional careers. A negative correlation was reported between disgust sensitivity and care behaviors such as accessibility, anticipation, and trust. Nursing students suggest avoiding the use of the word "disgust" and instead using other terms such as "difficult", and "challenge". In addition, students said that with time and exposure, many potential disgust inducers lose their effects and become habitual. Other measures were noted like the use of protective equipment. It was also reported that training staff could help students overcome difficult situations. Indeed, awareness of the importance of supporting students during training and assessing their disgust sensitivity is an essential stage to manage this emotion.According to the consulted articles, nursing students may experience disgust. Therefore, it is necessary to support them in both clinical and academic settings. It is also important to assess their sensitivity to disgust and help them to identify and to manage their emotions. In light of the lack of studies on disgust among nursing students, future research will enhance this field.

Therapeutic potential of fucoidan in dentistry: A review

Fucoidan, produced by the cell walls of brown seaweed, possesses biological effects, covering anticancer, antiviral, anti-inflammatory, antioxidant, and a potential for promoting angiogenesis and osteogenesis. This study aimed to compile diverse scientific results on fucoidan’s therapeutic prospect in dentistry and the mechanism of action in the therapy of oral diseases. A literature search was carried out using keywords with Boolean operators, including fucoidan (AND) oral (OR) dental (OR) dentistry, to identify related publications from PubMed, ScienceDirect, and Google Scholar databases. The results showed that fucoidan had various therapeutic potentials in the field of dentistry, including anticancer, anti-inflammatory, radioprotection, protection of dental pulp tissue, and bone regeneration. These characteristics were related to the sulfate composition and molecular weight. Fucoidan has various therapeutic potentials crucial for oral health. Hence, it might be used for material development and drug production in dentistry

420 Computable Phenotyping with “Big Data” as a Foundation for Artificial Intelligence Algorithm Construction: Puberty as a Transdisciplinary Case Example

OBJECTIVES/GOALS: Artificial intelligence (AI) depends on quality machine learning (ML) algorithms constructed with high-quality training data. This TL1 trainee project develops a disease-agnostic computable phenotype framework for ML algorithm construction, modeling male puberty as a case example. METHODS/STUDY POPULATION: A computable phenotype of male puberty was constructed to answer the question: “Does early pubertal timing increase the risk of developing type II diabetes (T2D) in males?” A computable phenotype of males < 18 years old was created in the TriNetX© Diamond Network utilizing Boolean operator data queries. TriNetX© contains patient electronic health record information (ICD-10 diagnoses, anthropometric measures). An exploratory analysis of patient counts reflecting various computable phenotypes allowed for outcome (T2D) comparison of males diagnosed with precocious puberty (E30.1, ICD code for early pubertal timing) to those without, controlling for body mass index (BMI). RESULTS/ANTICIPATED RESULTS: Subjects (n=12,996,132) displayed the following computable phenotype: Male, < 18 years old, without ever having a BMI documented >85th percentile. Males diagnosed with precocious puberty (E30.1) were 6.89 times more likely to develop T2D when aged 14-18 years old than those without (OR 6.89, 95% CI: 5.17-9.19, p<0.0001). Next steps involve training a ML model on each computable phenotype groupings’ health data, with anticipated results identifying underlying salient pathophysiologic variables. A generalized computable phenotype approach is further developed to: 1) explore clinical questions in large databases like TriNetX©, and 2) model disease development with AI/ML algorithm construction. DISCUSSION/SIGNIFICANCE: Computed phenotypes reveal males with precocious puberty may have increased T2D risk. Next steps utilize subject data to train an AI/ML algorithm, model development to identify salient pathophysiologic variables, and synthesize a generalized AI/ML developmental research framework for dissemination.

ANALYSIS OF PHYSICAL ACTIVITY TO IMPROVE STUDENTS BASIC MOVEMENT SKILLS PHYSICAL LITERACY BASED PRIMARY SCHOOL

Abstract This literature review study is based on this The current education pattern cannot accommodate the needs of each individual to grow optimally. Most current education patterns do not provide enough space for students' uniqueness in carrying out physical activities. Mastery of basic movements needs to be given to children in the form of physical activity. Physical activity that is designed needs to increase and stimulate children to move without compulsion. The physical activity provided can be in the form of Physical Literacy . The literature review method was carried out on three articles obtained from a number of databases, PubMed, EBSCO, and Springer Link. Keywords for searching articles are physical activity, physical literacy , basic movement skills, physical literacy . Researchers use "AND" as a Boolean operator. The results of the literature review are that the development of a physical activity model to improve elementary school students' basic movement skills is based on physical literacy. The results of the review article are: 1) Physical activity improves health, 2) Good physical literacy knowledge in children aged 7-12 years, 3) Developing physical literacy. The conclusion from the literature review is that understanding physical activity based on the concept of physical literacy can improve health. A high understanding of physical literacy is related to the holistic development of children aged 7-12 years, namely if a person's body is healthy then they will grow and develop optimally. Traditional games can develop elementary school students' physical literacy. These results are based on the improvement achieved by students in the aspects of understanding how to perform movements, movement skills and enjoyment.
 
 
 Keywords: Physical activity, basic movement abilities and Physical Literacy

Adaptable cascaded registration for personalized maxilla completion and cleft defect volume estimation.

Cone-beam computed tomography (CBCT) images provide high-resolution insights into the underlying craniofacial anomaly in patients with cleft lip and palate (CLP), requiring non-negligible annotation costs to measure the cleft defect for the guidance of the clinical secondary alveolar bone graft procedures. Considering the cumbersome volumetric image acquisition, there is a lack of paired CLP CBCTs and normal CBCTs for learning-based anatomical structure restoration models. Nowadays, the registration-based method relieves the annotation burden, though one-shot registration and the regular mask are limited to handling fine-grained shape variations and harmony between restored bony tissues and the defectedmaxilla. This study aimed to design and evaluate a novel method for deformable partial registration of the CLP CBCTs and normal CBCTs, enabling personalized maxilla completion and cleft defect volume prediction from CLPCBCTs. We proposed an adaptable deep registration framework for personalized maxilla completion and cleft defect volume prediction from CLP CBCTs. The key ingredient was a cascaded partial registration to exploit the maxillary morphology prior and attribute transfer. Cascaded registration with coarse-to-fine registration fields handled morphological variations of cleft defects and fine-grained maxillary restoration. We designed an adaptable cleft defect mask and volumetric Boolean operators for reliable voxel filling of the defected maxilla. A total of 36 clinically obtained CLP CBCTs were used to train and validate the proposed model, among which 22 CLP CBCTs were used to generate a training dataset with 440 synthetic CBCTs by B-spline deformation-based data augmentation and the remaining for testing. The proposed model was evaluated on maxilla completion and cleft defect volume prediction from clinically obtained unilateral and bilateral CLPCBCTs. Extensive experiments demonstrated the effectiveness of the adaptable cleft defect mask and the cascaded partial registration on maxilla completion and cleft defect volume prediction. The proposed method achieved state-of-the-art performances with the Dice similarity coefficient of 0.90 0.02 on the restored maxilla and 0.84 0.04 on the estimated cleft defect, respectively. The average Hausdorff distance between the estimated cleft defect and the manually annotated ground truth was 0.30 0.08 mm. The relative volume error of the cleft defect was 0.08. The proposed model allowed for the prediction of cleft defect maps that were in line with the ground truth in the challenging unilateral and bilateral CLP CBCTs. The results suggest that the proposed adaptable deep registration model enables patient-specific maxilla completion and automatic annotation of cleft defects, relieving tedious voxel-wise annotation and image acquisitionburdens.

Comparison of negative pressure wound therapy against normal dressing after vascular surgeries for inguinal wounds: A systematic review and meta-analysis

BackgroundNegative Pressure Wound Therapy (NPWT) is a therapeutic technique of applying sub-atmospheric pressure to a wound to reduce inflammation, manage exudate, and promote the formation of granulation tissue. It aims to optimise the natural physiological processes of wound healing for more effective recovery, and NPWT has emerged as a promising alternative to traditional dressings. MethodsThe protocol followed in the study was prospectively registered. Appropriate search terms and Boolean operators were used to search electronic databases for relevant articles. Screening of articles was performed, and data extraction was done. The effect measure was chosen according to the nature of the variable, and the effect model was chosen as per heterogeneity. Forest plot was used to give visual feedback. ResultsThis study included 11 randomized controlled trials (13 publications) with a total of 1310 patients (1497 inguinal wounds). The NPWT group had lesser odds of developing surgical site infection (OR: 0.40; 95 % CI: 0.29–0.54; n = 1491; I2 = 20 %; p-value ≤0.00001) and lesser odds of needing surgical wound revision (OR: 0.48; 95 % CI: 0.26–0.91; n = 856; I2 = 0 %; p-value = 0.02) as compared to the normal dressing group. No significant difference was observed in duration of hospital stay, cost of care, wound healing time, or other complications. ConclusionNPWT application in inguinal wounds significantly reduces the surgical site infection and the need for wound revision in patients who have undergone vascular surgery.

Singleton {NOT} and Doubleton {YES; NOT} Gates Act as Functionally Complete Sets in DNA-Integrated Computational Circuits.

A functionally complete Boolean operator is sufficient for computational circuits of arbitrary complexity. We connected YES (buffer) with NOT (inverter) and two NOT four-way junction (4J) DNA gates to obtain IMPLY and NAND Boolean functions, respectively, each of which represents a functionally complete gate. The results show a technological path towards creating a DNA computational circuit of arbitrary complexity based on singleton NOT or a combination of NOT and YES gates, which is not possible in electronic computers. We, therefore, concluded that DNA-based circuits and molecular computation may offer opportunities unforeseen in electronics.

Prevalence of autism spectrum disorder among children in Southeast Asia from 2002 to 2022: An updated systematic review and meta-analysis.

Autism spectrum disorder (ASD) is a neurodevelopmental condition that impacts the brain, characterized by challenges in social communication and interaction, often accompanied by repetitive behaviors or focused interests. This study sheds light on the prevalence of ASDwithin the Southeast Asian region. The study protocol was registered in PROSPERO (Registration No: CRD42023413915). Appropriate search terms and Boolean operators were employed to explore electronic databases for relevant articles. Data thus extracted were prepared in Excel and analyzed in Comprehensive Meta-Analysis Software. The effect measure utilized in the study was represented by the proportion, and the choice between a fixed or random-effect model depended on the observed heterogeneity. Visual feedback was provided through the use of forest plots and funnel plots. A total of 14studies were included in the qualitative and quantitative synthesis after screening the imported studies. The prevalence of ASDwas sixper 1000 population (proportion: 0.006; CI: 0.002-0.017; I 2: 99.263%). Among the ASD cases, 64.4% (proportion: 0.644; CI: 0.590-0.693; I 2: 9.937%) were males and 35.6% (proportion: 0.356; CI: 0.307-0.410; I 2: 9.937%) were females. The prevalence ofASDin Southeast Asia was estimated to be sixcases per 1000 individuals, with a higher prevalence among males. This study contributes to our understanding of ASD prevalence in the region, although it is essential to note certain limitations in estimating prevalence.

The Use of Rhinomanometry in Mouth Breathing: A Systematic Review of the Literature.

Introduction Mouth breathing generates imbalances in the musculature, in craniofacial morphofunctionality, and in the stomatognathic system. Therefore, it is essential to make a diagnosis of mouth breathing through the quantitative assessment of nasal permeability, which can be performed through rhinomanometry. Objective To investigate the effectiveness of rhinomanometry in the diagnosis of mouth breathing in pediatric patients through a systematic review of the literature. Data synthesis The guiding question was: "Is the use of rhinomanometry as an assessment tool effective in the diagnosis of mouth breathing in pediatric patients?". We conducted a search on the following databases: Latin American and Caribbean Center on Health Sciences Information (BIREME), Latin American and Caribbean Health Sciences Literature (LILACS), PubMed/Medical Literature Analysis and Retrieval System Online (MEDLINE), Scientific Electronic Library Online (SciELO), Web of Science, and Science Direct. The Health Sciences Descriptors (Descritores em Ciências da Saúde, DECS, in Portuguese) and Medical Subjects Headings (MESH) were combined with the Boolean operator AND in the search strategy: rhinomanometry AND mouth breathing AND diagnosis AND nasal pressure AND nasal airflow AND nasal resistance . Observational cohort and cross-sectional studies that addressed the effectiveness of rhinomanometry in the diagnosis of mouth breathing were included. The reviewers independently extracted the information and scored the review quality based on the Physiotherapy Evidence Database (PEDro) scale and the grading of evidence levels according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. Of the 1,536 articles identified, only 3 were selected for the present review after the application of the eligibility criteria. Conclusion There is great concern regarding the assessment of nasal function. There was a lack of standardization of rhinomanometry to test the effectiveness of nasal resistance as an aid in the diagnosis of breathing mode.

Implementation of Early Breastfeeding Initiation Challenges After Sectio Caesarea in Hospital

<div><table cellspacing="0" cellpadding="0" align="left"><tbody><tr><td align="left" valign="top"><p><em>Behavior of early initiation of breastfeeding in postpartum mothers is still a health problem in the world. Early initiation of breastfeeding has become an internationally and nationally recommended program as part of Mother and Baby Friendly Hospital services. Caesarean section is one of the obstacles in implementing early initiation of breastfeeding. This scoping review aims to assess the policy of early breastfeeding initiation after cesarean section in hospitals. This research design is a scoping review, using 4 databases, namely Google Scholar, Ebsco, Pro Quest, and Science Direct. The stages and flow of selecting research articles using PRISMA (Preferred Reporting Items For Systematic reviews and Meta-Analyses) Flowchart, and to assess the quality of the article researchers used a checklist from the Joanna Briggs Institute. Literature study that summarizes several accredited journal articles from 2018-2023 that are relevant to the title. This research selected quantitative and qualitative research articles with cross-sectional or case control research designs. In the journal search, researchers used boolean operators for predetermined keywords, adding "OR", "AND" according to the topic. The results found two themes and six subthemes from the 8 articles screened, namely the success factors of breastfeeding in post-cesarean section mothers, maternal knowledge, maternal attitudes, decisions in planning labor and implementation of early breastfeeding initiation. Meanwhile, efforts to make early breastfeeding initiation a success continue with the support of health workers and program policies. Support and policy efforts from health care providers have a positive influence on breastfeeding mothers, especially mothers who undergo cesarean delivery in hospitals.</em></p><p><em> </em></p></td></tr></tbody></table></div><strong><em>Keywords: Challenges, Early initiation of breastfeeding, Hospital, Post sectio caesarea</em></strong>

Primary Co-Occurrence of Gonadal and Extragonadal Central Nervous System (CNS) Germ Cell Tumors (GCTs): Case Report and Review of the Literature

Background: The primary co-occurrence of gonadal and extragonadal central nervous system (CNS) germ cell tumors (GCTs) has rarely been reported in the literature, and a common opinion on the underlying etiopathogenetic mechanism is lacking. Objective: We aim to investigate the pathophysiological mechanisms and genetic pathways underlying the primary co-occurrence of gonadal and CNS GCTs. Methods: We reviewed data from 29 consecutive patients with a diagnosis of CNS GCT, evaluated in our Hospital over the past 23 years, and searched for those who had at least a primary gonadal co-occurrence of GCT. A systematic review of the literature according to the PRISMA guidelines was also conducted. For a comprehensive and detailed search, PubMed, Ovid MEDLINE, and Ovid EMBASE databases have been consulted. Boolean operators and MeSH terms were used to find studies. Only articles published between 2000 and 2023 were considered. Results: Including our Institutional case report, a total of 7 patients with both testicular NGGCTs and CNS GCTs were identified (5 patients with metachronous tumors and patients with synchronous presentation). The average age at tumor diagnosis was 17 years. The cerebral histotypes reported were mixed GCTs (3 cases; 43%), pure germinomas (3 cases, 43%), and one yolk sac tumor (14%). Two out of seven cases (29%) were syndromic, one suffering from Down Syndrome and the other from Testicular Dysgenesis Syndrome. Regarding the etiology and molecular mechanism of GCT development, several gene mutations have been reported in the literature. Particularly, genetic alterations in the MAPK and/or PI3K/AKT/mTOR pathway, together with mutations of the KIT gene, have been shown to guarantee survival and transformation of mismigrated totipotent primordial germ cells, while suppressor genes allow their resistance against apoptotic death. Aberrant chromosomes have also been reported to be responsible for oncogenic transformation. It is also known that CNS and testicular GCTs share some genetic/epigenetic profiles. Conclusions: The primary co-occurrence of testicular NGGCT and extragonadal CNS GCTs is extremely rare. Genetic factors seem to play a paramount role in their etiopathogenesis. Additional research is needed to elucidate molecular mechanisms of oncogenesis in such patients.

Functional fitness benchmark values for older adults: a systematic review.

The use of normative values and/or standards of functional fitness in adults is relevant to overall health and well-being. The objectives of the study were: to identify the physical tests of the senior fitness test (SFT) that have been applied since its proposal and to describe the proposed percentiles according to age, sex and country. A systematic review study was conducted in the Pubmed and Scopus databases. As eligibility criteria, we considered the period from 1999 to 2022 that presented data on SFT test used in the population over 60 years of age and that described normative values through percentiles. MeSH were used as: (1) Physical fitness, Exercise test, Senior Fitness Test, Functional fitness, Cardiorespiratory fitness, (2) older adult, aged, (3) Reference standards, standards, standards of care. Boolean operators "AND" and "OR" were included. Data extracted from the selected studies included: year of publication, country, sample age, sample size, sample sex, fitness component. Seven studies were identified in five countries (03 in China, 01 in Poland, 01 in Portugal, 01 in Spain and 01 in United States). The age range ranged from 60 to 103 years. The studies were conducted in both sexes. The study with the smallest sample size was by Chung et al. (China) with 944 participants and the largest number of participants was the study by Rikli and Jones in the United States with 7,183 participants. In general, no study was able to complete 100% (8 components) of the tests proposed in the SFT. Normative values were presented through percentile distribution (p10, p50 and p90) organized by age ranges. Males presented better performance in FPF tests than females in all tests. Since the first publication of the SFT until 2022, seven articles have been published in countries such as United States, China (three regional studies), Poland, Portugal and Spain. No study has published the complete battery with its eight components. The percentiles of functional fitness reflect decline with advancing age. PROSPERO (CRD42023441294: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023441294).

Uptake of human papilloma virus vaccine and its determinants among females in East Africa: a systematic review and meta-analysis

IntroductionCervical cancer is the most common malignant tumor among women. It is the main cause of death among women in sub-Saharan African countries. Particularly, the incidence and mortality rates are highest in East Africa. Even though the burden of human papilloma virus-related cervical cancer is high in East Africa, there is no conclusive evidence about the prevalence of human papilloma virus vaccine uptake and its predictors.ObjectiveTo assess the pooled prevalence of human papilloma virus vaccine uptake and its determinants in East Africa.MethodEligible articles were searched on PubMed, Embase, Scopus, Cochrane Library, Google Scholar, and Google. Those articles incorporating the outcome of interest, both analytical and descriptive study designs, and published or unpublished articles at any time were included. Keywords and Medical Subjects Heading terms or synonyms of human papilloma virus vaccine and Boolean operators were used to retrieve the articles. To assure the quality of articles, Joana Brigg’s Institute critical appraisal checklist for cross-sectional studies was used. Sensitivity analysis was conducted to assess the heterogeneity among the studies, and a random effect model was used to analyze the pooled effect size.ResultA total of 29 articles were included, and the pooled prevalence of HPV vaccine uptake in East Africa was 35% (95% CI: 26–45%). Good knowledge (OR = 1.6, 95%CI; 1.43–1.8), positive attitude (OR = 2.54, 95% CI; 2.13–3.03), ever heard about HPV vaccine (OR = 1.41, 95% CI; 1.03–1.94), mother educational status above college (OR = 1.84, 95%CI; 1.03–3.31), middle wealth index (OR = 1.33, 95%CI; 1.04–1.7), ≥ 9 family size (OR = 0.76, 95%CI; 0.68–0.98), availability of promotion (OR = 2.53, 95%CI: 1.51–4.26), availability of adequate vaccine (OR = 4.84, 95%CI; 2.9–8.08), outreach vaccination practice (OR = 1.47, 95%CI; 1.02–2.12) and family support (OR = 4.3, 95% CI; 2.98–6.21) were the significant factors for the uptake of human papilloma virus vaccine.ConclusionAs compared to the global strategic plan, the pooled prevalence of HPV vaccine uptake in east Africa was low. The uptake of the HPV vaccine was higher among adolescents than youths. Knowledge about the HPV vaccine, attitude towards the HPV vaccine, ever hearing about the HPV vaccine, residence, mother’s educational status, mother’s occupational status, wealth index, and family size were the significant determinants of HPV vaccine uptake. Therefore, we recommend focusing on awareness creation and behavioral change to expand the uptake of vaccines in East Africa.