Bone Cholesteatoma Research Articles

Commentary “Petrous Temporal Bone Cholesteatoma: A New Classification and Long-Term Surgical Outcomes”

Commentary “Petrous Temporal Bone Cholesteatoma: A New Classification and Long-Term Surgical Outcomes”

Petrous Temporal Bone Cholesteatoma: A New Classification and Long-Term Surgical Outcomes

The goals of this retrospective case review were to analyze the long-term results of surgery for petrous temporal bone cholesteatomas and to propose a new classification system for these lesions. Patients with a surgically confirmed petrous temporal bone cholesteatoma were treated at Addenbrooke's Hospital, a tertiary referral center. Postoperative facial function, hearing, residual/recurrent cholesteatoma, and other complications were assessed in relation to preoperative signs, intraoperative findings, and surgical approach. Between 1983 and 2004, 43 patients were treated. There were no perioperative deaths. There was no long-term recurrence in 95.4% of the patients, possibly because of meticulous surgical technique, bipolar diathermy, and use of the laser to denature the cholesteatoma matrix that was adherent to the dura. At presentation, 95% of the patients had no socially useful hearing in the affected ear. Facial nerve function, however, was usually preserved. Both direct anastomosis and nerve grafting can improve facial nerve function from House-Brackmann grade VI to grade III if the palsy is not longstanding. Four patients had cerebrospinal fluid leakage; other complications were rare. The proposed classification facilitates surgical planning and predicts the postoperative outcome with regards to hearing.

Temporal Bone Cholesteatoma: Surgical Results and Management of the Facial Nerve

Petrous bone cholesteatomas (PBC) are rare, slow-growing, expansible lesions which may be congenital or acquired in origin. Acquired PBC are secondary to middle ear cholesteatoma which has extended medially to the otic capsule and fallopian canal. All require extensive surgical removal in order to avoid recurrence but the different types of extension raise individual diagnostic and therapeutic challenges. Sensorineural hearing loss, vertigo, and facial paresis are common signs of petrous bone cholesteatoma. Facial nerve dysfunction may be present in 30 to 60% of cases and this symptom is often associated with apical extension of the lesion. Disequilibrium and dizziness are symptoms related to labyrinth invasion and erosion. The preoperative radiologic examination in extensive intratemporal cholesteatoma is based on high-definition CT and MRI with gadolinium. The preoperative radiologic assessment is mandatory to distinguish the different routes of intratemporal extension of the cholesteatoma and to select the correct surgical approach. We present our experience of 43 petrous bone cholesteatomas treated surgically in our third referral center between 1994 and 2006, focusing on the preoperatory radiologic assessment, the surgical strategy, and the management of the facial nerve.

Petrous Temporal Bone Cholesteatoma: A New Classification and the Long-Term Results of Surgery

Petrous Temporal Bone Cholesteatoma: A New Classification and the Long-Term Results of Surgery

髄液耳漏を初発症状とした錐体部真珠腫例

A case of petrous bone cholesteatoma with sudden leakage of cerebrospinal fluid (CSF) was encountered. An 82-year-old man complained of sudden chill and left otorrher. Computed tomography of the brain demonstrated a large area of air density in the lateral ventricles. Imaging examinations showed a tumorlike shadow, with extensive bony destruction, located in the petrous bone. Cholesteatoma was removed by a combination of lateral trans-suboccipital and trans-mastoid approaches. At surgery, the cholesteatoma was invading the pons and leakage of cerebrospinal fluid through the internal auditory canal was found. Obliteration with temporal muscle and fibrin glue was performed.

Temporal Bone Cholesteatoma: Surgical Results and Management of the Facial Nerve

Temporal Bone Cholesteatoma: Surgical Results and Management of the Facial Nerve

Petrous Temporal Bone Cholesteatoma: A New Classification and the Long-Term Results of Surgery

Petrous Temporal Bone Cholesteatoma: A New Classification and the Long-Term Results of Surgery

Petrous bone cholesteatoma: clinical longitudinal study

The object of this retrospective study was to describe a series of patients with petrous bone cholesteatomas, paying particular attention to classification, diagnosis, surgical strategy, results, complications and recurrences. Furthermore, the study was designed to evaluate the impact of imaging techniques on an early diagnosis. Topographically, the petrous bone cholesteatomas of the present series were grouped using Sanna's classification and different surgical approaches were used. High resolution CT and/or MRI were used to follow-up the patients. The case notes of 52 patients with petrous bone cholesteatomas who were referred to our hospital for surgery between 1987 and 2003 were reviewed postoperatively. There were 45 primary cases and 7 recurrences. The facial nerve had been infiltrated and compressed by the cholesteatoma in 18 patients. Fourteen were managed with cable grafts using sural nerve or great auricular nerves. About 26 patients with preoperative grade I confirmed their normal facial function in 23 cases. In the other ten patients, the preoperative facial paralysis was due to compression by the cholesteatoma and its removal provided partial recovery of facial function in four patients. Our study compared two observation periods (1987-1996 and 1997-2003) when the diffusion and the availability of imaging techniques in our national health system had considerably increased. Two important factors emerged: firstly, the number of less extensive surgical approaches was higher in the more recent observation period, proving that cholesteatomas smaller in size had been diagnosed. Secondly, preoperative facial paralysis was less frequent in the same period-falling to 25% of cases of total facial paralysis from the 45.8% of the earlier period-practically half as much. The partial paralyses instead increased slightly, demonstrating that otologists have become more sensitive to and pay more attention to this symptom.

Petrous Bone Cholesteatoma: Management and Outcomes

Cholesteatoma of the petrous bone is a rare pathology that grows slowly and is often asymptomatic. High clinical suspect is recommended for its diagnosis. With the advancement of imaging, clinical diagnosis is confirmed and follow up is assured. The present study is presented to state our experience in management of petrous bone cholesteatoma (PBC) and an overview of the outcome results. This study was a retrospective case review conducted at a private quaternary referral center. From January 1984 to October 2004, 93 of 2,739 patients with chronic otitis media with cholesteatoma were treated surgically for PBC with varying location types. The mean age in this study was 46 years. Ninety-four percent of patients presented with hearing loss. Facial paralysis constituted 55% of the presented manifestations and grade VI palsy was the most common. A massive type of PBC was found to affect 45% of patients and it was mainly the acquired pathology. The surgical approaches varied according to the class type of PBC. Postoperative complications were minimal, and follow up was carried out after 1 year from the surgery date. Petrous bone cholesteatoma presents difficulties in its diagnosis and treatment. Adequate history-taking, high clinical suspicious, with the advancement of imaging techniques made its diagnosis more feasible. Improvement of the lateral skull base approaches rendered possible safe, adequate, and complete removal of the pathology.

Petrous Bone Cholesteatoma: Surgical Strategy, Results, and Complications

Petrous Bone Cholesteatoma: Surgical Strategy, Results, and Complications

Intracranial extension of acquired aural cholesteatoma.

Cholesteatoma of the petrous bone extending into the intracranial region is an unusual occurrence. Most cases have been attributed to secondary extension of a primary epidermal blastomatous malformation of the temporal bone into the middle or posterior fossae. Within the past two and a half decades, intracranial extension of acquired aural cholesteatoma has been recognized as a likely alternative to this mechanism. Recent literature has rejoined this observation by considering both primary and secondary cholesteatoma of the petrous bone as a single group, petrosal cholesteatoma. The present study is presented to analyze the clinical presentation, imaging findings, and surgical treatment of six patients with acquired aural cholesteatoma extending into the intracranial region. Findings in this study are compared with the extant literature on congenital and acquired cholesteatoma of the petrous bone. This study proposes that petrosal cholesteatoma is a valid anatomical construct; however, the pathogenesis of petrosal cholesteatoma is still important in understanding the clinical presentation and management of cholesteatoma that extends beyond the usual confines of the middle ear and mastoid. Retrospective case review conducted at a tertiary referral center. From 1985 to 1999, 477 patients were surgically treated for acquired aural cholesteatoma. Patients with intracranial extension of cholesteatoma were studied. Clinical presentation, imaging studies, operative findings, surgical treatment, and postoperative results were evaluated. Six cases in a series of 477 patients with acquired aural cholesteatoma had intracranial extension of disease. In this series, the most frequent pathway for intracranial extension was supralabyrinthine through the supratubal recess into the middle cranial fossa. A less frequent pathway was via the retrofacial air cells into the posterior cranial fossa. Surgical access for removal of intracranial cholesteatoma was accomplished through several approaches including translabyrinthine, transcochlear, retrolabyrinthine, and middle cranial fossa. In two patients who had reoperation for possible residual disease, one was free of residual disease and one was found to have residual cholesteatoma in the region of the horizontal facial nerve. Acquired aural cholesteatoma can extend into either the middle or posterior cranial fossae. In this study, cholesteatoma extended into the middle fossa through the supratubal recess along the labyrinthine facial nerve and into or above the internal auditory canal. A less frequent path is through the retrofacial air cells into the posterior fossa. Intracranial acquired cholesteatoma is generally small and presents with complaints related to underlying otitis media rather than the neurological deficits that are often associated with primary petrous bone cholesteatoma. While computed tomography and magnetic resonance imaging are both required to differentiate congenital petrous cholesteatoma from other lesions of the petrous bone, computed tomography of the temporal bone is usually sufficient to diagnosis and define intracranial extension of acquired aural cholesteatoma. These lesions can be completely excised rather than exteriorized.

Petrous bone cholesteatoma and facial paralysis.

This paper describes a series of patients with a petrous temporal bone cholesteatoma paying particular attention to the complications and their management. Sixteen patients who underwent surgery in our department were reviewed. Topographically, the petrous bone cholesteatomas were grouped into five categories according to the classification proposed by Sanna et al. There were five massive labyrinthine; five infralabyrinthine; one apical; four supralabyrinthine; and one infralabyrinthine-apical. Clinically, the presenting symptom of these lesions were facial nerve paralysis (10 patients) and unilateral deafness (13 patients). Total removal of the cholesteatomas was achieved in all patients using different surgical approaches according to their site and extent. Recurrences were observed in two patients after 8 months and 24 months, respectively. The facial nerve was infiltrated and compressed by the cholesteatoma in eight patients. Seven were managed with cable grafts using sural nerve. One of these patients was treated using a facial-hypoglossal anastomosis because of the failure of the graft. In the remaining patient, a baby-sitter procedure was employed. In the other two patients, the preoperative facial paralysis was due to compression by the cholesteatoma, and its removal allowed partial recovery of facial function. The rationale of the surgical management of petrous bone cholesteatoma is its radical and total removal. Our present policy is to prefer approaches which result in a closed cavity obliterating the eustachian tube and closing the auditory canal as a blind sac. Facial nerve function is the main complication of these lesions, Facial nerve involvement requires rapid management because the duration of the paralysis is directly related to poor recovery of facial function.

Management of petrous bone fractures in children: Analysis of 127 cases : Glarner H.; Meuli M.; Hof E.; Gallati V.; Nadal D.; Fisch U.; Stauffer U.G.J. Trauma (Che) (1994) 36/2 (198–201)

To analyze the pathology and surgical outcomes of lateral skull base (LSB) procedures in a pediatric population.Retrospective case review in a referral skull base center.Charts of pediatric patients who underwent defined LSB procedures from 1983 to 2015 for various pathologies were evaluated at our center. A systematic review of literature was performed and our results were compared with the literature.63 patients presented with 65 diseased ears. The mean age was 13 years. 29 (44.6%) presented with hearing loss and 28 (44.4%) and chronic otorrhea. The most common pathology was petrous bone cholesteatoma (27, 42.5%) followed by vestibular schwannoma (10, 15.8%). Subtotal petrosectomy (24, 35.8%) was the most common surgical procedure followed by, transotic (18, 26.8%). The facial nerve function was preserved in 45 (67.1%) and the hearing in 28 (41.7%) cases respectively. No major complications, including mortality was encountered in our series.In rare and extensive pathologies involving the skull base in a pediatric population, the surgeon is posed with the dilemma of trying to achieve facial and hearing preservation while dealing with total tumor clearance. Mastery over LSB procedures can ensure complete disease clearance with optimal functional outcomes.2b.

Petrous Bone Cholesteatoma

Petrous bone cholesteatoma is a rare pathologic entity and may be a difficult surgical challenge because of potential involvement of the facial nerve, carotid artery, dura mater, otic capsule, and risk of cerebrospinal fluid leak. The objective of this article is to present a personal classification of petrous bone cholesteatomas, a survey of recent surgical attitudes, and our present surgical strategy based on our experience with 54 operations between 1978 and 1990. Radical petromastoid exenteration with marsupialization and the middle cranial fossa approach were used only for small pure infra- or supralabyrinthine cholesteatomas, respectively. The enlarged transcochlear approach with closure of the external auditory canal was used for infralabyrinthine, infralabyrinthine-apical, and massive petrous bone cholesteatomas. Five cases with petrous bone cholesteatomas in different locations are described in detail to present the signs and symptoms together with the management.

Facial Nerve and Medially Invasive Petrous Bone Cholesteatomas

Eight patients with extensive petrous bone cholesteatomas that invaded the labyrinth and fallopian canal are presented. The eight cases are added to a tabulation of prior literature reports to elucidate concepts of routes of extension of medially invasive temporal bone cholesteatoma. Medially invasive petrous bone cholesteatoma develops insidiously, often without symptoms other than facial palsy and/or unilateral deafness. Typically, a history of chronic ear disease can be obtained. While hearing is unlikely to be preserved in this group of patients, facial nerve function can usually be preserved, and a facial nerve graft was not necessary in our series. Acute facial nerve palsy or facial nerve paresis progressing to palsy in patients with a history of chronic ear disease should be studied radiographically for petrous bone cholesteatoma, even if there is no physical evidence of cholesteatoma.

Computed Tomography of Local Complications of Temporal Bone Cholesteatomas

The preoperative temporal bone CT scans of 13 patients with surgically proven acquired cholesteatoma were retrospectively reviewed for bony erosions and for extension beyond the temporal bone. A correlation with the clinical and surgical findings was also carried out. The CT findings are discussed and illustrated as well as some pitfalls in the evaluation of bony erosions. The appearance of "autoantrectomy" caused by a dry, self-cleaning, well ventilated cholesteatoma is also discussed and illustrated.