The present article attempts to describe an assessment of the effects of accumulated permanent service strain on the degree of toughness losses, caused by reverse temper embrittlement (RTE) experienced by large turbine casing bolts during high temperature service. Effectively, it was established that (a) reported studies in this area were scarce, (b) the early work exhibited somewhat contradictory trends while (c) the post 1990 studies indicated that the presence of strain exacerbated the extent of RTE. The few modern day studies suggested that the effects of strain in low alloy steel bolts were greatest at low levels of up to around % ϵ∽0.5% and the trend could be described by the expression: C N= A(% ε) −0.8, where C N was the normalised ambient Charpy energy and A was a scaling coefficient. Also the Charpy fracture appearance transition temperature (FATT) was also shown to increase in proportion to (% ϵ) −0.8. One study has reported an embrittlement constant, termed C RTE, which was a function of grain size and bulk %P in the steel, and whose value determined the likelihood of bolt embrittlement during service, i.e., low values predicted embrittlement with high values indicating non-embrittlement during service. It was reported that strain decreased the value of C RTE. Within the strain range 0.2% to 0.6% one study established that the effects could be described as follows: C RTE =0.35−0.44×(% ε), while at lower strain values another study reported that C RTE=0.0772×(% ε)−0.64. Note that the exponent in the latter expression was similar to that which described the normalised Charpy energy trends. It has been suggested that the total RTE effects, or toughness losses, were the summation of two separate processes, viz., a temperature-time controlled grain boundary phosphorus segregation component and a strain induced grain boundary phosphorus segregation component. The latter was thought to be related to enhanced phosphorus movement along certain dislocation networks, caused by plasticity, to grain boundary locations. Although the data was scarce, it was suggested that the degree of grain boundary segregation by phosphorus during high temperature service increased with increasing levels of strain. This trend between the atomic fraction of grain boundary phosphorus C GB P and accumulated strain was simply described numerically as C GB P=10.54×(% ε) 0.35. Finally, actual bolt strain distributions with service times in real working situations are discussed together with considering both embrittlement and creep damage degradation acting together with time, or accumulated service strain.