Quality of life is one of the criteria currently used to evaluate healthcare interventions. The aim of this study is to assess the relationship between physical activity, nutritional status, and academic performance with the health-related quality of life of adolescents in East Bolaang Mongondow Regency. This research is a correlational study with a cross-sectional approach conducted in junior high schools and high schools in East Bolaang Mongondow Regency in October 2023, with a total sample size of 430. The instrument used in this study is a questionnaire, and the data were analyzed using univariate and bivariate analysis with the Chi-Square test. The results of the study showed that the variable of physical activity had a p-value < 0.05 in the domains of physical health (p=0.000), psychological health (p=0.000), and environment (p=0.000). However, for the social relationships domain, the p-value was > 0.05 (p=0.100). The variable of nutritional status had a p-value < 0.05 in the domains of physical health (p=0.000), psychological health (p=0.002), social relationships (p=0.000), and environment (p=0.000). The academic performance variable had a p-value > 0.05 for all domains. The conclusion of this study is that physical activity is associated with the quality of life in the domains of physical health, psychological health, and environment. Nutritional status is associated with all domains of quality of life, while academic performance is not associated with the quality of life in any domain.
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