Body Weight Categories Research Articles

294 Evaluation of Variation in Nursery Pig Growth Performance Utilizing Different Allotment Strategies

Abstract A total of 720 pigs (200×400, DNA) were used in two 42-day nursery trials (initial BW = 6.20 ± 0.12 kg and 5.63 ± 0.16 kg, respectively) to evaluate multiple strategies for allotting pigs to pens in research. At placement, the population was split into 3 cohorts with similar average BW and standard deviation. Each cohort was randomly assigned 1 of 3 allotment strategies. Strategy 1 (random) utilized a simple randomization strategy with each pig randomized to pen independent of all other pigs. Strategy 2 [bodyweight (BW) distribution] sorted each pig within the cohort into 1 of 5 BW groups. One pig from each weight group was then randomly assigned to pen, such that distribution of BW within pen was uniform across pens. Strategy 3 (BW grouping) sorted pigs within the cohort into 3 BW categories: light, medium, and heavy. Within each BW category, pigs were randomized to pen to create pens of pigs from each BW category. Within each experiment, there were 72 pens with 5 pigs per pen and 24 pens per allotment strategy. For all strategies, once pigs were allotted to pens, pens were allotted to 1 of 2 treatments for a concurrent trial. In Exp. 1, environmental enrichment using ropes tied near the pan of the feeder was compared with a control with no enrichment. In Exp. 2, treatment diets consisted of basal levels of Zn and Cu from the trace mineral premix for the duration of the study (110 and 17 mg/kg, respectively; NC), or diets (PC) with carbadox (50 g/ton; Mecadox, Phibro Animal Health, Teaneck, NJ) fed in phase 1 and 2, pharmacological levels of Zn and Cu (2,414 mg/kg Zn from ZnO; 168 mg/kg Cu from CuSO4) in phase 1 and only Cu (168 mg/kg Cu from CuSO4) in phase 2. There were no meaningful allotment × treatment interactions (P > 0.10) for either study (Table). In Exp. 1, there were no effects of environmental enrichment on growth performance (P > 0.10). In Exp. 2, pigs fed the PC diet had greater (P < 0.001) ADG, ADFI, G:F, and final BW compared with pigs fed the NC diet. The coefficient of variation (CV) within pen between all pens on that allotment strategy and for the entire population of that allotment strategy were calculated for both trials. For between-pen CV, pigs allotted using BW distribution and BW grouping strategies had the least CV at allotment and final weigh day in both trials. Results were used to estimate the replication required with each allotment strategy to obtain significant differences with different percentage responses. Fewer replications are required to discern significant differences in ADG when allotting pigs utilizing BW grouping. However, there is no meaningful difference between allotment strategies in replications required to detect significant differences for G:F.

297 Determining the Effects of Energy Concentrations and Diet Forms on Growth Performance of Nursery Pigs

Abstract Our objective was to determine the effects of two different dietary energy concentrations and diet forms on growth performance of nursery pigs. Barrows and gilts (n = 1,300 PIC337×Camborough, initial BW = 6.7±1.40 kg) were used in a 35-day growth trial with 52 pens in two rooms, 13 pens per treatment, and 25 pigs per pen. At the beginning of the trial, pens within each room were formed by segregating pigs into three body weight (BW) categories and gender, and then randomly allotted to one of four treatments in a randomized complete block design. Pigs were fed in three dietary phases and phase changes occurred based on assigned feed budget (Phase 1: 2 kg/pig, Phase 2: 4 kg/pig, and Phase 3: ad libitum until 35d post-weaning). Treatments consisted of a 2 x 2 factorial arrangement with one factor being the energy concentration of the diets with 2 levels (low and high) and the other factor being the diet form with 2 plans (mash throughout phases 1 to 3 or mash in phase 1 and 2 then pelleted in phase 3). Pellet size was 4 mm, and PDI measurements averaged 84.0 and 83.4% in the low and high energy diets, respectively. Growth performance data were analyzed using a generalized mixed model in Minitab and considered pen as the experimental unit. The statistical model considered fixed effects of BW category, energy, diet form, and their interaction, and random effects of room. All data are reported as least square means and considered statistically significant at P < 0.05. There was no evidence for a significant interaction between energy level and diet form (P > 0.10) for any response criteria. Increasing energy of the diet fed to nursery pigs did not result in significant differences (P > 0.10) in overall average daily gain (ADG; 356 and 367 g/d), average daily feed intake (ADFI; 501 and 510 g/d), or feed efficiency (G:F; 711 and 719 g/kg) between low and high energy, respectively. Feeding a pelleted diet in the last nursery phase resulted in increased (P = 0.004) overall ADG (368 vs 355 g/d), increased (P = 0.018) final BW (19.6 and 19.2 kg), and improved (P = 0.002) overall G:F (727 and 702 g/kg) compared with pigs fed mash diets throughout the entire nursery period. There was no evidence for differences in ADFI due to diet form. In addition, no evidence for treatment differences were observed for overall removal and mortality rates. In conclusion, under the conditions of this study, there was no evidence for an energy impact in nursery pig growth performance. Feeding a pelleted diet in the last nursery phase resulted in improvements in overall ADG, G:F, and final BW of nursery pigs.

229 Effect of Two Sources of Zinc on Growth Performance and Gut Health of Piglets with a Low or Normal Birth Weight

Abstract Zinc (Zn) is an essential trace element for piglets. The study aimed to compare effects of two Zn sources on piglets divided into two body weight (BW) categories. At birth, piglets were weighed and divided into low BW (LBW < 1 kg) or normal BW (NBW > 1 kg). At weaning (25 days of age, d 0), 64 piglets were divided into 4 groups (8 replicates of 2 piglets/group) as follows: 1) LBW piglets fed a standard diet plus 120 ppm of Zn from ZnSO4, 2) NBW piglets fed a standard diet plus 120 ppm of Zn from ZnSO4 (CO), 3) LBW piglets fed standard diet plus 120 ppm of Zn from a potentiated Zn source (HiZox, HZ), and 4) NBW piglets fed a standard diet plus 120 ppm of Zn from a potentiated Zn source HZ. Growth performance was measured at d 0, d 9, d 14, and d 21. The fecal index was recorded daily. On d 9 and d 21, one piglet per replicate was slaughtered. Blood and gut tissue were collected to evaluate the immune and inflammatory status of the piglets. The groups were arranged using a 2 x 2 factorial design, considering the class of birth BW (LBW and NBW) and the diet (CO and HZ). For the diarrhea index, a generalized linear mixed model fitting a Poisson distribution was used. Other variables were analyzed with a linear mixed model, in which the diet, class of BW and their interaction were included as fixed factors and litter of origin was included as a random factor. Piglets from the NBW group had consistently greater BW throughout the study (P < 0.01) than LBW piglets. The treatment HZ tended to improve BW gain from d 0 to d 9 and from d 9 to d 14 (P < 0.10), and significantly influenced the G:F ratio (P < 0.05). The fecal index was decreased by HZ from d 0 to d 14, and from d 0 to d 21 (P < 0.01), particularly for LWB piglets (P-interaction < 0.01). Haptoglobin and reactive oxygen metabolites decreased from d 9 to d 21 (P < 0.01) in serum. Expression of the NFKB-2 gene was less in NBW piglets than in LBW piglets and in HZ groups. In conclusion, potentiated Zn positively influenced the growth performance of LBW and NBW piglets.

108 Effects of Yeast Carbohydrates Fed to Lactating Sows on Sow and Offspring Performance

Abstract The objective of this study was to determine the optimal inclusion level of a yeast carbohydrate (YC) product in sow diets based on sow and suckling piglet performance. Forty-nine sows and gilts (Parity 0 to 5; 217 ± 30 kg) were randomly assigned to one of three YC supplementation levels (0%, 0.1%, and 0.2% of diet) in late gestation beginning at d 105 and lactation. Yeast carbohydrate was top-dressed using corn as a carrier to achieve daily active ingredient intake of 3 and 6 g/d in gestation (0.1 and 0.2% YC, respectively) and 7 and 15 g/d in lactation (0.1 and 0.2% YC, respectively) at the 0730 and 0800 h feed time in gestation and lactation, respectively. Variables measured included: sow body weight (BW), backfat (BF), feed intake (ADFI), litter characteristics at birth, piglet BW, piglet weight distribution at birth and weaning, and serum, colostrum, and milk immune status. Sows supplemented with 0.2% YC had 0.95 less stillborn pigs compared with control and 0.1% YC treatment groups (P = 0.04). Total born, born alive, and farrowing duration did not differ among treatment groups. The 0.2%YC treated sows weaned 1.04 more pigs (P = 0.09) than control and 0.1%YC groups. Colostral immunocrit ratio tended to be greater in 0.2%YC sows compared with control sows (P = 0.09; 0.66 vs 0.48 in 0.2%YC and control, respectively). Control litters had 14.9% greater proportion of light weight pigs at birth (< 1.20 kg) and both YC groups had 12.4% greater proportion of average weight pigs (1.20 to 1.65 kg; P < 0.01). Pig BW at weaning (5.96 vs 5.77 vs 5.61 kg in control, 0.1 and 0.2%, respectively) and overall ADG (0.24 vs 0.22 vs 0.22 kg/d in control, 0.1 and 0.2%, respectively) were greater in control group (P ≥ 0.05). The 0.2% YC group had a 3.7% and 10.4% greater frequency (χ2 < 0.01) of weaning light weight (< 5.00 kg) and average weight (5.00 to 6.40 kg) pigs, respectively. The YC groups both had greater frequency of pigs that fell into lighter BW categories between birth to weaning (2.9 vs 27.3 vs 25.9% in control, 0.1% and 0.2%, respectively; χ2 < 0.01). There was a 15.6% ldecreased pre-weaning mortality of light born pigs in 0.2% YC group compared with control and 0.1% YC groups (χ2 = 0.03). Suckling pigs from sows in the 0.2% YC group had a greater (P = 0.03) concentration of serum IgA at weaning (23.47 vs 23.83 vs 31.63 μg/mL in control, 0.1, and 0.2%, respectively). In conclusion, 0.2% YC supplementation in sow diet benefited both sow and litter performance with the capacity to wean more light born pigs as well as a greater colostral immunocrit ratio and offspring IgA concentrations at weaning.

Growth, sex reversal pattern, and reproductive characteristics of Barramundi (Lates calcarifer) broodstock candidates reared in floating cages

Sex reversal of male to female is a characteristic of barramundi (Lates calcarifer), which is affected by several factors, thereby changing the broodstock population. A study was conducted in floating cages in Langkawi, Malaysia, to determine the weight point at the onset of the sex reversal phenomena. A total of 75 female and 55 male adult individuals (3–4 weeks of age) were sampled from the fish cultured in cages to ascertain their sex at different weights. The water temperature and salinity values were 29.82 °C and 33.12 ppt, respectively. The specimens were classified into twelve bodyweight classes (2.00–8.00 ± 0.5 kg intervals). Female specimen body weight distribution was highest in the 6.01–6.50 kg class (22.6%), followed by the 5.51–6.00 kg and 4.51–5.00 class (13.3%), while male specimen body weight distribution was highest in the 4.51–5.00 kg class (32.1%), followed by the 4.01–4.50 kg class (30.3%). Length-to-weight relationships for females and males of Asian Seabass indicated positive allometric growth. The correlation between body weight and GSI, using Pearson’s correlation, for both sexes, for the male and female barramundi, there was a weak correlation between body weight and GSI, which was 37 and 30%, respectively. Based on the present study’s findings, it can be concluded that sex reversal from male to female in Barramundi largely occurred at 4.57 kg body weight and 66.8 cm total length.

Rapid Weight Loss Practices Within Olympic Weightlifters.

Gee, TI, Campbell, P, Bargh, MJ, and Martin, D. Rapid weight loss practices within Olympic weightlifters. J Strength Cond Res 37(10): 2046-2051, 2023-Rapid weight loss (RWL) practices are common among athletes to "make weight" for a chosen bodyweight class. This study's purpose was to investigate RWL prevalence, magnitude, and methods within Olympic weightlifters from Great Britain. Subjects (n = 39, male = 22, female = 17) were recruited from International Weightlifting Federation lifting populations (mandatory two-hour competition weigh-in). Subjects were categorized into competitive groups based on Sinclair coefficient total (high, mid, low) and also gender (male, female). The validated Rapid Weight Loss Questionnaire was used to establish RWL magnitude and practices. Of respondents, 33 of 39 (84.6%) had purposely acutely reduced body mass to compete, a higher proportion present within females (94.1%) than males (77.3%). The cohort's mean habitual precompetition acute body mass loss was 3.8 ± 1.7% and the "rapid weight loss score" (RWLS) was 23.6 ± 9.5. Across competitive groups there were no significant differences in habitual or highest precompetition body mass loss, postcompetition body mass gain or RWLS (p > 0.05). However, females attributed a significantly greater "highest" relative precompetition body mass loss compared with males (7.4 vs 4.9%, p = 0.045). For RWL methods used, frequencies of "always" and "sometimes" were reported highest for "restricting fluid ingestion" (81.8%), "gradual dieting" (81.8%), and "water loading" (54.5%). The prevalence of RWL is high among competitive Olympic weightlifters, and especially within the sampled female athletes. Magnitude of RWL was similar across different standards of athlete; however, female lifters demonstrated a higher maximum precompetition RWL.

Effect of Rye for Transition Sows on the Level of Piglet Serum Immunoglobulin Immunocrit

A sustainable increase in livestock productivity cannot be achieved without the use of sustainable animal feed. Due to the growing awareness of the long-term benefits of sustainability, there is an increasing interest in replacing traditional feed resources with the most sustainable feedstuffs in pig production. Rye production is relatively sustainable compared to wheat. This farm study investigated whether the newborn body weight as well as antibody transfer in piglets (serum immunoglobulin immunocrit) are affected by feeding rye instead of wheat grain to transition sows. A total of 237 sows and their piglets (n = 711) from three farms located in northern Germany participated in this study. During the transition period, the sows were fed either a wheat-based diet used as the control diet (CON) or a 30% rye diet (RYE) for 7 days before the calculated farrowing date. On the day of farrowing, piglet body weights within 24 h post-natal (PN) were recorded, and blood samples were taken from the lightest, medium, and heaviest piglets in each litter to determine the quantification of immunoglobulins in the piglets. Feeding rye-based diets to the sows showed no differences in the body weight of the newborns (within 24 h) compared to the CON group in all body weight categories, except on Farm C in light and medium piglets, where high BW were observed in the CON group. The immunocrit ratio did not show any differences between both feeding groups. A relationship between newborn body weight and immunocrit ratios in the CON and the RYE groups was observed only on farm A. Overall, this study showed that including amounts of rye up to 30% in sows’ diets during the transition period had no negative effects on newborn piglet body weight or on antibody transfer and therefore can be considered an adequate replacement for wheat (up to 30%) in diets for transition sows. However, future research is needed to determine whether a higher proportion of rye may be used.

Association between glomerular filtration rate and plasma N-terminal pro-atrial natriuretic peptide concentration in dogs.

To investigate the association between plasma N-terminal pro-atrial natriuretic peptide concentration and glomerular filtration rate in dogs. Dogs were classified into four categories by bodyweight. Dogs were divided into four groups (Groups 1 to 4) based on glomerular filtration rate estimates using plasma iohexol clearance per bodyweight category. Generalised linear models were built to explore the relationship between plasma N-terminal pro-atrial natriuretic peptide concentration and glomerular filtration rate and the effect of confounders on plasma N-terminal pro-atrial natriuretic peptide concentration. Fifty-three dogs were included (Group 1, 25; Group 2, seven; Group 3, five; and Group 4, 16). The medians (interquartile range) N-terminal pro-atrial natriuretic peptide concentrations for Groups 1 to 4 were 7224 pg/mL (4766 to 10,254 mg/dL), 8958 pg/mL (4935 to 11,271 mg/dL), 9280 pg/mL (9195 to 10,384 mg/dL) and 12,683 pg/mL (9133 to 19,217 mg/dL), respectively. Group 4, estimated to have the highest reduction in glomerular filtration rate, had a higher plasma N-terminal pro-atrial natriuretic peptide concentration than Groups 1 to 3. Based on the final generalised linear model, influencing factors for plasma N-terminal pro-atrial natriuretic peptide concentration were plasma iohexol clearance (-0.136; 95% confidence interval, -0.227 to -0.046) and bodyweight (-0.058; 95% confidence interval, -0.098 to -0.018). N-terminal pro-atrial natriuretic peptide concentration is associated with the glomerular filtration rate.

Suckling Behaviour of Piglets Affected by Body Weight and Sex

Piglet suckling behaviour has been extensively studied, but surprisingly, there are not many studies that specifically consider body weight and sex in this context. These two basic individual characteristics have been considered more as supporting data but not as main factors. Therefore, the objective of the present research was to examine the effect body weight on suckling behaviour of piglets during lactation separately by sex. The study comprised 14 litters with a total of 158 piglets (85 male, 73 female, litter size 6−15 piglets). Suckling behaviour was described in terms of suckling position (the teat at which the piglet suckled during suckling), suckling territory (the range two outermost suckling positions of the piglet encompasses) and sucklingstability (the tendency to suckle successively at the same position), and was observed in six periods: 0−3, 4−7, 8−10, 11−14, 15−21 and 22−32 days of age. In each period, piglets were also weighed. The udder was divided into three areas: anterior (1st-2nd teat pair), middle (3rd-5th teat pair) and posterior (6th-8th teat pair). Body weight affected suckling behaviour differently in male and female piglets (i.e., all traits in females, suckling stability only in males). The relative body weight of females decreased significantly from the anterior towards the posterior part. Heavy females (but not males) suckled considerably more frequently on the anterior area. Heavier piglets (male and female) established more stable suckling order. Suckling territory of males was quite large, but did not differ among body weight classes. Interestingly, light females visited significantly larger suckling territory than heavy females. The present results fill a gap in the otherwise broad knowledge of pig suckling behaviour, which is of great importance for litter management during lactation, especially when cross-fostering is implemented. In this context, knowledge of the detailed role of sex and body weight is of particular importance because breeders rely mainly on basic body traits when managing litters.

Life expectancy of mesocephalic, dolichocephalic and brachycephalic dog breeds in Switzerland

Lifespan and time of death of dogs died in Switzerland between 2016 and 2020 were evaluated in order to increase the awareness of the public to animal welfare-related consequences of extreme brachycephalic breeding and to clarify the torture breeding problem of dogs suffering from brachycephalic obstructive airway syndrome (BOAS). Skull shape, body size, country of origin and altitude of the registered place of residence at the time of death were analysed in a set of anonymized data from the national animal database Amicus as potential factors influencing the life expectancy. Death rate during summer months and the altitude of the reported place of residence at death were analysed in relation to the skull shape to demonstrate the heat intolerance of brachycephalic dog breeds. The final dataset included 137 469 dogs. The average age of death of the study population was 11,8 years, mixed breeds reaching a higher average age of 12,4 years than purebred dogs with 11,5 years. Bodyweight classification, skull shape and the origin of the dogs had a significant effect on the average lifespan. Giant breeds reached with 9,0 years the lowest mean age compared to the other bodyweight categories. The mean life expectancy of brachycephalic dogs was 9,8 years, i.e., 2,1 and 1,7 years less than mesocephalic and dolichocephalic dogs, respectively. Brachycephalic dogs and dogs imported from abroad showed increased mortality at a young age.

The study of relative age effects on weightlifting athletes in U15 and youth age groups

Within the sporting scope, the relative age effects refer to the possible advantages of participation and performance of athletes born in the first months of the year of selection in relation to others within the same age groups. The aim of this study was to investigate the relative age effects by comparing athletes in different body weight categories in the Under 15 (U-15) and youth age group athletes (males and females) in weightlifting. By using retrospective competition data from the Turkish Weightlifting Federation database, a total of 954 Olympic-style weightlifters (U15 and Youth age groups), 605 males and 349 females), who competed in the Turkish Weightlifting Championships between 2018 and 2019, were included in this study. The data on the birthdates of the athletes were divided into four quarters. The athletes were divided into three subset weight classes. The data were analyzed using the chi-square test. In males, the relative age effects were determined in lightweight athletes in the under 15 age group (χ²(3)= 10.00, p< .05), in lightweight athletes in the youth age group (χ²(3)= 10.83, p< .05), in middleweight category (χ²(3)= 14.09, p< .01) and heavyweight category (χ²(3)= 12.96, p< .01). However, relative age effects were not present in the female under 15 age group (p>.05). It can be stated that weightlifting athletes, under 15 age and youth age groups (except youth females), born in the first quarter of the year have a higher chance of success in athletic performance.

Ravulizumab pharmacokinetics and pharmacodynamics in patients with generalized myasthenia gravis

IntroductionThe terminal complement C5 inhibitor ravulizumab has a long elimination half-life, allowing maintenance dosing every 8 weeks. In the 26-week, double-blind, randomized, placebo-controlled period (RCP) of the CHAMPION MG study, ravulizumab provided rapid and sustained efficacy and was well tolerated in adults with anti-acetylcholine receptor antibody-positive (AChR Ab+) generalized myasthenia gravis (gMG). This analysis evaluated the pharmacokinetics (PK), pharmacodynamics (PD), and potential immunogenicity of ravulizumab in adults with AChR Ab+ gMG.MethodsData were analyzed from 86 patients who received ravulizumab in the CHAMPION MG RCP. Ravulizumab dosing was weight-based: initial loading dose of 2400/2700/3000 mg on Day 1 and maintenance doses of 3000/3300/3600 mg on Day 15 and then every 8 weeks. PK parameters were estimated from serum ravulizumab concentrations determined pre- and post-dose; PD effects of ravulizumab on serum free C5 concentrations were measured; and immunogenicity was assessed using anti-drug antibody and neutralizing-antibody assays.ResultsTarget serum ravulizumab concentrations (> 175 µg/mL) were achieved immediately after the first ravulizumab dose (within 30 min of infusion completion) and maintained throughout the 26-week treatment period irrespective of patient body weight. Following the final maintenance dose, mean Cmax was 1548 µg/mL and Ctrough 587 µg/mL; no meaningful differences were noted among body-weight categories. Inhibition of serum free C5 was immediate, complete (< 0.5 μg/mL), and sustained throughout treatment in all patients. No treatment-emergent anti-drug antibodies were observed.ConclusionsPK/PD evidence supports the use of ravulizumab every 8 weeks for immediate, complete, and sustained inhibition of terminal complement C5 in adults with AChR Ab+ gMG.Trial registrationClinicalTrials.gov ID: NCT03920293 (April 18, 2019).

RELATIVE RISK OF DIABETES MELLITUS AMONG OBESE POPULATION

Objective: Diabetes is more prevalent mainly in Asian population, but the incidence proportion and likelihood are still unknown due to lack of evidence and proper research, therefore in this research paper the main aim is to assess the relative risk of diabetes mellitus in obese people in Pakistan. Methodology: A case control study was conducted on 233 participants including diabetic and non-diabetic. The participants were approached from different clinics and hospitals from Nov 2021 to April 2022 using convenient sampling technique. Participants’ age, body mass index and weight category were measured. The odds and relative risk ratio were calculated for diabetic patients in obese people. Results: It was found that among the obese population, the odds of having diabetes were 3.85 times greater than that of non-obese adults whereas relative risk was also found to 2.17 times higher than that of non-obese population with the p-value &lt;0.05. Conclusions: The prevalence of obesity is higher in diabetic population as compared to non-diabetic individuals. This increases the chances of developing diabetes in obese population as compared to the individuals with normal weight.

Hipertenzija kod dece i adolescenata

Until recently, secondary hypertension used to be the most common form of hypertension in the paediatric population. Due to the increasing prevalence of obesity-related hypertension in children and adolescents, the share of secondary hypertension has decreased from 85% to 9%. Today, primary hypertension has become the dominant form of hypertension in the paediatric population. The purpose of this paper is to show the prevalence of various forms of hypertension and the prevalence of primary hypertension in children and adolescents relative to sex, age and body weight category in the General Hospital "Dr. Laza K. Lazarević" in Šabac. In children with secondary hypertension, the impact of body weight was not assessed since an organic cause of hypertension had been identified in these patients. All children from the age of a new-born to the age of 18 years with a diagnosis of hypertension (International Classification of Diseases, tenth revision (IDC-10), code I10-I15) in the period from 1 January 2013 to 31 December 2022 were selected from the medical digital database. This analysis included all children who showed blood pressure values above 95th percentile for age, sex and height in children under 13 and above 120/80 mmHg in children over 13, upon repeated measurements of blood pressure in the General Hospital, who were presumed to have hypertension. These children were referred to further evaluation at tertiary healthcare institutions, where a diagnosis of hypertension was made. Of the 134 children referred to the General Hospital due to elevated blood pressure levels measured in the primary care physician's office, hypertension was diagnosed in almost one in four subjects (24.6%). Primary hypertension was diagnosed in 18 (54.5%), secondary hypertension in 8 (24.2%) and white coat hypertension in 7 (21.2%) children. Primary hypertension was more common in boys (70.6%) than girls (37.5%). Among children with primary hypertension, overweight and obese children represented 66.7% of the group at the time of diagnosis. Statistical data analysis did not find a statistically significant difference in the prevalence of primary hypertension among the body weight or age categories. Since primary hypertension is the most significant and potentially reversible factor for the development of cardiovascular disease, early detection and treatment of primary hypertension in children is crucial in the prevention of cardiovascular disease in adults.

Temperatura, pH e comprimento de sarcômero de Caiman yacare em diferentes categorias de peso corporal ao abate

ABSTRACT The objective of this work was to characterize the internal temperature of the carcass, pH and sarcomere length in four categories of body weight at a slaughter. The categories were: category 1, animals up to 1.5 kg, category 2, animals from 1.501 to 2.5 kg, category 3, animals from 2.501 to 3.5 kg and category 4, animals over 3.501 kg. The time intervals evaluated were 0.5, 2, 4, 6, 8, 10, 12, 14, 16, 18, 24 and 36 hours after bleeding, therefore, a factorial scheme (4 x 12) was used, in which where four categories of pre-slaughter weight and the behavior of the carcasses during the post-slaughter time were evaluated. There was no interaction effect between the weight categories and the time for the variation of the carcass internal temperature, pH and sarcomere length, but when only the time of rigor was evaluated, there were significant differences for the analyzed parameters. The internal temperature of the initial average carcass (0.5 hours) was 16.02°C, reaching 3.80°C at 36 hours post-slaughter. In addition, the lowest average pH found was at 24 hours, with a value of 5.39. Regarding the sarcomere length, the smallest mean length observed was 1.41 µm at 16 hours post-slaughter and the final mean length (36 hours) was 1.89 µm. It was concluded that the analyzed margin of the categories of body weight at slaughter did not interfere in the variation of temperature, pH and sarcomere length during the post-mortem of the Pantanal caiman.

Effects of providing sensory attractants to suckling pigs during lactation and after weaning on post-weaning growth performance.

Three experiments were conducted to determine the effect of sensory attractants pre- and post-weaning on the growth performance of pigs after weaning. For each experiment, treatments were arranged as a 2 × 2 × 2 factorial with main effects of pre-weaning application (without or with), post-weaning application (without or with), and body weight category (representing the lightest or heaviest 50% of the population). In Exp. 1, 356 nursery pigs (initially 5.7 kg) were used in a 28-d trial with enrichment cubes used as the sensory attractant. A greater percentage of heavy pigs (P = 0.007) or pigs offered enrichment cubes pre-weaning (P = 0.044) lost BW from weaning to d 3 compared to light pigs or pigs not offered enrichment cubes pre-weaning. From weaning to d 7, a greater percentage of pigs lost weight when not offered cubes post-weaning (P = 0.002) compared to pigs offered cubes post-weaning. In Exp. 2, 355 nursery pigs (initially 5.6 kg) were used in a 29-d trial with a powder used as the sensory attractant. Providing a powder attractant both pre- and post-weaning reduced the percentage of pigs that lost weight from weaning to d 3 as compared with providing a powder either pre- or post-weaning only (interaction, P < 0.05). In Exp. 3, 355 nursery pigs (initially 5.9 kg) were used in a 24-d trial with a liquid spray used as the sensory attractant. A greater percentage of heavy pigs that did not receive liquid attractant lost weight from weaning to d 3, whereas a greater percentage of light pigs lost weight when they received liquid attractant only pre-weaning (three-way interaction; P = 0.016). Across all three experiments, sensory attractant application had limited effects on the growth performance of pigs after weaning; however, varying responses were observed for the percentage of pigs that lost weight in the first 3 to 7 d immediately post-weaning. In summary, environmental enrichment with cubes (Exp. 1) appears to have the greatest effect when applied post-weaning whereas flavor attractants (Exp. 2 and 3) appear to have the greatest effect when applied both pre- and post-weaning.

Associations of decayed teeth and localized periodontitis with mental stress in young adults: CHIEF oral health study

The associations of mental stress with decayed teeth in children and periodontitis in old-aged adults have been described. However, the associations for young adults were not clear. This study aimed to examine the associations of decayed teeth and localized periodontitis with mental stress in young adults. This study included 334 military recruiters, aged 19–45 years in Taiwan. Mental stress was assessed by the brief symptom rating scale-5 (BSRS-5), including five domains: anxiety, depression, hostility, interpersonal sensitivity and insomnia (maximum score of 20). Those with symptomatic mental stress were defined as having BSRS-5 > 5 (n = 34). Multiple linear and logistic regression models were used to determine the associations of decayed tooth numbers and periodontitis with BSRS-5, with adjustments for age, sex, education level, physical activity, body weight category and smoking status. The BSRS-5 was positively correlated with decayed tooth numbers [β: 0.26 (95% confidence interval: 0.01–0.52)]. Those who had more than two decayed teeth [odds ratio: 3.59 (1.52–8.46)] had a higher risk of symptomatic mental stress. In contrast, the correlation between BSRS-5 and localized severer periodontitis was null. Our study recommended that decayed teeth instead of localized periodontitis, was a risk factor for mental stress in young adults.

LBSAT229 Extended-release Calcifediol Effectively Raised 25-hydroxyvitamin D In CKD Despite Obesity

Abstract Inadequate levels of serum total 25-hydroxyvitamin D (25D) in chronic kidney disease (CKD) are associated with an increased risk of secondary hyperparathyroidism (SHPT). Serum 25D can be difficult to raise sufficiently with vitamin D supplements (cholecalciferol or ergocalciferol) to effectively lower elevated parathyroid hormone (PTH) levels especially in overweight patients. Obesity is common in CKD and requires attention when vitamin D repletion is considered. Vitamin D supplements are fat-soluble molecules which accumulate in adipose tissue. They have low affinity for serum vitamin D binding protein and are poorly mobilized from adipose tissue into circulation for hepatic activation. Recent studies suggest that serum 25D levels of ≥50 ng/mL are necessary to produce significant PTH reductions in nondialysis patients. Data were analyzed from two identical randomized clinical trials investigating the efficacy and safety of treating adult nondialysis patients with extended-release calcifediol (ERC; n=285) or placebo (n=144) to see if ERC raised 25D to at least 50 ng/mL in all body weight categories, with subgroup analyses by race, gender and age. On enrollment, subjects had eGFR of ≥15 and &amp;lt;60 mL/min/1.73 m2, PTH ≥85 and &amp;lt;500 pg/mL, serum 25D ≥10 and &amp;lt;30 ng/mL, corrected serum calcium ≥8.4 and &amp;lt;9.8, serum phosphorus ≥2. 0 and &amp;lt;5. 0, absence of nephrotic range proteinuria (&amp;gt;3 mg/mg creatinine) and no history of parathyroidectomy or renal transplantation. These subjects had mean (SD) age of 65.4 (10.9) years, serum 25D at baseline of 19.6 (5.4) ng/mL, body weight of 97.8 (24.3) kg and BMI of 34.7 (7.9) kg/m2. Fifty percent were male, 64. 0% White, 32.9% African-American or Black, and 3.1% Other, and 20% were Hispanic. A total of 356 subjects completed a 20- to 26-week treatment period per-protocol and were included in the analysis. Enrolled subjects ingested a 30 mcg capsule of ERC (OPKO Pharmaceuticals, Miami) daily for 12 weeks followed by one or two capsules (30 or 60 mcg) daily for a 14 more weeks. Control subjects received matching placebo. Mean (SD) serum 25D remained unchanged with placebo treatment but rose progressively with ERC treatment to 67.1 (21.6) ng/mL (mean of weeks 20-26). The observed increases in serum 25D were inversely related to body weight but exceeded 50 ng/mL in all body weight categories, irrespective of race (White vs. African-American or black), gender or age (&amp;lt;70 vs. ≥70 years). Side effects observed at these levels were similar to placebo. These data showed that ERC successfully raised mean serum 25D to at least 50 ng/mL irrespective of body weight, race, gender or age. Presentation: Saturday, June 11, 2022 1:00 p.m. - 3:00 p.m.

A comparative study of trait anxiety between female weightlifters and powerlifters

The aim of the study was to compare and wanted to see the sports competition anxiety between weightlifting and powerlifting. Sixty-eight female weightlifters and powerlifters (4 from each body weight category) who had participated in weightlifting and Powerlifting All India Inter University competition were selected as subject for the study. The participants were between the ages of 18 to 25. The Sports Competition Anxiety Test (SCAT) questionnaire designed by Martin (1990) was employed in this study. According to the literature review and researchers knowledge it was hypothesized that there might be significant difference between female weightlifters and powerlifters. For the analysis of the data independent‘t’ test was applied. The significant difference threshold was chosen at 0.05. There was no substantial difference between weightlifters and power lifters, according to the study's findings.

Risk variants of obesity associated genes demonstrate BMI raising effect in a large cohort.

Obesity is highly polygenic disease where several genetic variants have been reportedly associated with obesity in different ethnicities of the world. In the current study, we identified the obesity risk or protective association and BMI raising effect of the minor allele of adiponectin, C1Q and collagen domain containing (ADIPOQ), cholesteryl ester transfer protein (CEPT), FTO alpha-ketoglutarate dependent dioxygenase (FTO), leptin (LEP), and leptin receptor (LEPR) genes in a large cohort stratified into four BMI-based body weight categories i.e., normal weight, lean, over-weight, and obese. Based on selected candidate genetic markers, the genotyping of all study subjects was performed by PCR assays, and genotypes and allele frequencies were calculated. The minor allele frequencies (MAFs) of all genetic markers were computed for total and BMI-based body weight categories and compared with MAFs of global and South Asian (SAS) populations. Genetic associations of variants with obesity risk were calculated and BMI raising effect per copy of the minor allele were estimated. The genetic variants with higher MAFs in obese BMI group were; rs2241766 (G = 0.43), rs17817449 (G = 0.54), rs9939609 (A = 0.51), rs1421085 (C = 0.53), rs1558902 (A = 0.63), and rs1137101 (G = 0.64) respectively. All these variants were significantly associated with obesity (OR = 1.03-4.42) and showed a high BMI raising effect (β = 0.239-0.31 Kg/m2) per copy of the risk allele. In contrast, the MAFs of three variants were higher in lean-normal BMI groups; rs3764261 A = 0.38, rs9941349 T = 0.43, and rs7799039 G = 0.40-0.43). These variants showed obesity protective associations (OR = 0.68-0.76), and a BMI lowering effect per copy of the protective allele (β = -0.103-0.155 Kg/m2). The rs3764261 variant also showed significant and positive association with lean body mass (OR = 2.38, CI = 1.30-4.34). Overall, we report six genetic variants of ADIPOQ, FTO and LEPR genes as obesity-risk markers and a CETP gene variant as lean mass/obesity protective marker in studied Pakistani cohort.