Body Weight-supported Treadmill Training Research Articles

Effect of EMG-biofeedback robotic-assisted body weight supported treadmill training on walking ability and cardiopulmonary function on people with subacute spinal cord injuries \u2013 a randomized controlled trial

BackgroundBody weight supported treadmill training (BWSTT) is a frequently used approach for restoring the ability to walk after spinal cord injury (SCI). However, the duration of BWSTT is usually limited by fatigue of the therapists and patients. Robotic-assisted body weight supported treadmill training (RABWSTT) was developed to tackle the aforesaid limitation. Currently, limited randomized controlled trials are available to investigate its effectiveness, especially on cardiopulmonary function. The aim of this two-arm, parallel-group randomized controlled trial is to examine the feasibility of adapting an EMG-biofeedback system for assist-as-needed RABWSTT and its effects on walking and cardiopulmonary function in people with SCI.MethodsSixteen incomplete SCI subjects were recruited and randomly allocated into an intervention group or control group. The intervention group received 30 min of RABWSTT with EMG biofeedback system over the vastus lateralis muscle to enhance active participation. Dose equivalent passive lower limbs mobilization exercise was provided to subjects in the control group.ResultsSignificant time-group interaction was found in the Walking Index for Spinal Cord Injury version II (WISCI II) (p = 0.020), Spinal Cord Independence Measure version III (SCIM III) mobility sub-score (p < 0.001), bilateral symmetry (p = 0.048), maximal oxygen consumption (p = 0.014) and peak expiratory flow rate (p = 0.048). Wilcoxon signed-rank test showed that the intervention group had significant improvement in the above-mentioned outcomes after the intervention except WISCI II, which also yielded marginal significance level.ConclusionThe present study demonstrated that the use of EMG-biofeedback RABWSTT enhanced the walking performance for SCI subjects and improve cardiopulmonary function. Positive outcomes reflect that RABSTT training may be able to enhance their physical fitness.Trial registrationThe study protocol was approved by the Research Ethics Committee (Kowloon Central/ Kowloon East), Hospital Authority on 6 December 2013, and the Human Subjects Ethics Sub-committee of The Hong Kong Polytechnic University on 15 May 2013, with reference numbers KC/KC-13-0181/ER-2 and HSEARS20130510002 respectively. The study was registered in ClinicalTrials.gov on 20 November 2013, with reference number NCT01989806.)

A Randomized and Controlled Crossover Study Investigating the Improvement of Walking and Posture Functions in Chronic Stroke Patients Using HAL Exoskeleton - The HALESTRO Study (HAL-Exoskeleton STROke Study).

Background: The exoskeleton HAL (hybrid assistive limb) has proven to improve walking functions in spinal cord injury and chronic stroke patients when using it for body-weight supported treadmill training (BWSTT). Compared with other robotic devices, it offers the possibility to initiate movements actively. Previous studies on stroke patients did not compare HAL-BWSTT with conventional physiotherapy (CPT). Therefore, we performed a crossover clinical trial comparing CPT and HAL-BWSTT in chronic stroke patients with hemiparesis, the HALESTRO study. Our hypothesis was that HAL-training would have greater effects on walking and posture functions compared to a mixed-approach CPT.Methods: A total of 18 chronic stroke patients participated in this study. Treatment consisted of 30 CPT sessions and of 30 sessions of BWSTT with a double leg type HAL exoskeleton successively in a randomized, crossover study design. Primary outcome parameters were walking time and speed in 10-meter walk test (10MWT), time in timed-up-and-go test (TUG) and distance in 6-min walk test (6MWT). Secondary outcome parameters were the functional ambulatory categories (FAC) and the Berg-Balance Scale (BBS). Data were assessed at baseline, at crossover and at the end of the study, all without using and wearing HAL.Results: Our study demonstrate neither a significant difference in walking parameters nor in functional and balance parameters. When HAL-BWSTT was applied to naïve patients, it led to an improvement in walking parameters and in balance abilities. Pooling all data, we could show a significant effect in 10MWT, 6MWT, FAC and BBS, both therapies sequentially applied over 12 weeks. Thereby, FAC improve from dependent to independent category (3 to 4). One patient dropped out of the study due to intensive fatigue after each training session.Conclusion: HAL-BWSTT and mixed-approach CPT were effective therapies in chronic stroke patients. However, compared with CPT, HAL training with 30 sessions over 6 weeks was not more effective. The combination of both therapies led to an improvement of walking and balance functions. Robotic rehabilitation of walking disorders alone still lacks the proof of superiority in chronic stroke. Robotic treatment therapies and classical CPT rehabilitation concepts should be applied in an individualized therapy program.

IMPACT OF BODY WEIGHT SUPPORT TREADMILL TRAINING ON GAIT RECOVERY OF INDIVIDUALS WITH STROKE

Background: Restoration of independent gait in stroke patients is an essential part of the rehabilitation process, and is crucial for successful social and vocational reintegration. Gait restoration requires different techniques, and often demands considerable assistance from the therapist to help the subject support body weight and control balance. Considering that ground level is the most common locomotion surface, and that there is little information about individuals with stroke walking with body weight support treadmill training (BWSTT), it is important to investigate the use of BWSTT on ground level in these individuals to improve gait recovery. &#x0D; Methods: Sixty-nine subjects were assigned to this experiment, of which twenty-six were normal subjects and forty-three were stroke subjects, who were randomly divided into two groups; twenty-one subjects for the control group, and twenty-two subjects for the experimental group. The control group underwent regular rehabilitation care plus conventional gait training, while the experimental group underwent regular rehabilitation care plus BWSTT.&#x0D; Measurements were recorded for mean sagittal kinematics values, spatial-temporal values, and&#x0D; FIM™ locomotion &#x0D; Results: BWSTT proved superior to conventional gait training in sub-acute stroke subjects, resulting in better locomotor abilities. The use of BWSTT leads to significant improvements for most sagittal kinematics, spatial-temporal and all FIM™ locomotion measurements. &#x0D; Conclusion: The BWSTT system enabled individuals with stroke to walk safely and without physical assistance. The positive results of training by the use of body weight support on a treadmill could be due to a task-oriented type of training.

Effects of exercise interventions on cardiovascular health in individuals with chronic, motor complete spinal cord injury: protocol for a randomised controlled trial [Cardiovascular Health/Outcomes: Improvements Created by Exercise and education in SCI (CHOICES) Study

IntroductionRecent studies demonstrate that cardiovascular diseases and associated complications are the leading cause of morbidity and mortality in individuals with spinal cord injury (SCI). Abnormal arterial stiffness, defined by a...

Research on patients-passive control strategy of the rehabilitation exoskeleton based on NN-SMC

There are amounts of patients with locomotor dysfunction caused by stroke until now. Body weight supported treadmill training (BWSTT) has proved to be an efficient method of rehabilitation training for those people. The lower exoskeleton consists of two legs which is used to guide and assist motions of patients with the help of weight support devices and a treadmill. A prototype of the body weight support exoskeleton rehabilitation device (BWSERD) has been designed in this paper, which contains two pairs of direct drives at hip and knee joints. It has also four torque transducers and four encoders. In order to conduct the patients-passive rehabilitation training after stroke, a control strategy based on neuro network and sliding mode controller is developed. The effectiveness of the proposed method is confirmed by the simulation results.

The effect of body weight supported treadmill training and muscle tone on motor function of lower extremities of stroke survivors

Objective To observe the effect of body weight supported treadmill training (BWSTT) on function of lower extremities in stroke survivors, and analyze the influence of quadriceps femoris muscle tone on the therapeutic effect of BWSTT. Methods Thirty-six stroke survivors were randomly divided into a BWSTT group and a conventional therapy group (CT group) according to a random number table, each of 18. Both groups were given routine rehabilitation training, while the BWSTT group was additionally provided with BWSTT for 4 weeks. Before and after the treatment, Fugl-Meyer assessment for lower extremity (FMMS-LE), Berg balance scale (BBS) and Holden walking function rating scale (Holden) were used to assess the motor function of lower extremities, balance function and walking ability of both groups. Meanwhile, the patients in BWSTT group were further divided into a mild-spasm subgroup and a seriously-spasm subgroup according to the modified Ashworth scale assessment result of quadriceps muscle, and the results of their efficacy indexes were further compared. Results No significant difference was found in the average FMMS-LE, Berg and Holden scores between the BWSTT group and CT group before the treatment (P>0.05). However, significantly improvement was found in all the above measurements of both groups after the treatment (P 0.05). The change of FMMS (△FMMS) and Holden (△Holden) after treatment in the mild-spasm subgroup increased more significantly compared with those in the seriously-spasm subgroup, but no significant differences were observed regarding the change of Berg (△Berg) between the two subgroups. Conclusions BWSTT can significantly improve the motor function of lower extremities, balance function and walking ability of stroke survivors. However, hypertone of quadriceps femoris might have adverse effects on the therapeutic effect of BWSTT. Key words: Stroke; Body weight supported treadmill training; Motor function; Muscle tension

The effects of body weight-supported treadmill training on static and dynamic balance in stroke patients: A pilot, single-blind, randomized trial.

This study aims to compare effectiveness of isolated body weight-supported treadmill training (BWSTT) with conventional and combined training on balance, mobility, and fear of falling in stroke patients. Between November 2014 and November 2015, a total of 45 post-stroke patients (32 males, 13 females; mean age 53.1±13.2 years; range, 19 to 73 years) were randomly assigned to combined training group (CombTG), conventional training group (CTG), and BWSTT group (BWSTTG). The CombTG received 45 min conventional therapy for five days a week along with 45 min of BWSTT twice a week. The CTG received only conventional therapy for five days a week. The BWSTTG received only BWSTT twice a week. Training duration was six weeks for all groups. Primary outcome measures were the Berg Balance Scale (BBS), affected and non-affected side Single Leg Stance Test (e-SLST/n-SLST), and Timed Up and Go Test (TUG) results. Secondary outcomes were the Falls Efficacy Scale-International (FES-I), Rivermead Mobility Index (RMI), Comfortable 10-m Walk Test (CWT), and Stair Climbing Test (SCT) results. The mean change of outcome measures demonstrated that the improvements between groups were significantly different among the three groups, except for the CWT (p=0.135). In subgroup analysis, except for the RMI and CWT, all primary and secondary outcome measures improved significantly in favor of the CombTG, compared to the CTG and BWSTTG (p<0.016). However, no statistically significant difference was found in the mean change of the CTG and BWSTTG (p>0.05). This study demonstrates that combined training has considerable effects on balance, mobility, and fear of falling parameters, while lower frequency of isolated BWSTT is as much effective as higher frequency of conventional training in ambulatory post-stroke patients.

非外傷性不全脊髄損傷患者に対する体重免荷トレッドミルトレーニング (BWSTT) が歩行能力に及ぼす影響

非外傷性不全脊髄損傷患者に対する体重免荷トレッドミルトレーニング (BWSTT) が歩行能力に及ぼす影響

Effects of bioengineered scaffold loaded with neurotrophins and locomotor training in restoring H-reflex responses after spinal cord injury.

The combinational effects of a bioengineered scaffold loaded with neurotrophins and rehabilitation training on spasticity observed after spinal cord injury (SCI) has not been studied. We used an animal model of moderate contusion injury at T9/T10 that received bioengineered scaffold poly N-isopropylacrylamide-g-poly ethylene glycol (PNIPAAm-g-PEG) loaded with BDNF/NT3 followed by body weight supported treadmill training (BWSTT) and assessed the efficacy of the combinational bioengineered approaches in treating spasticity. Five animal groups were included: Group 1: Sham, Group 2: Injury (SCI), Group 3: SCI + BWSTT (BWSTT), Group 4: SCI + PNIPAAm-g-PEG loaded with BDNF/NT3 (Transplant), and Group 5: SCI + PNIPAAm-g-PEG loaded with BDNF/NT3 + BWSTT (Combinational). Results indicate no significant changes in the BBB scores of animals among various groups, however, a significant restoration in the rate depression property of H-reflex was observed in both BWSTT and Combinational animals. Transplant group reported no improvement in the rate depression property of H-reflex and were similar to SCI only group. Histological findings report restoration of the chloride cotransporter (KCC2) labeling in both BWSTT and Combinational animals and down-regulation of KCC2 in both SCI and Transplant only animals. Findings from this study confirm that rehabilitation training is critical in restoring H-reflex responses and transplantation therapies alone cannot restore these responses after SCI. Also, although no significant difference was observed between the BWSTT and Combinational animals, comparable improvements in the two groups does open new pathways to exploring unique tissue-engineering approaches with promising clinical application for individuals with SCI.

Biomechanical evaluation of virtual reality-based turning on a self-paced linear treadmill

BackgroundPatients with brain injuries such as Parkinson’s disease or stroke exhibit abnormal gait characteristics especially during gait transitions such as step initiation and turning. Since such transitions could precipitate falls and resultant injuries, evaluation and rehabilitation of non-steady state gait in those patients are important. Whereas body weight supported treadmill training (BWSTT) provides a safe and controlled environment for gait training, it is unable to adequately train for gait transitions since the typical linear treadmill does not allow for changes in walking direction and natural fluctuations in speed. Research questionThis paper verifies if the suggested virtual reality (VR) based walking interface combined with the unidirectional treadmill can stimulate the user to initiate turning gait. MethodsTo validate whether initiation of turning was successfully achieved with the proposed walking system, we developed the VR-based walking interface combined with the self-paced treadmill and compared kinematics, kinetics, and muscle activation levels during the VR-based turning and overground (OG) turning as well as between straight walking and turning within conditions. ResultsDespite walking on a linear treadmill, subjects showed significant increases in head rotation, pelvic rotation, right hip abduction, left hip adduction, foot progression, medial-lateral ground reaction forces, right medial hamstring activation level, and changes in step width during the VR turn compared to straight walking. SignificanceThe developed VR-based turning interface can provide a safe and controlled environment for assessment of turning in healthy controls and may have a potential for assessment and training in patients with neurological disorders.

Advantage in muscle activation in gait with support of body weight in spinal cord injury

Abstract Introduction: The locomotor training with body weight support has been proposed as an alternative for the rehabilitation of people with spinal cord injury, in order to develop most of the residual potential of the body. Objective: To compare the levels of muscle activation of the main muscle involved in gait during body weight-supported treadmill training and body weight-supported overground training in incomplete spinal cord injured patients. Methods: It was a prospective cross-sectional study, in which 11 incomplete injured patients were submitted to two modalities of gait with body weight support, the first one on the treadmill (two different speeds: 1 and 4km/h), and the second one with the walker on fixed floor. The electromyographical acquisition was done in the rectus femoris (RF), vastus medialis (VM), vastus lateralis (VL) and gluteus maximus (GM). Results: There was a greater muscle activation of all muscles analyzed in the treadmill training as compared to the over groundtraining, both at 4 km/h (RF: p=0.00), (VM: p=0.00), (VL: p=0.00) e (GM: p=0.00) and at 1km/h (RF: p=0.00), (VM: p=0.00), (VL: p=0.00) e (GM: p=0.00). When comparing the two modalities of treadmill training, at 4 and 1km/h, there was no statically significant difference between them (RF: p=0.36), (VM: p=1.00), (VL: p=1.00) e (GM: p=0.16). Conclusion: The gait training with body weight support is more effective in activating the muscles involved in the gait training on treadmill compared to overground training in patients with incomplete spinal cord injury.

The Effects of Lower Body Positive Pressure Treadmill Training on Dynamic Balance of Children with Cerebral Palsy.

We aimed to characterize the therapeutic effects of Anti-gravity (AlterG) body weight supported treadmill training on the impaired balance of children with cerebral palsy (CP). Four spastic CP children participated; two received AlterG training 3 times a week for 8 weeks and the other two received typical occupational therapy accordingly. Their dynamic balance was evaluated before the start of the treatment and 2 months after it. Features related to the center of pressure (COP) and the center of mass (COM) were considered as dynamic balance parameters. Our results showed that the maximum velocity and acceleration of the COP and COM, the average variability (RMS) and peak to peak of the COM-COP separation, and RMS of velocity and acceleration of the COM and COP were all improved for both AlterG training patients (15-90%), though there was a limited improvement of 0.2-24% in some features of the control patients. Our results demonstrate that intensive sessions of the AlterG training program could have the potential to be used as a therapeutic tool that can produce dynamic balance improvements in CP children compared to that of typical occupational therapy.

편마비 환자의 트레드밀과 체중지지의 트레드밀 훈련이 균형능력 및 보행능력에 미치는 영향

편마비 환자의 트레드밀과 체중지지의 트레드밀 훈련이 균형능력 및 보행능력에 미치는 영향

The effects on gait speed and activity level of a novel body weight supported treadmill training program on a 39-year-old patient with right hemiparesis

Background and Purpose: Stroke is a disease that can cause neurological impairments that can affect a patient’s ability to ambulate. Research suggests that body weight supported treadmill training (BWSTT) may improve gait speed and reduce the risk of falls for those with difficulty ambulating. The purpose of this case report is to describe the effects of a novel BWSTT device on the gait speed and fall risk on a 39-year-old patient who had suffered a stroke. Case description: The patient was a 39-year-old female who had suffered a stroke resulting in right side hemiplegia. Over a 4-week period, the patient completed seven sessions of BWSTT with the GlideTrak. The duration of each session and the intervals within the session were performed at the patient’s tolerance for treadmill speed and duration of the interval. Outcomes: Improvement of 35% on the Activities-specific Balance Confidence (ABC) Scale and 25% on the Timed Up and Go (TUG) indicate that the intervention may have lowered the risk for falls but a 14% increase in the 10 Meter Walk Test time indicated that the intervention didn’t improve the patient’s gait speed as predicted. Discussion: This case report indicates that one month of body weight supported treadmill training using the GlideTrak does not improve gait speed in a patient with hemiplegia, but is shown to have a positive effect on patient’s balance. This intervention may have a role in maintaining a patient’s cardiovascular and overall fitness, but should not be the sole intervention to improve gait speed.

A Challenge-Based Approach to Body Weight-Supported Treadmill Training Poststroke: Protocol for a Randomized Controlled Trial.

BackgroundBody weight support treadmill training protocols in conjunction with other modalities are commonly used to improve poststroke balance and walking function. However, typical body weight support paradigms tend to use consistently stable balance conditions, often with handrail support and or manual assistance.ObjectiveIn this paper, we describe our study protocol, which involved 2 unique body weight support treadmill training paradigms of similar training intensity that integrated dynamic balance challenges to help improve ambulatory function post stroke. The first paradigm emphasized walking without any handrails or manual assistance, that is, hands-free walking, and served as the control group, whereas the second paradigm incorporated practicing 9 essential challenging mobility skills, akin to environmental barriers encountered during community ambulation along with hands-free walking (ie hands-free + challenge walking).MethodsWe recruited individuals with chronic poststroke hemiparesis and randomized them to either group. Participants trained for 6 weeks on a self-driven, robotic treadmill interface that provided body weight support and a safe gait-training environment. We assessed participants at pre-, mid- and post 6 weeks of intervention-training, with a 6-month follow-up. We hypothesized greater walking improvements in the hands-free + challenge walking group following training because of increased practice opportunity of essential mobility skills along with hands-free walking.ResultsWe assessed 77 individuals with chronic hemiparesis, and enrolled and randomized 30 individuals poststroke for our study (hands-free group=19 and hands-free + challenge walking group=20) from June 2012 to January 2015. Data collection along with 6-month follow-up continued until January 2016. Our primary outcome measure is change in comfortable walking speed from pre to post intervention for each group. We will also assess feasibility, adherence, postintervention efficacy, and changes in various exploratory secondary outcome measures. Additionally, we will also assess participant responses to a study survey, conducted at the end of training week, to gauge each group's training experiences.ConclusionsOur treadmill training paradigms, and study protocol represent advances in standardized approaches to selecting body weight support levels without the necessity for using handrails or manual assistance, while progressively providing dynamic challenges for improving poststroke ambulatory function during rehabilitation.Trial RegistrationClinicalTrials.gov NCT02787759; https://clinicaltrials.gov/ct2/show/NCT02787759 (Archived by Webcite at http://www.webcitation.org/6yJZCrIea)

A narrative review of gait training after stroke and a proposal for developing a novel gait training device that provides minimal assistance

Background: Gait impairment is common in stroke survivors. Recovery of walking ability is one of the most pressing objectives in stroke rehabilitation.Objectives: Of this report are to briefly review recent progress in gait training after stroke including the use of partial body weight-supported treadmill training (PBWSTT) and robot-assisted step training (RAST), and propose a minimal assistance strategy that may overcome some of limitations of current RAST.Methods: The literature review emphasizes a dilemma that recent randomized clinical trials did not support the use of RAST. The unsatisfactory results of current RAST clinical trials may be partially due to a lack of careful analysis of movement deficiencies and their relevance to gait training task specificity after stroke. Normal movement pattern is implied to be part of task specificity in the current RAST. Limitations of such task specificity are analyzed.Results: Based on the review, we redefine an alternative set of gait training task specificity that represents a minimal assistance strategy in terms of assisted body movements and amount of assistance. Specifically, assistances are applied only to hip flexion and ankle dorsiflexion of the affected lower limb during swing phase. Furthermore, we propose a conceptual design of a novel device that may overcome limitations of current RAST in gait training after stroke. The novel device uses a pulling cable, either manually operated by a therapist or automated by a servomotor, to provide assistive forces to help hip flexion and ankle dorsiflexion of the affected lower limb during gait training.Conclusion: The proposed minimal assistance strategy may help to design better devices for gait or other motor training.

편마비 환자의 트레드밀과 체중지지의 트레드밀 훈련이 균형능력 및 보행능력에 미치는 영향

편마비 환자의 트레드밀과 체중지지의 트레드밀 훈련이 균형능력 및 보행능력에 미치는 영향

Effective robotic assistive pattern of treadmill training for spinal cord injury in a rat model.

The purpose of the present study was to establish an effective robotic assistive stepping pattern of body-weight-supported treadmill training based on a rat spinal cord injury (SCI) model and assess the effect by comparing this with another frequently used assistive stepping pattern. The recorded stepping patterns of both hind limbs of trained intact rats were edited to establish a 30-sec playback normal rat stepping pattern (NRSP). Step features (step length, step height, step number and swing duration), BBB scores, latencies, and amplitudes of the transcranial electrical motor-evoked potentials (tceMEPs) and neurofilament 200 (NF200) expression in the spinal cord lesion area during and after 3 weeks of body-weight-supported treadmill training (BWSTT) were compared in rats with spinal contusion receiving NRSP assistance (NRSPA) and those that received manual assistance (MA). Hind limb stepping performance among rats receiving NRSPA during BWSTT was greater than that among rats receiving MA in terms of longer step length, taller step height, and longer swing duration. Furthermore a higher BBB score was also indicated. The rats in the NRSPA group achieved superior results in the tceMEPs assessment and greater NF200 expression in the spinal cord lesion area compared with the rats in the MA group. These findings suggest NRSPA was an effective assistive pattern of treadmill training compared with MA based on the rat SCI model and this approach could be used as a new platform for animal experiments for better understanding the mechanisms of SCI rehabilitation.

Author Correction: Is body-weight supported treadmill training or robotic-assisted gait training superior to overground gait training and other forms of physiotherapy in people with spinal cord injury? A systematic review.

The original article can be found online at https://doi.org/10.1038/sc.2017.31 .

The Efficacy of Gait Training Using a Body Weight Support Treadmill and Visual Biofeedback in Patients with Subacute Stroke: A Randomized Controlled Trial.

Background This study was designed to determine whether or not gait training based on the use of treadmill with visual biofeedback and body weight support (BWS) would produce better effects in patients with subacute stroke compared to BWS treadmill training with no visual biofeedback. Materials and Methods 30 patients with subacute stroke were randomly assigned to do body weight supported treadmill training with visual biofeedback (BB group) or BWS treadmill training without visual biofeedback. Their gait was assessed with a 3D system (spatiotemporal gait parameters and symmetry index) and by means of 2-minute walk test (2 MWT), 10-metre walk test (10 MWT), and Timed Up & Go test. Subjects in both groups participated in 15 treadmill training sessions (30 minutes each). Results The participants from both groups achieved a statistically significant improvement in spatiotemporal gait parameters, walking speed, endurance, and mobility. The average change in the BB group after the end of the programme did not differ significantly compared to the change in the control group. The change in the symmetry index value of stance phase in the BB group was 0.03 (0.02) and in the control group was 0.02 (0.02). The difference was not statistically significant (p = 0.902). The statistically significantly higher improvement in the BB group was found in the range of walking speed (p = 0.003) and endurance (p = 0.012), but the difference between groups was of low clinical significance. Conclusions The findings do not confirm that BWS treadmill training with the function of visual biofeedback leads to significantly greater improvement in gait compared to BWS treadmill training with no visual biofeedback at an early stage after stroke. This study was registered at ClinicalTrials.gov, ID: ACTRN12616001283460.