Nephroprotective drugs used in the management and treatment of kidney ailments are most times associated with numerous side effects. The desire to search for alternative safer drugs become imperative, hence, the need to explore nephroprotective drugs from the leaf of indigenous plants. This study evaluates the ameliorative effects of ethanolic leaf extract of Clausena anisata on chlorpromazine-induced renal toxicity in Wistar rats. Twenty-five male Wistar rats were grouped into five groups of five rats each. Group 1 rats served as control and received distilled water; Group 2 rats were induced with Chlorpromazine only every other day for 30 days; Group 3, 4 and 5 rats were intraperitoneally administered with Chlorpromazine for 1h and subsequently followed with 50mg/kg bwt, 100mg/kg body weight and 150mg/kg body weight ethanol extract orally every other day for 30 days respectively. The food was withdrawn from the rats and the rats were fasted overnight. The rats were sacrificed, dissected and blood samples were collected through ocular puncture. Nephroprotective effects of the extracts were evaluated by estimating the concentration levels of renal biomarkers such as albumin, creatinine and total protein concentration. Renal histopathological study of the rats was also investigated to validate the findings obtained from the in vivo study. The results concluded that Clausena anisata ethanol leave extract is safe at a dose of 50mg/kg body weight and 100mg/kg body weight; hence, it could be employed at appropriate concentration as an alternative synthetic pharmaceutical with promising effect in the management and treatment of kidney damage.