Abstract
Purpose: Diabetes mellitus is one of the major endocrine disorders, characterized by impaired insulin action and deficiency. Traditionally, Artocarpus heterophyllus stem bark has been reputably used in the management of diabetes mellitus and its complications. The present study evaluates the ameliorative activity of ethanol extract of Artocarpus heterophyllus stem bark in alloxan-induced diabetic rats.Methods: Diabetes mellitus was induced by single intraperitoneal injection of 150 mg/kg body weight of alloxan and the animals were orally administered with 50, 100 and 150 mg/kg body weight ethanol extract of Artocarpus heterophyllus stem bark once daily for 21 days.Results: At the end of the intervention, diabetic control rats showed significant (p<0.05) weight reduction, abnormal haematological parameters, high serum lipids (except high density lipoprotein) concentrations, increased creatinine, bilirubin and urea levels with decreased in albumin level when compared with non-diabetic control rats. All these alterations were reverted to normal after administered with different doses of ethanol extract of Artocarpus heterophyllus stem bark most especially at 150 mg/kg body weight which exhibited no significant (p>0.05) different with non-diabetic rats.Conclusion: The results suggest that ethanol extract of Artocarpus heterophyllus stem bark may be useful in ameliorating complications associated with diabetes mellitus patients.
Highlights
Diabetes mellitus is a chronic metabolic disorder characterized by derangements in carbohydrate, protein and lipid metabolisms, due to defective or deficiency in insulin secretion and action.[1]
Insulin is a hormone secreted by the beta cells of the Islets of Langerhans of the pancreas, it helps in glucose uptake by the cells, thereby prevents increase in fasting blood glucose levels.[2]
It has been reported that screening of medicinal plants for therapeutic purposes, is an important aspect in drug development because they may possess anti-aneamia, anti-dyslipideamia, anti-nephropathy and anti-hepatopathy which may be useful in the management of diabetes mellitus.[9]
Summary
Diabetes mellitus is a chronic metabolic disorder characterized by derangements in carbohydrate, protein and lipid metabolisms, due to defective or deficiency in insulin secretion and action.[1]. The present study was designed to examine the ameliorative effects of ethanol extract of Artocarpus
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