Body Weight Cyclophosphamide Research Articles

The effect of cyclophosphamide on the growth and cellular kinetics of a transplantable rat fibrosarcoma.

The gross response of a transplantable fibrosarcoma (RIB(5)) in rats treated with a single dose of 10, 50, 100 or 200 mg/kg body weight of cyclophosphamide (CP) is reported. The variation in mitotic and tritiated thymidine ((3)H-TdR) labelling indices after a single dose of 100 mg/kg CP was studied. Examination of chromosome spreads has shown the time course of the visible damage to DNA caused by CP and a transient arrest of cells in G(2) was demonstrated by microdensitometry. The effects of 100 mg/kg body weight CP given in 2 equal doses separated by various time intervals were examined in an attempt to relate tumour response to its altered cellular state at the time of the second dose.

MAMMALIAN BLASTOPATHIOS DUE TO DRUGS.

To determine the phenocritical phases for the anlagen of various external organs in domestic rabbits, I injected cyclophosphamide or nitrogen mustard intravenously in pregnant females at specific times after mating, from 19 h (post-coitum) (stage of zygote formation) at intervals of 12 h for 9 days p.c. A single injection was given to each female in a dose of 40 mg/kg body-weight or 10 mg/kg body-weight cyclophosphamide or 0.1 mg/kg body-weight nitrogen mustard.