Abstract Background Cellulite affects 80 to 98% of post-pubertal females, and most patients with the condition are bothered by it. Targeted Verifiable Subcision™ (TVS; Avéli® [Revelle Aesthetics, Inc., Mountain View, CA]) is a minimally invasive mechanical subcision device which reduces the appearance of cellulite dimples in the buttocks and thighs. While clinical trials have demonstrated efficacy, information on real-world, surgical and non-surgical approaches on the buttocks and thighs is needed. Objectives To describe how TVS is being used by the authors to improve patient outcomes in the lower body in both the surgical and non-surgical setting. Methods Each of the authors described their current practices using TVS for lower body rejuvenation. Author practices have varied proportions of surgical vs. non-surgical cases (from 10 to 100% surgical cases) and a variety of focuses, ranging from primarily facial aesthetics to near exclusive focus on body contouring. Results The authors’ diverse approaches to integrating TVS into clinical practice are detailed, along with pearls for clinical success. TVS is discussed as a companion treatment for surgical procedures, while the patient is already under anesthesia, as well as part of a non-surgical approach, where the local anesthesia required for TVS can make additional energy-based procedures more comfortable for the patient. The authors provide several examples and include considerations for optimal timing and ordering of treatments. Conclusions TVS may become a valuable addition to the treatment armamentarium for surgical or nonsurgical buttock and thigh rejuvenation and can be integrated into surgical and non-surgical workflows.