Primary changes in the physiological status of animals can be traced in the deviation from the norm of indicators of a number of substances in biological fl uids, since biochemical indicators are a kind of indicator of processes occurring in the body. Having knowledge of hematological changes in the body of cattle, managers and specialists of livestock farms can manage the productivity and health of highly productive animals. The purpose of the research was to determine and analyze the biochemical parameters of the blood of cows in the dry period and at the increasing the milk yield when wet crushed corn grain was introduced into their ration. The research has been carried out on cows of Black-and-White breed in LLC “Agrofi rma “Urozhai” in the Zonal district in the Altai Territory. During the research the prevalence of productivity indicators of cows of the experimental group over analogues from the control group was proved. Thus average daily milk yield for the accounting period (60 days) it was 30,9 kg, which was 5,2 kg more than the control herdmates (P > 0,95). The total productivity of one head was 1541,57 kg of milk in the control group and 1854,69 kg in the experimental group, which was 313,12 kg more (P > 0,95). It has been found that most of the studied biochemical parameters corresponded to the physiological norm. The exception was the increased content of total protein in the blood of lactating cows of the experimental group 5 g/l above the upper limit of the norm (P > 0,999). A low albumin content in the blood of animals of the experimental group has been noted, and this indicator was signifi cantly lower than that in the control group by 3,45 g/l (P > 0,99). An excess of the physiological norm of globulin in the blood of animals of both groups has been found, the indicators of the experimental group signifi cantly exceeded the control group by 9,5 g/l (P > 0,99). There was a low level of chlorides after the increasing the milk yield 88,1 mmol/l in the control group and 89,2 mmol/l in the experimental group, then excess of manganese after the increasing the milk yield was 4,50 mmol/l in the control group and 8,14 mmol/l in the experimental group, which could be associated with the increased content of this element in feed and soil.
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