Body Mass Index Status Research Articles

Nucleobindin-2 derived nesfatin-1 in polycystic ovary syndrome: a PRISMA and GRADE-compliant systematic review and meta-analysis with diagnostic test accuracy.

Nesfatin-1 is a satiety peptide secreted by central, peripheral nervous system and some peripheral tissues. This meta-analysis was conducted to explore the associations with diagnostic accuracy of circulatory nesfatin-1 in polycystic ovary syndrome (PCOS). Relevant studies were retrieved by online database and manual searching. The standardized mean differences (SMDs) with 95% confidence intervals (CIs) were obtained by a random-effects meta-analysis. The subgroup analysis based on the Body Mass Index (BMI), fasting insulin (F-INS), and the homeostasis model assessment-estimated insulin resistance (HOMA-IR) was conducted. Meta-analysis of correlations and meta-regression were performed for the associations of nesfatin-1 with metabolic and hormonal covariates. The diagnostic test accuracy (DTA) meta-analysis was conducted for the utility of nesfatin-1 in PCOS. The publication bias was tested with Egger's and Begg's regression tests. The combined effect size including a total of 14 studies showed a significantly higher nesfatin-1 level in PCOS as compared to controls (SMD=0.93, Z=2.17, P=0.03). The nesfatin-1 was found to be significantly higher in a subgroup of studies with mean BMI>25 kg/m2 (SMD=1.35, Z=2.06, P=0.04), F-INS <13 mIU/mL (SMD=2.74, Z=3.59, P=0.0003), and HOMA-IR >2.7 (SMD=1.58, Z=2.65, P=0.008). The DTA meta-analysis produced a pooled diagnostic odds ratio of 19.58 and area under curve were of 0.888 for nesfatin-1 in PCOS. The results indicate a multifactorial involvement such as endocrine and metabolic alterations in the form of BMI, insulin and HOMA-IR status with the higher nesfatin-1 levels in PCOS. The promising results of DTA meta-analysis warrants further research into the clinical and prognostic utility of nesfatin-1 in PCOS.

Trends in Maternal Weight Disparities: Statewide Differences in Rural and Urban Minnesota Residents From 2012 to 2019.

Despite research showing substantial weight disparities along the rural-urban continuum, little work has attempted to identify differences in prepregnancy weight status or gestational weight gain (GWG) outcomes between rural and urban birthing people. As such, the goals of this research were to 1) document the prevalence of prepregnancy overweight and obesity and excessive GWG in rural and urban birthing people and 2) examine changes in rural and urban prepregnancy overweight or obesity and excessive GWG over time. Birth certificate data provided sociodemographic variables, prepregnancy body mass index, GWG, and rurality status on 465,709 respondents who gave birth in Minnesota from 2012 to 2019. A series of regression models estimated risk differences in 1) prepregnancy weight status and 2) excessive GWG between rural and urban respondents over time, controlling for relevant covariates. Rural individuals had a 4.9 percentage-point (95% confidence interval, 4.5-5.3) higher risk of having prepregnancy overweight or obesity compared with urban individuals, and a 2.6 percentage-point (95% confidence interval, 1.9-3.3) higher risk of gaining excessive gestational weight. The disparities in prepregnancy overweight or obesity and excessive gestational weight between rural and urban individuals widened over time. These findings contribute to accumulating evidence documenting notable health disparities between rural and urban individuals during the perinatal period and support the need to develop prevention and treatment efforts focused on improving the weight-related health of individuals living in rural communities.

Protocol For Intervention Study In Reducing Elevated Blood Pressure Through Intermittent Fasting.

To chart out a protocol for conducting an intervention-based study to compare the efficacy of intermittent fasting intervention and usual diet in reducing elevated blood pressure among working adults. The quasi-experimental study with single-blinded parallel groups will comprise subjects from two civil departments. The intervention group will be required to conduct 2 days of fasting and 5 days of ad libitum diet in a week, while the control group will follow the usual healthy lifestyle. The largest sample size will be taken to achieve a power of 80% and an alpha value of 5%. Based on the 30% attrition rate, the total sample size needed in the study will be 140 participants, with 70 in each of the two arms. This study will use SPSS 24 for statistical analysis. The study describes a unique protocol of intermittent fasting mimicking the Muslim Sunnah of fasting among people with elevated blood pressure. The findings will contribute to decrease blood pressure among those with elevated blood pressure. If proven to be effective, the intermittent fasting method would be useful for developing an effective programme to prevent elevated blood pressure among adults. The protocol will contribute to efforts to find whether or not intermittent fasting can improve elevated blood pressure as well as body weight, body mass index, waist circumference and nutrition status among adults. The study was registered with clinicaltrials.gov (NCT04953650).

Survei indeks massa tubuh dan kondisi fisik Siswa Ganthari Soccer School

This study aims to know and examine the body mass index profile and physical condition of Ganthari Soccer School students in Malang City aged 15-18 years. This study used a survey method using data collection techniques in the form of tests and measurements. Subjects in this study amounted to 30 students. To collect data to determine the status of physical condition using norms for children aged 15-18 years, while to determine the status of body mass index (BMI) using instruments measuring weight, age and height with classification norms from the Indonesian Ministry of Health. This study resulted in scores from the BMI test in the normal category and the Physical Condition test in the form of a speed test in the medium category, agility in the very good category and endurance in the very good category. So in this study it can be found that Ganthari Soccer School students are quite good at maintaining their Body Mass Index and have good physical condition for ages 15-18 years.

The Relationship between Plasma Glutamate Levels and Sleep Quality in HIV Patients

Background: Disturbance sleep quality is often found in sufferers of human immunodeficiency virus (HIV). Disturbed sleep quality can affect immunity, which ultimately can increase patient morbidity and mortality. Impaired sleep quality in HIV sufferers is related to neurotoxicity due to the HIV virus, which damages sleep architecture. HIV infection can cause an increase in brain extracellular glutamate. Elevated glutamate plays a role in neuronal and glial damage and death. This study aimed to assess the relationship between plasma glutamate levels and sleep quality in HIV sufferers.&#x0D; Methods: The research uses a cross-sectional design. The samples were HIV sufferers in a polyclinic voluntary counseling test (VCT) internal medicine of Dr. M. Djamil General Hospital Padang, who met the inclusion and exclusion criteria. Samples are selected by consecutive methods. Sleep quality was assessed using a questionnaire called the Pittsburgh sleep quality index (PSQI). Plasma glutamate levels were measured using the ELISA method. Statistical analysis using SPSS with a p-value &lt;0.05 was considered statistically significant.&#x0D; Results: The research sample consisted of 82 people. The median plasma glutamate level was 16.39 µg/mL. Impaired sleep quality was found in 45 (54.9%) HIV sufferers. There was no significant relationship between plasma glutamate levels (p= 0.506), age (p=0.795), gender (p=0.547), education (p=0.358), occupation (p=0.255), disease duration (p=0.348), stage (p=0.309) and type of ARV therapy (p=0.791) with sleep quality in HIV sufferers. From this research, a significant relationship was found between sleep quality, body mass index (BMI) (p= 0.015), and marital status (p= 0.039).&#x0D; Conclusion: There is no relationship between plasma glutamate levels and sleep quality in HIV sufferers. There are other factors that influence sleep quality, namely BMI and marital status.

Concurrent changes in physical activity and physical functioning during retirement transition-a multi-trajectory analysis.

Physical activity and physical functioning have been reported to change over retirement transition, but the results have been inconsistent, and the two constructs have not been studied concurrently. The objective of this study was to examine concurrent changes in physical activity and physical functioning during transition to retirement among public sector employees, and to examine if occupation, sex, marital status, body mass index (BMI), alcohol consumption and smoking status are associated with observed different multi-trajectory paths. 3,550 participants of the Finnish Retirement and Aging study responded to an annual survey on physical activity and physical functioning (SF-36) before and after retirement. Group-based multi-trajectory analysis was used to identify clusters with dissimilar concurrent changes in physical activity and physical functioning. Multinomial regression analysis was used to describe the associations between covariates and the probability of being classified to a certain cluster. Participants were 63.4 (SD 1.4) years old, 83% women, 65% professional workers. Four trajectories of concurrent changes in physical activity and physical functioning were identified, one with decreasing physical functioning and low activity, one with increasing high activity and stable high functioning and two with fluctuating moderate physical activity and stable high functioning. Single, women, obese participants and risk-users of alcohol were more likely to be classified into group with low physical activity and declining physical functioning. Low physical activity below the level usually recommended was associated with lower physical functioning during retirement transition. These findings could be useful when planning interventions for retirees to maintain their physical functioning level.

Body mass index conditions and eating attitudes in young nurses: a pilot psycho-immune-endocrine investigation

Purpose. To investigate a cohort of young Italian nurses to identify whether the body mass index (BMI) and eating flexibility differed and were associated according to the basic characteristics of sex, smoking behavior, or shift activity, the levels of neutrophils, lymphocytes, or platelets in blood, and the psychological conditions of anxiety, depression, stress, or insomnia. Materials and Methods. The data include sex, BMI, smoking behavior, shift activity, neutrophil, lymphocyte, and platelet levels, eating flexibility [measured using the eating disorder flexibility index (EDFLIX) and the subdimensions EDFLIX-GF for general flexibility, EDFLIX-FoEx for food and exercise flexibility, and EDFLIX-WeSh for weight and shape flexibility], and mental health [assessed using the depression, anxiety, and stress scale (DASS-21) and the insomnia severity index (ISI)]. Results. Differences in BMI with shift work (P=0.042) and anxiety with total EDFLIX (P&lt;0.001), EDFLIX-GF (P&lt;0.001), and EDFLIX-WeSh (P=0.044) scores were significant. Having depression was associated with significant differences in total EDFLIX (P&lt;0.001), EDFLIX-GF (P=0.005), and EDFLIX-WeSh (P&lt;0.001) scores. Nurses with moderate stress reported high total EDFLIX (P&lt;0.001), EDGLIX-FoEx (P&lt;0.001), and EDFLIX-WeSh (P=0.013) scores. Nurses with mild stress reported high EDFLIX-GF scores (P&lt;0.001). Nurses without insomnia symptoms reported significantly high EDFLIX- FoEx scores (P&lt;0.001). Associations between lymphocyte levels and EDFLIX-FoEx (β=-0.264; P=0.003), stress and EDFLIX-total (β=-0.436; P&lt;0.001), EDFLIX-GF (β=-0.466; P&lt;0.001) and EDFLIX-WeSh (P=0.022), and also between insomnia and EDFLIX-FoEx (β=-0.245; P&lt;0.001) were significant. Conclusions. Nurses, from the beginning of their careers, should be monitored and encouraged to avoid adverse health practices that negatively influence their quality of life.

Burden of chronic cough on social participation, healthcare resource utilisation and activities of daily living in the Canadian Longitudinal Study on Aging (CLSA)

BackgroundChronic cough is a common troublesome condition, but it is unclear whether dry or productive chronic cough and sex, impacts the burden of cough differently. MethodsThe Canadian Longitudinal Study on Aging is a nationally generalizable, stratified random sample of adults aged 45–85 years. Chronic cough was identified based on a self-reported daily cough in the last 12 months assessed at baseline (2011–2015) and follow-up (2015–2018). Odds ratios (95 % CI) for cough status and change in social participation activities (SPA), healthcare resource utilisation (HCRU), basic activities of daily living (ADLs) and instrumental activities of daily living (IADLs) were estimated using a weighted generalised estimating equation (WGEE). Results were stratified by sex, and adjusted for age, sex, smoking, body mass index, education, respiratory diseases and retirement status. ResultsOverall, chronic cough was associated with less SPA, greater HCRU and impaired ADL/IADLs. Productive chronic cough in males was associated with SPA limited by health, ED visits and hospitalisation. Females with productive chronic cough was associated with reduced frequency of SPA and ED visit. Dry chronic cough in females was associated with SPA limited by health and ED visits. Both types of cough was associated with at least 1 impaired basic ADL, but only in females with productive chronic cough was there an association with any impairment in IADLs. ConclusionChronic cough is associated with a greater burden on social participation, healthcare use and personal care.

Associations of advanced liver fibrosis with heart failure with preserved ejection fraction in type 2 diabetic patients according to obesity and metabolic goal achievement status.

Heart failure with preserved ejection fraction (HFpEF), a major cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM), is frequently coexisted with obesity, poor glycemic, blood pressure (BP), and/or lipid control. We aimed to investigate the associations of nonalcoholic fatty liver disease (NAFLD) and its advanced fibrosis with HFpEF according to obesity, glycated hemoglobin A1c (HbA1c), BP, and low-density lipoprotein cholesterol (LDL-C) goal achievement status in T2DM patients. A total of 2,418 T2DM patients who were hospitalized were cross-sectionally assessed. Liver fibrosis was evaluated by non-invasive biomarkers. Logistic regression analysis was used to evaluate the independent and combined associations of fibrosis status and diabetic care goal attainments with HFpEF risk. Simple steatosis was not associated with HFpEF risk compared with patients without steatosis, while advanced liver fibrosis was found to have significantly higher odds for HFpEF risk (odds ratio,1.59; 95% confidence interval, 1.22-2.08). Advanced fibrosis in NAFLD was significantly associated with an increased risk of HFpEF, regardless of obesity status, HbA1c, BP, and LDL-C goal achievement status. P values for the interactions between fibrosis status and HbA1c control status, fibrosis status and BP control status, fibrosis status and LDL-C control status, and fibrosis status and body mass index (BMI) status on HFpEF risk were 0.021, 0.13, 0.001, and 0.23, respectively. In patients with T2DM, advanced hepatic fibrosis was significantly associated with HFpEF risk, irrespective of obesity status, HbA1c, BP, and LDL-C goal attainment status. Further, HbA1c and LDL-C goal attainment status modified this association.

The Relationship Between Nutrition Knowledge, Attitude and Practice (NKAP), Self-Efficacy of Healthy Eating with Body Mass Index (BMI) Status Among Undergraduate Students in USM Kubang Kerian, Kelantan: A Cross-Sectional Study

Introduction: Healthy eating is an approach to prevent obesity, hypertension, diabetes mellitus, and cardiovascular disease. This study aimed to determine the level of nutrition knowledge, attitude, and practice (NKAP), level of self-efficacy of healthy eating, and their relationship with body mass index (BMI) among undergraduate students in USM Kubang Kerian, Kelantan.Study Design: A cross-sectional study was conducted on 107 undergraduate students aged 19 to 28 years old, selected using convenience sampling in USM Kubang Kerian, Kelantan from August 2021 until October 2021. A self-administered questionnaire including the KAP questionnaire and self-efficacy of the healthy eating scale was distributed to the participants via Google Form. Findings: The prevalence of good knowledge was 95.3%, good attitude was 79.4% but good practice was only 36.4%. Overall, the prevalence of nutrition knowledge, attitude, and practice (NKAP) was good at 82.2%. The total median score of self-efficacies in healthy eating was 28.0 (7.0). A significant association was found between the availability of healthy and unhealthy foods with practice (p=0.012, p=0.019). Moreover, a significant association was found between age and awareness of the Malaysian Food Pyramid with NKAP (p=0.039, p=0.005 respectively). Hence, a significant association was found between NKAP and self-efficacy of healthy eating (p=0.008). However, the present study revealed that there was no significant association between NKAP with BMI, and self-efficacy of healthy eating with BMI (p=0.541, p=0.064).Conclusion: We found that having good nutrition knowledge and attitude alone was insufficient for the changes in individuals' healthy eating practices as most university students had suboptimal eating behaviour in their daily lifestyle. Therefore, strategies were needed to practice good and healthy eating among university students.

A study on the factors affecting polycystic ovary syndrome in young women

Aims: The aim of this study was to define the incidence of polycystic ovary syndrome (PCOS) in young women and the affecting characteristics. In this study, environmental factors and demographic characteristics of women with PCOS were compared with the control group, which included healthy young women. Methods: This is a retrospective study with control in young women aged 18-25, suffering from PCOS and healthy women, referred to our clinic between September 2018- August 2020. Women's socio-demographic characteristics such as age, weight, height, economic status, employment status, education status, smoking and alcohol abuse, chronic disease, exercise status, family history of cancer, and menstrual irregularity of participants were compared. Results: Results did not show a statistically significant association between case and control regarding age, economic status, education status, family history of cancer, smoking and alcohol abuse (p&gt;0.05). There was a statistically significant difference between groups regarding menstrual irregularity, chronic disease, body mass index (BMI), exercise and working status (p&lt;0.05). Healthy women exercise more, and a higher percentage of them are employed. Chronic diseases were more common in women with PCOS. Women with PCOS were fatter and had more menstrual irregularities problems. Conclusion: BMI, working status, exercise status, menstrual irregularity, and chronic disease status helped diagnose PCOS in young women.

Potential beneficial effects of long-term aspirin use on the prevalence of colorectal cancer: a population-based study of the US Nationwide Inpatient Sample.

Whether long-term aspirin usage is associated with colorectal cancer (CRC) risk needs more evidence. The study evaluated the association between long-term aspirin use and prevalence of CRC in a large, nationally representative database. Hospitalized patients aged ≥ 50years during 2018 were identified in the United States (US) National Inpatient Sample (NIS). Patients without complete information of age, sex, race, income, and insurance status were excluded, as well as those with inflammatory bowel disease (IBD) or malignancies other than CRC. Propensity score matching (PSM) was applied to balance the characteristics between patients with and without long-term aspirin use. Logistic regressions were performed to determine the relationship between long-term aspirin use and the presence of CRC. CRC and aspirin use were identified through the administrative International Classification of Diseases (ICD) codes. Data from 3,490,226 patients were included, in which 688,018 (19.7%) had a record of long-term aspirin use. After 1:1 PSM, there remained 1,376,006 patients, representing 6,880,029 individuals in the US after weighting. After adjusting for confounders, long-term aspirin use was significantly associated with lower CRC odds (adjusted odds ratio [aOR] = 0.64, 95% confidence interval [CI] 0.62, 0.67). This association was not changed when stratified by age, sex, race, body mass index (BMI), and smoking. From a national inpatient dataset, US adults ≥ 50years on long-term aspirin are less likely to have CRC, regardless of age, sex, race, BMI, and smoking status.

Association of abdominal aortic calcification and lower back pain in patients with degenerative spondylolisthesis.

Abdominal aortic calcification (AAC) is hypothesized to lead to ischemic pain of the lower back. This retrospective study aims to identify the relationship between AAC and lower back pain (LBP) in patients with degenerative lumbar spondylolisthesis. Lower back pain was assessed preoperatively and 2 years after surgery using the numeric analogue scale. Abdominal aortic calcification was assessed according to the Kauppila classification and was grouped into no, moderate, and severe. A multivariable regression, adjusted for age, sex, body mass index, hypertension, and smoking status, was used to assess the association between AAC and preoperative/postoperative LBP as well as change in LBP after surgery. A total of 262 patients were included in the final analysis. The multivariable logistic regression demonstrated an increased odds ratio (OR) for preoperative LBP ≥ 4 numeric analogue scale (OR = 9.49, 95% confidence interval [CI]: 2.71-40.59, P < 0.001) and postoperative LBP ≥ 4 (OR = 1.72, 95% CI: 0.92-3.21, P = 0.008) in patients with severe AAC compared with patients with no AAC. Both moderate and severe AAC were associated with reduced improvement in LBP after surgery (moderate AAC: OR = 0.44, 95% CI: 0.22-0.85, P = 0.016; severe AAC: OR = 0.41, 95% CI: 0.2-0.82, P = 0.012). This study demonstrates an independent association between AAC and LBP and reduced improvement after surgery. Evaluation of AAC could play a role in patient education and might be considered part of the differential diagnosis for LBP, although further prospective studies are needed.

Maternal and perinatal outcomes in primiparous singleton pregnancies conceived with assisted reproductive technology in British Columbia

ObjectiveTo evaluate the odds of developing adverse maternal and perinatal outcomes in primiparous singleton pregnancies conceived with assisted reproductive technology (ART) compared with pregnancies conceived without ART. Study designA retrospective population-based cohort study using data from the British Columbia Perinatal Data Registry. The population included primiparous women with singleton live or stillbirths delivering at or after 20 weeks’ gestation between April 1st 2008–March 31st, 2021. Women who conceived with ART were compared with those who conceived without ART. The main outcome measures were gestational diabetes, hypertensive disorders of pregnancy, preterm birth, low birth weight, neonatal intensive care unit admission, stillbirth, and 5-minute Apgar score. Adjusted odds ratios were calculated. ResultsThe study population included 191,059 primiparous women: 183,819 conceived without ART, 7,240 conceived using ART. After controlling for age, body mass index, pre-gestational diabetes, and smoking status, singleton pregnancies conceived by ART had significantly higher odds of gestational diabetes (OR 1.18, 95 % confidence interval [CI] 1.10–1.26) and hypertensive disorders of pregnancy (OR 1.39, 95 % CI 1.29–1.51). There were also significantly increased odds of preterm birth (OR 1.35, 95 % CI 1.25–1.46), low birth weight (OR 1.35, 95 % CI 1.23–1.49), and neonatal intensive care unit admission (OR 1.21, 95 % CI 1.11–1.32). There was not a statistically significant difference in the odds of stillbirth (OR 1.06, 95 % CI 0.72–1.57) or 5-minute Apgar score < 7 (OR 1.10, 95 % CI 0.97–1.26). ConclusionThere is an increased odds of developing several adverse maternal or neonatal outcomes in primiparous singleton pregnancies conceived by ART including gestational diabetes, hypertensive disorders of pregnancy, preterm birth, low birth weight, and increased incidence of neonatal intensive care unit admissions.

A nutritional supplement taken during preconception and pregnancy influences human milk macronutrients in women with overweight/obesity and gestational diabetes mellitus.

Maternal overweight/obesity and gestational diabetes mellitus (GDM) are associated with an increased risk of their offspring developing overweight/obesity or type 2 diabetes later in life. However, the impacts of maternal overweight/obesity and dysglycemia on human milk (HM) macronutrient composition are not well understood. Through a double-blind randomised controlled trial, we investigated the effects of maternal supplementation from preconception throughout pregnancy until birth on HM macronutrient concentrations, in association with maternal and infant factors including maternal pre-pregnancy body mass index (BMI) and GDM status. In addition, we aimed to characterise longitudinal changes in HM macronutrients. The control supplement contained calcium, iodine, iron, β-carotene, and folic acid. The intervention supplement additionally contained zinc, vitamins B2, B6, B12, and D3, probiotics, and myo-inositol. HM samples were collected across seven time points from 1 week to 12 months from Singapore and/or New Zealand. HM macronutrient concentrations were measured using a MIRIS Human Milk Analyser. Potential differences in HM macronutrient concentrations were assessed using linear mixed models with a repeated measures design. Overall, HM macronutrient concentrations were similar between control and intervention groups. Among the control group, overweight/obesity and GDM were associated with higher HM fat and energy concentrations over the first 3 months. Such associations were not observed among the intervention group. Of note, mothers with GDM in the intervention group had lower HM fat by 10% (p = 0.049) and energy by 6% (p = 0.029) than mothers with GDM in the control group. Longitudinal changes in HM macronutrient concentrations over 12 months of lactation in New Zealand showed that HM fat and energy decreased in the first 6 months then increased until 12 months. HM lactose gradually decreased from 1 week to 12 months while crude protein decreased from 1 week to 6 months then remained relatively constant until 12 months of lactation. Maternal overweight/obesity or GDM were associated with increased HM fat and energy levels. We speculate the intervention taken during preconception and pregnancy altered the impact of maternal BMI or GDM status on HM macronutrient composition. Further studies are required to identify the mechanisms underlying altered HM macronutrient concentration in the intervention group and to determine any long-term effects on offspring health. ClinicalTrials.gov, NCT02509988, Universal Trial Number U1111-1171-8056. Registered on 16 July 2015. This is an academic-led study by the EpiGen Global Research Consortium.

Overview of the Incidence of Hypotension After Spinal Anesthesia Induction in Sectio Caesarea Patients During Intra Anesthesia at Juanda Kuningan Hospital West Java

Purpose: This study aimed to identify the incidence of hypotension after spinal anesthesia induction in SC patients during intra-anesthesia based on Body Mass Index (BMI), age, and baseline systolic blood pressure at Juanda Kuningan Hospital. Methods: This study used a quantitative descriptive method with a cross sectional approach. The sample in this study were all SC patients with spinal anesthesia techniques who met the criteria. The sampling technique used was purposive sampling with the slovin formula resulting in 90 respondents. And data analysis using univariate analysis. Findings: The results showed that the majority of respondents who experienced mild hypotension with excessive BMI status were 50 respondents (58.8%), the majority of respondents who experienced mild hypotension with early adulthood were 52 respondents (61.2%) and the majority of respondents who experienced mild hypotension with initial systolic blood pressure were at initial systolic blood pressure &lt;120 mmHg and 120-130 mmHg as many as 31 respondents (36.5%). Conclusions: The results of this study illustrate that the majority of respondents will experience hypotension after spinal anesthesia induction. This is because spinal anesthesia can block sympathetic nerves, resulting in a decrease in circulating arterial tone, this condition causes peripheral arterial vasodilation. This vasodilating effect can result in a decrease in vascular resistance (hypotension). For further researchers to be able to develop this study to look for other variables that may be associated with the incidence of hypotension after induction of spinal anesthesia in SC patients so that the results of the study will show more variation.

Association Between Serum Vitamin D Levels and Body Mass Index Status: A Cross-Sectional Study at King Khalid Hospital, Jeddah, Saudi Arabia, From 2019 to 2020.

Introduction Low vitamin D levels have been associated more with overweight and obese people in previous studies. One of the possible explanations behind this association is the lipophilic property of vitamin D that causes the vitamin to deposit in adipose tissue and reduces the serum concentration of the vitamin, which still warrants further evaluation. Objective This study estimated the association between serum vitamin D levels and body mass index (BMI) among male patients in Jeddah, Saudi Arabia. Methods This is a cross-sectional study of male patients that was carried out in King Khalid Hospital, Jeddah, Saudi Arabia. Patients were included between October 2019 and November 2020. Results We concluded that almost half of the patients, 1,132 (48.3%), had adequate vitamin D, followed by 773 (33%) with vitamin D inadequacy, and only 288 (12.3%) had vitamin D deficiency. There was a significant relationship between age and vitamin D levels; younger people had lower vitamin D levels compared to older people (p<0.001). It was found that there was no significant relationship between BMI categories and vitamin D levels (p>0.05). Conclusion According to the findings of the current study, there was no discernible relationship between serum vitamin D levels and BMI. However, there was a substantial correlation between age and vitamin D levels, with younger age groups having lower amounts than older individuals. Future studies should adopt a prospective design encompassing multiple centers and preferably include the risk factors for developing vitamin D deficiency, such as sun exposure, dietary habits, comorbidities, etc. Such studies can provide a more accurate assessment of the association between BMI and vitamin D levels.

The Significant Impacts of Interleukin-8 Genotypes on the Risk of Colorectal Cancer in Taiwan.

Interleukin-8 (IL-8), a pro-inflammatory cytokine, is upregulated in CRC and plays an important role in its development and progression. Genetic variants in the IL-8 gene may impact the risk of CRC by modulating IL-8 levels. Our primary objective was to investigate the role of IL-8 genotypes in the development of CRC. To accomplish this, we employed the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method to analyze the genotypes of IL-8 rs4017, rs2227306, rs2227543, and rs1126647 in 362 CRC patients and 362 controls. Additionally, we evaluated the interactions between these genotypes and factors such as age, gender, smoking, alcohol consumption, and body mass index (BMI) status in relation to the risk of CRC. Furthermore, we utilized quantitative reverse transcription-PCR to measure the serum IL-8. The results demonstrated a significant difference in the distribution of rs4017 genotypes between the control and case groups (p for trend = 0.0059). Logistic regression analysis revealed that individuals with variant AA genotype had a 1.92-fold higher CRC risk (95% confidence interval [CI] = 1.28-2.89, p = 0.0023). Moreover, carriers of the IL-8 rs4017 AT + AA genotypes exhibited a significant association with CRC risk (odds ratio [OR] = 1.39, 95% CI = 1.02-1.91, p = 0.0460). Additionally, individuals with IL-8 rs4017 AA genotype displayed significantly elevated serum IL-8 compared to those with TT genotype at a 1.73-fold level (p < 0.0001), indicating a correlation between genotype and phenotype. In conclusion, the genotypes of IL-8 rs4017, along with their associated expression levels, can potentially serve as predictive markers for the risk of CRC.

Relationship between Urinary Tract Infections and Various BMI Categories: A Prospective Research Study

Introduction: Throughout the globe, there is increase in obesity as well as Urinary Tract Infection (UTI). Body mass index (BMI) and low socio economic status were reported to be the risk factors of UTI. There were no reports on in this area. Hence a study was conducted to find the correlation between sociodemographic features and the incidence of UTI.&#x0D; Methods: It was a prospective research conducted from May 2021 to May 2022. Individuals aged &gt; 18 with the symptoms of UTI were included, malignant individuals, those on steroid treatment were excluded. The participants clinical history was recorded in the proforma. Sociodeconomic data was recorded as per the Modified Kuppuswamy scale and BMI was estimated by entering height and weight in the National Institute of Health (NIH) website and divided in to 4 categories. Sample size, specimen collection, culture were practised as per the guidelines. Logistic regression analysis was applied and P &lt;0.05 were considered to be statistically significant.&#x0D; Results: UTI was detected in 322 (100%). The mean age of the study members was 37.2 years, 123 were male and 199 were female participants, the female male ratio was 1.7. Highest number of UTI was detected in lower class (78; 24.2%) followed by middle class (73; 22.7%), upper class (64; 19.8%), upper middle class (59; 18.3%) and lower middle class (48; 24.2%). Maximum (102; 31.7%) UTI was diagnosed in obesity followed by over weight (96; 29.8%). Logistic regression analysis did not show any association between BMI and UTI (OR = 0.986, 95% CI: 0.923-1.024, P = 0.810).&#x0D; Conclusions: UTI is common among sexually active female. As per the study findings low socioeconomic status and obesity are the common risk factors for UTI. Hence individuals with a high BMI should be evaluated for UTI if symptoms are noticed.

FRI098 Triglyceride Glucose Index Is Associated With Elevated Blood Pressure, Independent Of Body Mass Index: Analysis From NHANES Study

Abstract Disclosure: H. Ayesh: None. K.D. Niswender: None. Introduction: Triglyceride glucose index (TyG) is a novel marker of insulin resistance. Elevated blood pressure is associated with significant morbidity and mortality. Early identification of individuals at-risk for cardiovascular disease is essential for effective prevention. There are multiple reports in the literature that triglyceride glucose index (TyG), is associated with elevated blood pressure. In this study, we determined the association of TyG with elevated blood pressure, independent of body mass index (BMI), age, and diabetes status. Methods: A sample of 6799 individuals from the NHANES study population (2011-2020) consisting of all individuals who are above 18 years of age and have serum glucose and serum triglyceride levels available to calculate TyG. Elevated blood pressure status was assigned based on the question“Ever told you had high blood pressure” from NHANES survey.”. TyG was calculated using the formula “ln[fasting TG (mg/dL) × fasting plasma glucose (mg/dL)/2]”. TyG values were divided into 4 quartiles as follow: 1st(&amp;lt;4.36), 2nd (&amp;lt; 4.56), 3rd(&amp;lt; 4.77), 4th(&amp;gt; 4.77). Logistic regression analysis was performed to assess the association between TyG and elevated blood pressure. The analysis was adjusted for age, BMI, and diabetes status. Results: The analysis revealed a significant association between elevated blood pressure and TyG independent of age, BMI and diabetes status. The odds of elevated blood pressure were higher in the 4th quartile TyG compared to the 1st quartile with an odds ratio of 1.39 (95% CI 1.21-1.59), P value &amp;lt; 0.001. Discussion/Conclusion: These results indicate that TyG can serve as a screening tool to identify individuals at risk for elevated blood pressure. Serum triglyceride and glucose measurement are affordable and routine in clinical practice. Implementation of auto-calculation of TyG based on serum triglyceride and glucose values in electronic health records may provide helpful screening and monitoring tools to identify individuals at risk for elevated blood pressure, especially with normal BMI. Future high-quality prospective studies will be helpful to further understand the association. Presentation: Friday, June 16, 2023