Body Functions Research Articles

The efficiency of Complementary Law No. 101 of 05/04/2000 (Fiscal Responsibility Law) in municipal public bodies

The Fiscal Responsibility Law (LRF) is essential to guarantee the financial health and sustainability of public accounts, contributing to the country's economic and social progress. The efficiency of the LRF can be assessed by considering various positive aspects that contribute to improving transparency, balance and efficiency in financial administration. In this context, the general objective of this work is to provide a comprehensive overview of the efficiency of the LRF in the control and transparency of financial accounts, as well as to understand how this legislation influences the functioning of municipal public bodies. In order to achieve the objective, a bibliographical survey was used, focusing on in-depth understanding of human phenomena, processes and experiences through existing writings. As a result of the research, it can be said that in municipal public bodies, the application of the LRF has a direct impact on budgetary, financial and asset management. It establishes limits for personnel expenses, determines transparency in the disclosure of fiscal information, and requires planning and control of public accounts.

Single and Combinations of Rosuvastatin, Celecoxib, and Colchicine Effects on Biochemical and CBC Parameters of Wistar Albino Rats

Drug resistance became a well-known problem in different areas of pharmacology, including anti-cancer therapy and antibiotics. The overcoming of drug resistance either by different drugs or doses, increases the risk of tissue toxicity. The combination of single FDA-approved drugs became one of the solutions shorting the time for new drug approval, and lowering the cost of manufacturing and transporting of drug to pharmacy shelves. Every day a new combination is investigated to narrow the gap in different pharmacological requirements. Lipid-lowering and anti-inflammatory drugs are widely used and are widely available globally. The study aimed to investigate four probabilities of combinations of three single drugs Rosuvastatine (Ro), Celecoxib (Ce), and Colchicine (Co) on biochemical and Complete Blood Count parameters (CBC) to evaluate the reliability and probable effects of these drugs on normal body function. Nine groups (n=6) of Wistar Albino Rats were inoculated with single and combinations of drugs for eight days using the maximum normal human doses of each drug, blood samples were collected in the middle, and at the end of the experiment. Results showed that combinations induced abnormal biochemical, and CBC parameters in ALT, AST, Creatinine, and RBC parameters in all but one (Rosuvastatine-Celecoxibe-Colchicine) of the combination. The study concluded that the combination could be used except that showed a higher level of abnormal physiological parameters, and percussions should taken by more pharmacological and physiological investigation in a bigger scale of studies including longer durations and different animal models before the combinations utilized by human.

The analysis of the essential metal contents in khat (Catha edulis Forsk) from Meru County, Kenya

BackgroundChemical composition of plants has attracted considerable interest in recent years with considerable research tailored into determining metal contents in food substances. Particularly, essential elements which are necessary for normal human body functioning and are strongly recommended in optimal proportions for better health. This study determined the levels of essential elements; calcium (Ca), magnesium (Mg), sodium (Na), potassium (K) and manganese (Mn) in eleven khat (Catha edulis Forsk) samples collected from Meru County. Methodology1.0 g of dry ground khat samples were wet-digested in a solvent mixture of 10 mL of HCl, HNO3 and 20 vol of H2O2 for 3 h at variable temperature of 50–90 °C and later reconstituted in 25 mL 0.05 molL−1 HCl before analysis. The samples were analyzed using inductively coupled plasma atomic emission spectrometry (ICP AES) after acid digestion whereas Hierarchical cluster analysis (HCA) and principal component analysis (PCA) were used to investigate elemental characteristics and determine the sources of essential metals in khat. In addition, Pearson correlation coefficient (PCC) was used to evaluate the relationships between the essential metals. ResultsSpinach leaves certified reference material (CRM 1750a) was analyzed and the percentage recoveries (%) of 98.4 and 101.7 determined showing that the digestion method employed in this work had adequate accuracy. The validated method was employed for the analysis of all the khat samples. The analyzed metal concentration ranges (mg100g−1) in fresh-weight basis per day of five metals were 160.9–267.3, 44.6–81.7, 2.0–3.0, 237.6–393.6, and 220.3 -349.0 for Ca, Mg, Mn, K, and Na, respectively. Both HCA and PCA results showed that these elements could be linked to natural soils and anthropogenic sources. PCC reported significant correlations between Na and K indicating they may have been derived from the same source. The daily metal intakes were below the World Health Organization (WHO) permissible limits implying no associated health risks for khat users. ConclusionBased on the findings of this study, the consumption of khat from regions of Meru County may be a potential source for essential elements required for human biological processes.

Predictors of the development of disorders of body functions in children with cerebral palsy

Abstract. Among the diseases of the nervous system, cerebral palsy (cerebral palsy) is the most common cause of disability in children. Cerebralpalsy is characterized by disorders of statodynamic, mental, speech, sensory functions, as well as the presence of secondary complications due to changes in muscle tone and joint functions. The above functions are evaluated during a medical and social examination. To optimize the process of establishing the category of «disabled child» for children with cerebral palsy, it is relevant to identify predictors in determining the severity of persistent functional disorders as one of the criteria for establishing disability. The purpose of the work. To determine the predictors of the development of persistent functional disorders in children with cerebral palsy using discriminant analysis. Material and methods: The study used information from the acts and protocols of the medical and social examination of 1229 children with cerebral palsy, reflecting clinical, instrumental, psychophysical, integral indicators of the condition of patients. A correlation analysis was carried out to determine the relationship between integral health parameters and the severity of persistent disorders of body functions in order to select indicators for discriminant analysis. Using discriminant analysis, predictors of the development of persistent disorders of body functions in children with cerebral palsy were determined. Statistical significance was verified by means of a p-value with established significance levels of 0.05 to determine the significance of the correlation and 0.01 to select predictors based on the results of discriminant analysis. Results. According to the results of correlation and discriminant analysis, significant (p<0.01) predictors of the development of functional disorders included: assessment of the patient’s general condition on the GMFCS scale, lack of control of pelvic organ function, delayed psychomotor development in the first year of life, delayed speech development, the presence of pseudobulbar syndrome, the disease code according to ICD- 10. The accuracy of the created linear model was determined at the level of 0.92 in the task of classifying the severity of persistent disorders of body functions in children with cerebral palsy. Conclusion. The health indicators indicated in the results in children with cerebral palsy can be considered as significant predictors of the development of disorders of body functions. The developed classification model based on the selected predictors showed high accuracy (0.92) in the tasks of classifying the severity of persistent disorders of body functions in children with cerebral palsy.

Factors Associated With Physical Activity and Sedentary Behavior in People With Parkinson Disease: A Systematic Review and Meta-Analysis.

The goal of this review was to investigate factors associated with physical activity and sedentary behavior in people with Parkinson disease (PD). The magnitude of these associations were investigated in line with the International Classification of Functioning, Disability and Health components. A systematic literature review was conducted until February 2023, searching 4 databases (PubMed, EMBASE, Web of Science, and Scopus) for original articles investigating associations with physical activity or sedentary behavior in people with PD. Two independent researchers performed data extraction, and the risk of bias in the included studies was assessed using the Quality in Prognosis Studies tool. Meta-analyses were conducted to determine the magnitude of the associations, and significant regression models from the included studies were described. Forty-two studies were included. Twenty-one factors associated with overall physical activity were identified. Higher levels of physical activity had small association with cognition and body mass index, and fair association with 17 factors related to self-efficacy, physical function, mobility, quality of life, age, PD symptoms, and more. Better manual dexterity and functional gait had moderate to good association with higher levels of physical activity. The regression model with the higher magnitude was composed mostly of contextual factors, except for the body max index. The magnitude of factors associated with physical activity intensity or sedentary behavior could not be identified. Functional gait and manual dexterity were the strongest factors related to physical activity in people with PD. Further investigation is needed to understand the factors associated with physical activity intensity and sedentary behavior. This study emphasizes the significance of considering contextual factors alongside body function and structure, activity and participation, and the health condition to enhance physical activity improvement during the rehabilitation process. By adopting such holistic approach, rehabilitation professionals can optimize the overall health and wellbeing of individuals with Parkinson disease.

Synthesis of Yolk-Shell CoNi2S4 Spheres Modified Flexible Carbon Cloth Electrode for Highly Sensitive Detection of Neurotransmitter Dopamine

Dopamine (DA) is a neurotransmitter that is connected with transitory information in the mammalian central nervous system; changes in its concentration in the body are directly related to mental activity. The absence and/or low level of DA can cause symptoms of several disorders, including Parkinson’s and schizophrenia. As a result, detecting DA in patients is critical for regulating body function. Many efforts have been made to build electrochemical sensing devices to detect DA in human body or biological fluids due to its inherent advantages of high sensitivity, speed, simplicity, and affordability. However, surface modification with nanomaterials, polymers, pretreatments, or simple functionalization are required to improve the performance of these sensing electrodes. Further, exploration of earth-abundant electro-catalysts with high activity and stability is also important for the development of highly selective and sensitive electrochemical sensing interfaces. With these considerations in mind, our study describes the construction of yolk-shell CoNi2S4 spheres modified flexible carbon cloth (CC) electrode for the sensitive detection of DA. The synthesized material's surface and morphological study were examined, and the successful synthesis was confirmed. The yolk-shell CoNi2S4 spheres shown good electrochemical sensing performance towards DA detection due to their unique surface morphology with large specific surface area and synergistic effects. In comparison to unmodified CC, the yolk-shell CoNi2S4 spheres modified CC demonstrated a low detection limit (5.1 nM), great sensitivity, and a wide linear range (0.01 – 5.2 µM). The detection selectivity was also tested in the presence of a high quantity of the common interference ascorbic acid. Selectivity, stability, and repeatability have also been demonstrated to be satisfactory. Furthermore, the fabricated sensor’s flexibility endows it with significant potential in the fabrication of wearable and soft electronics for human healthcare monitoring.

Functional patient-reported outcome measures after hip or knee arthroplasty: A systematic review and content analysis using the International Classification of Functioning, Disability and Health (ICF).

This systematic review aimed to identify the existing patient-reported outcome measures (PROMs) used in hip or knee arthroplasty for adults with osteoarthritis and assess their content validity using the modified International Classification of Functioning, Disability and Health (ICF) core set for osteoarthritis (OA). Four databases were systematically searched to identify disease or joint-specific PROMs evaluating function after hip or knee arthroplasty. Two reviewers independently evaluated the content of PROMs based on established ICF linking rules. From 449 studies included in this review, 50 PROMs were identified. The mobility chapter of activities and participation was the most common component, followed by sensory function and pain chapter of body function and structure. The most frequent ICF activity and participation categories were d451:going up and down stairs, d4701:using private motorized transportation, d4104:standing, and d4154:maintaining a standing position. However, 11 ICF categories of the modified OA coreset were not captured in any PROMs. This ICF-based content analysis of PROMs revealed that included activity and participation categories vary widely, with little overlap between PROMs. The Knee injury and Osteoarthritis Outcome Score and Hip disability and Osteoarthritis Outcome Score had the most coverage for activity and participation (36.7%). Even though our search identified 50 specific PROMs, there remain gaps in content related to activity and participation coverage. By providing a content analysis of the PROMs used after hip or knee arthroplasty, this study may help clinicians select PROMs based on covered categories and relevant clinical objectives.

Factors influencing functional recovery after limb-salvage surgery for lower extremity musculoskeletal tumours: a qualitative study combining patients’ and healthcare professionals’ perspectives

Purpose Survival rates of lower extremity musculoskeletal tumours (LEMTs) have been increasing. However, patients continue to experience functional limitations after LEMT followed by limb-salvage surgery (LSS). This study aimed to identify factors influencing functional recovery after LSS for LEMT. Methods A qualitative study was conducted using semi-structured interviews with a purposive sample of adult patients who underwent LSS for LEMT (n=7) and healthcare professionals (HCPs) with expertise in orthopaedic oncology (n=7). Recruitment continued until data saturation. A combination of deductive and inductive qualitative content analysis was performed to analyse the transcribed data, producing subthemes under the main International Classification of Functioning, disability and health (ICF)-model domains. Results Four themes were described: (1) bodily functions and structures, (2) activities and participation, (3) environmental factors, and (4) expectations. Physical aspects such as larger resection size and complications negatively affected recovery. The importance of communication strategies of tertiary HCPs and the unfamiliarity of the primary physical therapists with the disease, its surgical treatment, and related consequences were emphasised by both the interviewed patients and HCPs. Conclusions Functional recovery after LSS for LEMT is a multifactorial process. To improve patient care, improving (intercollegiate) communication strategies on treatment details and expectations about functional outcomes is warranted. Implications for rehabilitation Healthcare professionals should be aware some patients experience limited functional recovery after limb-salvage surgery (LSS) for lower extremity musculoskeletal tumours. Healthcare professionals should use multiple communication strategies to bridge the gap between the information provided and what the patient recalls. Knowledge exchange and communication between primary and tertiary care should be more extensive. Multidisciplinary consultations and/or case managers are needed to address all aspects of the individual’s functional recovery after LSS.

Evaluating the Efficacy of Gross-Motor-Based Interventions for Children with Developmental Coordination Disorder: A Systematic Review.

Objectives: This review quantitatively evaluates the effectiveness of gross-motor-based interventions in children with developmental coordination disorder (DCD), examining treatment aspects such as group interventions, therapy duration, and frequency. Methods: A systematic literature review, spanning January 2010 to December 2022, identified 11 relevant articles involving 492 children. Results: Positive outcomes were observed, with a moderate to large overall effect size (Cohen's d) indicating significant improvements in motor function through strategies emphasizing activity, bodily function, games, and small group events. Notably, interventions targeting complex motor skills were crucial for enhancing preparedness and activity engagement, improving fitness, and preventing obesity in children with DCD. Conclusions: The review underscores the effectiveness of activity-oriented and body-function-focused therapies in enhancing motor skills and functioning, emphasizing the need for interventions aligned with real-world activities. Future research should explore the long-term effects and retention of motor improvements, offering valuable insights for designing targeted interventions to promote overall well-being in children with DCD.

Genome-wide analysis and identification of the TBL gene family in Eucalyptus grandis.

The TRICHOME BIREFRINGENCE-LIKE (TBL) gene encodes a class of proteins related to xylan acetylation, which has been shown to play an important role in plant response to environmental stresses. This gene family has been meticulously investigated in Arabidopsis thaliana, whereas there have been no related reports in Eucalyptus grandis. In this study, we identified 49 TBL genes in E. grandis. A conserved amino acid motif was identified, which plays an important role in the execution of the function of TBL gene family members. The expression of TBL genes was generally upregulated in jasmonic acid-treated experiments, whereas it has been found that jasmonic acid activates the expression of genes involved in the defense functions of the plant body, suggesting that TBL genes play an important function in the response of the plant to stress. The principle of the action of TBL genes is supported by the finding that the xylan acetylation process increases the rigidity of the cell wall of the plant body and thus improves the plant's resistance to stress. The results of this study provide new information about the TBL gene family in E. grandis and will help in the study of the evolution, inheritance, and function of TBL genes in E. grandis, while confirming their functions.

Role of opioid receptors in phagocytosis regulation and production of Th1/Th2 cytokines under acute cold stress in non-immune mice

Endogenous opioid system plays an important role in the regulation of body functions under stress, providing stress-protective, analgesic and immunoregulatory effects. The aim of this work was to assess the effect of acute cold stress on the in vivo production of adaptive immunity cytokines IL-2, IL-4, IFNγ, phagocytosis, and production of reactive oxygen species in non-immunized mice with induced blockage of opioid receptors. The object of the study were male white mice subjected to acute cold stress at -20 °C for 10 or 60 minutes. To block opioid receptors, naloxone hydrochloride was used, which was administered subcutaneously at a dose of 0.2 mg/kg 20 min before inducing the stress. After the cold exposure, spleen and peritoneal lavage were obtained from the animals. The cytokine concentrations were determined using ELISA technique. The absorption activity of CD11+ cells of the peritoneal cavity was assessed using FITC-stained St.cohnii with a flow cytometer; the production of reactive oxygen species was assessed using the reaction of luminol-dependent chemiluminescence. It was found that the both cold stress regimens caused naloxone-independent inhibition of spontaneous IFNγ production. In stimulated cultures, an inhibitory effect on IFNγ secretion was registered in animals subjected to stress for only 60 min, being also independent on the opioid receptor blockade. IL-2 production decreased in stimulated cultures against the background of 60 min stress naloxone independently. Both variants of cold stress had no effect on IL-4 production. Stress for 60 min inhibited absorption activity of CD11+ cells from the peritoneal lavage and activated production of oxygen radicals, being, however, canceled by naloxone administration. Hence, acute cold stress led to naloxone-independent inhibition of Th1 cytokine production by splenocytes, naloxone-dependent inhibition of phagocytosis and activation of the microbicidal potential of peritoneal cavity cells.

Biological analysis method based on the relationship between athlete’s PSI rhythm and sports injury

Biorhythm is the law of cyclical changes in individual life activity characteristics as time changes. Biorhythm is an internal law of a biological organism, which comes from the changes that a biological organism is affected by changes in the external environment during natural activities, so its change law is similar to the cycle of the natural environment. Biological rhythms play an important role in mediating human body functions, vital activities, body temperature and other physiological reactions. The balance and stability of biological rhythms can ensure the healthy life activities of the human body. Disrupting the balance of biological rhythms may cause various kinds of human body. In this paper, the research of biological analysis method based on the relationship between athlete’s PSI (Physical, Sensitive, Intellectual) rhythm and sports injury is mainly introduced, and ideas and directions are intended to be provided for analyzing the relationship between athlete’s physical strength, emotion, intelligence and sports injury. This paper proposes a research strategy based on the biological analysis method of athlete’s PSI rhythm and sports injury, including measurement of biological rhythm, literature retrieval method, expert interview method, questionnaire survey method, clustering algorithm-based biological analysis method. A research experiment on the biological analysis method of the relationship between PSI rhythm and sports injury is conducted. The experimental results of this paper indicated that most sports injuries of athletes occur in the critical period of PSI rhythm, with an average incidence of 70.14%. Athletes’ training and competition can be avoided in this critical period as much as possible.

Yogistic efficacy on cardiopulmonary capacities, endurance efficiencies and musculoskeletal potentialities in female college students.

Physical exercise participation among female students is significantly compromised throughout the academic periods of college or university due to scholastic demands and also by less parental and community encouragements. Thus, physical inactivity in female college students leads to less musculoskeletal efficiency and work performance. Customized yogic module may be considered to enhance both aerobic and anaerobic power, pulmonary capacity and musculoskeletal efficiency for the improvement of systemic body functions among female college students. A randomized, controlled parallel study design (n = 60; age = 20.16±2.05 years), on sedentary female college students practicing customized yogic module (n = 30) for 5 days / week for 3 months (60 min daily in the morning) to observe anthropometric, physiological, cardiopulmonary and muscular endurance indices. After yogic practice, a significant reduction in body fat (p < 0.05) (%), heart rate (p < 0.001), systolic blood pressure (p < 0.001), double product (p‹0.01) and rate pressure product (p < 0.05) were estimated. Significant improvement (p < 0.001) in vital capacity, forced expiratory volume in 1 sec was also observed. Evaluation of hand grip strength, maximal oxygen consumption and physical work capacity showed significant increase (p < 0.01) after yogic intervention. A three-month customized yogic training improved resting physiological activities, cardiopulmonary functions, musculoskeletal strength and endurance fitness due to focused breathing, mindfulness meditation and by stretching-strengthening patterns for achieving recreational physical activity among female college students.

Physiological concept of modern medical and biological it methods, used at school in physical culture lessons

The physiological substantiation of the use of IT methods, implemented in the form of ACS "Varicard", is given to monitor the adaptation and health of schoolchildren during classes with them in the subject "physical culture" (PK). The use of the proposed physiological and pedagogical control is aimed at using an individual approach in the selection of motor loads and means of physical activity in accordance with the Federal State Educational Standard, based on the identification of types of autonomic regulation of body functions and the cardiovascular system of those involved.

Confirmatory analysis of the 13-MD and ranking of its meta-dimensions and items.

The 13-MD is a new generic instrument developed to measure general health-related quality of life (GHRQoL). This instrument considers all aspects of health (i.e., physical, mental, and social) in a balanced way. A previous study led to minor changes in the original version of the 13-MD. The objective of this study was to confirm the validity of the modified 13-MD. Validity was assessed with recent data from the general population of Quebec, Canada. The meta-dimensions and items composing the 13-MD were also subjected to a ranking procedure, which allowed to determine the most important aspects for respondents. A total of 1337 French-speaking participants were recruited with 1099 completing the 13-MD for validation purposes and 1084 completing the ranking procedure. The 13-MD showed very satisfactory results and confirmed to be a valid instrument. The ranking of the meta-dimensions revealed that "Well-being" received the most points, followed by "Sleep and energy" and "Body functioning." These results will be very useful in the continuous improvement of the 13-MD, ultimately leading to the valuation stage (i.e., development of a value set).

Effect of Swimming Training on Bone Tissue in Humans

Introduction and purpose: The skeletal system performs many important functions in the human body. It primarily bears the heavy loads associated with movement, protects internal organs, and participates in the regulation of mineral homeostasis. Through continuous processes of bone remodeling and modeling, optimal levels of calcium and phosphorus in the serum are achieved. The balanced removal of old bone tissue by osteoclasts and the formation of new bone by osteoblasts maintain the mechanical properties necessary for the proper functioning of the musculoskeletal system. Bone modeling has been shown to be activated in response to mechanical loading from physical activity. Conversely, the absence of significant loading (as in space travel, i.e., microgravity conditions) leads to increased bone resorption. Osteocytes, as the most numerous group of cells in the skeletal system, are mechanosensitive and are thought to respond to stimuli such as fluid flow, mechanical deformations, and hydrostatic pressure. In response, they regulate the work of osteoclasts and osteoblasts, translating into the regulation of processes occurring in the bone matrix.[1] It is suspected that the type, intensity, and nature of physical exercises can significantly influence these processes. The aim of this work is to gather information on the impact of swimming training (an example of physical exercise in conditions of partial gravity reduction) on the human skeletal system.

The Viennese waltz: social transformation and the shock of the new

ABSTRACT The Viennese waltz was the first vernacular, modern dance. Modern, here, Carrie’s the meaning of modernity. Such dances have an expressive relationship with the body and this requires a specific discursive understanding of what a body is and how it can be experienced. That is, modern, vernacular dancing is a function of the modern body. The modern body evolved as part of the social transformation of society from a feudal order to one founded on capitalism and industrialisation. The modern body is understood, and experienced, as limited by the body’s physical form, distinct from its environment. The body is the site of the individual, and, at the same time, it is the expressive site of mental stimulation. Notoriously, René Descartes theorised this construction in terms of a distinction between the ‘mind’ and the ‘body’ in Meditationes de Prima Philosophia published in 1641. A problem for modern, bourgeois society then became, how to control the expressiveness of the body in dance. This problem of management pervades modernity and is central to this article. The Viennese Waltz was the first modern dance, the first manifestation of dance as individual expression and, consequently, the first time the problem of how to control expression presented itself, and what the consequences might be if the dancing body was not controlled.

Employment of Specially-Abled People in the Hotel Industry—An Indian perspective

Abstract A person with a disability implies a personage with a defined impairment of not less than 40% as per the Gazzette of India. Disability is a collective term that covers (1) impairments (a body function or structure problem), (2) limitations on the operation (related to difficulties in performing a task or action), and (3) constraints on participation (an issue found in life circumstances involvement); The International Classification for Functioning (ICF) definition of disability that states “disability is caused by a complex relationship between body structures, functions and impairments, reflecting the circumstances in which a person lives” will be used. Research conducted by the American India Foundation (AIF) identified different career opportunities for specially-abled persons in India, including examples from the hotel and catering industries. The present scenario of specially-abled people in the Indian hotel industry was explored to understand the opportunities and hindrances in the process and how they can be resolved to increase their employment for a dignified life and an inclusive Indian society as a presumed national goal by the NITI Aayog. This study connects the demand for a competent workforce in the Indian hotel sector with the employment needs of specially-abled people.

Natural active ingredients in cosmetics for mature skin

The human skin performs key functions in the human body, while also being a reflection of the many changes occurring within it. The face, which is most exposed to external factors, is the area where the skin ageing process progresses most rapidly. The study aimed to review the most commonly used active ingredients in natural cosmetics for mature skin, available on the Polish cosmetics market. Raw materials of natural origin are a rich source of active substances, which are widely used in cosmetics. These substances not only moisturise, nourish, cleanse, soften and smooth the skin, but also stimulate circulation in blood vessels, eliminating redness and swelling. The use of active ingredients of natural origin can effectively maintain mature skin in good condition, significantly delaying the ageing processes occurring within it.

Hypoxia, NSAIDs, and autism: A biocultural analysis of stressors in gametogenesis.

Cultural and generational trends have increasingly favored "anti-inflammatory" action, innovating a new class of analgesic, non-steroidal anti-inflammatory drugs (NSAIDs) in the 20th century. The modern human body has been molded over evolutionary time and while acknowledging inflammation can be pathologically entwined, it also serves an important role in healthy folliculogenesis and ovulation, shaping cues that drive needed vascular change. This review argues that because of anti-inflammatory action, the cultural invention of NSAIDs represents a particular stressor on female reproductive-age bodies, interacting with natural, underlying variation and placing limits on healthy growth and development in the follicles, creating potential autism risk through hypoxia and mutagenic or epigenetic effects. Since testes are analogs to ovaries, the biological grounding extends naturally to spermatogenesis. This review suggests the introduction of over-the-counter NSAIDs in the 1980s failed to recognize the unique functioning of reproductive-age bodies, challenging the cyclical inflammation needed for healthy gamete development. NSAIDs are framed as one (notable) stressor in an anti-inflammatory era focused on taming the risks of inflammation in modern human life.