Multimodal training (Resistance, Interval, Stretching, and Endurance, RISE) improves body composition in overweight adults. However, it’s unclear how RISE might affect active normal weight women and whether high dietary protein intake (P) might modify the responses to RISE (PRISE), including the effects on performance outcomes. PURPOSE: To determine the effect of RISE alone, or PRISE on performance outcomes, cardio-metabolic health, and body composition in active normal weight women. METHODS: 27 healthy active females (BMI < 30kg/m2; 42±8 yrs) were recruited for this study and randomized to either standard dietary protein intake (CON: 1.0 g/kg/body weight/day) or high dietary protein intake (HP: 2.0 g/kg/bw/d). Baseline assessment of performance assessed via abdominal, upper and lower body muscular strength (situps, pushups, 1 RM bench and leg presses), power (jump squats and bench throws), aerobic power (5km cycling time trial), flexibility (sit and reach), and balance (stork stand), cardiovascular health (blood pressure, and augmentation index (AIx)), body composition (iDEXA: Fat free mass, fat mass, abdominal/visceral fat, %body fat), hunger/satiety ratings (visual analog scales), and cardio-metabolic profile (energy expenditure, fasting lipids, glucose, insulin). RESULTS: At baseline, no differences existed between groups in any variable. Some aspects of performance, while improved from baseline (1RM bench 10±15 [INCREMENT]lbs, 1RM leg press 123±120 [INCREMENT]lbs, SJ peak power 90±207 [INCREMENT]watts, flexibility 3±2 [INCREMENT]cm, balance 5.5±3 [INCREMENT]sec, 5km TT -28±11 [INCREMENT]sec, p<0.05), were not different between groups. However, other improvements in performance were enhanced in the HP group (Situps 6±7 v. 10±7 [INCREMENT]reps, Pushups 8±13 v. 14±12 [INCREMENT]reps, bench throw peak power 11±35 v. 44±34 [INCREMENT]watts, CON v. HP, p<0.05). BP and AIx were improved with training, but the changes in AIx (1±9 v. -5±11 %) and DBP (-5±9 v. -11±11 mmHg) were greater in the HP group (p<0.05). All aspects of body composition were improved, but no group differences existed. CONCLUSION: The RISE protocol improves multiple aspects of performance, cardiovascular health, and body composition and inclusion of high dietary protein (PRISE) seems to confer additional benefit in terms of strength, power, and cardiovascular health. Funding was provided by Isagenix International LLC to PJA