Body Composition Measurements Research Articles

Are Muscle and Fat Loss Predictive of Clinical Events in Pancreatic Cancer? The Importance of Precision Metrics

ContextMuscle and fat loss from cancer may have prognostic significance. Skeletal muscle and fat areas measured at L3 on a CT scan correlate with body muscle and fat mass. We wished to know if reduced skeletal muscle area or fat on diagnostic CT scans or changes from initial CT scans in patients with pancreatic cancer who died in 2018 and 2019 predicted mortality. MethodElectronic records of 112 patients with locally advanced or metastatic pancreatic cancer were used to extract stage, age, gender, comorbidities, weight, and height at the time of the first CT scan. Survival (in days) was defined from the first CT scan to the death date. Patients had at least one CT scan of the abdomen. I. Two trained medical students read scans independently using TeraRecon software (Durham, NC). Results were averaged, and the differences determined precision. Interclass correlation coefficient (ICC), coefficient of variation, and least significant change determined the precision between readers. Independent prognostic modeling included age and BMI. ResultsAn evaluable sample of 104 with an average age of 67, 56 were male. Nearly half had a TNM Stage of IV (45%). The average Charlson Comorbidity index is 7.2. In those undergoing repeat scans, most were in the timeframe of 60–120 days. Changes in visceral fat in men in the unadjusted Cox proportional hazard model and reduced skeletal muscle area in the age-adjusted model of men predicted mortality. In contrast, myosteatosis in women marginally predicted improved survival. ICC's precision between readers was adequate but by least significant change would have missed subtle, clinically important changes. DiscussionMuscle loss during chemotherapy in men predicted mortality in men but not women. Precision is an important metric when measuring body composition. ConclusionMuscle loss in men during chemotherapy of pancreatic cancer predicts mortality.

A Workplace Physical Activity Intervention and a Smartphone App for Overweight and Obese Sedentary Women.

The sedentary aspects of many U.S. occupations and the amount of time American workers spend in the workplace make it an ideal location to implement health promotion programs. This study assessed the effectiveness of a free smartphone app with a goal-setting feature to increase physical activity (PA) and impact anthropometric, body mass (BM), and body composition (BC) changes among overweight and obese women within a community health workforce. Eighteen overweight and obese (body mass index [BMI] = 32.18 ± 4.48 kg/m2), adult (50.73 ± 8.76 years), female volunteers, tracked daily steps with a free smartphone app (StridekickTM) over an 8-week period. Pre- and post-program body composition (BC) measurements included: relative (%) body fat (BF), fat mass (FM), fat-free mass (FFM), and lean mass (LM), using dual X-ray absorptiometry (DEXA scan), and five anthropometric measurements (biceps, waist, abdomen, hips, and thigh). Pre- to post-program average daily steps resulted in significant anthropometric changes for biceps, hips, and thigh measures, with encouraging changes in FFM, LM, and relative (%) BF. The goal-setting feature of the app did not result in significant differences between the experimental and control groups. No differences were noted in FM, BMI, waist, and abdomen or step goals compared with steps completed. An occupational PA health promotion intervention program that tracked daily steps through the StridekickTM smartphone app resulted in anthropometric, BM, and BC changes. The workplace is an ideal location to affect change in health behaviors via a free smartphone app to increase PA and improve health.

Validity Of Bia And Skinfolds For The Measurement Of Body Composition In Collegiate Gymnasts

Validity Of Bia And Skinfolds For The Measurement Of Body Composition In Collegiate Gymnasts

Agreement of measurement of body composition with seven alternative electrode positions on the hand compared to the standard protocol with single-frequency 50 khz bioelectrical impedance in healthy young adults

Agreement of measurement of body composition with seven alternative electrode positions on the hand compared to the standard protocol with single-frequency 50 khz bioelectrical impedance in healthy young adults

Differences between self-perceived and objectively measured body composition in HIV patients using InBody

Introduction: Body composition is a critical aspect of health, particularly for individuals living with HIV. This study investigates the differences between self-perceived body composition and objectively measured body composition using the InBody machine in HIV outpatients. Methods: A total of 383 HIV-infected outpatients receiving ARV treatment were invited to participate. Patients’ perceptions of their weight, muscle mass, fat mass, water, and mineral content were collected through face-to-face interviews. Subsequently, patients underwent body composition analysis using the InBody machine, and the data were classified into three groups according to each individual’s reference level. Results: Among the 383 patients, 77.5% were male, with the highest age group being 30–45 years, accounting for 56.1%. Nearly two thirds (66.3%) of the patients had been living with HIV for five years or more. The results revealed significant differences between patients’ perceptions and the objective measurements of body composition in 4 out of 5 indicators, except for fat mass. Conclusion: Self-perception of health is important as it influences decisions to seek medical services and other forms of assistance. The discrepancies between HIV patients’ perceptions of their body composition and objective measurements highlight the necessity of regular body composition assessments and improved patient education to enhance health outcomes. Keywords: Body composition, HIV, ARV, Inbody, outpatient

Impact of Elexacaftor–Tezacaftor–Ivacaftor Therapy on Body Composition, Dietary Intake, Biomarkers, and Quality of Life in People with Cystic Fibrosis: A Prospective Observational Study

Background: The combination of elexacaftor–tezacaftor–ivacaftor modulators (ETI) has improved clinical outcomes for people with cystic fibrosis (pwCF). Objectives: This study aimed to evaluate changes in nutritional and morphofunctional assessments, as well as anxiety, depression symptoms, and quality of life, in pwCF after starting ETI therapy. Methods: This was a prospective observational study. We measured body composition (fat mass [FM] and fat-free mass [FFM]) using bioelectrical impedance analysis (BIA) and skinfold thickness measurements (SMs). We also assessed hand grip strength, dietary intake via surveys, blood and stool biomarkers, symptoms of anxiety and depression using the Hospital Anxiety and Depression Scale [HADS], and quality of life through the Cystic Fibrosis Questionnaire—Revised (CFQR). Results: A total of 31 pwCF were evaluated. Significant improvements were observed in respiratory function and quality of life, alongside an average weight increase of approximately 5 kg (60% FM and 40% FFM). The prevalence of malnutrition, based on BMI and the FFM index, decreased significantly, while the rate of overweight/obesity increased. Biomarker analysis indicated better nutrient absorption and reduced intestinal inflammation, as evidenced by significant changes in faecal calprotectin, nitrogen, and fat levels, as well as blood lipid and vitamin profiles. Conclusions: Despite a reduction in caloric intake, an increase in weight was observed one year after initiating ETI. This increase was attributed to gains in both FM and FFM, suggesting improved metabolic efficiency and nutrient absorption. Both SM and BIA were found to be useful assessment tools. These findings indicate the need to modify the nutritional approach, focusing on the quality rather than the quantity of intake, and aiming for an appropriate body composition (FFM) rather than solely focusing on BMI.

Correlations and consistency of body composition measurement indicators and BMI: a systematic review.

It is critical to accurately determine the level of obesity and health status since overweight/obesity has become a main global public health problem. This systematic review attempted to evaluate the consistency and correlation between body composition measurement indicators and body mass index (BMI) in childhood and adolescence. Seven electronic databases (Web of Science, PubMed, Cochrane Library, Embase, CNKI, WANFANG DATA, SinoMed) were searched to collect the literature published since 1999 with the focus on the relationship between body composition measurement indicators and BMI to measure obesity in childhood and adolescence. Among the 28 articles included, 13 articles reported a moderate to very strong correlation between %BF and BMI in obesity measurement (range: 0.49-0.907), while two articles reported a strong to very strong correlation between FM and BMI (range: 0.60-0.86). Six articles reported good to excellent obesity measurement consistency between %BF and BMI (range: 0.441-0.876), one article reported WC (0.58) and WHtR (0.46) in the moderate consistency with BMI, and one article reported a relatively poor to fair consistency between FM and BMI (range: 0.167-0.409). WC, WHtR, and BMI showed the moderate consistency in pre-adolescent children. In pre-adolescence and adolescence, the measurement consistency between %BF and BMI was higher than that between FM and BMI. Gender difference existed in the consistency between %BF and BMI during adolescence. A range of body composition indicators such as %BF, WC, WHtR, and FM could provide valuable body composition measurements, complement BMI for obesity assessment in children and adolescents, and facilitate efficient and comprehensive surveillance of childhood obesity. PROSPERO CRD42024506932.

Addressing health disparities. Measuring body composition as a complementary predictor of cardiovascular risk

Introduction. Obesity, increased waist circumference and elevated visceral fat are positively correlated with cardiovascular disease (CVD) risk, in contrast to Mediterranean Diet. Objective: To analyze the association between increased waist circumference (WC), visceral fat (VF), body mass index (BMI), age, sex, total cholesterol, total fat percentage, muscle mass and adherence to a Mediterranean Diet. Methods. 566 office workers with increased WC (WHO criteria) were included in this multicentre, cross-sectional observational study, when they attended to their job-specific health checkup in Madrid (2023). BMI and body fat distribution (VF, total fat and muscle mass) was obtained using bioimpedance (TANITA™). Sex, age, waist circumference, total cholesterol and PREDIMED questionnaire (adherence to Mediterranean diet) were also collected. Results. 95.3% of the employees were obese or overweight (BMI). 76.3% had increased TF or were in the obese range. 63% had medium or low adherence to the Mediterranean diet. 50.5% had normal visceral fat. 51.2% had normal cholesterol levels. High VF showed a statistically significant association (P<0.001) with BMI ≥30 (obesity).Being male was associated to greater obesity (P<0.001), high VF (P<0.001) and lower adherence to the Mediterranean diet (P<0.03).Being a woman was associated to high TF (P<0.001).A low adherence to the Mediterranean diet was associated to more VF (P<0.017). Conclusions.Individual CVR prediction can be completed by clinicians using tools like bioimpedance that considers sex, VF, TF, in addition to BMI and WC.

Interleukin-15 and high-intensity exercise: relationship with inflammation, body composition and fitness in cancer survivors.

Pre-clinical murine and in vitro models have demonstrated that exercise suppresses tumour and cancer cell growth. These anti-oncogenic effects of exercise were associated with the exercise-mediated release of myokines such as interleukin (IL)-15. However, no study has quantified the acute IL-15 response in human cancer survivors, and whether physiological adaptations to exercise training (i.e. body composition and cardiorespiratory fitness) influence this response. In the present study breast, prostate and colorectal cancer survivors (n=14) completed a single bout of high-intensity interval exercise (HIIE) [4×4min at 85-95% heart rate (HR) peak, 3min at 50-70% HR peak] before and after 7months of three times weekly high-intensity interval training (HIIT) on a cycle ergometer. At each time point venous blood was sampled before and immediately after HIIE to assess the acute myokine (IL-15, IL-6, IL-10, IL-1ra) responses. Markers of inflammation, cardiorespiratory fitness and measures of body composition were obtained at baseline and 7months. An acute bout of HIIE resulted in a significant increase in IL-15 concentrations (pre-intervention: 113%; P=0.013, post-intervention: 102%; P=0.005). Post-exercise IL-15 concentrations were associated with all other post-exercise myokine concentrations, lean mass (P=0.031), visceral adipose tissue (P=0.039) and absolute peak (P=0.032). There was no significant effect of 7months of HIIT on pre- or post-HIIE IL-15 concentrations (P>0.05). This study demonstrates HIIE is a sufficient stimulus to increase circulating IL-15 and other myokines including IL-6, IL-10 and IL-1ra which may be clinically relevant in the anti-oncogenic effect of exercise and repetitive exposure to these effects may contribute to the positive relationship between exercise and cancer recurrence. KEY POINTS: Exercise has been demonstrated to reduce the risk of cancer recurrence. Pre-clinical murine and in vitro models have demonstrated that exercise suppresses tumour and cancer cell growth, mediated by exercise-induced myokines (IL-6 and IL-15). High-intensity interval exercise significantly increased myokines associated with the anti-oncogenic effect of exercise and the magnitude of response was associated with lean mass, but training did not appear to influence this response. Given IL-15 has been implicated in the anti-oncogenic effect of exercise and is being explored as an immunotherapy agent, high-intensity interval exercise may improve outcomes for people living beyond cancer through IL-15-mediated pathways. Interventions that increase lean mass may also enhance this response.

Ultrasound for assessing paediatric body composition and nutritional status: Scoping review and future directions.

This scoping review aims to assess the utility of ultrasound as a prospective tool in measuring body composition and nutritional status in the paediatric population. We provide a comprehensive summary of the existing literature, identify gaps, and propose future research directions. We conducted a systematic scoping review following the PRISMA Extension for Scoping Reviews guidelines. This involved screening titles and abstracts of relevant studies, followed by a detailed full-text review and extraction of pertinent data. We identified and synthesised 34 articles. The review revealed that while ultrasound has been used to assess body composition and bone properties in children, significant gaps remain in the literature. These include limited studies on ultrasound performance, insufficient attention to relevant sample characteristics, reliance on manual image measurements, and limited sample diversity. Point-of-care ultrasound shows significant promise for assessing paediatric body composition and nutritional status. To validate and enhance its effectiveness, further research is needed. Future studies should include larger and more diverse patient cohorts and conduct longitudinal investigations to evaluate nutritional interventions. Additionally, developing artificial intelligence (AI) for standardising and automating data interpretation will be crucial in improving the accuracy and efficiency of ultrasound assessments.

Abstract B013: Host phenotype profiling predicts progression to resection in neoadjuvant pancreatic cancer

Abstract Introduction Neoadjuvant chemotherapy offers a modest survival benefit in pancreatic cancer. Current methods for assessing response to chemotherapy are limited to CA19-9 and post- treatment imaging. However, these methods are not without caveats and focus heavily on tumour biology and staging the tumour, without consideration of host biology or staging the host. We sought to explore the relationship between host biology and outcomes in neoadjuvantly- treated pancreatic cancer, and determine the utility of host phenotype profiling as a tool for predicting chemotherapy response and subsequent progression to resection. Methods Host phenotype profiling was performed by measuring body composition (BC) pre- and post- neoadjuvant chemotherapy in a large international pancreatic cancer cohort (n = 301). Patients with resectable or borderline resectable disease were included if they received chemotherapy with neoadjuvant intent. BC was determined with contrast-enhanced CT scans by measuring single-slice L3 cross-sectional area. Results There were significant differences in BC change from baseline to post-treatment between resected (n = 174) and non-resected patients (n = 127). Patients who did not progress to resection exhibited greater loss in all BC compartments vs those who progressed to resection (muscle area -3.4 vs -0.7, visceral fat -10.1 vs -2.1, subcutaneous fat -12.0 vs -1.4, all p < 0.001, median percentage change per 100 days). We used these values to define a adverse and favourable host phenotypes, which significantly correlated with progression to resection (58.8% adverse phenotype, 74.3% favourable phenotype, p < 0.001). The independence of this effect was confirmed in a logistic regression model with well-established clinico-pathological variables including CA19-19 rise (adverse phenotype OR of non-resection 4.57, 95% CI 1.55-13.48, p = 0.006). Conclusion Host phenotype profiling represents a useful addition to an otherwise limited toolbox of methods for assessing treatment response and selecting for surgery in neoadjuvant pancreatic cancer. Clinicians will be familiar with the subjective “gut feeling” of identifying patients in the clinic who are unlikely to be candidates for surgery, and we demonstrate an objective measurement of this. Early identification of patients on an adverse trajectory may highlight those who would benefit from early intervention such as prehabilitation, salvage change of chemotherapy regimen, or nutritional optimization to switch the phenotype from adverse to favourable and reverse adverse host biology. Citation Format: Adam Bryce, Stephan Dreyer, Ross Dolan, Fieke Froeling, Dario Solinas, Alice Cattelani, Antonio Pea, David Chang. Host phenotype profiling predicts progression to resection in neoadjuvant pancreatic cancer [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Advances in Pancreatic Cancer Research; 2024 Sep 15-18; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2024;84(17 Suppl_2):Abstract nr B013.

52 Differences in body composition measurements for developing Angus heifers

Abstract The profitability of beef cow-calf operations relies on the reproductive ability of females to calve at 2 yr of age and provide a calf each subsequent year for her lifetime. The management of replacement heifers could affect her ability to conceive early, calve, and rebreed. Common management practices use heifer body weight (BW) (and body condition score (BCS) as indicators of puberty onset but do not indicate body composition and fat deposition. The objective of this study was to use ultrasound measurements of carcass traits to compare the effect of different diet management practices on muscle development and fat deposition of post-weaning heifers. The heifers placed on a higher energy diet are expected to have greater mean carcass trait measurements than the lower energy diet heifers. A total of 124 purebred Angus heifers from the Iowa State University McNay Memorial Research and Demonstration Farm were used for this study. Two diets were administered in this study. One group of heifers (G1; n = 61) was developed on a low-energy roughage diet to reach a target BW of 55% of mature BW at the time of breeding. The second group (G2; n = 63) was developed on a grain diet to reach the target BW of 65% mature BW at breeding. Body weight and ultrasound measurements for backfat (BFAT), ribeye area (REA), and intramuscular fat (IMF) were collected over three time points (0-d, 55-d, and 123-d) during the study to quantify the development of body composition characteristics. The initial measurements were collected 1 wk post-weaning. Significant mean differences between the two groups were observed for BW, BFAT, and REA at 55-d (P = 0.027, P = 0.008, and P < 0.0001, respectively), and 123-d (P < 0.001). The mean differences for BW, BFAT, and REA at 123-d between G1 and G2 were 30.98 kg, 0.10 cm, and 7.81 cm2, respectively No significant difference was found between the groups for IMF measurements at 55-d (P = 0.927) or 123-d (P = 0.169). This suggests IMF is not significantly influenced by diet during the early, post-weaning heifer developmental stage. Although further research is needed, the results from this study suggest the development of weight, BFAT, and REA in early post-weaning beef heifers is influenced by the energy concentration of the diet.

Physical Fitness Determinants of a Military Casualty Evacuation Test.

Casualty evacuation has been identified as a typical and essential single military task which every soldier should be able to perform rapidly during combat. Previous studies suggest that casualty evacuation is typically conducted by dragging and demands e.g., lean body mass and anaerobic performance. Association of physical fitness with casualty evacuation by dragging has been studied widely but previous studies lack comprehensive assessment of all physical fitness determinants. The purpose of the present study was to examine comprehensively how casualty emergency evacuation (CEE) performance associates with physical fitness and body composition. A total of 25 conscripts (20 men, 5 women) volunteered for measurements of height, weight, waist circumference, body composition, 1-min sit-ups and push-ups, grip strength, isometric bench and leg press, standing long jump, 30-s cycle ergometer test, and 12-min run test. Subjects performed a CEE test in which evacuation time (ET), heart rate, blood lactate concentration, and rate of perceived exertion were measured. In the CEE test, subjects wore combat gear (11.7 ± 1.6 kg) and dragged a doll wearing combat gear (80.2 kg) 28 m while crawling (go round two cones, Z-pattern) and 20 m upright (straightforward). Correlations and backward regression analysis were used for statistical analyses. The level of significance was set to P ≤ .05. Evacuation time lasted on average 87 ± 32 s with a peak heart rate of 184 ± 6 bpm, lactate concentration of 9.4 ± 2.7 mmol/l, and RPE of 17 ± 1. Evacuation time correlated inversely and strongly with anaerobic capacity and power (r = -0.72-0.78, P ≤ .001), but not with aerobic fitness. Inverse and strong correlations were observed between ET and maximal strength variables (r = -0.58-0.69, P ≤ .01), whereas muscular endurance and ET revealed non-significant correlations. Evacuation time correlated moderate to strongly with body fat percentage (r = 0.48, P ≤ .05) and inversely with lean body mass (r = -0.74, P ≤ .001) and body height (r = -0.53, P ≤ .01). The backward regression analysis showed that anaerobic capacity (standardized β = -0.52, P ≤ .001), fat percentage (standardized β = 0.40, P ≤ .001), and isometric leg press (standardized β = -0.25, P ≤ .1) together explained the variance of ET significantly (adjusted R2 = 0.84, P ≤ .001). This study examined thoroughly how different physical fitness dimensions and body composition relate to a CEE test performed by a combination of dragging while crawling and in upright position. Casualty emergency evacuation was discovered as a high-intensity military task, which demands most importantly high anaerobic performance, lean body mass, and maximal strength capabilities. Improving these dimensions of physical fitness should be considered highly important as CEE is essential and possibly one of the most demanding military tasks which every soldier should be able to conduct in combat. From operational perspective, it is relevant that soldiers are able to perform CEE during operations; therefore, further research is needed on how acute operational stress changes the nature of CEE and its physical determinants.

Body composition between obstructive and non-obstructive bladder cancer: A retrospective study

Background: Body composition measurement during cancer follow-up would increase its role in improving nutritional status. Using a CT scan for nutritional evaluation with scheduled cancer screening or follow-up would add other useful information to help the physician gain a better understanding of the patient’s nutritional status, especially in adipose tissue. Objective: To evaluate the correlation of measured adipose tissue and skeletal muscle between obstructive and non-obstructive uropathy in bladder cancer on a CT scan. Background: Body composition measurement during cancer follow-up would increase its role in improving the nutritional status. Using a CT scan for nutritional evaluation with scheduled cancer screening or follow-up would add other useful information to help the physician gain a better understanding of the patient’s nutritional status, especially in adipose tissue. Objective: To compare the measured adipose tissue and the skeletal muscle between obstructive and non-obstructive uropathy in bladder cancer on a CT scan. Materials and Methods: A total of 69 patients, who underwent a CT scan of the abdomen including the pelvis before surgery and/or chemotherapy between January 2013 and December 2022, were enrolled. Analyses of the volume of visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and skeletal muscle tissue (SMT) calculated based on CT images were performed. Results: There was significantly lower VAT (p = 0.012) in the obstructive group than in the non-obstructive group. SAT, SMT, age, weight, height, BMI, and tumor size were not significantly different between both groups. Conclusion: In patients with bladder cancer, those with obstructive uropathy showed lower VAT than non-obstructive uropathy.

Visceral fat area and subcutaneous fat area as measures of body composition in soft tissue sarcoma.

Soft tissue sarcomas (STS) are a heterogenous group of malignancies of mesenchymal origin. Given recent data linking obesity as well as the pattern of fat distribution with cancer outcomes, we sought to investigate the association of visceral fat area (VFA) and subcutaneous fat area (SFA) with oncologic outcomes in patients with STS undergoing surgery. We analyzed data from 88 patients with STS diagnosed from 2008 to 2022. Predictor variables included body mass index (BMI), VFA, and SFA. VFA and SFA were obtained from computed tomography of the abdomen and pelvis. Univariable and multivariable Cox regression analysis was used to analyze associations between predictor variables and overall survival and recurrence-free survival. Although BMI was closely correlated with VFA (r = 0.69, p < 0.0001) and SFA (r = 0.80, p < 0.0001), there was no significant association between high BMI, VFAor SFA, and worse oncologic outcomes. Although VFA and SFA are strongly correlated with BMI, we did not observe BMI nor imaging metrics of fat composition to be associated with worse oncologic outcomes. Further research is needed to elucidate any links between body fat content and metabolic or immune factors governing oncologic outcomes in STS.

P130 TO ASSESS THE SENSITIVITY OF ANKLE BRACHIAL INDEX, WAIST TO THIGH RATIO AND HEIGHT TO WAIST RATIO AS A PREDICTOR OF HYPERTENSION

Materials and Methods: This cross-sectional study included 1000 subjects and spanned from August 2021 to December 2023. It compared Height to Waist Ratio (HtWR), Ankle Brachial Index (ABI), Waist to Thigh Ratio (WTR), and Wrist to Arm Ratio (WAR) against established markers like Waist to Height Ratio (WHtR), Waist to Hip Ratio (WHR), and Body Mass Index (BMI) to assess their effectiveness in measuring body composition. Results: Out of 750 participants, 40% (n=400) were males and 60% (n=600) were females. Among them, 44% (n=440) were non-hypertensive, while 56% (n=560) were hypertensive. For males, HtWR (AUROC: 0.677) and Inverse ABI (AUROC: 0.611) showed superior predictive capability for hypertension compared to other measures. Conversely, among females, Waist to Thigh Ratio (AUROC: 0.669) was the most effective predictor. Cut-off values for WTR in females were 1.55, while for males, HtWR and Inverse ABI were 2.3 and 2.84, respectively. Conclusion: Among males, height to waist ratio and inverse ABI proved more reliable for predicting hypertension, while in females, waist to thigh ratio was more sensitive. Among males, HtWR (AUROC: 0.677) and Inverse ABI (AUROC: 0.611) were superior predictors of hypertension, while females showed a higher predictive capability with Waist to Thigh Ratio (AUROC: 0.669). Specific cut-off values were established: 1.55 for WTR in females, and 2.3 for HtWR and 2.84 for Inverse ABI in males. These gender-specific findings inform tailored hypertension risk assessment strategies. This study suggests incorporating inverse ABI into both clinical and community-based hypertension screenings to enable earlier detection.

Hypothalamic-pituitary-ovarian axis suppression is common among women during US Army Basic Combat Training

ObjectiveLess than half of servicewomen report loss of menses during initial military training. However, self-reported menstrual status may not accurately reflect hypothalamic-pituitary-ovarian (HPO) axis suppression and may underestimate reproductive health...

Body composition asymmetry between dominant and non-dominant arms in experienced overhead throwing sports athletes.

Overhead throwing can cause asymmetric physical characteristics induced by certain repeated asymmetric movements. Characterizing these physical properties could provide insights for health promotion, conditioning, and training planning. The status of asymmetric body composition and physical function in overhead throwing sports athletes remains unclear. The aim of this study was to investigate body composition asymmetries in experienced overhead throwing sports athletes. This study included 77 college students classified into three groups, overhead throw sports, non-overhead throw sports, and non-sports experience groups, based on past and current sports activities and years of experience. A body composition analyzer was used to measure body composition variables. The asymmetry in body composition variables between limbs was evaluated using the asymmetry index. Differences between groups were compared using one-way analysis of variance and post-hoc tests. The lean muscle mass asymmetry index of the arms in the overhead throw group was significantly higher than that in the other groups. The dominant arm lean muscle mass in the overhead throw group was significantly higher than that in the other groups. However, the non-dominant arm lean muscle mass in the overhead throw group was significantly higher than that in the non-sports experience group. Overhead throwing sports results in increased muscle mass in the dominant arm and produces asymmetry in muscle mass between the arms. This asymmetry may be induced by repeated and frequent asymmetrical motions. Our findings highlight the importance of characterizing the effect of sports activities on the athletes and may provide insights for conditioning regimens for them.

Primerjava ultrazvočnega merjenja premera spodnje votle vene in merjenja sestave telesa z metodo bioelektrične impedance za oceno tekočinskega stanja pri novorojenčkih

Background: Neonatal medical conditions often disrupt the physiological processes that regulate fluid balance, so assessing fluid status in sick neonates is important for clinical management. In clinical practice we use clinical signs, which, however, on their own, do not provide a reliable assessment of fluid status. We aimed to compare two methods: i) diameters and collapsibility index of vena cava inferior (VCI) measured by ultrasonography and ii) analysis of body composition by bioelectrical impedance (BIA) and to evaluate their relation to changes in body mass. Methods: In a cohort-prospective clinical trial we included 27 neonates aged 1–7 days with various pathologies. Ultrasound measurements of VCI transversely and longitudinally, measurements of body composition by BIA and measurements of body mass were performed in each subject at least three times with an interval of 24–72 hours. Simultaneous measurements of the same subject were then analysed and evaluated. Results: The average proportion of total body water (TBW) decreased in the first days after birth, from 80.3% (Day 1) to 73.1% (Day 8) (p = 0.006). The decrease in the average proportion of extracellular water (ECW) in the first days after birth was not statistically significant. The association between ECW and body mass over time was statistically significant (p &lt; 0.001). The association between transversely measured large VCI diameter during inspiration, body mass, and ECW was statistically significant (p = 0.024). No statistically significant association with ECW or body mass was proven for the other ultrasound-measured variables. Conclusions: By measuring body composition with BIA, we confirmed the reduction of the average proportions of TBW after birth and the association between body mass, ECW, and transversely measured maximal diameter of VCI during inspiration. BIA is an appropriate method for monitoring fluid status in a newborn. Additional research on a larger number of subjects is needed to define the significance of VCI measurements for assessing fluid status.

The Effectiveness of Physical Activity Intervention at School on BMI and Body Composition in Overweight Children: A Pilot Study

(1) Background: Overweight children usually have lower levels of physical activity (PA) than their normal-weight peers. Low PA predisposes to an increase in body fat mass. The aim of this study was to evaluate the effectiveness of school-based PA intervention on the anthropometric indicators and body composition of overweight and obese children during a two-year observation period, from the age of 10 to 12. (2) Materials and methods: The research included 148 children with overweight or obesity who were born in 2007. There were two groups of children with standard and elevated PA at school (SPA and EPA; 4 and 10 h of physical education lessons a week, respectively). Anthropometric and body composition measurements were carried out. Body mass index (BMI), fat mass (FM), fat-free mass (FFM), skeletal muscle mass (SMM), and total body water (TBW) were estimated. In total, five measurements were conducted at intervals of 5–6 months. (3) Results: In EPA group, the percentage of obese children decreased from 46% to 35.25%, and in SPA group, this percentage increased from 42.75% to 46%. Only 3.33% of children in the standard PA group (one child) and 17.2% in the elevated PA group (six children) changed their BMI and FM categories from overweight to normal body mass. In EPA children, FM decreased from 28.65% to 26.41%, and in SPA children, it increased from 30.31% to 31.75%. The highest increase in FFM was in EPA boys, while SPA boys recorded the highest decrease. In SPA children, SMM increased by 0.43% from 38.85% to 39.28%, and in EPA children, it increased by 2.51% from 40.27% to 42.78%. In EPA children, TBW slightly increased from 53.26% to 53.59%, and in SPA children, it decreased from 50.70% to 49.93%. (4) Conclusions: Elevated PA at school has a positive effect on the BMI and body composition of children who are overweight or obese. Increasing the mandatory number of physical education lessons in school curricula is an efficient strategy for reducing obesity in school-aged children.