Body Parts Research Articles

Quorum quenching mediated biofilm impediment in Chromobacterium violaceum and Staphylococcus aureus by leaf extracts of Delonixelata

Biofilms are complex communities of microorganisms that cause systemic infections, resistance development and delay in healing wounds. Biofilms can form in various parts of the human body, such as the teeth, lungs, urinary tract, and wounds. Biofilm complicates the effects of antibiotics in treating infections. In search of a cure, a plant-based phyto component was selected for this investigation as an anti-quorum-mediated biofilm restricting agent in Gram-negative Chromobacterium violaceum and Gram-positive Staphylococcus aureus. The bioactive components in Delonix elata (DE) ethyl acetate extract were identified using Gas chromatography and mass spectrometry. The extract was examined for toxicity using 3T3 cell lines and brine shrimp and ascertained to be non-toxic. Violacein was inhibited up to 68.81 % in C. violaceum at 0.6 mg/ml concentration. Hemolysin synthesis impediments in C. violaceum and S. aureus were 80 % and 51.35 %, respectively, at 0.6 mg/ml of DE extract. At 0.6 mg/ml, EPS was abated by up to 49 % in C. violaceum and 35.26 % in S. aureus. DE extract prevented biofilm formation in C. violaceum and S. aureus up to 76.45 % and 58.15 %, respectively, while associated eDNA was suppressed up to 67.50 % and 53.47 % at the respective sub-MIC concentrations. Expression of genes such as cviI, cviR, vioA, vioB, and vioE were dramatically reduced in C. violaceum, while genes such as agrA, sarA, fnbA, and fnbB were significantly reduced in S. aureus. Docking demonstrates that two or more DE molecules bind efficiently to the QS receptors of C. violaceum and S. aureus. Thus, DE extract can be investigated for therapeutic purposes against pathogenic microorganisms by rendering them less virulent through quorum quenching mediated action.

Spatio-Temporal Articulation & Coordination Co-attention Graph Network for human motion prediction

Human motion prediction, the task of forecasting future poses from a given observed sequence, is crucial for advancing human-centric computer vision. Significant progress has been made by employing fixed or adaptively learned spatiotemporal Graph Neural Networks (GNNs) for skeleton sequences. However, many existing GNN-based methods often yield counterfactual predictions by overlooking the inherent correlations between body parts essential for balance and coordination. In this study, we propose an end-to-end Spatio-Temporal Articulation & Coordination Co-attention Graph Network (ST-A&CCGN) that leverages both the physical and kinematic regularities of the human motion system. Specifically, we construct articulated and coordination graphs as prior knowledge to explicitly model the connectivities among articulated body parts and their coordination. Subsequently, we design a consistent module employing a parameter-sharing strategy to extract embeddings consistently representing both physical articulation and dynamic coordination. An attention mechanism is introduced to simultaneously learn adaptive weights for articulated, coordinated, and consistent embeddings. Finally, we utilize a multi-head temporal encoding module to capture temporal dependencies among spatial features. Extensive qualitative and quantitative evaluations conducted on three widely used benchmarks, namely Human3.6M, AMASS, and 3DPW, validate the effectiveness of the proposed framework. Additionally, ablation studies are conducted to emphasize the importance of integrating various modules. Remarkably, our model surpasses state-of-the-art (SOTA) competitors.

The prevalence and risk factors of work-related musculoskeletal disorders among nurses in China: A systematic review and meta-analysis

BackgroundWork-related musculoskeletal disorders significantly impact the job performance and quality of life of nursing personnel in China, necessitating an understanding of their prevalence and risk factors to enhance occupational health and improve medical safety. ObjectiveTo systematically evaluate the prevalence and risk factors of work-related musculoskeletal disorders among clinical nurses in China. DesignSystematic literature review and meta-analysis. MethodsA computerized search was conducted on databases, including the China Knowledge Resource Integrated Database, Wanfang Database, China Biomedical Literature Database, Weipu Database, Embase, PubMed, Web of Science, the Cochrane Library, and CINAHL, covering studies from inception to February 28, 2024, addressing the risk factors for work-related musculoskeletal disorders among clinical nursing professionals in China. The meta-analysis was performed using Review Manager 5.4 and Stata 14 software. ResultsThe analysis included 23 articles, involving a total of 21,042 cases, and revealed a prevalence rate of 79 % (95 % CI: 73 %–84 %) for work-related musculoskeletal disorders among clinical nursing staff in China. Subgroup analysis revealed that the prevalence of work-related musculoskeletal disorders was highest among those with length of service >15 years, at 87 %; the 31–40 age group had a higher prevalence than other age groups, at 85 %; female nurses exhibited a prevalence rate of 80 %, surpassing male nurses at 77 %, while surgical nurses had a higher prevalence rate (83 %) than those in other departments. The most affected body parts were the neck (58 %), waist (57 %), shoulders (49 %), and back (35 %). Identified risk factors for work-related musculoskeletal disorders among clinical nurses in China included age >35 years (OR = 1.69, 95 % CI: 1.16–2.45), length of service ≥10 years (OR = 3.30, 95 % CI: 1.84–5.92), marital status (married) (OR = 2.19, 95 % CI: 1.91–2.50), heavy workload (OR = 2.46, 95 % CI: 1.25–4.83), weekly work hours >40 h (OR = 1.50, 95 % CI: 1.34–1.67), daily work hours >8 h (OR = 1.71, 95 % CI: 1.32–2.21), strong sense of work fatigue (OR = 1.47, 95 % CI: 1.22–1.76), and high night shift frequency (OR = 1.81, 95 % CI: 1.62–2.02). Regular physical exercise was found to be a protective factor (OR = 0.68, 95 % CI: 0.56–0.82). ConclusionThe overall prevalence of work-related musculoskeletal disorders among clinical nursing staff in China was 79 %. Age >35 years, length of service ≥10 years, marital status (married), heavy workload, weekly work hours >40 h, daily work hours >8 h, strong sense of work fatigue, and night shift frequency were identified as risk factors. Nursing administrators and staff can take proactive measures against the aforementioned factors to reduce the risk of illness and ensure the safety of medical care. RegistrationPROSPERO: CRD42023479433.

Case Report Penurunan Tingkat Nyeri Pada Pasien Fraktur Femur Dengan Balut Bidai Di IGD RSUD Tidar Kota Magelang

Fracture is one of the causes of disability caused by trauma due to an accident. Fractures can be caused by direct trauma, for example a collision or blow that results in a broken bone. Splinting is an action carried out as first aid for musculoskeletal injuries so that the injured body part can rest, avoid shifting of the injured bone and reduce the level of pain. By using a splint, the skeletal muscles that are experiencing spasm will slowly relax, thereby reducing the level of pain and holding parts of the body from shifting and reducing pain. To determine the application of splint therapy to reduce the pain level of femur fracture patients in IGD at RSUD Tidar Magelang. The research method used a case report with the nursing intervention of providing splints on the pain level of fracture patients. Conducted 3 observations every 30 minutes on the patient Mr. M, 27 years old, who was involved in a traffic accident. From the results of the research, a nursing intervention was carried out, namely by providing a splint dressing for 3 observations every 30 minutes. The result was that there was a decrease in the level of pain before and after the splint dressing. Based on research conducted with Mr. Therefore, the reduction in pain levels in femur fracture patients with splint dressing in the emergency room at Tidar Hospital Magelang can be concluded that splint therapy has an effect on the pain level of fracture patients by reducing the level of the pain scale.

Removing snares is an effective conservation intervention: a case study involving chimpanzees.

Wild chimpanzees (Pan troglodytes) are caught in snares set for other animals and sometimes injure or lose body parts. Snaring can compromise the health, growth, survival, and behavior of chimpanzees and, thus, represents a threat for the conservation of this endangered species. During a long-term study of chimpanzees at Ngogo in Kibale National Park, Uganda, we started a project to remove snares in and around their territory. We compared the number of times chimpanzees were snared during the 12.75years after the start of this project with the number of times individuals were snared during the previous 14years. Only one chimpanzee was snared after we began removing snares compared with 12 individuals caught during the period before. This represents a clear reduction in the risk created by snaring at this site and suggests that removing snares can be employed to protect chimpanzees.

Foot, Toe, and Nail Changes: Are They Interdependent?

Plain Language SummaryThe foot of man is a strong organ consisting of 26 bones, 33 joints, of which 20 are actively movable, and more than 100 muscles, tendons and connective tissue bands keeping this complex body part together. The foot is usually divided into three parts, the hind, mid, and forefoot. The latter contains the toes as their most forward-pointing parts. They are covered by the nails, which are plates of hard horn substance. The toes increase the weight-bearing surface of the foot and are thus important for balance while standing and walking, for running and jumping. If the foot is not healthy this will seriously influence its function and also change the toenails. An examination of more than 1,600 persons’ toenail photographs was performed to find out, whether foot anomalies can be found in patients with toenail changes. This was in fact the case in a very high number of the patients.

Developmental stage dependent effects of posterior and germline regeneration on sexual maturation in Platynereis dumerilii

Regeneration, regrowing lost and injured body parts, is an ability that generally declines with age or developmental transitions (i.e. metamorphosis, sexual maturation). Regeneration is also an energetically costly process, and trade-offs occur between regeneration and other costly processes such as growth, or sexual reproduction. Here we investigate the interplay of regeneration, reproduction, and developmental stage in the segmented worm Platynereis dumerilii. P. dumerilii can regenerate its whole posterior body axis, along with its reproductive cells, thereby having to carry out the two costly processes (somatic and germ cell regeneration) after injury. We specifically examine how developmental stage affects the success of germ cell regeneration and sexual maturation in developmentally young versus developmentally old organisms. We hypothesized that developmentally younger individuals (i.e. with gametes in early mitotic stages) will have higher regeneration success than the individuals at developmentally older stages (i.e. with gametes undergoing meiosis and maturation). Surprisingly, older amputated worms grew faster and matured earlier than younger amputees. To analyze germ cell regeneration during and after posterior regeneration, we used Hybridization Chain Reaction for the germline marker vasa. We found that regenerated worms start repopulating new segments with germ cell clusters as early as 14 days post amputation. In addition, vasa expression is observed in a wide region of newly-regenerated segments, which appears different from expression patterns during normal growth or regeneration in worms before gonial cluster expansion.

Gray Rainbows.

"You fooled me. I never dreamt," George said to the pasty gray face in the mirror. As a child, he had worked out complicated schemes of how the world must be constructed. This led to that, and that led to this. When this and that no longer fit together, he began to squint, and limit his view to the essential. At any moment, the sky might break open and rain body parts and end times. He never imagined that it would be colors that would give way.

Epidemiological and clinical characteristics of hospitalized unintentional injuries among children in central China from 2017–2023

ObjectivesTo examine the epidemiological and clinical characteristics of hospitalized unintentional injuries among children in Central China and theoretically propose preventive and control measures.MethodsWe conducted a retrospective study of children aged 0–18 years with unintentional injuries who were admitted to a tertiary hospital in Central China from January 2017 to December 2023. We examined various aspects of the unintentional injuries, including age, gender, urban-rural distribution, external causes, trends, location of injury, cost, and length of stay.ResultsA total of 20,166 children with hospitalized unintentional injuries were enrolled. The median age with IQR was 2.8 (1.6, 5.1) years, with majority of the patients (57.0%) were aged 1–3 years, while the fewest were aged 11–18 years. The male-to-female ratio was 1.8:1, and the urban-to-rural ratio was 1.1:1. The most common external causes were foreign bodies (41.7%), exposure to inanimate mechanical forces (25.1%), and falls (22.1%). The most frequently injured body parts were head (72.5%). The total number of unintentional injuries exhibited an increasing trend from 2017–2022, and a decreasing trend from 2022–2023. The urban-rural distribution reversed after 2020. The overall hospitalization cost was 20,810,870.4 USD, with an median cost of 758.7 (556.4, 1,186.2) USD per person.ConclusionUnintentional injuries imposed a heavy burden on society and families. However, the number of cases and the urban-rural distribution showed significant trend changes from 2017–2023. The external causes varied by age group, gender, and region, while prevention and control measures should be developed accordingly.

A LiDAR-based Recommendation System to Improve Sitting Posture Respecting Privacy.

Poor posture is becoming more widespread due to the rising number of jobs that require workers to sit for extended hours. Maintaining proper leg positioning is essential for good overall posture and long-term health. However, current monitoring methods involve multiple sensors and cameras, leading to discomfort and privacy concerns. This paper presents a privacy-preserving recommendation system using Light Detection and Ranging (LiDAR) to monitor leg positions. The system captures the horizontal leg outline at knee height and extracts domain-specific features, while a stacked autoencoder reproduces the latent representation of the leg outline. The system comprises three modules, including one-class and multi-class support vector machines, to identify 15 leg positions and reject unrecognized ones. Data from 30 healthy volunteers during work activities trained the system. When tested on new participants, the system achieved an accuracy of over 98%. In addition to monitoring leg positions while respecting privacy and ergonomics, our system alerts workers about poor leg positions and generates intuitive dashboards with posture statistics that help safety engineers identify at-risk workers and body parts. This offers a promising solution for improving desk workers' posture and reducing long-term health issues, respecting privacy.

The gustatory stalk of the Remo flounder exemplifies how complex evolutionary novelties may arise

The appearance of evolutionary novelties is a central issue in biology. Since Darwin’s theory, difficulties in explaining how novel intricate body parts arose have often been used by creationists and other deniers to challenge evolution. Here, we describe the gustatory stalk of the Remo flounder (Oncopterus darwinii), an anatomically and functionally complex organ presumably used as a chemoreceptor probe to detect prey buried in the substrate. We demonstrate that the gustatory stalk is derived from the first dorsal-fin ray, which acquired remarkable modifications in its external morphology, integument, skeleton, muscles, and nerves. Such structural innovations are echoed in both functional and ecological specializations. We reveal that the gustatory stalk arose through the gradual accumulation of changes that evolved at different levels of the phylogenetic tree of ray-finned fishes. At least five preconditions arose in nodes preceding Oncopterus darwinii. This finding constitutes an interesting example of how evolution can deeply remodel body parts to perform entirely new functions. In this case, a trivial support structure primitively used for swimming became a sophisticated sensory tool to uncover hidden prey.

Improving Anorexia Nervosa Treatment with Virtual Reality Body Exposure and Attentional Bias Modification: A Single Case Study

This case study explores the potential of integrating attentional bias modification training (ABMT) with mirror exposure therapy (MET), utilizing virtual reality and eye-tracking, for a 14-year-old girl diagnosed with anorexia nervosa (AN). The ABMT-MET intervention was used alongside a standard treatment program called Home Treatment (HoT), which combines cognitive behavioral therapy with family-based therapy. Though the patient began HoT with a 3-week inpatient phase, the ABMT-MET intervention specifically took place during the subsequent Home Treatment sessions. The experimental treatment, comprising five consecutive weekly sessions, was bookended by pre- and post-assessment sessions and included a six-month follow-up. During the sessions, the patient engaged in systematic and hierarchical exposure to a virtual representation of her silhouette, with gradual adjustments made to the avatar’s body mass index (BMI) toward a healthier range. ABMT sessions, conducted before each MET session, aimed to redistribute the patient’s focus evenly across her body, successfully neutralizing her initial attentional bias toward non-weight-related body parts. The patient demonstrated consistent decreases in anxiety and fear of weight gain, effectively progressing through the BMI hierarchy in the virtual setting. Post-treatment assessments indicated significant enhancements in body dissatisfaction, drive for thinness, body-checking behaviors, and body appreciation, with these gains preserved at the six-month follow-up, although the attentional bias returned to pre-treatment levels. Though the single-case design limits definitive conclusions, these findings suggest ABMT-MET may be a promising adjunct therapy for AN, requiring further research for confirmation.

Investigation of the Ergonomics and Workload of Farm Women during in Planting and Weeding Operations

The study was done to determine the anthropometric, physical, physiological, and workload characteristics of women operators (N=7) during manual sowing and weeding activities for several medicinal plants. The planting and weeding activities were done using a shovel and a hand hoe. Anthropometric measurements were taken for women aged 20 to 50. The physiological fluctuations in chosen participants' energy and strength during different agricultural operations, as well as the implications in body part discomfort score, were evaluated. The average resting and working heart rates, EER, OCR, and BPDS are all measured to assess physiological characteristics. Female responders reported an average resting heart rate of 78.91 bpm for weeding and 81.46 bpm for planting. Planting and weeding had an average working heart rate of 100.85 and 97.14 (bpm, respectively). The average EER and OCR values for the relevant procedures were 6.35 and 5.31 (kJ/min) and 0.52 and 0.45 (l/min), respectively. The BPDS levels of the chosen participants were 19.5 and 21.4, respectively. The data imply that the workers were more compatible and comfortable when weeding using a hand hoe.

Further Studies in the Pollination of some Indian Asclepiads

Mechanism of pollination, attachment of pollinia with various body parts of insect visitors of order hymenoptera and lepidoptera and their role in pollination of a few asclepiads, viz. Asclepias curassavica L., Calotropis procera (Ait.) R. Br, Wattakaka volubilis (L.) Stapf. Leptadenia reticulata R.Br., Sarcostemma (Oxystelma) secamone (L.) Bennett. and Pergularia daemia (Forsk) Blatt. has been discussed. However, autophily by insu germination of Pollinia in three genera, viz., Hemidesmus indicus Br. Gymnema sylvestre Br. and Tylophora hirsuta (Burm f.) Merr. has been reported for the first time in family Asclepiadaceae.

Widespread form of Majocchi's granuloma in a kidney transplant recipient.

Kidney transplantation is the encouraged kidney replacement therapy due to providing more prolonged survival with a better quality of life. Unfortunately, kidney transplant recipients are susceptible to infections because of long-term utilization of immunosuppression. Despite dermatophyte infections are generally not life-threatening, the clinical significance has been recently enhanced by an increasing number of immunocompromised patients. We have presented a rare dermatophytosis course, Majocchi's granuloma, that spreads to all extremities during the early post-transplant period. A young kidney transplant recipient was exposed to intensive immunosuppression therapy due to acute rejection in the early period of post-transplantation. After four months, numerous nodular skin lesions were raised on various body parts. An invasive fungal infection was identified in the skin biopsy. Also, Trichophyton rubrum was isolated in the tissue cultures. Consequently, the patient was diagnosed with Majocchi's granuloma. An effectual treatment was attained with an oral terbinafine tablet. Majocchi's granuloma is a distinct form of dermatophytosis characterized by the spreading of infection into the dermis. In this unexpected case, we alerted physicians to opportunistic infections in the kidney transplant recipient.

External vs Internal Focus of Attention in Procedural Skills Learning: A Randomized Study.

The Optimizing Performance Through Intrinsic Motivation and Attention for Learning theory postulates that directing attention to the intended movement effect or outcome (external focus) is more effective than directing attention to the internal body motion or body part (internal focus). This study compared external vs internal focus of attention as novice students learned ultrasound-guided peripheral cannulation. The authors hypothesized that conditions promoting an external (vs internal) focus of attention would result in better performance on immediate and delayed (retention) testing. The authors conducted a randomized, experimental study from October 2022 to February 2023 comparing external and internal focus using ultrasound-guided peripheral venous cannulation followed by practice using an ultrasound training block. Undergraduate health science students performed 4 practice trials with instructions to focus on the needle tip (external focus) or their hands (internal focus), followed by an immediate assessment and a retention assessment 2 weeks later. The primary outcome was time to successful cannulation. Results were compared using Kaplan-Meier curves and parametric survival analysis regression (accelerated failure time) models. Seventy participants completed the immediate assessment. The external focus group completed successful cannulation a mean of 2.33 times faster (95% CI = 1.47, 3.67; P < .001) than those in the internal focus group (median time, 12.0 vs 29.5 seconds). Results also favored the external focus group during practice, with the external focus group successfully completing the task a mean of 1.83 times faster (95% CI = 1.04, 3.21; P = .04) than the internal focus group. In the retention assessment, the external focus group successfully completed the task a mean of 2.37 times faster (95% CI = 1.19, 4.74; P = .02) than the internal focus group. External focus of attention compared with internal focus of attention improves medical motor skill learning in novice learners.

Versatile multiple object tracking in sparse 2D/3D videos via deformable image registration.

Tracking body parts in behaving animals, extracting fluorescence signals from cells embedded in deforming tissue, and analyzing cell migration patterns during development all require tracking objects with partially correlated motion. As dataset sizes increase, manual tracking of objects becomes prohibitively inefficient and slow, necessitating automated and semi-automated computational tools. Unfortunately, existing methods for multiple object tracking (MOT) are either developed for specific datasets and hence do not generalize well to other datasets, or require large amounts of training data that are not readily available. This is further exacerbated when tracking fluorescent sources in moving and deforming tissues, where the lack of unique features and sparsely populated images create a challenging environment, especially for modern deep learning techniques. By leveraging technology recently developed for spatial transformer networks, we propose ZephIR, an image registration framework for semi-supervised MOT in 2D and 3D videos. ZephIR can generalize to a wide range of biological systems by incorporating adjustable parameters that encode spatial (sparsity, texture, rigidity) and temporal priors of a given data class. We demonstrate the accuracy and versatility of our approach in a variety of applications, including tracking the body parts of a behaving mouse and neurons in the brain of a freely moving C. elegans. We provide an open-source package along with a web-based graphical user interface that allows users to provide small numbers of annotations to interactively improve tracking results.

Pottery kiln from the second half of the 13th century in Žďár nad Sázavou – Staré Město (Czech Republic)

This study investigates a medieval pottery kiln and its fill excavated at a 13th-century settlement site near the Žďár Cistercian monastery. The short 30–40 year lifespan of the settlement provides valuable insight into how pottery was made and appeared in a chronologically specified timeframe of the mid-13th century. The kiln was a single-chamber type, either with an open-topped or domed superstructure with a very narrow stoking channel in terms of height. Technological analysis of the pottery inside the kiln points to consistent production techniques utilising a combination of coiling and early rotational devices with rapid firing practices. The interpretation of the forming technique is backed by 3D scanning, which quantifies the wall thickness variability over various vessel body parts. Cross-analysis with settlement finds shows a uniform ceramic morphology and technological nuances, with petrographic data suggesting both local and external material influences. The study enhances the understanding of the socio-economic dynamics during medieval colonisation based on the case of the Žďár region and provides a benchmark for regional ceramic research.

Assessment of body metrics, weight, and carcass yields in dusky grouper (Epinephelus marginatus) through correlation and path analysis: Implications for optimizing genetic breeding programs

One of the objectives of aquaculture selective breeding programs is to enhance body conformation traits, often by using indirect criteria like correlation between live body measurements and carcass traits. This research investigated the relationship between live body measurements and carcass traits in dusky grouper (Epinephelus marginatus). We assessed the relationship between body measurements and carcass traits in 150 farmed dusky groupers with an average weight of 680 ± 221 g. The fish were measured for length, width, height, and length of head, and then processed to obtain weights (body, fillet, steaks, head, and residues) and yields (carcass, fillet, steaks, head, and residues). Path analysis was employed to estimate direct and indirect effects, with body part weight and yields as dependent variables and morphometric measurements and relationships as explanatory variables. The findings indicate that morphometric measurements can be used to estimate farmed dusky grouper body weights and carcass yields. Among the morphometric measurements and relationships examined, fish body height and standard length were identified as the main factors influencing variation in body weights and carcass yields.

Unlocking Desire: Exploring the Impact of Seductive Forces of Political Risk, Financial Inclusion, and Competition on Bank Stability in Emerging Markets

This research inquiry overlaps financial services inclusion and a national government's risk of political instability, competition, and banking system stability. It is the analysis of 22 emerging market countries from 2016 to 2021. The research is going to be based on GMM-System dynamic data panel estimate method and the aim is to illuminate the interplay of these factors and to detect their impact on the banking industry sustainability. The point estimates derived from the GMM-System estimation reveal that several of the main conclusions have been reached. The main point to note is that, in general, the more inclusive financial system, the more stable banking sector there will be in the world. What this finding stresses is the necessity of an inclusive financial system to strengthen banks by being a part of the ever-growing body of evidence on how financial inclusion can foster economic growth and stability. Not only does the evidence support the assumption that political unrest and financial markets have a strong relationship, but also the numbers show that this relationship is highly likely. In the case of a country where political instability is reduced, the financial sector turns out to be more viable, the study reveals. Political risk is of a great significance for financial markets and banking systems, and therefore call for political stability as a fundamental for the reliable banking system. Taken together, the finding of the study will be very useful for not only government officials but also the banking sector. The output reaffirms the fact that financial inclusion, competition and political risks are the key components for the sector stability increase. Such factors have a very important influence on the policy, regulation, and strategic decision of banking. These findings show the imperativeness of political and corporate leaders to make progress in increasing financial accessibility, allowing fair competition, and safeguarding political stability so that banking sectors may be reinforced and thus, the world's banking systems may become more resilient.Keywords: Political Risk, Financial Inclusion, Bank Stability, Emerging Economies, Competition.