Blue Range Research Articles

Thin film deposition of organic-inorganic quinoline-tin dioxide p-n junction for optoelectronic devices

Tin dioxide (SnO2) is an oxide semiconductor with n-type characteristics, with high transparency in the UV–Vis, where the donors are usually associated with oxygen vacancies and interstitial tin ions. Quinoline derivatives (QD) are usually p-type semiconductors with emission in the blue range. We report photo-induced properties of the QD 4-(6-(diethylamino)-4-phenylquinolin-2-yl)benzoic acid and the combination with the inorganic semiconductor oxide SnO2, both layers in the form of thin film, which forms a heterostructure. Thin film is a very convenient format for integration in optoelectronics. Emission of the QD takes place in blue range (470–485 nm) and depends on the solvent when in solution, being used acetone and tetrahydrofuran (THF). However, when in the form of thin film, it does not depend on the solvent. Concerning the heterostructure, it is explored under distinct device architecture: 1) combination in a transport profile perpendicular to the films (transverse contacts) leading to a rectifying behavior similar to a p-n junction, which is evidence of the p-type-like electrical behavior of the QD; 2) in parallel conduction profile, where there seems to exist some sort of interfacial phenomenon similar to a two-dimensional electron gas (2-DEG), a property that can be explored in transparent high-mobility transistors.

End Cap Effect on Solution-Processable Deep Blue Lasing Materials with Low-Amplified Spontaneous Emission Thresholds.

Organic lasers have attracted increasing attention owing to their superior characteristics such as lightweight, low-cost manufacturing, high mechanical flexibility, and high emission-wavelength tunability. Recent breakthroughs include electrically pumped organic laser diodes and an electrically driven organic laser, integrated with an organic light-emitting diode pumping. However, the availability of efficient deep blue organic laser chromophores remains limited. In this study, we develop two novel rigid oligophenylenes, end-capped with carbazole and phenylcarbazole groups, to demonstrate exceptional optical and amplified spontaneous emission (ASE) properties. These oligophenylenes are not only solution processable but also exhibit remarkably high solution photoluminescence quantum yields (PLQYs) of 90% and high radiative rates of 1.35 × 109 s-1 in the deep blue range. Our theoretical calculations confirm that the carbazole and phenylcarbazole end groups play a pivotal role in enhancing the optical transitions of the oligophenylene laser chromophores, thereby elevating their emission oscillator strengths. Remarkably, these materials demonstrate low solid-state ASE threshold values of 1.0 and 1.5 μJ/cm2 (at 431 and 418 nm, respectively). To the best of our knowledge, these ASE thresholds represent the lowest reported at these specific ASE wavelengths in the literature, regardless of whether they are solution-processed or thermally evaporated films. Furthermore, they exhibit excellent thermal and photostability, low triplet quantum yields, as well as negligible overlap of excited-state absorption within the ASE emission region, making them excellent candidates for a new class of deep blue materials for organic lasers. By integrating insights from theoretical calculations and experimental validation, our study provides a comprehensive understanding of the design principles behind these high-performing organic laser chromophores, paving the way for the development of advanced organic lasers with enhanced performance characteristics.

A Comprehensive Systematic Review of the Effects of Photobiomodulation Therapy in Different Light Wavelength Ranges (Blue, Green, Red, and Near-Infrared) on Sperm Cell Characteristics in Vitro and in Vivo.

Around 7% of the male population in the world are entangle with considerable situation which is known as male infertility. Photobiomodulation therapy (PBMT) is the application of low-level laser radiation, that recently used to increase or promote the various cell functions including, proliferation, differentiation, ATP production, gene expressions, regulation of reactive oxygen spices (ROS), and also boost the tissue healing and reduction of inflammation. This systematic review's main idea is a comprehensive appraisal of the literatures on subjects of PBMT consequences in four light ranges wavelength (blue, green, red, near-infrared (NIR)) on sperm cell characteristics, in vitro and in vivo. In this study, PubMed, Google Scholar, and Scopus databases were used for abstracts and full-text scientific papers published from 2003-2023 that reported the application of PBM on sperm cells. Criteria's for inclusion and exclusion to review were applied. Finally, the studies that matched with our goals were included, classified, and reported in detail. Also, searched studies were subdivided into the effects of four ranges of light irradiation, including the blue light range (400-500 nm), green light range (500-600 nm), red light range (600-780 nm), and NIR light range (780-3000 nm) of laser irradiation on human or animal sperm cells, in situations of in vitro or in vivo. Searches with our keywords results in 137 papers. After primary analysis, some articles were excluded because they were review articles or incomplete and unrelated studies. Finally, we use the 63 articles for this systematic review. Our category tables were based on the light range of irradiation, source of sperm cells (human or animal cells) and being in vitro or in vivo. Six% of publications reported the effects of blue, 10% green, 53% red and 31% NIR, light on sperm cell. In general, most of these studies showed that PBMT exerted a positive effect on the sperm cell motility. The various effects of PBMT in different wavelength ranges, as mentioned in this review, provide more insights for its potential applications in improving sperm characteristics. PBMT as a treatment method has significant effectiveness for treatment of different medical problems. Due to the lack of reporting data in this field, there is a need for future studies to assessment the biochemical and molecular effects of PBMT on sperm cells for the possible application of this treatment to the human sperm cells before the ART process.

With Blue Light against Biofilms: Berberine as Natural Photosensitizer for Photodynamic Inactivation of Human Pathogens

Evolving antibiotic resistance of bacteria is a prevailing global challenge in health care and requires the development of safe and efficient alternatives to classic antibiotics. Photodynamic Inactivation (PDI) has proven to be a promising alternative for treatment of a broad range of microorganisms. Photodynamic Inactivation uses photoactive molecules that generate reactive oxygen species (ROS) upon illumination and in the presence of oxygen, which immediately kill pathogenic target organisms. Relevant photoactive properties are provided by berberine. Originally extracted from Barberry (Berberis vulgaris), it is a natural compound widely used in Traditional Chinese Medicine for its antimicrobial and anti-inflammatory effects. With this study, we demonstrated the potential of berberine chloride hydrate (Ber) as a photosensitizer for PDI of important human pathogens, Gram(+) Staphylococcus capitis subsp. capitis, Gram(+) Staphylococcus aureus, and Gram(−) Escherichia coli. In vitro experiments on planktonic and biofilm cultures were conducted focusing on Ber activated with visible light in the blue wavelength range. The number of planktonic S. capitis cells was reduced by 7 log10 steps using 100 µM Ber (5 min incubation, illumination with 435 nm LED array, radiant exposure 25 J/cm2). For an antibacterial effect of 4 log10 steps, static S. capitis biofilms required 1 mM Ber, a drug-to-light interval of 60 min, and illumination with 100 J/cm2. Almost all planktonic cells of Staphylococcus aureus could be photokilled using 100 µM Ber (drug-to-light interval of 30 min, radiant exposure 25 J/cm2). Biofilms of S. aureus could be phototreated (3 log10 steps inactivation) when using 1 mM Ber incubated for 5 min and photoactivated with 100 J/cm2. The study is highlighted by the proof that PDI treatment using Ber showed an antibacterial effect on Gram(−) E. coli. Planktonic cells could be reduced by 3 log10 steps with 100 µM Ber (5 min incubation, 435 nm, 25 J/cm2). With 5 mM ethylenediamine tetraacetic acid disodium salt dihydrate (Na2EDTA) or 1.2% polyaspartic acid (PASA) in addition, a relative inactivation of 4 log10 steps and 7 log10 steps, respectively, was detectable. Furthermore, we showed that an antibacterial effect of 3.4 log10 towards E. coli biofilms was given when using 1 mM Ber (5 min incubation, 435 nm, 100 J/cm2). These results underscore the significance of PDI-treatment with Ber as a natural compound in combination with blue light as valuable antimicrobial application.

Electrochemical applications of CdO-Co-ZnO nanocomposites, their synthesis and characterization reveal their multifunctional abilities

In this study, we investigated the electrochemical catalysis potential of hybrid nanocomposites containing CdO, Co and ZnO nanocomposites, as opposed to Zn-O doped Co nanocomposites, have weaker Coulomb interactions due their ionic bonds. Because CdO and Co form a covalent bond, Co interacts more strongly with O than Zn. In order to reduce nanoparticle crystallinity, oxygen defects improve the interaction between −O and oxygen defects in the lattice. From SEM micrographs, it appears that CdO does not completely change under the influence of dopants. It can be seen from the SEM image that both materials have very tightly packed particles. The Co and CdO dopants in ZnO nanocomposites prevent them from absorbing a large range of visible wavelengths. It is more energy-dense for nanocomposites with 5.28 eV to compare to 5.14 eV nanocomposites. The fact that CdO matrix has a tuneable bandgap is evident since different types of dopants are used in its manufacture. There are at least three distinct absorption modes in Co nanocomposites doped with CdO, around 450, 498, and 676 cm−1. In addition to its absorption from 450 cm−1 and 498 cm−1 vibrational modes, Co-O stretching absorption along the [101] plane has also been observed at 676 cm−1. As a method of studying charge carriers, photoluminescence spectroscopy is usually used. This method can be used to analyze electron-hole pairs (e−/h+) formed by semiconducting particles. It is in the blue emission range between the luminescence band of 615 nm and the valence band of 635 nm. With increasing cobalt and zinc concentrations, CdO nanomaterials lose their remanent magnetization. CdO has been demonstrated to have significant coercive effects in both pure and additively incorporated solutions regardless of their anisotropic, morphological, porosity, and particle size distribution. Electrochemical impedance spectrum measurements were conducted between 100 kHz and 0.01 Hz. According to the Nyquist plot, purity CdO, CdO doped Co, and CdO doped ZnO nanocomposites show a high frequency resistance to charge transfer. Nanocomposites that contained CdO doped Co & ZnO were exposed to UV light for 120 min to remove the solution. The degradation of MO is virtually nonexistent when no photocatalyst is present, but with a photocatalyst, degradation can reach 92.56 %.

Pattern search algorithm-aided structural color Sb2S3-based dynamic hybrid all-dielectric metasurface

The versatility and dynamic tunability of reconfigurable photonic devices hold paramount significance in optics. Nevertheless, most such dynamically adjustable all-dielectric metasurfaces, particularly those utilized in structural color applications, are usually resonators made exclusively of phase-change materials. The elevated absorption coefficients exhibited by phase-change materials in the short-wavelength band (particularly within the blue light range) often culminate in suboptimal performance for generating colors. To address this challenge, we designed a hybrid all-dielectric metasurface that achieved reflectivities of 60%, 75%, and 96% across blue, green, and red-light bands, respectively and achieved dynamic tunability of the metasurface by generating chromatic aberrations of 19.626, 3.341, and 17.354 via the reversible phase transition of Sb2S3. The device exhibits good angular robustness, maintaining nearly constant color within a viewing angle range of ±20°. Meanwhile, we employ a pattern search algorithm to accelerate the inverse design process of metasurfaces. The algorithm can reduce the design time by a factor of at least two orders of magnitude relative to the genetic algorithm, substantially improving design efficiency. The algorithm applies to high degree-of-freedom inverse design problems for intricate physical systems with similar design relationships. It offers a promising avenue for rapid and dependable optical device design.

Biocompatible polymer-coated magneto-fluorescent super nanoparticles for the homing of mesenchymal stem cells

Stem cell plays an important role in the clinical field. However, the effective delivery of stem cells to the targeted site relies on the efficient homing of the cells to the site of injury. In view of that, fluorescent magnetic nanoparticles stick out due to their wide range of enabling functions including cellular homing and tracking. The present study unravels the synthesis of polymer-coated biocompatible and fluorescent magnetic nanoparticles (FMNPs) by a single-step hydrothermal synthesis method. Importantly, the facile method developed the biological super nanoparticles consisting of the magnetic core, which is surrounded by the fluorescent nanodot-decorated polymeric shell. The synthesized particles showed an amorphous nature, and superparamagnetic properties, with efficient fluorescence properties of emission at the blue range (̴ 410 nm). The FMNP labeling showed the mesenchymal stem cell (MSC) homing to the desired site in the presence of an external magnetic field. The in-house synthesized nanoparticles showed significant cytocompatibility and hemocompatibility in vitro as well as in vivo conditions owing to their surface coating. This unprecedented work advances the efficient internalization of FMNPs in MSCs and their enhanced migration potential provides a breakthrough in stem cell delivery for therapeutic applications. Statement of significanceThe bi-modal fluorescent magnetic nanoparticles hold a promising role in the biomedical field for mesenchymal stem cell homing and tracking. Hence, in this study, for the first time, we have synthesized the fluorescent magnetic nanoparticle with polymer coating via an easy single-step method. The nanoparticle with a polymer coat enhanced the biocompatibility and effortless internalization of the nanoparticle into mesenchymal stem cells without hampering the native stem cell properties. Furthermore, the enhanced migration potential of such magnetized stem cells and their homing at the target site by applying an external magnetic field opened up avenues for the smart delivery of mesenchymal stem cells at complex sites such as retina for the tissue regeneration.

Improved piezoelectric and photoluminescence properties in Ce-doped PSN-PMN-PT piezoelectric ceramics by multiscale coordination

The large piezoelectric coefficient (d33) and high mechanical quality factor (Qm) are essential for piezoelectric ceramics used in high-power devices. It is pity that the two parameters are usually opposite, with higher d33 corresponding to lower Qm. In order to well-balance the d33 and Qm, the rare-earth element Ce with multi-valence was introduced into the 0.06 Pb(Sc1/2Nb1/2)O3-0.61 Pb(Mg1/3Nb2/3)O3-0.33PbTiO3 (xCe-PSN-PMN-PT) ceramics in this work. The structure, electrical properties and optical properties of ceramics were systematically analyzed. Optimal electrical performances (d33 = 719 pC/N, Qm = 256, and dielectric loss tanδ = 0.007) were obtained in 0.02Ce-PSN-PMN-PT ceramics. These excellent performances originate from the multiscale coordination effects among defect dipoles, local structural heterogeneity, domain structure, phase structure, and grain size. The xCe-PSN-PMN-PT ceramics exhibit excellent photoluminescence properties in the blue wavelength range. Our research provides a new paradigm for deep-sea electro-optical communication.

Efficacy of Morning Shorter Wavelength Lighting in the Visible (Blue) Range and Broad-Spectrum or Blue-Enriched Bright White Light in Regulating Sleep, Mood, and Fatigue in Traumatic Brain Injury: A Systematic Review.

Traumatic brain injury (TBI) profoundly affects sleep, mood, and fatigue, impeding daily functioning and recovery. This systematic review evaluates the efficacy of morning shorter wavelength lighting in the visible (blue) range and broad-spectrum or blue-enriched bright white light exposure in mitigating these challenges among TBI patients. Through electronic database searches up to May 2023, studies assessing sleep, circadian rhythm, sleepiness, mood, and fatigue outcomes in TBI patients exposed to morning shorter wavelength lighting in the visible (blue) range and broad-spectrum or blue-enriched bright white light were identified. Seven studies involving 309 participants met the inclusion criteria. Results indicated consistent advancement in sleep timing among individuals with mild TBI, alongside improvements in total sleep time, mood, and reduced sleepiness with both types of light exposure, particularly in mild TBI cases. Notably, two studies demonstrated alleviation of fatigue exclusively in severe TBI cases following light exposure. Despite promising findings, evidence remains limited, emphasizing the need for future research with standardized protocols to confirm the potential and optimize the benefits of light therapy for TBI recovery.

High transmission of circularly polarized light and circular dichroism with all-dielectric metamaterial

The optical chirality of metamaterials gives birth to distinct responses of left circularly polarized (LCP) and right circularly polarized (RCP) light, leading to asymmetric transmission and circular dichroism (CD) of circularly polarized light. In this work, meta-atom structure composed of square and semicircular combinations were designed, which exhibits extreme high ratio of transmission, reflection and CD values in blue light range. In compare to other reported structures, the structure composed of semicircular and square combinations can achieve better asymmetric transmission. At the wavelength of 460 nm, the incident LCP light can be mostly converted to RCP light, and the incident RCP light can be almost completely reflected. Furthermore, the geometric phase can be controlled by designing the orientation angle of the meta-atom, and the metamaterial can function under any linear or circular polarization and achieving the regulation of the light field. The designed metamaterial provides promising insights into the high CD and possible applications in optical integrated devices, such as anomalously refracted, focusing, and holograms, etc.

Star-shaped hosts based on phenyls substituted carbazole: Effects of trifluoromethyl and tert-butyl moieties

To investigate the effects of trifluoromethyl and tert-butyl moieties on the general optoelectronic properties of star-shaped hosts based on phenyls substituted carbazole, we used 3,6,9-tris (4-(tert-butyl)-phenyl)-9H-carbazole (M1) as a reference, and different numbers of electron-withdrawing 3,5-bis(trifluoromethyl) benzene were introduced into 3, 6 and 9 positions of carbazole to obtain compounds 9-(3,5-bis(trifluoromethyl)phenyl)-3,6-bis(4-(tert-butyl)phenyl)-9H-carbazole (M3), 3,6-bis(3,5-bis(trifluoromethyl)phenyl)-9-(4-(tert-butyl)phenyl)-9H-carbazole (M5) and 3,6,9-tris(3,5-bis(trifluoromethyl)phenyl)-9H-carbazole (M6). After the introduction of 3,5-bis (trifluoromethyl) benzene, the thermal temperature at 5 % mass loss of M3, M5 and M6 decreased to 344 °C, while the glass transition temperature and melting point of M3 and M5 showed a significant increase. However, M6 did not show obvious glass transition, but its melting point also showed a significant increase. M3 crystallized at 125 °C as evidenced by differential scanning calorimetry, and the linking model of M3 is helpful to crystalize. In addition, when compared with those of M1, the fluorescence emission peaks of M3 and M6 showed a blue-shift, while M5 showed a red-shift, all of which were in the deep blue emission range. The color purity of blue light for M1 in tetrahydrofuran solution is the highest, and M1 exhibit aggregation-induced emission characteristics. Compared to the photoluminescence quantum efficiency (PLQY) of compound M1 of 39 % in toluene, the PLQYs of M3 and M6 decreased to 34 % and 29 %, and the PLQY of M5 increased to 46 %. The function of the lowest unoccupied molecular orbital trap of M3 film under the external electrical field will increase, which not only offsets the increasing effect of the electrical field to the electron carrier and further decreases the carrier mobility when the electrical field increase, and the same situation is also feasible for the highest occupied molecular orbital traps in M5, M6 and M1. The organic blue light emitting diodes were prepared by using M1, M3, M5 and M6 as the hosts of bis [2-(4,6-difluorophenyl)pyridinato-C2,N](picolinato)iridium, and the optimized device of M1 as the host showed the best performance with a maximum luminescence brightness of 2978 cd/m2, maximum current efficiency of 39.42 cd/A and maximum external quantum efficiency of 18.36 %.

Apache Point Observatory (APO)/SMARTS Flare Star Campaign Observations. I. Blue Wing Asymmetries in Chromospheric Lines during Mid-M-Dwarf Flares from Simultaneous Spectroscopic and Photometric Observation Data

We conducted the time-resolved simultaneous optical spectroscopic and photometric observations of mid-M-dwarf flare stars YZ CMi, EV Lac, and AD Leo. Spectroscopic observations were obtained using Apache Point Observatory 3.5 m and Small and Moderate Aperture Research Telescope System 1.5 m telescopes during 31 nights. Among the 41 detected flares, seven flares showed clear blue wing asymmetries in the Hα line, with various correspondences in flare properties. The duration of the blue wing asymmetries range from 20 minutes to 2.5 hr, including a flare showing the shift from blue to red wing asymmetry. Blue wing asymmetries can be observed during both white-light and candidate non-white-light flares. All of the seven flares showed blue wing asymmetries also in the Hβ line, but there are large varieties on which other chromospheric lines showed blue wing asymmetries. One among the 7 flares was also observed with soft X-ray spectroscopy, which enabled us to estimate the flare magnetic field and length of the flare loop. The line-of-sight velocities of the blueshifted components range from –73 to –122 km s−1. Assuming that the blueshifts were caused by prominence eruptions, the mass of upward-moving plasma was estimated to be 1015–1019 g, which are roughly on the relation between flare energy and erupting mass expected from solar coronal mass ejections (CMEs). Although further investigations are necessary for understanding the observed various properties, these possible prominence eruptions on M-dwarfs could evolve into CMEs, assuming the similar acceleration mechanism with solar eruptions.

Blue-light-enhanced avalanche photodiode with amulti-finger grating structure for fluorescence detection.

The responsiveness of the photodetectors is critical to the accuracy of the fluorescent fiber optical temperature sensor. However, the current gain and signal-to-noise ratio (SNR) of traditional photodiodes (PDs) is low, which makes it difficult to meet the high-precision detection requirements of the system. In response to the above problems, this paper achieves a novel, to the best of our knowledge, multi-finger grating (MFG) avalanche photodiode (APD). The device combines the polysilicon gate and the space charge region formed by P+/N-Well to detect photon signals. The conversion capability of the photodetector can be significantly enhanced by the MFG structure. The principle of the device is simulated and verified by technology-computer-aided design (TCAD). The standard grating APD (SG-APD), 2-finger grating APD (2FG-APD), 3-finger grating APD (3FG-APD), and 4-finger grating APD (4FG-APD) are fabricated based on 0.18µm CMOS process. The optoelectronic detection characteristics of these devices are analyzed by establishing an optoelectronic test platform. At 480nm, the responsivity of 2FG-APD, 3FG-APD, and 4FG-APD increases by 79.3%, 96.9%, and 70.2%, respectively, compared to SG-APD (4.021A/W). The test results indicate that 3FG-APD exhibits a strong photon response in the blue light range. The device has broad application prospects in the field of fluorescence detection.

Tuning white light emission using single-component tetrachroic Dy3+ metallacrowns: the role of chromophoric building blocks.

White light production is of major importance for ambient lighting and technological displays. White light can be obtained by several types of materials and their combinations, but single component emitters remain rare and desirable towards thinner devices that are, therefore, easier to control and that require fewer manufacturing steps. We have designed a series of dysprosium(iii)-based luminescent metallacrowns (MCs) to achieve this goal. The synthesized MCs possess three main structural types LnGa4(L')4(L'')4 (type A), Ln2Ga8(L')8(L''')4 (type B) and LnGa8(L')8(OH)4 (type C) (H3L', HL'' and H2L''' derivatives of salicylhydroxamic, benzoic and isophthalic acids, respectively). The advantage of these MCs is that, within each structural type, the nature of the organic building blocks does not affect the symmetry around Dy3+. By detailed studies of the photophysical properties of these Dy3+-based MCs, we have demonstrated that CIE coordinates can be tuned from warm to neutral to cold white by (i) defining the symmetry about Dy3+, and (ii) choosing appropriate chromophoric building blocks. These organic building blocks, without altering the coordination geometry around Dy3+, influence the total emission profile through changing the probability of different energy transfer processes including the 3T1 ← Dy3+* energy back transfer and/or by generating ligand-centered fluorescence in the blue range. This work opens new perspectives for the creation of white light emitting devices using single component tetrachroic molecular compounds.

High photoinduced birefringence in thermally treated layers of the azopolymer PAZO with significantly changed absorbance spectrum

In this experimental work we present the effect of thermal treatment of azopolymer thin films on their absorbance spectra and how that influences the photoinduced birefringence of the azopolymer. The azopolymer we use – PAZO (poly[1-[4-(3-carboxy-4-hydroxyphenylazo)benzenesulfonamido]-1,2ethanediyl, sodium salt]) is commonly investigated material for polarization holography because it is easily accessible and has well pronounced photoanisotropic properties. In a recent study it was discovered that its absorbance spectrum gradually changes upon heating to 250°C and as a result the absorbance in the range 400-600 nm is increased. That raises the question is it possible to increase the photoinduced birefringence for wavelengths that are far away from the peak of absorbance of the azopolymer PAZO, located approximately at 360 nm. For example, there are powerful lasers at 532 nm, which could be used for optical recording instead of traditionally used lasers in the blue and UV range. To answer this question, we investigated thin film samples of PAZO deposited on quartz substrate and measured continually their spectra of absorbance while heating the samples from room temperature to 250°C. We also measured the photoinduced birefringence using pump laser at 532 nm before and after the thermal procedure. Thus, we report significant increase of the birefringence at 532 nm after the thermal treatment and mention some potential applications.

Effect of blue range light-emitting diode radiation on platelets and blood coagulation factors in patients with chronic ischemia of lower limbs

To study the effectiveness of blue range visible radiation combined with basic therapy to improve hemostasis in patients with CAILL. The number of male patients with CAILL equal 63 aged 43-57 years was examined. Blood flow parameters on a fixed part of femoral artery outside the occlusion area were registered based on subjective criteria, number of painless steps and ultrasound doppler flowmetry according to the Fontaine-Pokrovsky classification. The second degree of ischemia was diagnosed in 38 patients, the third degree - in 25 patients. All patients received basic pharmacotherapy. Patients were divided into 2 groups by simple randomization method: control group included 18 patients with II degree of ischemia and 12 patients with III degree of ischemia who received basic pharmacotherapy combined with photohemotherapy (PHT). A set of commonly used laboratory methods for examination of blood coagulation system was applied to assess the effectiveness of PHT. The number of apparently healthy people equal 26 was examined to evaluate normal value of hemostasiological parameters. Basic pharmacological treatment had a certain positive effect on studied hemostasis parameters and its thrombotic component. However, they did not differ statistically significantly from similar parameters before treatment on the 14th day after treatment. As a result of comprehensive therapy the changes in hemostasis system had identical and statistically significant in percentage terms changes compared to norm and baseline in patients' subgroups of study group with II and III degrees of ischemia. In addition, most hemostasis parameters in patients with II degree of ischemia were close to those of apparently healthy volunteers. Hemostasis parameters in patients with III degree of ischemia decreased to the levels of patients with II degree of ischemia before treatment. The use of basic pharmacological therapy with optical exposure to blood by blue light allows to correct hemostasis and its thrombotic component in patients with CAILL.

Exploiting the photophysical features of DMAN template in ITQ-51 zeotype in the search for FRET energy transfer.

The combination between photoactive molecules and inorganic structures is of great interest for the development of advanced materials in the field of optics. Particularly, zeotypes with extra-large pore size are attractive because they allow the encapsulation of bulky dyes. The microporous aluminophoshate Mg-ITQ-51 (IFO-type structure) represents an ideal candidate because of the synergic combination of two crucial features: the IFO framework itself, which is composed of non-interconnected one-dimensional extra-large elliptical channels with a diameter up to 11 Å able to host bulky guest species, and the particular organic structure-directing agent used for the synthesis (1,8-bis(dimethylamino)naphthalene, DMAN), which efficiently fills the IFO pores, and is itself a photoactive molecule with interesting fluorescence properties in the blue range of the visible spectrum, thus providing a densely-incorporated donor species for FRET processes. Besides, occlusion of DMAN dye in the framework triggers a notable improvement of its fluorescence properties by confinement effect. To extend the action of the material and to mimic processes such as photosynthesis in which FRET is essential, two robust laser dyes with bulky size, rhodamine 123 and Nile Blue, have been encapsulated for the first time in a zeolitic framework, together with DMAN, in a straightforward one-pot synthesis. Thus, photoactive systems with emission in the entire visible range have been achieved due to a partial FRET between organic chromophores protected in a rigid aluminophosphate matrix.

LED ДЖЕРЕЛА УЛЬТРАФІОЛЕТОВОГО ВИПРОМІНЮВАННЯ: МЕТОДИЧНЕ ТА ПРИЛАДОВЕ ЗАБЕЗПЕЧЕННЯ З УРАХУВАННЯМ ГАРМОНІЗАЦІЇ ЗАКОНОДАВСТВА ЄС ТА УКРАЇНИ

One of the effective means of disinfecting premises is its irradiation with ultraviolet bactericidal radiation (UVBV), which is in the UV-C region (200 nm - 280 nm) and for mercury lamps has a radiation peak at a wavelength of 254 nm. However, UVBV should be used competently and with appropriate caution in terms of its intensity and safety, avoiding risks of damage to human skin and eyes. Therefore, UVBV is used indoors, mainly in the absence of a person. But when using sources of this type of optical radiation in the presence of a person, proper attention should be paid to controlling the intensity of UVBV and the time of its exposure. At the same time, it should be noted that the active processes of harmonization of the legislation of the EU and Ukraine require the modernization of the regulatory and methodological base for the measurement and hygienic assessment of ultraviolet radiation in the production environment and in the environment, significantly expanding the possibilities of using UVB sources, including in the presence of humans. Therefore, the purpose of the study is to create the basis for appropriate methodological recommendations for the use of bactericidal ultraviolet monochrome LED sources for disinfection of air and surfaces in rooms, as well as the formulation of appropriate requirements for UV radiometers, which should ensure control of the technical parameters of the mentioned ultraviolet monochrome LED sources. As a result of the research, scientific principles were proposed for the instrumental and methodical control of the safe use of bactericidal ultraviolet monochrome LED sources for the improvement of air and surfaces in premises of various purposes, taking into account the requirements of the legislation of Ukraine and the EU. The technical characteristics of the available UVBV LED sources were analyzed, based on which the medical and technical requirements for UV radiometers were formulated, which should ensure control of the intensity and actinic dose of UV radiation in accordance with the requirements of DSTU EN 62471:2017 "Safety of photobiological lamps and lamp systems (EN 62471:2008 , IDT; IES 62471:2006, MOD)". Design approaches to the formation of the spectral range of RG sensitivity by using appropriate light filters, including for the blue light range (380-480 nm), have been determined. A technique for correcting the spectral characteristic of the RG sensitivity is proposed, which contributes to the reduction of the intensity measurement error created by different LED sources.

Efficient and Traceable Tamoxifen Delivery to Breast Cancer Cells Using Folic Acid‐Decorated and PEGylated Graphene Quantum Dots

AbstractGraphene quantum dots (GQDs) possess potential properties for the targeted transport and tracking of anticancer medication to tumor cells. For this purpose, the synthesized GQDs were decorated with folic acid (FA) and methoxy polyethylene glycol (mPEG2000), and finally loaded with tamoxifen (TMX) drug. The synthesized nano‐drug was characterized using FTIR, XRD, UV‐Vis, PL, HRTEM, FESEM, and DLS analytical devices. Based on the obtained data, the average hydrodynamic diameter of particles dissolved in water was 294.7 nm and the size of dehydrated particles was between 53 and 210 nm. PL data showed that prepared nanoparticles have an emission wavelength of 438 nm, which is in the blue fluorescent wavelength range, thus making these nanoparticles suitable for cell imaging. The encapsulation efficiency and loading percentage of tamoxifen in nanoparticles were calculated at about 52.5 % and 30 %, respectively, and cumulative drug release reached 89 % within 42 hours. The cytotoxicity effects of nanoparticles were investigated. According to IC50 results, the targeted mPEG‐GQDs‐FA/TMX (TMX‐FPGs) nano‐drug was more toxic than free TMX on MCF‐7 cells and had reduced side effects on healthy HDF cells. TMX‐FPGs induced apoptosis cell death, significantly. The confocal imaging experiments showed that TMX‐FPGs are appropriate for monitoring and targeting MCF‐7 cells.

Aerosol absorption using in situ filter-based photometers and ground-based sun photometry in the Po Valley urban atmosphere

Abstract. Light-absorbing aerosols (LAAs) are short-lived climate forcers with a significant impact on Earth's radiative balance. LAAs include dust aerosols, black carbon (BC) and organic light-absorbing carbonaceous aerosol (collectively termed brown carbon, BrC), which have also been proven to be highly toxic. In this study, aerosol absorption at five wavelengths (ranging from ultraviolet to infrared) was monitored continuously using filter-based photometers during two winter seasons in 2020 and 2021 in the city of Modena (southern central Po Valley, northern Italy), at two regulatory air quality monitoring sites, along with other pollutants (coarse particulate matter, PM10; fine particulate matter, PM2.5; O3; NO; NO2; and C6H6) and the vehicular traffic rate. The aerosol optical depth (AOD) and other column aerosol optical properties were concurrently monitored at four wavelengths by an AErosol RObotic NETwork (AERONET) sun photometer under urban background conditions within Modena. In situ absorption levels were apportioned to both sources (fossil fuel and biomass burning) and species (BC and BrC), while columnar absorption was apportioned to BC, BrC and mineral dust. The combined analysis of the atmospheric aerosol and gas measurements and of the meteorological conditions (in situ and from the ERA5 reanalysis) identified the location of potential urban sources of BC and BrC, most likely related to traffic and biomass burning. In situ data show different diurnal/weekly patterns for BrC from biomass burning and BC from traffic, with minor differences between the background and the urban traffic conditions. AERONET version 3 absorption aerosol optical depth (AAOD) retrievals at four wavelengths allowed the estimation of the absorptive direct radiative effect due to LAAs over the same period under the reasonable assumption that the AOD signal is concentrated within the mixing layer. AERONET retrievals showed a modest correlation of columnar absorption with planetary boundary layer (PBL)-scaled in situ observations, although the correlation improved significantly during a desert dust transport event that affected both in situ aerosol and columnar absorption, particularly in the blue spectrum range. A low correlation occurred between the contribution of BrC to aerosol absorption for the in situ and the columnar observations, with the BrC contribution being generally larger for in situ observations. Finally, evidence of a highly layered atmosphere during the study period, featuring significant spatial mixing and modest vertical mixing, was shown by ERA5-based atmospheric temperature profiles and by the large correlation of concurrent AERONET AOD retrievals in Modena and in Ispra (on the northwestern side of the Po Valley, ca. 225 km from Modena).