This concerns the global strong solutions to the Cauchy problem of the compressible Magnetohydrodynamic (MHD) equations in two spatial dimensions with vacuum as far field density. We establish a blow-up criterion in terms of the integrability of the density for strong solutions to the compressible MHD equations. Furthermore, our results indicate that if the strong solutions of the two-dimensional (2D) viscous compressible MHD equations blowup, then the mass of the MHD equations will concentrate on some points in finite time, and it is independent of the velocity and magnetic field. In particular, this extends the corresponding Du's et al. results (Nonlinearity, 28, 2959-2976, 2015, [4]) to bounded domain in $ \mathbb{R}^2 $ when the initial density and the initial magnetic field are decay not too show at infinity, and Ji's et al. results (Discrete Contin. Dyn. Syst., 39, 1117-1133, 2019, [10]) to the 2D Cauchy problem of the compressible Navier-Stokes equations without magnetic field.