Blood Pressure In Postmenopausal Women Research Articles

EFEITOS DO SUCO DE UVA TINTO INTEGRAL NA PRESSÃO ARTERIAL DE REPOUSO DE MULHERES CLIMATÉRICAS

Systemic Arterial Hypertension (SAH) is a disease that, in most cases, involves genetic factors and lifestyle that affects approximately 21.4% of the Brazilian population, with 55% of this number represented by women and individuals over 75 years, accounting for 22.6% of deaths in Brazil. In women, the increased risk of developing SAH occurs in the period corresponding to the climacteric. Considered as a moment of transition between a woman's reproductive and non-reproductive period, the climacteric occurs between 40 and 60 years and involves the following phases: premenopause, perimenopause and postmenopause. It is known that treatment for SAH is more effective when it involves nutritional and lifestyle strategies combined with drug treatment. Among the alternatives, studies indicate the existence of a hypotensive effect in substances derived from grapes. Thus, this study aimed to observe the effect of ingestion of whole red grape juice on resting blood pressure in climacteric and hypertensive women in the interior of São Paulo. This is a randomized controlled, exploratory study, which included women aged 40 to 60 years with more than three months of amenorrhea and at least two climacteric symptoms. They were randomly divided into 2 groups: Control Group (CG) and Intervention Group (IG) to ingest 190 ml of whole grape juice for 28 days. The volunteers answered self-administered questionnaires and underwent physical examinations and measurement of resting blood pressure data during the first and last visit to compare the effect of the intervention. After the experimental protocol, it was observed that the protocol and dose used were able to cause a decrease in diastolic blood pressure in the intervention group, without causing significant changes in other parameters. Despite the need for further studies with greater control in the organization of groups, in addition to more doses and treatment times, this work corroborates the data that whole grape juice is a potential aid in controlling blood pressure in postmenopausal women.

Effectiveness of exercise training on arterial stiffness and blood pressure among postmenopausal women: a systematic review and meta-analysis

BackgroundThe acute and long-term benefits of exercise training on cardiovascular health have been well established. The systematic review and meta-analysis aimed to systematically assess the effectiveness of exercise training on arterial stiffness and blood pressure among postmenopausal women with elevated blood pressure.MethodsA comprehensive search was conducted on PubMed, Embase, Web of Science, ProQuest, Cochrane Library, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov website from inception to September 30, 2023, to identify the randomized controlled trials (RCTs), which evaluated the effectiveness of exercise training on arterial stiffness and blood pressure in postmenopausal women. Standardized mean differences (SMD), weighted mean differences (WMD), and 95% confidence intervals (95% CIs) were calculated using random/fixed effects models. Quality assessment was performed using the modified Jadad scale and the Cochrane Risk of Bias Tool. Sensitivity analysis and subgroup analysis were conducted based on drug dosage, treatment duration, and age of administration to further explore potential heterogeneity. Funnel plots were performed to assess publication bias and Begg’s regression test was carried out for funnel plot asymmetry.ResultsTwenty-two RCTs involving 1978 participants were included in the quantitative analysis. The mean quality of eligible studies was 4.2 out of 7 based on the modified Jadad scale. The results indicated that exercise training had a significant effect on reducing brachial-ankle pulse wave velocity [MD = − 0.69, 95%CI (− 1.11, − 0.27), P = 0.001], decreasing augmentation index (AIx) [MD = − 6.00, 95%CI (− 6.39, − 5.61), P < 0.00001] and AIx normalized to a heart rate of 75 beats per minute (AIx@75%) [MD = − 7.01, 95%CI − 7.91 to − 6.12, P < 0.00001], lowering systolic blood pressure [MD = − 6.19, 95%CI − 9.24 to − 3.15, P < 0.0001], diastolic blood pressure [MD = − 3.57, 95%CI (− 6.10, − 1.03), P = 0.006) and pulse pressure [MD = − 8.52, 95%CI (− 16.27, − 0.76), P = 0.03]. Subgroup analysis revealed that baseline blood pressure levels had a large impact on the effect of exercise training.ConclusionsThe systematic review and meta-analysis suggested that exercise training may ameliorate arterial stiffness and reduce blood pressure in postmenopausal women with elevated blood pressure. However, the optimal mode of exercise training that improves arterial stiffness and blood pressure in this population requires further investigation.Systematic review registrationPROSPERO CRD42021211268

Effect of whole-body vibration on blood pressure in obese postmenopausal women. A randomized controlled study

Background. Menopause constitutes a natural biological process that reflects the end of the reproductive life of women and has been related to elevated risk factors for multiple strokes. Multiple studies have revealed that healthy women during menopause have increased abdominal obesity, triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL), fasting blood glucose, body mass index (BMI), and blood pressure (BP) besides reduced high-density lipoprotein (HDL). Aim. We aim to determine the impact of whole body vibration (WBV) on BP and blood lipid profile in obese postmenopausal women. Subjects and methods. Our study enrolled 30 postmenopausal women with hypertension (HTN) who were aged 55–65 years old and had a BMI of 30–34.9 Kg/m2. An experienced physician diagnosed the participants with either pre-HTN or stage 1 HTN, with BP measurements of 140/90–159/99 mmHg. The participants were assigned into two equal groups (n = 15) in a random manner. Group A received a dietary regimen, whereas Group B received the dietary regimen along with a two-month whole body vibration (WBV) training program for 30 min, 3 sessions/week. Measurements were obtained for all participants, including their BP and serum TC, TG, HDL, and LDL levels pre- and post-therapy. Results. The results demonstrated that average systolic blood pressure (SBP), diastolic blood pressure (DBP), TC, TG, and LDL values significantly decreased in both groups, with a significant reduction favoring group B. Additionally, the average HDL value exhibited a statistically significant increase in both groups, with a significant increase favoring group B. Conclusion. WBV conjugated with a suitable nutritional intervention is considered a safe, user-friendly, and highly efficient physical therapy strategy for ameliorating blood lipid levels and lowering BP in postmenopausal women with HTN.

Biosocial predictors and blood pressure goal attainment among postmenopausal women with hypertension.

In postmenopausal states, women may not maintain blood pressure (BP) in the same way as men, even though most women follow their treatment plans and prescriptions more consistently than men. Biological and lifestyle factors influence the progression of hypertension in postmenopausal women (PMW). This study aimed to determine biosocial predictors associated with achieving the target BP in PMW with hypertension. A prospective observational study was conducted in the General Medicine Department at Karuna Medical College Hospital, Kerala, India. The definition of BP goal attainment was established based on the guidelines outlined by the VIII Joint National Committee 2014 (JNC VIII). Multivariate logistic regression analysis was used to analyse biosocial predictors, such as educational status, employment status, body mass index (BMI), number of children, age at menarche, age at menopause, and number of co-morbidities, associated with BP goal achievement. Of the patients, 56.4% achieved their BP goals on monotherapy and 59.7% achieved it on combination therapy. Level of education [odds ratio (OR) = 1.275, 95% confidence interval (CI): 0.234-7.172], employment status (OR = 0.853, 95% CI: 0.400-1.819), age at menopause (OR = 1.106, 95% CI: 0.881-1.149), number of children (OR = 1.152, 95% CI: 0.771-1.720), BMI (OR = 0.998, 95% CI: 0.929-1.071), and number of co-morbidities (OR = 0.068, 95% CI: 0.088-1.093) did not show a significant relationship, and age at menarche (OR = 1.577, 95% CI: 1.031-2.412) showed a significant association with BP goal attainment among hypertensive postmenopausal women. Half of the hypertensive postmenopausal women did not achieve their BP goals. Interventions are required to expand screening coverage and, under the direction of medical professionals, there should be plans to improve hypertension control and increase awareness of the condition.

Long-Term Effects of Microfiltered Seawater and Resistance Training with Elastic Bands on Hepatic Parameters, Inflammation, Oxidative Stress, and Blood Pressure of Older Women: A 32-Week, Double-Blinded, Randomized, Placebo-Controlled Trial.

The bulk of research on microfiltered seawater (SW) is based on its short-term effects. However, the long-term physiological adaptations to combining SW and resistance training (RT) are unknown. This study aimed to analyse the impact of an RT program using elastic bands combined with SW intake on hepatic biomarkers, inflammation, oxidative stress, and blood pressure in post-menopausal women. Ninety-three women voluntarily participated (age: 70 ± 6.26 years; body mass index: 22.05 ± 3.20 kg/m2; Up-and-Go Test: 6.66 ± 1.01 s). RT consisted of six exercises (32 weeks, 2 days/week). Nonsignificant differences were reported for hepatic biomarkers except for a reduction in glutamic-pyruvic transaminase (GPT) in both RT groups (RT + SW: p = 0.003, ES = 0.51; RT + Placebo: p = 0.012, ES = 0.36). Concerning oxidative stress, vitamin D increased significantly in RT + SW (p = 0.008, ES = 0.25). Regarding inflammation, interleukin 6 significantly decreased (p = 0.003, ES = 0.69) in RT + SW. Finally, systolic blood pressure significantly decreased in both RT groups (RT + placebo: p < 0.001, ES = 0.79; RT + SW: p < 0.001, ES = 0.71) as did diastolic blood pressure in both SW groups (RT + SW: p = 0.002, ES = 0.51; CON + SW: p = 0.028, ES = 0.50). Therefore, RT + SW or SW alone are safe strategies in the long term with no influences on hepatic and oxidative stress biomarkers. Additionally, SW in combination with RT positively influences vitamin D levels, inflammation, and blood pressure in older women.

Beneficial effects of one-year menaquinone-7 supplementation on vascular stiffness and blood pressure in post-menopausal women

Abstract Background Cardiovascular disease (CVD) is responsible for 35% of total deaths worldwide. Sex hormones, such as oestrogen and progesterone, have a cardiovascular protective role in women. After menopause, women are more prone to hypertension and vascular stiffness, accelerated vascular aging and risk for CVD. Menaquinone-7 (MK-7) is a fat-soluble vitamin K2 and serves as cofactor for vitamin K-dependent protein carboxylation. The vitamin K-dependent matrix Gla protein (MGP) is synthesized in the vasculature and has shown to inhibit vascular calcification and stiffness. Purpose To investigate effects of MK-7 on vascular stiffness in pre/peri- versus post-menopausal women. Methods In a double-blind placebo-controlled clinical intervention trial (NCT02404519), 166 women (age 40-70; dephosphorylated-undercarboxylated MGP (dp-ucMGP) &amp;gt; 400 pmol/L at baseline) received daily 180 µg of MK-7 (n=83) or a matching placebo (n=83) for one year. Blood was sampled during intake (inclusion/exclusion), at baseline and at the end of the study to determine dp-ucMGP levels. Regional carotid-femoral (cf-PWV) and carotid-radial (cr-PWV) pulse wave velocities, vessel wall characteristics (e.g., intima-media thickness, arterial diameter, and local carotid artery PWV (caPWV), and arterial blood pressure were measured at baseline and after one year of vitamin K2 supplementation. Pre/peri- and post-menopausal women were sub-divided according to arterial stiffness (high b-stiffness index: &amp;gt; overall median 9.83). Results Post-hoc analyses showed a significant decrease in dp-ucMGP plasma levels of MK-7 supplemented pre/peri-menopausal (n=34; -8.58% ± 27.65; p=0.009) and post-menopausal women (n=48; -13.40% ± 27.45; p&amp;lt;0.001). At baseline, vascular parameters were significantly increased in post-menopausal women compared to pre/peri-menopausal women, e.g., intima media thickness (p=0.013), carotid artery diameter (p=0.007), and caPWV (p=0.012). MK-7 treatment significantly attenuated vascular stiffness in post-menopausal women (Young’s modulus; placebo +49.14% ± 77.38; MK-7 +9.38% ± 67.10; p=0.044). Post-menopausal women with a high stiffness index showed significantly improved vascular markers after MK-7 treatment, e.g., decreased blood pressure at brachialis (-3.03% ± 9.04; p=0.012), decreased blood pressure at carotid artery (-4.49% ± 11.66; p=0.008), increased distensibility coefficient (+13.25% ± 32.34; p=0.040), and increased compliance coefficient (±12.66% ± 32.64; p=0.040). Conclusions Our results confirm that hormonal changes affect the vasculature, and that post-menopausal women suffer from increased vascular stiffness reflected by functional vascular damage. Further, MK-7 supplementation significantly attenuates arterial stiffness in post-menopausal women, in which women with increased stiffness benefit most on blood pressure. Further research is needed to unravel the mechanisms by which MK-7 executes this beneficial role in post-menopausal women.

The Effects of Vitamin D Supplementation on C-Reactive Protein and Systolic and Diastolic Blood Pressure in Postmenopausal Women: A Meta-Analysis and Systematic Review of Randomized Controlled Trials

BackgroundAn inverse relationship between vitamin D supplementation and C-reactive protein (CRP) and hypertension has been reported, mostly through observational data. This inverse relationship, however, has not been confirmed in randomized controlled trials (RCTs). A meta-analysis of RCTs is needed to provide more robust evidence. ObjectiveThis systematic review of RCTs was conducted to assess the effect of vitamin D supplementation on CRP, systolic blood pressure (SBP), and diastolic blood pressure (DBP) in postmenopausal women. MethodsFour databases (PubMed, Web of Science, Embase, and Scopus) were systemically searched to identify relevant RCTs published in international scientific journals up to January 2023. Changes from baseline and SDs of CRP, SBP, and DBP were compared between postmenopausal women who received vitamin D supplementation and those who did not (controls). These parameters were applied to compute the overall effect sizes using the random-effects model. Data were summarized as mean difference (MD) with 95% CI. Heterogeneity among arms was scrutinized using the Cochrane’s Q test and I2 statistic. Publication bias was judged by means of funnel plots and Egger's test. ResultsSeven studies with 6 arms on CRP, 6 arms on SBP, and 6 arms on DBP were included in the meta-analysis. Combined effect sizes suggested a significant effect of vitamin D supplementation on CRP (MD = –0.65 mg/L; 95% CI –0.93 to –0.37 mg/L; P < .001). In addition, CRP concentrations were significantly reduced after vitamin D supplementation in studies with a duration of more than 3 months (MD = –0.91 mg/L; 95% CI –1.37 to –0.45 mg/L; P < .001) and studies involving doses of ≤1,000 IU/d (MD = –2.10 mg/L; 95% CI –2.51 to –1.68 mg/L; P < .001). Vitamin D supplementation did not reduce SBP significantly (MD = –1.06 mm Hg; 95% CI –2.43 to 0.30 mm Hg; P = .127) and DBP (MD = 0.003 mm Hg; 95% CI –0.86 to 0.86 mm Hg; P = .994) levels compared with control groups. ConclusionsThis meta-analysis concluded that vitamin D supplementation is associated with reduced CRP concentrations among postmenopausal women.

The Effect Of Steeping Grated Turmeric On Blood Pressure In Hypertensive Menopausal Women

Menopause is an important phase in a womans reproductive cycle. Menopause or the cessation of menstrual periods is defined as the process of transition from productive to non-productive periods caused by decreased levels of the hormones estrogen and progesterone. This study will look at the factors that influence the effect of steeping grated turmeric on blood pressure in postmenopausal women with hypertension in Cipariuk Village,Tegal Village, Cikedal District, Pandeglang Regency, Banten.Researchers used a pre and post test design with a control group. The population in this study were all menopausal women who experienced hypertension as many as 30 people. It was carried out in March 2021. The sampling technique was total sampling divided into 2 groups, namely 15 experimental groups who were given grated turmeric 2x a day 250 cc for 7 days and 15 people in the experimental group control. Blood pressure can be lowered by steeping grated turmeric. between the control and experimental groups in postmenopausal women in Cipariuk Village, Tegal Village, Cikedal District, Pandeglang Regency, Banten in 2021 with a significance value of 0.000.There is an effect of steeping grated turmeric on blood pressure between the control and experimental groups in menopausal women. It is expected that postmenopausal women, before using blood pressure lowering drugs with chemicals, should use treatment with herbal ingredients, one of which is turmeric regularly with various processing, one of which is in the form of turmeric drinks because the ingredients are cheap and easy to obtain, especially if you have the plant.

The Effect of Giving a Combination of Sweet Carambola Juice and Honey on Blood Pressure in Menopausal Women

Hypertension is when a person experiences an increase in blood pressure above average and most often occurs in old age. Based on the results of the initial survey of the posyandu in the corner village, the Sukorame Health Center, Kediri City working area in September 2016, menopausal patients who experienced hypertension were 40 people (54.79%). This study aimed to determine the effect of giving a combination of sweet starfruit juice and honey on the blood pressure of postmenopausal women at the Posyandu, Pojok Village, the working area of ​​the Sukorame Health Center, Kediri City in 2016. The research design used was a pre-experimental study; the population studied were menopausal women with hypertension at the Posyandu in Pojok Village, with a total population of 40 people using a purposive sampling technique, and a sample of 16 people was obtained. The research instruments used were observation sheets and tension meters as measuring devices. The results of the study were then tested for normality with the Shapiro-Wilk and statistical tests in this study using the Wilcoxon test. The results showed that blood pressure before administration of a combination of sweet starfruit juice and honey was 146/95 mmHg. In contrast, it was 133/86 mmHg after administration, so systolic blood pressure decreased by 13.00 mmHg and diastolic by 9.00 mmHg. The value of ρ=0.000 and ρ=0.002. This shows that H0 is rejected and H1 is accepted. So there is an effect of giving a combination of sweet star fruit juice and honey at the Posyandu, Pojok Village, the working area of ​​the Sukorame Health Center, Kediri City, in 2016. Based on the results of this study, menopausal women are expected to consume a combination of sweet star fruit juice and honey as a non-pharmacological treatment for lowering blood pressure.

Assessment of Blood Pressure Variability in Postmenopausal Women.

Introduction: Increase in blood pressure is the leading cause of comorbidity, especially cardiovascular and cerebrovascular disease, but its variability represents an independent risk factor for the same in menopausal women. Dramatic decrease of estrogen production in menopause interferes with many metabolic pathways leading to insulin resistance, increased body mass index (BMI) and dyslipidemia hence cardiovascular morbidity and mortality. In this study an assessment of the variability of blood pressure in postmenopausal women and its association with BMI have been highlighted.Method: In this cross‐sectional study, a total of 175 postmenopausal females more than 50 years of age who were admitted to or visited medicine wards with no known major medical condition were enrolled between June and July 2019. Recording of both diastolic and systolic blood pressure of postmenopausal women was done at 6 am, 12 pm and 7 pm manually by mercury sphygmomanometer. In addition, BMI, neck circumference, and lipid profile values were also recorded.Results: Variation of both systolic and diastolic blood pressure at 6 am, 12 pm and 7 pm in association with various parameters like BMI (more than 25 kg/m2 ) were 128.57 ± 12.68/78.93 ± 9.56; 124.64 ± 12.32/77.14 ± 5.35 and 124.29 ± 12.60/75.36 ± 6.37 mmHg respectively. Neck circumference (>32 cm) was similar at 128.89 ± 13.49/79.86 ± 8.47; 124.58 ± 12.99/77.08 ± 7.59 and 125.56 ± 12.21/76.94 ± 7.62 mmHg respectively.Conclusion: BMI and neck circumference as well as triglyceride and cholesterol increase may all independently contribute to the blood pressure variability in menopausal women.

Effects of Acute Aquatic High-Intensity Intermittent Exercise on Blood Pressure and Arterial Stiffness in Postmenopausal Women with Different ACE Genotypes.

The present study investigated the effects of acute aquatic high-intensity intermittent jumping (HIIJ) on blood pressure (BP) and arterial stiffness in postmenopausal women with different angiotensin-converting enzyme genotypes (ACE). We recruited 12 postmenopausal women carrying the ACE deletion/deletion (DD) genotype and 61 carrying the insertion/insertion or insertion/deletion (II/ID) genotype. The participants performed 12 trials of 30 s, 75% heart rate reserve (HRR) jumping, and 60 s, 50% HRR recovery, and 3 trials of 40 s upper limb resistance exercises were performed as fast as possible. The heart rate (HR) and BP were measured before exercise, immediately, 10 min, and 45 min after exercise. The brachial-ankle pulse wave velocity (baPWV) was measured before and after exercise. The systolic blood pressure (SBP) of the DD genotype increased more significantly than those with the II/ID genotype post-exercise (30.8 ± 4.48 vs. 20.4 ± 2.00 mmHg, p = 0.038). The left and right sides of baPWV increased significantly after exercise (1444.8 ± 29.54 vs. 1473.4 ± 32.36 cm/s, p = 0.020; 1442.1 ± 30.34 vs. 1472.0 ± 33.09, p = 0.011), and there was no significant difference between the two groups. The HIIJ increased baPWV. The postmenopausal women with the DD genotype have a higher SBP increased post-exercise than those with II/ID genotype. These findings suggest that the aquatic exercise program has better effects in decreasing blood pressure in postmenopausal women with the II/ID genotype. Those with the DD genotype should pay attention to the risk of increasing blood pressure after aquatic HIIJ exercise.

The effect of calcium and vitamin D supplements on blood pressure in postmenopausal women: myth or reality?

Hypertension is a highly prevalent disease with serious cardiovascular and renal complications. Many studies have demonstrated a weak correlation between the consumption of calcium (or calcium plus vitamin D) and blood pressure, suggesting that calcium supplements might reduce blood pressure. However, the results to date remain controversial. In this study, we assessed the effect of calcium and vitamin D supplementation on the blood pressure of postmenopausal women with hypertension as a population group in which the use of calcium supplements is prevalent. This triple-blind randomized clinical trial enrolled 98 women of postmenopausal age with hypertension in 2019. The study period was 8 weeks with close follow-up. We used 24-h ambulatory blood pressure monitoring to record the initial and final blood pressure in all participants. The changes in both the mean systolic (p = 0.047) and diastolic blood pressure (p = 0.015) were suggestive of an increase in blood pressure after consuming calcium and vitamin D supplements. Among patients who had been using calcium channel blockers, calcium and vitamin D supplementation caused a notable increase compared to baseline systolic (p = 0.019) and diastolic blood pressures (p = 0.001). The present results differ from those of previous studies. This suggests that calcium supplementation for postmenopausal women with hypertension requires the close observation of blood pressure to prevent any further increase, especially in women who are being treated with calcium channel blockers (clinicaltrial.gov registration: NCT04618952).

17 EFFECTS OF WHOLE-BODY VIBRATION TRAINING ON BLOOD PRESSURE IN POSTMENOPAUSAL WOMEN WITH HYPERTENSION: A SYSTEMATIC REVIEW

Background: Menopause is considered an important determinant of hypertension in women, with 41% of postmenopausal women are hypertensive. Increased blood pressure (BP) in postmenopausal women can be caused by arterial stiffness, renin-angiotensin system activation, endothelial dysfunction, lack of estrogens, sympathetic activation, anxiety, and depression. Hence, they should be given special treatment, such as exercise therapy, to improve the quality of their hypertensive therapy. Whole-body vibration training (WBVT) is a resistance training known for its ability to improve arterial stiffness. However, its ability to decrease BP is still controversial. Objective: This study aims to identify the effects of WBVT on blood pressure in postmenopausal women with hypertension. Method: A systematic literature search was performed using particular keywords with medical subheading (MeSH) terms on three journal databases, including Pubmed, Proquest, and Cochrane. The search results were screened and assessed using inclusion and exclusion criteria, double article, and full text availability by three independent authors. The quality of the randomized control trial (RCT) was evaluated using the Jadad scale. Result: Four Randomized controlled trials (RCTs) consisting of 114 total patients were eligible to fulfil the criteria. All studies showed that WBVT significantly decreased systolic (10-12 mmHg) and diastolic (5-6 mmHg) BP compared with the control group. One study also showed a reduction of mean arterial pressure (9 mmHg). Conclusion: WBVT might be beneficial as an adjuvant therapy to reduce blood pressure in postmenopausal women with hypertension, but further research that includes more subjects is needed to confirm this result.

The Effects of Different Antihypertensive Drugs on Postmenopausal Mild-to-Moderate Hypertension: A Network Meta-analysis

Abstract Background To compare the effects of different antihypertensive drugs on the reduction of blood pressure in postmenopausal women with hypertension. Methods PubMed, EMBASE, Cochrane Library, ClinicalTrails, WanFang, VIP, and CNKI databases were electronically retrieved. The retrieval time limit was from the establishment of the database to April 2020. The efficacy of 2 or more antihypertensive agents or placebos in postmenopausal hypertensive females was investigated. Mainly, the changes of systolic and diastolic blood pressure were compared. Two reviewers independently screened the literature and extracted the data. Cochrane’s “risk of bias” method was used to evaluate the methodological quality of randomized controlled trials. A network meta-analysis was performed by Stata15.0 software. Results Eight studies were involved in this meta-analysis. Angiotensin receptor blockers (ARBs) showed the most significant antihypertensive effects on systolic blood pressure as compared with placebo [standardized mean differences (SMDs) = −9.25, 95% credibility intervals (CIs) −12.24 to −6.26]. Surface under the cumulative ranking (SUCRA) suggested ARB (SUCRA = 76.3%) and diuretics (SUCRA = 72.4%) was the cumulative probability of the best treatment. Diuretics showed the best effect on diastolic blood pressure (SMD = −11.98, 95% CI −14.42 to −0.95) and its cumulative probability was the highest (SUCRA = 94.9%). Conclusions For postmenopausal females with hypertension, ARB was optimal on systolic blood pressure while diuretics was optimal on diastolic blood pressure among the different antihypertensive drugs.

Effect of combined aerobic and resistance exercise on blood pressure in postmenopausal women: A systematic review and meta-analysis of randomized controlled trials.

The purpose of this study is to evaluate the effects of combined aerobic and resistance exercise on blood pressure (BP) in postmenopausal women. The results of this study will provide an effective means for postmenopausal women to control BP and reduce the morbidity and mortality of cardiovascular disease (CVD). Eligible studies were searched in five electronic databases until November 2020, and 11 randomized controlled trials that met the inclusion criteria were included in this systematic review and meta-analysis. The random-effects model was used to calculate overall effect sizes of weighted mean differences (WMD) and 95% confidence interval (CI). This study was registered in PROSPERO with the registration number: CRD42021225546. Compared with the control group, the aerobic combined resistance exercise significantly decreased the systolic blood pressure (SBP) and diastolic blood pressure (DBP) by 0.81mmHg (95% CI, -1.34 to -0.28) and 0.62mmHg (95% CI, -1.11 to -0.14), respectively. The results of the meta-analysis also indicated that a significant reduction in brachial-to-ankle pulse wave velocity (baPWV) of - 1.18m/s (95% CI, -1.81 to -0.56) and heart rate (HR) of -0.22 beats/min (95% CI: -0.42 to -0.02) after combined aerobic and resistance exercise intervention. Subgroup analysis showed that postmenopausal women ≥60years of age who were overweight or had a normal baseline BP were more sensitive to the combined aerobic and resistance exercise. When combined aerobic and resistance exercise frequency<3 times/week, weekly exercise time≥150min, or the duration of exercise lasted for 12weeks, the SBP and DBP of postmenopausal women could be reduced more effectively. The present study indicates that combined aerobic and resistance exercise can significantly reduce BP in postmenopausal women. Accordingly, combined aerobic and resistance exercise may be an effective way to prevent and manage hypertension in postmenopausal women.

Capnometric feedback training decreases 24-h blood pressure in hypertensive postmenopausal women

BackgroundHigh normal resting pCO2 is a risk factor for salt sensitivity of blood pressure (BP) in normotensive humans and has been associated with higher resting systolic BP in postmenopausal women. To date, however, no known studies have investigated the effects of regular practice of voluntary mild hypocapnic breathing on BP in hypertensive patients. The objective of the present research was to test the hypothesis that capnometric feedback training can decrease both resting pCO2 and 24-h BP in a series of mildly hypertensive postmenopausal women.MethodsA small portable end tidal CO2 (etCO2) monitor was constructed and equipped with software that determined the difference between the momentary etCO2 and a pre-programmed criterion range. The monitor enabled auditory feedback for variations in CO2 outside the criterion range. 16 mildly hypertensive postmenopausal women were individually trained to sustain small decreases in etCO2 during six weekly sessions in the clinic and daily sessions at home. 24-h BP monitoring was conducted before and after the intervention, and in 16 prehypertensive postmenopausal women in a control group who did not engage in the capnometric training.ResultsFollowing the intervention, all 16 capnometric training participants showed decreases in resting etCO2 (− 4.3 ± 0.4 mmHg; p < .01) while 15 showed decreases in 24-h systolic BP (− 7.6 ± 2.0 mmHg; p < .01). No significant changes in either measure was observed in the control group. In addition, nighttime (− 9.5 ± 2.6; p < .01) and daytime (− 6.7 ± 0.2 mmHg) systolic BP were both decreased following capnometric training, while no significant changes in nighttime (− 2.8 ± 2.2 mmHg; p = .11) or daytime (− 0.7 ± 1.0 mmHg; p ≤ .247) systolic BP were observed in the control group.ConclusionsThese findings support the hypothesis that regular practice of mild hypocapnic breathing that decreases resting etCO2 reliably decreases 24-h blood pressure in hypertensive postmenopausal women. The extent to which these effects persist beyond the training period or can be observed in other hypertensive subgroups remains to be investigated.

Effects of Acupuncture on Lowering Blood Pressure in Postmenopausal Women with Prehypertension or Stage 1 Hypertension: A Propensity Score-Matched Analysis.

Postmenopausal women have a higher prevalence of hypertension compared to premenopausal women. Hypertension is a risk factor for cardiovascular diseases, the prevalence of which is ever increasing. This study investigated the effects of long-term acupuncture on lowering the blood pressure of postmenopausal women with prehypertension and stage 1 hypertension. Participants were 122 postmenopausal women aged less than 65 years, diagnosed with prehypertension or stage 1 hypertension (systolic blood pressure 120–159 mmHg or diastolic blood pressure 80–99 mmHg). We used a propensity score-matched design. The experimental group (n = 61) received acupuncture for four weeks every six months over a period of two years. The control group (n = 61) received no intervention. An Analysis of covariance (ANCOVA) was performed for the primary efficacy analysis. Relative risk ratios were used to compare group differences in treatment effects. Acupuncture significantly reduced the participants’ diastolic blood pressure (−9.92 mmHg; p < 0.001) and systolic blood pressure (−10.34 mmHg; p < 0.001) from baseline to follow-up. The results indicate that acupuncture alleviates hypertension in postmenopausal women, reducing their risk of developing cardiovascular diseases and improving their health and quality of life.

Effects of combined 17β-estradiol and progesterone on weight and blood pressure in postmenopausal women of the REPLENISH trial

Objective:To examine the impact of a single-capsule 17β-estradiol (E2)/progesterone (P4) on weight and blood pressure (BP) when treating moderate to severe vasomotor symptoms in postmenopausal women with a uterus.Methods:Healthy postmenopausal women with a uterus (aged 40-65, body mass index ≤34 kg/m2, BP ≤140/90 mm Hg) were randomized to daily E2/P4 (mg/mg; 1/100, 0.5/100, 0.5/50, 0.25/50) or placebo in the phase 3 REPLENISH trial (NCT01942668). Changes in weight and BP from baseline to month 12 were evaluated. Potentially clinically important changes were defined as increases or decreases from baseline in weight by ≥15% and ≥11.3 kg, systolic BP by ≥20 mm Hg (absolute value ≥160 or ≤90 mm Hg), and diastolic BP by ≥15 mm Hg (absolute value ≥90 or ≤60 mm Hg).Results:Overall mean changes in weight and BP from baseline to month 12 with E2/P4 were modest and generally not statistically or clinically significant versus placebo. Incidence of potentially clinically important changes was low for weight (E2/P4 vs placebo: 1.1-2.6% vs 2.2%), systolic BP (0.3-1.1% vs 1.1%), and diastolic BP (1.4-4.2% vs 3.2%). A small number of women had treatment-related, treatment-emergent adverse events of weight gain (1.4-2.6% vs 1.3%) or hypertension (0.2-1.2% vs 0%). Few women who discontinued E2/P4 had weight gain (1.6%) or hypertension (0.6%) as a primary reason. Efficacy profile on VMS was consistent with previous findings and not modified by body mass index.Conclusions:Twelve-month use of E2/P4 had no clinically meaningful impact on weight or BP in postmenopausal women of the REPLENISH study.

Effects Of Resistance Exercise Training On Estradiol, Gh, Igf-1, Dhea-s, And Blood Pressure In Postmenopausal Women With Stage 1 Hypertension

PURPOSE: Menopause is often accompanied by decreased estradiol, growth hormone (GH), insulin-like growth factor-1 (IGF-1) and dehydroepiandrosterone sulfate (DHEA-s) and increased blood pressure (BP), which may collectively increase risks for cardiovascular disease (CVD). It is important to combat the negative effects on estradiol, GH, IGF-1, DHEA-s, and BP by incorporating appropriate lifestyle interventions, such as exercise. We sought to examine the effects of resistance exercise training program on estradiol, GH, IGF-1, DHEA-s, and BP in postmenopausal with stage 1 hypertension. METHODS: : Postmenopausal women (n=20) were recruited and randomly assigned to a resistance exercise group (EX, n=10) or control group (CON, n=10). The EX group performed a total-body resistance band exercise training program for 12 weeks. Levels of estradiol, GH, IGF-1, DHEA-s, as well as BP were assessed before and after 12 weeks RESULTS: There were significant group by time interactions (p<0.05) for estradiol (∆ 0.8±0.0), GH (∆ 0.5±0.1), IGF-1 (∆ 5.7±1.2), and DHEA-s (∆ 10.4±5.5) which significantly increased (p<0.05), and systolic BP (∆ 3.0±1.7) which significantly decreased (p<0.05) after exercise training compared to no changes in CON. There were no significant differences (p>0.05) in diastolic BP after 12 weeks CONCLUSIONS: These results indicate that resistance exercise training may be an effective, easily accessible, and cost efficient intervention for improving estradiol, GH, IGF-1 and DHEA and decline BP in postmenopausal women with stage 1 hypertension

The effectiveness of therapy with valsartan and hydrochlorothiazide and its effect on the left atrial myocardium condition in women with arterial hypertension in postmenopause

Purpose - to evaluate the effectiveness of the combination of valsartan and hydrochlorothiazide and its effect on the structural and functional parameters of the left atrial myocardium in postmenopausal women with arterial hypertension.Materials and methods. An open prospective controlled study included 100 postmenopausal women with uncomplicated arterial hypertension. Transthoracic and speckle tracking echocardiography was performed on a Vivid E9 XDClear Console 4D Expert 100 ultrasound scanner (General Electric, USA) with ECG-synchronization. Ambulatory blood pressure monitoring was performed using the device ABPM-04 (Meditech, Hungary). After 6 months of treatment with the antihypertensive combination of valsartan and hydrochlorothiazide, all women were re-examined in full. Statistical analysis of the results was performed using the Statistica 13.0 software package. All tests were two-way, statistically significant considered differences at P < 0.05.Results. As a result of our study, office systolic and office diastolic blood pressure in postmenopausal women with arterial hypertension significantly decreased (P < 0.001) due to a 6-month treatment with valsartan and hydrochlorothiazide. The target level of blood pressure, according to office measurements, was reached by 64 % of patients. A significant decrease of the SBP time index in the daytime in 1.6 times (P = 0.012), morning rise of SBP (P = 0.021) and the average pulse blood pressure (P = 0.012) was observed. Analysis of the LA deformation dynamics under the 6-month antihypertensive therapy did not reveal significant changes in the longitudinal strain of the LA in postmenopausal women with AH, unlike left ventricular strain.Conclusions. Combined antihypertensive therapy with valsartan and hydrochlorothiazide in postmenopausal women is effective, safe and well-tolerated. The use of this therapy for 6 months does not significantly affect the size and deformation properties of the left atrium, in contrast to the positive structural and functional remodeling of the left ventricle.