ObjectivesThe comparison of metabolic and inflammatory responses following the ingestion of cereal products high in Slowly Digestible Starch (SDS) was studied in subjects with impaired glucose tolerance.MethodsIn a cross‐over design, 20 (13F/7M) healthy overweight subjects with high metabolic risk participated to 3 sessions: one session testing a glucose solution (54g which is the amount of carbohydrates provided by the two other breakfasts), two sessions testing either a biscuit high in SDS or a rusk without SDS with 250 mL of semi‐skimmed milk and a hot beverage. The 2 sessions with cereal products followed a 3‐week period where the corresponding cereal product was daily consumed. Glycemia, insulinemia, blood lipid profile and markers for inflammation and oxidative stress were followed during a 240‐minute postprandial period.ResultsGlycemic responses following both cereal products were lower compared to glucose solution. iAUC(0‐120 min) glycemia was significantly lower (‐32 %) following the breakfast with biscuit high in SDS compared to rusk without SDS. The insulinemic response was also lower following the breakfast with the biscuit compared to the 2 other sessions. No significant difference was observed between the 2 groups with cereal products for blood lipid profile and for the makers of inflammation and oxidative stress.ConclusionBreakfast with a high‐SDS biscuit led to lower glycemic and insulinemic responses compared to breakfast including a rusk with no SDS in subjects with high metabolic risk. The ingestion for 3 weeks of the cereal products did not modified fasting and postprandial markers of inflammation and oxidative stress.