Blood Group Analysis Research Articles

Identical Twins Simultaneously Concordant for Anorexia Nervosa

Identical twin girls, whose monozygosity was determined by blood group analysis, simultaneously developed anorexia nervosa at the age of 11. Treatment consisting of individual, outpatient, insight-oriented psychotherapy for each girl by separate therapists, and work with the parents by a social worker, uncovered significant conflict in the area of identity formation, apparently exacerbated by the twinship. Resolution of the anorexia and significant ego growth in both twins rapidly followed exploration of the twinship dynamics in therapy. Gains made during the relatively brief therapy were well maintained at a 2-year follow-up evaluation.

Exclusion of the localization of the Gm, Pi, and C3 genes on 6q25?6qter through blood group analysis of the patients of Schmid, D'Apuzzo and rossi (Hum. Genet. 46, 279?284, 1979)

Exclusion of the localization of the Gm, Pi, and C3 genes on 6q25?6qter through blood group analysis of the patients of Schmid, D'Apuzzo and rossi (Hum. Genet. 46, 279?284, 1979)

血液型分析による同腹子豚の卵性についての考察

血液型分析による同腹子豚の卵性についての考察

Blood groups and serum cholesterol among 10,000 adult males

An analysis of blood groups and cholesterol has been made as part of a longterm prospective investigation of ischemic heart disease among 10,000 Israeli males, aged 40 and over. The total mean serum cholesterol level for men of blood group A1 was found to be significantly higher than the mean for the combined ABO groups, although this did not hold for every individual country of origin. Among the Rh, MN, Kell, Duffy, and Kidd blood groups, Kell was the only one which showed a significant association with mean serum cholesterol. Men with both A1 and Kell+ exhibited a higher mean cholesterol level than either group separately. The question is raised whether the significant statistical associations in this study population have biological implications.

Down's syndrome with XYY: 48,XYY, G+.

An infant with a karyotype of 48, XYY, G + presented with the usual findings of Down's syndrome except for the absence of epicanthal folds and a prominent occiput. This condition would be expected to occur at a frequency of 1:480,000 male births. This estimate is based on the assumption that the two events occur independently. Analysis of blood groups, haptoglobins, and dermatoglyphics was unrevealing. No clear modifications of the mongoloid phenotype by the additional Y are apparent.

A haptoglobin mating frequency, segregation and ABO blood-group intraction analysis for additional series of families.

SUMMARYData for a further eight series, comprising a total of 2349 families with 5701 tested children, has been analysed for evidence of disturbances in mating frequency, number of offspring and segregation with respect to haptoglobin type. Five of the series were examined also for interaction effects between the ABO blood‐group and haptoglobin systems.There was no significant departure from expectation for the frequency of matings in the haptoglobin system with the exception of the mating class Hp 1‐1 × 2‐1 in series no. 2. However, a comparison of the number of matings in the reciprocal mating classes 1‐1 × 2‐1 and 2‐1 × 1‐1 shows a significant excess of 2‐1 × 1‐1 matings. This excess is reflected even more in the number of children in the 2‐1 × 1‐1 mating class compared with the number in the reciprocal 1‐1 × 2‐1 class.There is a significant distortion in the Hp types of offspring in the Hp2‐1 × 2‐2 mating class for all series combined as well as for series nos. 1 and 8 considered individually, the Hp2‐1 offspring being in excess. Series no. 7 shows a deviation also, but in the opposite direction to that in the other series.A comparison of the Hp1 gene frequencies among children born to parents who are classified as either compatible or incompatible for the ABO blood‐group system shows that the Hp1 frequency is higher for the incompatible class in each of the five series for which information is available, the difference being significant in series nos. 2 and 3.

On intrauterine selection by abo-incompatibility with special reference to maternal age.

As follows from the analysis of AB0 system blood-groups for 3186 mothers with children, a selection takes place in the period of intrauterine growth, this selection being directed against AB0-incompatible zygotes (fetuses). Only in the age-group of mothers below 26 a statistically significant (P>99%) selection effect is observed.

Detection of heterozygotes for phenylketonuria by column chromatography and discriminatory analysis.

Extract: Phenylalanine (100 mg/kg) was administered orally to 19 parents of patients with phenylketonuria and to 26 control subjects. Concentrations of phenylalanine and tyrosine in plasma were determined by column chromatography before phenylalanine administration and at 1, 2, 3, and 4 hours after loading. The values of two control subjects (C 21 and C 25) and of two parents (P 4 and P 6) were unusually low or high. Excluding subjects C21, C25, P4, and P6, the following calculations of the values after loading were made: Mean and SD of mean of phenylalanine levels at each time: in spite of a significant difference, there was a slight overlap. Sum of the phenylalanine values: significant difference, no overlap. Sum of the phenylalanine/tyrosine ratios: significant difference, no overlap. Using these criteria, control subjects C21 and C25 were considered to be heterozygotes. The values of subject P 4 (father of a known patient) were within the range of the control group; paternity was excluded by blood group analysis. The values of subject P 6 were unusually high and could not be explained satisfactorily. The concentrations of phenylalanine and tyrosine after loading were evaluated by discriminatory analysis. Thus, subjects C 21, C 25, and P 4 were excluded, but values were calculated both including and excluding subject P 6. To compare the different criteria of evaluation, the index of Penrose (discriminatory power = D/s) was calculated. A better separation was obtained with discriminatory analysis than with the sum of the phenylalanine values or of the phenylalanine/tyrosine ratios. The use of column chromatography and evaluation by discriminatory analysis seems to improve the possibilities of detection of heterozygotes for phenylketonuria. Speculation: With discriminatory analysis, the separation of heterozygotes for phenylketonuria from normal subjects was better than with other criteria of evaluation. We believe that this method could be used successfully for determination of heterozygosity in other inborn errors of metabolism with recessive inheritance when several variables are available for each subject examined.

Salivary Secretion of Blood-Group Factors in Cancer

Several recent papers have indicated that a relationship exists between the clinical course of cancer and the blood-group substance secretor factor in saliva. 1,2 An etiologic relation in 88 cases of primary bronchogenic carcinoma in the Salt Lake City area described a distinct lack of nonsecretors. 3 To confirm this finding, an analysis was conducted of the frequency of this particular genetic factor occurring in a series of patients with various cancers at the Lemuel Shattuck Hospital. Methods In 1966, studies were made on 195 patients with cancer who admitted to the Lemuel Shattuck Hospital. Blood-group analysis and salivary-secretor status were obtained; an analysis of the clinical course of the patient was made. Five milliliters of saliva was collected; standard techniques were used for treatment of saliva and for testing it with an extract of Ulex europaeus . 4 All nonsecretor saliva was retested with the extract and with 0 cells.

Dermatoglyphics of twins: a study based on a new systematics.

Summary1. The Author has investigated on a twin material of 34 twin pairs the papillary line patterns on the fingers, the interdigital areas of the palms, and the hallucal area of the soles according to a systematics accounted for by the Author in earlier works.2. The diagnosis of zygosity has been based on a comparison for the morphological particularities and on blood group analyses, in the cases in which the relative chance for dizygosity for the concordant pairs has been calculated.3. The frequency distribution for the papillary line patterns of the twin pairs showed no significant divergence with respect to the large Swedish population, earlier investigated.4. The 19 MZ twin pairs showed a concordance of 84.2-89.5% for the total qualitative value, total ridge-count and for the hallucal patterns.

Autosomal Trisomy in a Discordant Monozygotic Twin

TURPIN et al.1 investigated a patient with Turner's syndrome who was found to have an apparently normal twin brother. Analysis of blood groups, plasma proteins and secretor status showed that they were probably monozygotic (P = 0.0075), and reciprocal transplants of skin tissue showed no signs of rejection after 78 days2. Chromosome analysis revealed an XO karyotype in the patient and an XY sex chromosome constitution in the normal brother. Since then, five other cases of monozygotic twins with discordant karyotypes have been described3–7. This communication describes a case of autosomal trisomy in an amorphous monozygotic twin.

CHAPTER 6: ANALYSIS OF BLOOD GROUPS

Acta Medica ScandinavicaVolume 176, Issue s416 p. 76-77 CHAPTER 6: ANALYSIS OF BLOOD GROUPS First published: January/December 1964 https://doi.org/10.1111/j.0954-6820.1964.tb04706.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume176, Issues416January/December 1964Pages 76-77 RelatedInformation

Problems in Blood Group Analysis

Problems in Blood Group Analysis

An analysis of the ABO Blood-Group records of the North of England

An analysis of the ABO Blood-Group records of the North of England

TÜRKLERİN KAN GRUPLARI VE KAN GRUPLARININ ANTROPOLOJİK KARAKTERLERLE İLGİSİ ÜZERİNE BİR ARAŞTIRMA

Analyses of blood groups have lately caused great improvement in the solution of two problems, which are the question of heredity and the anthropological analysis of blood groups. Thus, in this research the ancestry of nations are studied with graphics of blood groups; in the meantime the geographical distribution of nations are analyzed, and it is determined that blood groups definitely do not inform on racial identity.