Diabetes Blood Glucose Levels Research Articles

Therapeutic potential of aquatic Stevia extract in alleviating endoplasmic reticulum stress and liver damage in streptozotocin-induced diabetic rats.

Misfolded proteins accumulate in the liver due to endoplasmic reticulum stress (ERS) caused by high blood glucose levels in diabetes. This triggers the unfolded protein response (UPR), which if persistently activated, results in cellular dysfunction. Chronic ER stress increases inflammation, insulin resistance, and apoptosis. There is growing interest in using native plants and traditional medicine for diabetes treatment. The stevia plant has recently gained attention for its potential therapeutic effects. This study investigates the protective effects of aquatic stevia extract on liver damage, ER stress, and the UPR pathway in streptozotocin (STZ)-induced diabetic rats. Rats were randomly divided into four groups: a control group that received 1ml of water; a diabetic group induced by intraperitoneal injection of STZ (60mg/kg); a diabetic group treated with metformin (500mg/kg); and a diabetic group treated with aquatic extracts of stevia (400mg/kg). After 28 days, various parameters were assessed, including inflammatory markers, oxidative stress indices, antioxidant levels, gene expression, stereology, and liver tissue pathology. Compared to the diabetic control group, treatment with stevia significantly decreased serum glucose, liver enzymes, inflammatory markers, and oxidative stress while increasing body weight and antioxidant levels. Additionally, stevia extract manipulated UPR gene expression and reduced apoptosis pathway activation. Histological examination revealed improved liver tissue morphology in stevia-treated diabetic rats. These findings suggest that aquatic stevia extract mitigates ER stress in diabetic rats by modulating the IRE-1 arm of the UPR and apoptosis pathways, highlighting its potential therapeutic benefits for diabetes-related liver complications.

Design and Validation of a Monte Carlo Method for the Implementation of Noninvasive Wearable Devices for HbA1c Estimation Considering the Skin Effect.

To diagnose diabetes early or to maintain stable blood glucose levels in diabetics, blood glucose levels should be frequently checked. However, the only way to check blood glucose levels regularly is to use invasive methods, such as pricking the fingertip or using a minimally invasive patch. These invasive methods pose several problems, including being painful and potentially causing secondary infections. This study focuses on noninvasively measuring glycated hemoglobin (HbA1c) using PPG signals. In particular, the study relates to a method and a hardware design technology for removing noise that may be present in a PPG signal due to skin contact with a noninvasive HbA1c measurement device. The proposed HbA1c measurement device consists of the first sensor (PPG sensor) module including an optical barrier and the second sensor (cylindrical sensor) module for removing the skin effect. We have developed a Monte Carlo method to implement accurate, noninvasive HbA1c measurement by considering different skin properties among different subjects. Implementing this model in wearable devices will allow end users to not only monitor their glycated hemoglobin levels but also control diabetes with higher accuracy without needing any blood samples. This will be a groundbreaking advancement in modern wearable medical devices.

Morin ameliorates myocardial injury in diabetic rats via modulation of inflammatory pathways

BackgroundHigh blood glucose levels in diabetes lead to vascular inflammation which accelerates atherosclerosis. Herein, Morin was orally administered in male Wistar rats, at the dose of 40 mg/kg for 28 days, and on the 27th and 28th day, ISO was administered to designate groups at the dose of 85 mg/kg s.c., to induce myocardial infarction.ResultsFree radical generation, including ROS, in diabetes following ISO administration, leads to the activation of both intrinsic and extrinsic pathways of apoptosis. Morin significantly (p ≤ 0.05) reduced oxidative stress (GSH, MDA, SOD), cardiac injury markers (CK-MB, LDH), inflammation (TNF, IL-6), and apoptosis (Bax, BCl2, Caspase-3). In addition, it also reduced insulin and blood glucose levels. Akt/eNOS, Nrf2/HO-1, MAPK signaling pathways, and Insulin signal transduction pathways were positively modulated by morin pre-treatment.ConclusionsMorin attenuated oxidative stress and inflammation and also modified the activity of various molecular pathways to mitigate cardiomyocyte damage during ISO-induced MI in diabetic rats.

The Potential of Noni (Morinda citrifolia L.) as an Anti-Diabetic

Background: Diabetes Mellitus (DM) is still a major health problem in the world today because the prevalence remains increasing. Type 2 diabetes is the most common type of diabetes, accounting for over 90% of all diabetes cases. This disease is characterized by insulin resistance, where the body cannot fully respond to insulin. As a result, glucose levels in the blood continue to increase (hyperglycemia). The main of Type 2 DM management is a healthy lifestyle. In addition, pharmacological therapy is also needed to keep blood glucose levels in diabetics under control. However, antidiabetic medicines can cause some side effects. Therefore, the development of alternative diabetes therapy has been done to minimize side effects. One of the herbal ingredients that are being studied for its potential as an anti-diabetic is noni (Morinda citrifolia L.).Objective: The aim of the study is to review and find out more about the potential of noni (Morinda citrifolia L.) as an anti-diabetic.Methods: This research is included in the type of literature review. The kinds of literature are English and Indonesian language research articles related to the topic searched by using database sources from ProQuest, PubMed, ScienceDirect, and Google Scholar. The research articles were published in the last 10 years (2012 to 2022). Results: There are 14 kinds of literature that match the topic of study. A total of 12 kinds of literature are in vivo studies on animals and 2 literature studies on humans. The result shows that noni has an antidiabetic effect by lowering blood glucose levels and improving other parameters. Parts of Noni that have the potential to control Type 2 DM are fruit and leaves, which can be in the form of extracts, juices, or fermented products. Further research is needed to evaluate the toxicity, the content of active compounds, and the expression of genes related to Type 2 DM for ensuring the mechanism of noni in controlling hyperglycemia. Human studies with more respondents are also needed to confirm the findings of existing studies. Conclusion: Noni has an antidiabetic effect by lowering blood glucose levels and improving other parameters. Based on human studies, noni fruit juice can serve as a suitable addition to the diet of Type 2 DM patients.

Closed Loop Control of Blood Glucose Levels in Diabetes Using an Artificial Neural Network Controller

Regulating blood glucose levels (BGL) is of paramount significance for those with Type 1 Diabetes (T1D), as it can lead to severe health issues, including cardiovascular complications. Our research is centred around the development of an automated closed-loop system, rooted in the minimal Bergman model and driven by a carefully trained artificial neural network (ANN) controller. This approach, evaluated on three T1D patients, effectively keeps blood glucose within the desirable range of 70 to 140 mg/dl, holding the promise of enhancing the overall health and well-being of individuals living with T1D. The potential impact of this research extends to an improved quality of life and a reduction in healthcare burdens.

Inhibitory Effects of Vernonia amygdalina Leaf Extracts on Free Radical Scavenging, Tyrosinase, and Amylase Activities.

Cytotoxicity and instability are the limitations when using bioactive compounds in cosmetic and pharmacology products. This study assesses Vernonia amygdalina leaf extracts for their antityrosinase, antiamylase, and antioxidant activities. Group A extracts were obtained using an aqueous solvent system [70% (v/v) of methanol (BTL70ME), ethanol (BTL70ET), and acetone (BTL70AC)]. Group B extracts were obtained using organic solvents of varying polarities. The results displayed that all extracts exhibited antityrosinase, antiamylase, and antioxidant activities in vitro. The most potent antityrosinase activity was observed in BTL70AC, with a half-maximal inhibitory concentration (IC50) value of 20 μg/mL. BTL_Ethyl acetate and BTL70AC showed potential antiamylase activity. BTL_Isopropanol and BTL_Ethanol exhibited potential antioxidant activity, with IC50 values of 4.0 μg/mL. The total phenolic content of BTL70ME, BTL70ET, and BTL70AC was 72.29±14.14, 65.98±11.91, and 69.37±7.72 mg gallic acid/g extract, respectively. The total flavonoid content was 53.04±5.22, 44.35±13.17, and 61.74±13.17 mg quercetin/g extract, respectively. Group A extracts contained polyphenols, flavonoids, saponins, terpenoids, steroids, and cardiac glycosides. These biological properties can potentially be attributed to the types and quantities of phytochemicals present. Bioactive compounds in the extracts may exert synergistic effects in vitro by interfering with the conformational changes of tyrosinase during substrate binding. Both groups of extracts have the potential to suppress biomolecule degradation, promote antiaging and antimelasma effects, and their phytochemicals can help lower blood glucose levels in diabetes.

Islamic Spiritual Guidance on Changes In Blood Sugar Levels In Type 2 Diabetes Mellitus Patients

Diabetes Mellitus in Indonesia is increasing every year. Diabetes mellitus can be prevented, delayed and slowed down by controlling blood glucose levels. Controlling blood glucose levels in diabetics can be done with Islamic spiritual guidance. This study aims to analyze the effect of Islamic spiritual guidance on changes in blood sugar levels in Type 2 Diabetes Mellitus patients. The research method used was quasi-experimental using a pretest-posttest two group design. A sample of 22 respondents for the intervention group and 22 respondents for the control group. Data analysis used Wilcoxon test, dependent t-test, and Spearman rank correlation. The results showed that the mean blood sugar levels of the intervention group decreased 17.96 mg / dl. Statistically there is influence of Islamic spiritual guidance on blood sugar level (p = 0,000). The total energy requirement is a confounding variable that affects changes in blood sugar levels (p = 0.002). Diabetes mellitus patients are expected to apply spiritual guidance of Islam regularly to control blood sugar levels in order to improve the health of the body and prevent complications of diabetes.

Glucose intolerance is associated with resting heart rate among individuals without diabetes

Elevated resting heart rate is associated with cardiovascular diseases and all-cause mortality. Unmanaged diabetes is associated with high blood pressure and high resting heart rate. Persistent high blood glucose levels in diabetes is known to contribute to the dysfunction of the autonomic nervous system including cardiovascular autonomic nerve fibers leading to higher resting heart rate, heart failure and stroke. In a population without diabetes, however, there is limited knowledge about the relationship between glucose tolerance and indicators of cardiovascular health, therefore, the purpose of the study was to determine how glucose intolerance is associated with resting heart rate and blood pressure in individuals without diabetes. We hypothesized that glucose intolerance will be associated with resting heart rate and blood pressure in a healthy population without diabetes. Eighty five (32 males, 53 females) individuals without diabetes from the border region of El Paso participated in this study (age 26.69±9.45years; BMI 27.85±6.45kg/m2; fasting blood glucose 95.38±10.09mg/dL; resting heart rate 66.15±10.54 bpm; systolic blood pressure 109.2±11.74 mmHg and diastolic blood pressure 71.24±9.03 mmHg). Following an overnight fast of at least 8 hours, resting heart rate systolic blood pressure and diastolic blood pressure were measured with a sphygmomanometer. Fasting blood glucose was measured and a 3-hour oral glucose tolerance test (OGTT) was performed by consuming 75 grams of glucose drink and measuring blood glucose at 15, 30, 90, 120, 150 and 180 minutes after the glucose consumption via a handheld glucometer. Glucose tolerance was assessed by calculating glucose area under the curve (AUC) during OGTT. Spearman’s correlations were performed at 0.05 alpha to determine the associations. Glucose area under the curve, AUC positively correlated with resting heart rate (r=0.39, p=0.0005) whereas fasting blood glucose did not (r=0.02, p=0.9). Blood glucose concentrations at 15 minutes (r=0.10, p=0.4), 30 minutes (r=0.07, p=0.6), and 60 minutes (r=0.2, p=0.1) did not correlate with resting heart rate while blood glucose concentrations at 90 minutes (r=0.3, p=0.02), 120 minutes (r=0.35, p=0.002), 150 minutes (r=0.33, p=0.003), and 180 minutes (r=0.29, p=0.01) during OGTT positively correlated with resting heart rate. Glucose area under the curve was not associated with neither systolic (r=-0.02, p=0.9) nor diastolic (r=0.2, p=0.2) blood pressures. Fasting blood glucose was not associated with neither systolic (r=0.2, p=0.2) nor diastolic (r=0.1, p=0.4) blood pressure. Glucose intolerance rather than fasting blood glucose is reflective of elevated resting heart rate among a healthy population without diabetes. Dodson Grant This is the full abstract presented at the American Physiology Summit 2023 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

VGF nerve growth factor inducible has the potential to protect pancreatic β-cells.

VGF nerve growth factor inducible (VGF) is a secreted polypeptide involved in metabolic regulation. VGF-derived peptides have been reported to regulate insulin secretion in the plasma of patients with type 2 diabetes and model mice. However, the protective effects of VGF on pancreatic β-cells in diabetic model are not well understood. In this study, we aimed to elucidate the β-cell protective effect of VGF on a streptozotocin (STZ)-induced diabetic model using VGF-overexpressing (OE) mice and also examined the therapeutic effect by a small molecule, SUN N8075 which is an inducer of VGF. VGF-OE mice improved blood glucose levels and maintained β-cell mass compared to wild-type (WT) mice on STZ-induced diabetic model. In addition, VGF-OE mice showed better glucose tolerance than WT mice. In culture, AQEE-30, a VGF-derived peptide, suppressed STZ-induced β-cell death in vitro and attenuated the decrease in the phosphorylation of Akt and GSK3β. Furthermore, SUN N8075 suppressed the blood glucose levels and increased VGF expression in the pancreatic islet. SUN N8075 also protected STZ-induced β-cell death in vitro. These findings indicate that VGF plays a hypoglycemic role in response to blood glucose levels in diabetes and protects β-cells from STZ-induced cell death. Therefore, VGF and its inducer have the therapeutic potential by preserving β-cells in diabetes.

A Role of Sodium-Glucose Co-Transporter 2 in Cardiorenal Anemia Iron Deficiency Syndrome.

Heart failure, renal dysfunction, anemia, and iron deficiency affect each other and form a vicious cycle, a condition referred to as cardiorenal anemia iron deficiency syndrome. The presence of diabetes further accelerates this vicious cycle. Surprisingly, simply inhibiting sodium-glucose co-transporter 2 (SGLT2), which is expressed almost exclusively in the proximal tubular epithelial cells of the kidney, not only increases glucose excretion into the urine and effectively controls blood glucose levels in diabetes but can also correct the vicious cycle of cardiorenal anemia iron deficiency syndrome. This review describes how SGLT2 is involved in energy metabolism regulation, hemodynamics (i.e., circulating blood volume and sympathetic nervous system activity), erythropoiesis, iron bioavailability, and inflammatory set points in diabetes, heart failure, and renal dysfunction.

Determinants of blood glucose concentrations following a high carbohydrate meal in type 2 diabetes: A multiple linear regression analysis

This study showed that in relatively well-controlled type 2 diabetes blood glucose levels after a high carbohydrate meal were associated positively with fasting blood glucose, but also positively with gastric emptying in the first hour and negatively with the increments in plasma glucagon-like peptide-1 (GLP-1) in the later postprandial phase.

Molecular modelling and biological evaluation of phyto-molecules as potential activators of gluconolactone oxidase (GULO)

Diabetes, the cause of colossal economic and disease burden, is a key area of research in drug discovery programs. Elevated blood glucose levels in diabetes lead to several adverse consequences due to the formation of advanced glycation end products and free radicals. Vitamin C, a potent antioxidant, protects the body’s cells and tissues from oxidative damage and dysfunctions. Glucose is the precursor of Vitamin C synthesis in plants and some mammals. L-gulono lactone oxidase (GULO) is the rate-limiting enzyme in producing Vitamin C. However, it is not synthesized in bats, primates, humans, and guinea pigs because of the pseudogene. Several phytomolecules having antioxidant properties are hypothesized to be promising and selective activators of GULO. Therefore, the present study focused on screening agonists of GULO from phytomolecules as an effective augmentor for Vitamin C synthesis, thereby suppressing the sequela of diabetic events. The 3D structure of GULO was generated by the ab-initio method. Subsequently, molecular docking explored the possible binding patterns of GULO protein with different plant phenolic compounds, followed by supplementation of the potent phytomolecules to diabetic guinea pigs. It is noteworthy that Resveratrol and Hydroxytyrosol showed better binding affinity. The molecular simulation also confirmed that Resveratrol is an activator of the GULO enzyme. Interestingly, it was also established that Vitamin C levels were improved in diabetic guinea pigs supplemented with the phytomolecules and comparatively Resveratrol modulates the concentration of glucose and Vitamin C levels substantially, thereby alleviating hyperglycemia. However, further studies are warranted to study the mechanisms. Communicated by Ramaswamy H. Sarma

Multimeric adiponectin nanoparticles regulate glucose metabolism by activating phosphatidylinositol-3-kinase, protein kinase B and T-cadherin

Adiponectin (AP), especially its multimeric form, is closely related to diabetes, obesity, cardiovascular disease and cancer and plays a positive role in maintaining metabolic homoeostasis. In this study, we designed and prepared nanoparticles anchored with AP to mimic multimeric AP. Due to the hydrophobic interaction of the polyhydroxyalkanoate granule binding protein (PhaP) region in the tail of the protein, the AP monomer can be anchored to the surface of poly (lactic-co-glycolic acid) (PLGA) / polyhydroxybutyrate (PHB) nanoparticles during incubation, thus mimicking multimeric AP. Similar to previous studies on the natural multimeric form of AP, the multimeric AP mimetic nanoparticles can upregulate NF-κB and have no obvious effect on AMPK in muscle or endothelial cells. Meanwhile, the nanoparticles showed different activities compared to AP monomer on the cell cycle of MCF7 breast cancer cells. Further studies showed that the multimeric AP nanoparticles can activate PI3K, AKT and the multimeric AP receptor T-cadherin, thereby reducing blood glucose and serum glycoprotein levels in ob/ob mice. Due to the ability to regulate glucose metabolism, it may provide a meaningful strategy for regulating blood glucose levels in diabetes or obesity.

Integrated experimental-computational analysis of a HepaRG liver-islet microphysiological system for human-centric diabetes research.

Microphysiological systems (MPS) are powerful tools for emulating human physiology and replicating disease progression in vitro. MPS could be better predictors of human outcome than current animal models, but mechanistic interpretation and in vivo extrapolation of the experimental results remain significant challenges. Here, we address these challenges using an integrated experimental-computational approach. This approach allows for in silico representation and predictions of glucose metabolism in a previously reported MPS with two organ compartments (liver and pancreas) connected in a closed loop with circulating medium. We developed a computational model describing glucose metabolism over 15 days of culture in the MPS. The model was calibrated on an experiment-specific basis using data from seven experiments, where HepaRG single-liver or liver-islet cultures were exposed to both normal and hyperglycemic conditions resembling high blood glucose levels in diabetes. The calibrated models reproduced the fast (i.e. hourly) variations in glucose and insulin observed in the MPS experiments, as well as the long-term (i.e. over weeks) decline in both glucose tolerance and insulin secretion. We also investigated the behaviour of the system under hypoglycemia by simulating this condition in silico, and the model could correctly predict the glucose and insulin responses measured in new MPS experiments. Last, we used the computational model to translate the experimental results to humans, showing good agreement with published data of the glucose response to a meal in healthy subjects. The integrated experimental-computational framework opens new avenues for future investigations toward disease mechanisms and the development of new therapies for metabolic disorders.

FUNCTIONAL AND NUTRACEUTICAL CHARACTERIZATION OF CINNAMON

Cinnamon has been using as a fragrant plant and spice. Cinnamon is a member of family Lauraceae. Cinnamon has been used as a traditional medicine to reduce blood glucose level in diabetes and to control Blood pressure, Tumor Growth, Parkinson's and Alzheimer's diseases. Cinnamon nutritional composition revealedthat it contained a significant value of mineral, vitamins, and the main bioactive component is cinnamaldehyde. Cinnamon caloric content was determined as ofcarbohydrate (CHO), protein, fat, fiber, moisture and ash. Cinnamon contained the uppermost amount of carbohydrate(53.37%) in T1 and the lowermost amount of ash (1.25%) in T3. The mineral content of macro-elements and micro-elements were determined fromchromium (Cr), manganese (Mn), iron (Fe), zinc (Zn), magnesium (Mg), phosphorus (P), calcium (Ca), potassium (K) and sodium (Na). The content of minerals in Cinnamon contained the highest amount of potassium (135.2) in T1 and the lowest sodium in T2. The content of vitaminsin Cinnamon contained the fat-solubleand water-soluble vitamins A, K, E, D, β-caroteneand C, B12, B9, B6, B3, B2, B1were determined. Amongst the vitamins, cinnamon contained the uppermostvalue ofβ-carotene (112) and the lowermostvalue of vitamin B6 (0.158). Bioactive compounds of Cinnamon were determined cinnamaldehyde, cinnamyl acetate, β-caryophyllene and coumarin. Among the bioactive compounds in Cinnamon contained the uppermostvalue of cinnamaldehyde (64.56). The antioxidant capacity of cinnamon bark extract was (49 μg/mL). Conclusively,cinnamon is enriched with nutritional values. So, it can be used in the treatment of various disease.

Effect of L-tryptophan on intestinal glucagon like peptide-1(GLP-1) in streptozotocin (stz) induced diabetic rat model

Introduction and Aim: The management of diabetes is a great challenge in this era due to several factors. The financial burden of the medications and the complications of diabetes create management demanding especially in the Indian population. A high protein-rich diet is beneficial in controlling hyperglycemia in diabetic patients. Different amino acids play roles in reducing blood glucose levels in diabetes. Certain amino acids trigger hypoglycemia in diabetes by inducing the gut hormone, Glucagon-like peptide -1(GLP-1) secretion. L-tryptophan is one among them and is present in many of the food items like poultry, beans, seeds, nuts, etc., This study using albino rats focuses on the effect of L-tryptophan on intestinal GLP-1 secretion in diabetic rats by evaluating the blood glucose level, intestinal GLP-1, and intestinal histology of diabetic rats after tryptophan administration.Materials and Methods: Single dose of intraperitoneal injection of STZ (50mg/kg) used to develop diabetic model and orogastric gavage of tryptophan (50mg/kg) was done. Intestinal GLP-1 and blood glucose assay and intestinal histology were the parameters studied.Results: The results showed a significant reduction in blood glucose level and an increased secretion of intestinal GLP-1(p=0.001) in diabetic rats by tryptophan administration and recovery was seen in intestinal histology. In conclusion, in our study, the administration of L- tryptophan in diabetic rats induced a hypoglycemic effect by GLP-1 secretion and restored normal histology.Conclusion: Tryptophan administration showed hypoglycemic effect on diabetic rats as the blood glucose level was reverted to normal and the hypoglycemic effect of L-tryptophan in diabetic rats could be due to increased GLP-1 secretion.

Development of sugar free cookies with novel biodegradable packaging film

The use of alternative sweeteners can help manage weight and normal blood glucose levels of diabetics. Development and standardization of sugar free, low glycemic index and high fibre cookies using wheat flour, oats, trans free bakery shortening, and almonds. Physiochemical analysis of the raw materials used for cookie preparation and the finished product was conducted. Cookies were analysed for diameter, height, spread ratio, texture, and water activity. Sensory analysis using semi-trained panellists was done to establish the acceptability of the product. The formulated cookies were well accepted by the semi-trained panellists as well as the people with diabetes who were randomly selected for the study. The overall appearance, texture and flavour of the cookies were moderately liked by the panellists as indicated in the qualitative descriptive analysis. The product did not change much with the storage of 90 days. The cookies were high in dietary fibre (2.5g per serving), out of which ?- glucan, a soluble fibre was found to be 0.8g per serving which offers a healthy alternative for consumers. The biodegradable polymer used for packaging the cookies was prepared using terpolymer. The chemical and physical properties of the polymer were determined using acid value which was between 0.0195 and 0.0200, hydroxyl value; 0.0260 and 0.023 and the molecular weight was in the range of 10,256 ? and 10,000 ? of the terpolymer A and B, respectively. The polymer demonstrated good mechanical strength as well as and water vapours barrier properties to be used as a primary package for cookies.

Immediate Effect of Stretching Versus Strengthening Excercises on Blood Glucose Level in Chronic Diabetes Mellitus

Background : Diabetes mellitus affects the muscles as muscle play notable role in the regulation of blood sugar level. The lack of glucose can lead to muscle cells atrophying and therefore loss of muscle mass. Stretching can increase cellular glucose uptake. Strengthening may improve strength , enlarged muscle mass and to improve insulin sensitivity and glycaemic control. Their paucity of literature on immediate effect of stretching versus strengthening exercises on blood glucose level in diabetes mellitus . Objective: To find out immediate effect of stretching on blood glucose level in diabetes mellitus individuals. To find out immediate effect of strengthening exercises on blood glucose level in diabetes mellitus individuals. To compare the immediate effectiveness of stretching and strengthening exercises on blood glucose level in diabetes mellitus individuals. Methodology: the study was conducted in Krishna hospital, in physiotherapy department. 44 subjects were selected with simple random sampling method. Chronic type 2 diabetes mellitus individuals were divided in to two groups. Group A (stretching) and group B (strengthening exercises)was given. The pre- and post –treatment postprandial Blood glucose values was measured by glucometer. Result: In conducted study, postprandial BGL showed statistically significant difference between pre and post treatment values in both group A and B. Conclusion: from the above conducted study it concludes that both stretching and strengthening exercises are effective in decreasing postprandial blood glucose level in type 2 diabetes mellitus, as there is no significant difference between both the groups . Strengthening exercises increased more flexibility in females than passive stretching and males were benefited with both stretching and strengthening exercises.

The effect of the glycemic control on the aqueous humor glucose levels in diabetic patients undergoing elective cataract surgery.

Aqueous humor glucose levels play a role in the anterior segment disorders' pathophysiology, mainly in diabetics. Our purpose was to evaluate the ratio of aqueous humor glucose levels to blood glucose levels in diabetics and to evaluate the correlation between this ratio and blood glycated hemoglobin (HbA1c) levels. This prospective study was performed in Sheba Medical Center during 2016-2018. The study included type 2 diabetic patients admitted for elective cataract surgery. Blood glucose levels were measured immediately before surgery. HbA1c was obtained within 3 months preoperatively. At the beginning of surgery, 0.05-0.1 mL aqueous humor was drawn. Main outcome measures were aqueous humor glucose/blood glucose ratio and the correlation between HbA1c and aqueous humor glucose/blood glucose ratio. Thirty-seven patients (mean age 75.2 ± 11.2 years) were recruited. The average aqueous humor glucose/blood glucose ratio was 0.69 ± 0.20. A significant positive correlation was found between aqueous humor and blood glucose levels, Pearson coefficient constant R = 0.63 (p < 0.01), and specifically stronger among older patients R = 0.89 (p < 0.01), females R = 0.74 (p < 0.01), patients with short-term disease (<10 years) R = 0.80 (p < 0.01), and patients treated with oral anti-diabetic treatment R = 0.74 (p < 0.01). A significant strong positive correlation was found between HbA1c levels and aqueous humor glucose/blood glucose ratio R = 0.62 (p < 0.01), and specifically stronger among older patients R = 0.82 (p < 0.01), males R = 0.70 (p < 0.01), patients with prolonged disease (⩾10 years) R = 0.540 (p < 0.05), and patients treated with oral anti-diabetic treatment R = 0.62 (p < 0.01). A significant strong correlation was found between aqueous humor glucose levels and blood glucose levels. Poor glycemic control was strongly correlated with an increased ratio, reflecting an increased anterior chamber's glucose permeability. Older age group was found to have stronger correlation of poor glycemic control with this ratio.

The analysis of reducing blood glucose levels of diabetics with diabetes mellitus by giving a secang wood stew (Caesalpinia sappan L.) to menopausal women in Makassar City

Being the basis for the creation of products from sappan wood (Caesalpinia sappan L.) to reduce and control blood glucose levels and to find out the effectiveness of secang boiled water on the decrease in blood glucose levels of patients with diabetes mellitus at menopause. This research used quasi-experimental research method with pre-test and post-test design in one treatment group. It was obtained the result of diabetic's blood glucose level before and after giving treatment (decoction of sappan wood) by using this method. The number of samples was 30 respondents (menopausal women). Data collection utilized observation sheets and blood glucose check-up. The test results showed that there were significant differences between blood glucose levels before and after treatment. It was obtained that t-count (10,939)>t-tab (1,714) with a sig value.<0.05. There is the Effect of Giving Mixed Secang Wood Decoction (Caesalpinia sappan L.), and Aloe Vera Leaves on Blood Glucose in Mice (Mus musculus). Result of paired sample t-test was obtained p=0.005<α=0.05. It meant that H0 was rejected or there is the affectivity decoction of sappan wood toward reducing blood glucose level to menopause women with diabetes mellitus in 2018 of Makassar city.