Blood Glucose In Diabetic Patients Research Articles

Recent drug development of dorzagliatin, a new glucokinase activator, with the potential to treat Type 2 diabetes: A review study.

Type 2 diabetes mellitus (T2DM) is a complicated disease related to metabolism that results from resistance to insulin and sustained hyperglycemia. Traditional antidiabetic drugs cannot meet the demand of different diabetes patients for reaching the glycemic targets; thus, the identification of new antidiabetic drugs is urgently needed for the treatment of T2DM to enhance glycemic control and the prognosis of patients suffering from T2DM. Recently, glucokinase (GK) has attracted much attention and is considered to be an effective antidiabetic agent. Glucokinase activators (GKA) represented by dorzagliatin could activate GK and mimic its function that triggers a counter-regulatory response to blood glucose changes. Dorzagliatin has shown great potential for glycemic control in diabetic patients in a randomized, double-blind, placebo-controlled Phase 3 trial (SEED study) and had a favorable safety profile and was well tolerated (DAWN study). In the SEED study, dorzagliatin significantly reduced glycosylated hemoglobin (HbA1c) by 1.07% and postprandial blood glucose by 2.83 mol/L, showing the great potential of this drug to control blood glucose in diabetic patients, with good safety and good tolerance. An extension of the SEED study, the DREAM study, confirmed that dorzagliatin monotherapy significantly improved 24-h glucose variability and increased time in range (TIR) to 83.7% over 46 weeks. Finally, the clinical study of dorzagliatin combined with metformin (DAWN study) confirmed that dorzagliatin could significantly reduce HbA1c by 1.02% and postprandial blood glucose by 5.45 mol/L. The current review summarizes the development of GK and GKA, as well as the prospects, trends, applications, and shortcomings of these treatments, especially future directions of clinical studies of dorzagliatin.

A Study of Methods for Predicting and Controlling Blood Glucose in Diabetic Patients

With the development of society and the improvement of people's living standard, diabetes has gradually become one of the world public health problems that endanger human life safety and affect the development of global economy. Type 1 diabetes is a chronic metabolic disorder that prevents the pancreas from producing insulin and requires lifelong treatment with daily insulin injections to prevent high blood sugar. The lack of insulin leads to the continuous high level of blood sugar in patients. The most important thing for patients is to monitor blood sugar changes and control blood sugar within the normal range. In this paper, a systematic literature search is carried out to study these two aspects, and key information such as the learning model adopted in the literature, the main results, the development of relevant technologies, and the limitations are summarized. From the perspective of glucose-insulin prediction model, due to the complex structure of physiological model, many parameters and difficult to identify, most of the modeling methods are data-driven. There is a great room for improvement in the research on how to mine and utilize existing models to effectively establish accurate glucose prediction models for different objects. From the perspective of control theory, after insulin injection, there is a certain delay in the reduction of blood glucose concentration, and the onset time is different depending on the injection site. The rapid development of deep learning and the increase in available data offer the possibility of addressing these challenges in the near future. When designing closed-loop glucose algorithms, consider using a variety of approaches to establish a personalized glucose control algorithm for each diabetic patient.

Comparison between effect of etomidate and thiopentone on blood glucose in diabetic patients - A randomised controlled trial.

Comparison between effect of etomidate and thiopentone on blood glucose in diabetic patients - A randomised controlled trial.

Dragon fruit versus soybean: impact on blood glucose of diabetic patients

Introduction: Diabetes Mellitus (DM) is a serious problem with a sharp increase in incidence. DM can attack almost all groups of people around the world. The number of DM sufferers continues to increase from year to year because of today's human lifestyle which tends to rarely move and unhealthy eating patterns. Objectives: The purpose of this study was to compare the effect of giving soy milk and red dragon fruit on fasting blood glucose levels in type 2 diabetes mellitus patients. Methods: The type of research used was quasy experiment with pre-test-post-test design with two group comparison treatment. The research subjects were Type 2 Diabetes Mellitus sufferers in the working area of the Guguk Panjang Health Center in Bukittinggi City with a total sample of 54 people, divided into an intervention group of 18 who were given 200 grams of red dragon fruit for 7 days, 18 were given 50 grams of soy milk dissolved in 250 ml of water and 18 people in the control group. Results: The results showed that the P-value <0.05 (P=0.035) and the t-value (2.198) ≥ t-table (2.110), meaning that there is an effect of giving soy milk on blood glucose levels in Type 2 Diabetes Mellitus sufferers. There is an effect of giving red dragon fruit on fasting blood sugar levels and blood pressure where the p value was obtained for fasting sugar levels P = 0.018 (p <0.05) and the t count (2.198) was greater than t table (2.11). The results of the ANOVA test showed that the effectiveness of giving red dragon fruit was more effective with an average decrease in blood sugar of 32.56, compared to the effectiveness of giving soy milk with an average decrease in blood sugar of 22.50. Conclusions: In conclusion, red dragon fruit is more effective in lowering blood sugar levels and blood pressure in type 2 diabetes mellitus patients with hypertension, because the content of red dragon fruit can repair damaged pancreatic cells.

Self-Care Behavior of Type 2 Diabetes Patients with Symptoms of Peripheral Neuropathy during the Covid-19 Pandemic: A Qualitative Study

Purpose: This study aims to explore the experiences and perceptions of type 2 diabetes patients with symptoms of Diabetic Peripheral Neuropathy (DPN) in managing their self-care behavior during the COVID-19 pandemic. Methods: Qualitative research with a descriptive phenomenological approach reveals diabetes self-care behavior during the COVID-19 pandemic. Individual interviews were conducted at the participants’ homes with a semi-structured interview guide on twelve type 2 diabetes patients. All interviews were transcribed verbatim and analyzed using thematic content analysis. Results: A total of five themes were identified from the interview analysis, namely: 1) Perception of diabetes self-management; 2) Efforts to control blood sugar; 3) Barriers to blood sugar control; 4) Perceived disturbance; 5) Social support. Since its emergence, the Covid-19 pandemic has become a new obstacle in controlling blood glucose in diabetic patients. In addition to the covid-19 pandemic, negative spiritual coping, low self-motivation, and perceived physical effects are inhibiting factors for blood glucose control in type 2 diabetes patients with symptoms of DPN. Conclusions: Obstacles in efforts to control blood glucose in type 2 diabetes patients with symptoms of DPN include physical, psychological, social, and spiritual aspects. The suggestion in this study is that during the COVID-19 pandemic, it is necessary to adjust and modify diabetes self-management for patients with DPN symptoms. The interventions provided should not only focus on the physical aspect but also need holistic attention to the psychosocial and spiritual aspects simultaneously by involving family participation in the management of the patient’s diabetes.

Effects of glargine on hyperglycemia in patients with diabetes mellitus type II undergoing off-pump coronary artery bypass graft: A randomized, controlled, double-blind clinical trial.

Introduction: In this trial, effects of glargine on hyperglycemia in patients with diabetes mellitus type II who were undergoing off-pump coronary artery bypass graft (CAGB), were examined. Methods: Seventy diabetic patients who were candidate for off-pump CABG were randomly divided into the following two groups (1) Control group who were treated with normal saline+regular insulin and (2) Glargine group who received glargine+regular insulin. Normal saline and glargine were administered subcutaneously 2 hours before surgery, and regular insulin was injected before, during and after the surgery in the intensive care unit (ICU) in both groups. Finally, levels of blood sugar before, 2 hours after starting the surgery and at the end of the surgery, were recorded. Blood sugar levels during ICU stay were also measured every 4 hours for 36 hours. Results: There were no significant differences in blood sugar levels between the groups at the three time points (i.e. before, 2 hours after starting the surgery and at the end of the surgery). In addition, during 36 hours of ICU stay, blood sugar levels did not show significant variations between the groups; however, 20 hours after ICU admission, blood sugar level was significantly higher in the glargine group (P=0.04). Conclusion: The results indicated that both glargine and regular insulin effectively control the blood glucose in diabetic patients undergoing CABG. However, the blood sugar fluctuation was less in the glargine group than control group.

Tenebrio molitor Proteins-Derived DPP-4 Inhibitory Peptides: Preparation, Identification, and Molecular Binding Mechanism.

Inhibition of dipeptidyl peptidase-4 (DPP-4) is an effective way to control blood glucose in diabetic patients. Tenebrio (T.) molitor is an edible insect containing abundant protein. T. molitor protein-derived peptides can suppress the DPP-4 activity. However, the amino acid sequence and binding mechanism of these DPP-4 inhibitory peptides remain unclear. This study used the flavourzyme for T. molitor protein hydrolysis, identified the released peptides with DPP-4 inhibitory effect, and investigated the binding interactions of these peptides with DPP-4. The results showed that flavourzyme efficiently hydrolyzed the T. molitor protein, as demonstrated by the high degree of hydrolysis, disappearance of protein bands in SDS-PAGE, and changes to protein structure. The 4-h flavourzyme hydrolysates showed a good inhibitory effect on DPP-4 (IC50 value of 1.64 mg/mL). The fragment of 1000-3000 Da accounted for 10.39% of the total peptides, but showed the strongest inhibitory effect on DPP-4. The peptides LPDQWDWR and APPDGGFWEWGD were identified from this fraction, and their IC50 values against DPP-4 were 0.15 and 1.03 mg/mL, respectively. Molecular docking showed that these two peptides interacted with the DPP-4 active site via hydrogen bonding, hydrophobic interactions, salt bridge formation, π-cation interactions, and π-π stacking. Our findings indicated that T. molitor protein-derived peptides could be used as natural DPP-4 inhibitors.

Baihu renshen decoction ameliorates type 2 diabetes mellitus in rats through affecting gut microbiota enhancing gut permeability and inhibiting TLR4/NF-κB-mediated inflammatory response.

Baihu Rensheng decoction (BHRS) can effectively improve insulin resistance (IR) and decrease blood glucose in diabetic patients. However, its specific mechanism of action remains unclear. In this study, a type 2 diabetes mellitus (T2DM) rat model was established using a high-fat diet combined with streptozotocin (STZ) injection and treated with BHRS. Firstly, the therapeutic and anti-inflammatory effects of BHRS on T2DM were evaluated. Secondly, the effects of BHRS on gut permeability were evaluated and western blot was used to detect the changes of TLR4/NF-κB pathway-related protein expressions in liver. Finally, 16S rRNA sequencing was used to detect alteration of gut microbiota diversity and abundance in rats after BHRS treatment. Our results showed that BHRS could alleviate the hyperglycemia, hyperlipidemia, IR, and pathological changes of liver, pancreas, and kidney in T2DM rats. BHRS could also decrease the levels of pro-inflammatory cytokines and inhibit the oxidative stress. Immunohistochemistry showed BHRS could increase the expression tight junction-related proteins (ZO-1 and occludin) in colon. Besides, the level of LPS in serum was decreased after BHRS treatment. Western blot results showed that the protein expression of TLR4, MyD88 and the phosphorylation IκB, and NF-κBp65 were lowered after BHRS treatment. 16S rRNA sequencing showed that BHRS treatment altered the diversity of gut microbiotra and decreases the Firmicutes/Bacteroidetes (F to B) ratio at the phylum level. At the genus level, BHRS could increase the relative abundances of Lactobacillus, Blautia, and Anaerostipes and decrease the relative abundances of Allobaculum, Candidatus Saccharimonas, and Ruminococcus. In conclusion, our study revealed the various ameliorative effects of BHRS on T2DM, including improving the liver and kidney functions and alleviating the hyperglycemia, hyperlipidemia, pathological changes, oxidative stress and inflammatory response. The mechanisms of BHRS on T2DM are likely linked to the repair of gut barrier and the inhibition of TLR4/NF-κB-mediated inflammatory response and the improvement in the dysbiosis of gut microbiota.

Spline Longitudinal Multi-response Model for the Detection of Lifestyle- Based Changes in Blood Glucose of Diabetic Patients.

Blood sugar and lifestyle problems have long been problems in diabetes. There has also been a lot of research on that. However, we see that diabetic patients are still increasing even though many patients are not aware of the start of the disease occurrence. Therefore, we consider it very important to examine these two main problems of diabetes by using a more flexible statistical approach to obtain more specific results regarding the patient's condition. The form of data for type 2 diabetes patients is repeated measurements so that it is approached through longitudinal studies. We investigated various intervals of pattern change that can occur in blood glucose, namely fasting, random, and 2 hours after meals based on blood pressure and carbohydrate diets in diabetic patients in South Sulawesi Province, Indonesia. This research is a longitudinal study proposing a flexible and accurate statistical approach. It is a weighted spline multi-response nonparametric regression model. This model is able to detect any pattern of changes in irregular data in large dimensions. The data were obtained from Hasanuddin University Teaching Hospital in South Sulawesi Province, Indonesia. The number of samples analyzed was 418 from 50 patients with different measurements. The optimal spline model was obtained at 2 knots for blood pressure and 3 knots for carbohydrate diets. There are three blood pressure intervals that give different patterns of increase in patient blood glucose levels, namely below 126.6 mmHg, 126.6-163.3 mmHg, and above 163.3 mmHg. It was found that blood sugar rose sharply at blood pressure above 163.3 mmHg. Furthermore, there are four carbohydrate diet intervals that are formed, which are below 118.6 g, 118.6-161.8 g, 161.8-205 g, and above 205 g. The result is that blood sugar decreased significantly at intervals of carbohydrate diet 161.8-205 g. Blood glucose increases with a very high increase in blood pressure, whereas for a carbohydrate diet, there is no guarantee that a high diet will be able to reduce blood glucose significantly. This may be affected by the patient's saturation of a very high carbohydrate diet.

Intrapatient variability of 18F-FDG uptake in normal tissues.

ObjectivesTo investigate the effect of serum glucose level and other confounding factors on the variability of maximum standardized uptake value (SUVmax) in normal tissues within the same patient on two separate occasions and to suggest an ideal reference tissue.Materials and MethodsWe retrospectively reviewed 334 18F-FDG PET/CT scans of 167 cancer patients including 38 diabetics. All patients had two studies, on average 152 ± 68 days apart. Ten matched volumes of interest were drawn on the brain, right tonsil, blood pool, heart, lung, liver, spleen, bone marrow, fat, and iliopsoas muscle opposite third lumber vertebra away from any pathological 18F-FDG uptake to calculate SUVmax.ResultsSUVmax of the lungs and heart were significantly different in the two studies (P = 0.003 and P = 0.024 respectively). Only the brain uptake showed a significant moderate negative correlation with the level of blood glucose in diabetic patients (r = −0.537, P = 0.001) in the first study, while the SUVmax of other tissues showed negligible or weak correlation with the level of blood glucose in both studies.The liver showed significant moderate positive correlation with body mass index (BMI) in both studies (r = .416, P = <0.001 versus r = 0.453, P = <0.001, respectively), and blood pool activity showed significant moderate positive correlation with BMI in the first study only (r = 0.414, P = <0.001). The liver and blood pool activities showed significant moderate negative correlation with 18F-FDG uptake time in first study only (r = −0.405, P-value = <0.001; and r = −0.409, P-value = <0.001, respectively).In the multivariate analysis, the liver showed a consistent effect of the injected 18F-FDG dose and uptake duration on its SUVmax on the two occasions. In comparison, spleen and muscle showed consistent effect only of the injected dose on the two occasions.ConclusionThe liver, muscle, and splenic activities showed satisfactory test/retest stability and can be used as reference activities. The spleen and muscle appear to be more optimal reference than the liver, as it is only associated with the injected dose of 18F-FDG.

The Effects of Snack Control Education and Telephone Coaching on Self-Management, Social Support, Self-Efficacy, and Blood Glucose in Diabetes Patients

Dietary therapy for diabetes is the most basic way to manage blood glucose. Currently, the nutritional intake rate of diabetic patients in Korea is beyond the recommended rate of the Korean Diabetes Association, showing large amounts of carbohydrates in foods consumed as snacks with an additional focus on sugar. Thus, it is necessary to support healthy dietary habits through snack control. This study is a random assignment experimental study with a total of 56 participants; 28 participants were in the control group, while the remaining 28 patients had type 2 diabetes and had visited Kyung Hee University Hospital. The experimental group with snack control education and telephone coaching exhibited a higher self-management score (t = –9.494, &lt;i&gt;P&lt;/i&gt; &lt; 0.001), perceived social support score (t = 7.201, &lt;i&gt;P&lt;/i&gt; &lt; 0.001), and self-efficacy score (t = 7.185, &lt;i&gt;P&lt;/i&gt; &lt; 0.001) than the control group. Additionally, the experimental group showed lower levels of glycosylated hemoglobin and average blood glucose compared to the control group (t = –4.820, &lt;i&gt;P&lt;/i&gt; &lt; 0.001). Thus, snack control education and telephone coaching are effective in improving diabetes self-management behavior, perceived social support, self-efficacy, and reducing glycosylated hemoglobin and average blood glucose. These results confirm the usefulness of snack education materials, and I suggest snack control education as a means of arbitration to improve the self-care of diabetics.

Anti-Diabetic Activity of Polypeptide-K Isolated from Momordica Charantia: A Retrospective Study of 142 Cases

Diabetes Mellitus occurs when the pancreas fails to produce sufficient insulin, or the body is unable to use the insulin produced effectively. In order to regulate the blood glucose of diabetic patients, Diabegard®, a herbal antidiabetic medicine and daily supplement, contains polypeptide-k which exists in the seed of Momordica Charantia (bitter gourd) was prescribed. Purpose: A retrospective study is therefore done with the aim to examine the effectiveness of Diabegard®, polypeptide-k in regulating the blood glucose and cholesterol level of diabetic patients who took Diabegard® for four weeks with a dose of 60 mg per day. Methods: A database record of 105 male and 37 female (ages 25-81) treated with Diabegard®, polypeptide-k was assessed. The effectiveness of Diabegard®, polypeptide-k in blood glucose regulation was determined based on four aspects: gender, three different age categories, four different categories of duration of the disease and five different categories of severity of the disease. The Pearson's correlation was used to find the correlation among variables. Paired sample t-test was used to compare the means of pre- and post-treatment of blood glucose level. One-way ANOVA was used to compare the means of different groups for each aspect. Results: Result showed that age and duration of disease (r2=0.469), pre-treatment of blood glucose and post-treatment of blood glucose (r2=0.606) showed positive relationship. Both paired sample T-test of pre-and post-treatment of blood glucose showed significant difference (p&lt;0.05). Categories with very mild (7 mmol/L), severe (13.9-19.4mmol/L) and very severe (&gt;19.4mmol/L) diabetes showed significant difference (p&lt;0.05). Other tests showed no significant difference. Conclusion: In conclusion, this present retrospective study showed that Diabegard®, polypeptide-k was effective in controlling blood glucose level of all diabetic patients especially in patients with mild (26.87% reduction), severe (40.43% reduction) and very severe diabetes (49.27% reduction).

Analysis of the Influence of Humanized Nursing Intervention on Blood Glucose in Diabetic Patients Nursing

Analysis of the Influence of Humanized Nursing Intervention on Blood Glucose in Diabetic Patients Nursing

Near-infrared optical spectroscopy for pancreas shrinkage estimation with multi synchrosqueezing transform and multivariate regression model.

In this article, we proposed a method to estimate pancreas shrinkage with pancreas β cell insulin secretion. The β cells in the pancreas secrete insulin and digestive enzymes after food consumption. Conventionally, the pancreas structure estimation is done with magnetic resonance imaging (MRI) and ultrasound imaging techniques. However, the structure of the pancreas changes due to islet cell death. The presence of islet cells is detected through near infrared (NIR) spectroscopy signal acquired from the epigastric region (pancreas) of the abdomen. Subsequently, the NIR spectroscopy signal from the pancreas is analyzed with multi synchrosqueezing transform (MSST); whereas, the β cell insulin secretion varies for diabetic and nondiabetic persons. The existence of β cell and insulin secretion correlates with Root Mean Square (RMS) and kurtosis via a multivariate regression model to evaluate pancreas shrinkage. In terms of numerical results, NIR spectroscopy signal from the pancreas was obtained for about 20 nondiabetic and 20 diabetic persons. The pancreas shrinkage was estimated with 88% accuracy. The results are validated with MRI pancreas images for earlier detection of the apoptotic pancreas. The pancreas shrinkage causes lower insulin emission and unpredictable blood glucose in diabetic patients. Analysis of NIR spectroscopy signals of the pancreas with MSST was done to obtain higher-order and lower-order frequency components.

Interference of high dose intravenous vitamin C with blood glucose testing in a patient with COVID-19 infection

Flash glucose monitoring system (FGMs) is an option for patients to monitor their glucose however, the presence of interfering substances can result in false blood glucose readings. The COVID-19 (SARS-2-Cov) pandemic has resulted in substantial damage to the public and currently, no effective treatment is available for this deadly disease. Intravenous vitamin C (VC) has been shown to attenuate the cytokine storm in COVID-19 infection. Studies suggest that vitamin C supplementation reduces blood glucose in diabetic patients. On the other hand, VC can affect glucose readings obtained by devices in varying degrees. Here, we present a diabetic patient diagnosed with COVID-19 infection, who had false increased blood glucose readings on FGM after VC treatment. A 45-year-old woman with T2DM was diagnosed with a COVID-19 infection. Intravenous VC at a dose of 2500mg five times was added to the standard treatment protocol due to COVID-19 pneumonia. Her flash glucose levels were consistently elevated during intravenous VC infusion and returned to her normal average values after cessation of infusion. Insulin was not given at the time of fluctuations in blood glucose readings because both fingerstick and venous blood glucose measurements at the time of VC infusion were not consistent with the FGM readings. False increase in blood glucose readings due to interfering substances should be kept in mind since correction with insulin or antidiabetics may lead to a potential for dangerous life-threatening hypoglycemic events.

Specific detection of glucose by an optical weak measurement sensor.

Diabetes is an important public health problem and finding quick testing methods with high accuracy, reliability, and convenience are important to control the blood glucose of diabetic patients. In this study, a sensor based on a weak measurement scheme was developed for the specific detection of glucose for the first time. The detection of glucose using the proposed method was completed by the high sensitivity and resolution of the weak measurement based on optical rotation detection, as well as the change in the optical rotation before and after the specific oxidation of glucose. The resolution of the as-obtained glucose sensor was around 2.71×10-3 g/L (1.50×10-2 mmol/L), and the detection range was 0-11 g/L (0-61 mmol/L).

The Influence of Sleep on Glycated Hemoglobin in Pregnancy With Gestational Diabetes

Background: Sleep disturbances have been associated with poor glycemic control in differential clinical settings. Both short and long sleep duration, influence insulin resistance and blood glucose in diabetic patients. Pregnancy is an additional risk for reduced sleep quality and quantity, and the presence of hyperglycemia, as a complicating factor, has being increasingly frequent. Different measures of sleep evaluation, both objectively and subjectively, can provide additional information about the influence of sleep in metabolic control in Gestational Diabetes Mellitus (GDM). Objective: To investigate the influence of sleep quality and objective sleep measures on glycated hemoglobin (HBA1C) in patients with GDM. Methodology: This is a cross-sectional study examining patients with GDM from 2nd to 3rd trimester of pregnancy. Clinical data and behavior questionnaires were collected by a face-to-face interview. Self-Rated Sleep Quality was evaluated by Pittsburgh Sleep Quality Index- (PSQI). In order to improve the accuracy of the information, a 14-day sleep log was obtained, and objective sleep measurements were registered by actigraphic record (5 to 7 days). Results: Overall, GDM patients (N=311), aged from 20 to 46 y (33.1±5.6) were evaluated. Sleep duration ≤6 hours/night was found in 43.4%, and 63.9% reported poor sleep quality (PSQI>5). Sleep duration measured by actigraphy was correlated with sleep duration registered by sleep log (r=.45, p=.04), and with PSQI (r=-.33, p=.002). Sleep quality and sleep duration registered by either actigraphy or sleep log were not correlated with Hba1c. Amongst all, Hba1c varied from 4.3 to 7.0 mg/dL (5.9 ±.53). Sleep fragmentation, measured by the length of time patient spends awake after sleep onset (WASO) was correlated withHba1c level in patients with GDM (r=.41, p=0.04). Conclusion: Sleep duration obtained from the sleep log was a reliable measure correlating with objective sleep parameters registered by actigraphy and with sleep quality. In GDM patients, increased wake time after sleep onset was correlated with higher Hba1c.

Effect of Drugs and Combination of Diets with Exercise on Biochemical Parameters in Patients with Type 2 Diabetes Mellitus in Barishal, Bangladesh: A Follow up Study

Diabetes Mellitus is a chronic metabolic disorder associated with an increased rate of glucose which can be reduced by diets, drugs, lifestyle changes and physical activity. The present study aimed to investigate the comparison of the effectiveness of drugs and combination of diets with exercise on biochemical parameters of Type 2 Diabetes mellitus patients. A follow up study of 150 diabetes patient’s biochemical test >30 years of age were conducted in two phages before and after three months from Diabetes Hospital, Barishal. The investigator categorized two groups of diabetes patients where intervention of diets with exercise was given to 75 respondents and on the other hand 75 respondents by drugs to find out which intervention was more effective. This study found the incidence of reduced blood glucose from 50% to 13.33% by diets with exercise and 50% to 10.67% by drugs during fasting after three months of intervention. After 2 hours eating, blood glucose reduced to 14% and 18% respectively. Analyst established diets with exercise and drugs both had a great effect on fasting glucose, after two hours glucose and serum creatinine which was statistically significant between two phages of same respondents (P<.05). Drugs over fasting glucose, after 2 hours glucose and serum creatinine were statistically significant. Diets with exercise over fasting glucose, after 2 hours glucose, LDL and serum creatinine were also highly significant. Combination of diets and physical activity targeting this factor has proven to be superior to conventional drug use for reducing blood glucose of diabetic patients.

The Potential of Noni (Moringa citrifolia) in Lowering Blood Glucose Levels in Diabetes Mellitus Patients

Background: Diabetes Mellitus is a chronic metabolic disorder caused by insulin resistance. Noni juice has the potential as herbal medicine which believed to reduce blood glucose levels. This study aims to determine the effect of noni juice on blood sugar levels on diabetic patients. Methods: This study used 16 respondents. They divided two groups, a control group and a treatment group. Each group consists of 8 respondents. The intervention group received 150 ml of noni juice which was given once a day for ten days. Glucose testing was carried out by the glucose-check method. The blood was taken from the respondent's fingertips capillary. The blood glucose levels between the control group and the intervention group were analyzed using independent t-test. Results: The average blood glucose level in the intervention group was 199.88 mg/dl, while the control group was 326.25 mg/dl. The test results of the mean blood glucose levels between the control group and the intervention group had a significant difference with a value of p = 0.003 (p ≤ 0.05). This indicates a significant effect between blood glucose levels in the control group and the intervention group. Conclusion: Noni can reduce blood glucose levels because it contains flavonoid. It has a hypoglycemic effect. Health workers can suggest consuming noni juice to decrease blood glucose in diabetic patients.&#x0D; &#x0D;

The Effect of Herbal Medicine on Blood Glucose in Type 2 Diabetes Patients: A Retrospective Study

Objective: This study was conducted to evaluate the effect of herbal medicine on blood glucose in diabetic patients. Methods: The subjects were patients with diabetes mellitus (DM) who had been admitted to Kyung Hee University Korean Medicine Hospital for more than 8 weeks for a primary diagnosis other than DM and who had taken herbal medicine for more than 8 weeks from January 2010 to February 2020. The medical records were analyzed retrospectively to confirm the characteristics of the subjects, and examination results included hemoglobin A1c (HbA1c), total cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN), and creatinine. Changes in HbA1c before and after taking herbal medicine and changes according to subgroups were analyzed. Results: A total of 149 subjects with type 2 DM were selected as participants. After taking the herbal medicine, the HbA1c value was significantly decreased, and the statistical significance was maintained even when the effect of controlling antidiabetic agents was excluded. The decrease in HbA1c was higher in the poor glycemic control group. Liver and kidney functions did not show any significant changes after taking the herbal medicine. Conclusions: Administration of herbal medicine for a long period of 8 weeks or longer did not increase HbA1c in patients with DM complicated by other various diseases. Keywords: diabetes mellitus (DM), herbal medicine, blood glucose, Hemoglobin A1c (HbA1c)