ABSTRACT Introduction/Purpose This study aimed to investigate the effects of isovolumetric training with and without blood flow restriction (BFR) on muscle hypertrophy, power, strength, and aerobic capacity. Methods Twenty participants (30.2 ± 7.7 yr, 69.6 ± 15.0 kg, 166.8 ± 7.3 cm) were randomized to a control (n = 11) or BFR group (n = 9). Testing sessions included measurement of bilateral thigh circumference, cross-sectional area of the vastus lateralis and biceps femoris via ultrasound imaging, determination of maximum oxygen consumption (V̇O2max) and power output via rowing, and estimated one-repetition maximum (1-RM) deadlift. Participants trained twice weekly for 4 wk. The BFR group (applied to thighs bilaterally at 80% occlusion) rowed at 40% maximum power output and lifted 30% 1-RM for 1 × 20 reps and 3 × 10 reps. The control group rowed at 80% power and lifted 60% 1-RM for 1 × 10 reps and 3 × 5 reps. Results Analyses indicated a main effect over time (P = 0.001) for power (P = 0.001), cross-sectional area of vastus lateralis and biceps femoris bilaterally (P = 0.001 for both), and V̇O2max (P = 0.003), indicating that both groups improved over time. Results also indicated that the control group had higher ratings of perceived exertion than the BFR group during training (P = 0.04). Conclusions The two types of training did not produce different results, except the BFR group had a higher output in maximum power. BFR training can be a feasible option for individuals unable to train at 60%–80% of maximum allowing for progressive rehabilitation with lower intensity.