Blood Circulation In Tissues Research Articles

Functional state of dermal circulation in patients with lichen planus

Lichen planus belongs to the group of the most common dermatoses. The etiology and mechanisms of development of lichen planus are not fully understood. This dermatosis is characterized by a variety of clinical forms, as well as a chronically relapsing course, and a fairly frequent resistance to traditional therapies. The chronically relapsing course and susceptibility to complications and deterioration in the quality of life of patients with lichen planus give this dermatosis the status of a medical and social problem. Objective — to investigate the state of blood circulation in the areas of skin lesions of patients with lichen planus, depending on the stage of the clinical course of dermatosis. Materials and methods. We observed 37 patients with lichen planus with a typical (classical) clinical form (22 men and 15 women) aged 20 to 44 years. The comparison group consisted of 30 apparently healthy individuals, comparable by sex and age. In 19 patients, the progressive stage of dermatosis was diagnosed, in 18 — the stationary stage. The duration of the course of the disease in the subjects ranged from two weeks to six months. In all the examined patients, the microcirculation index (MI), the mean quadratic deviation of the microcirculation indicators, the coefficient of variation (KV), as well as maximum amplitude of slow oscillations (ALF), maximum amplitude of rapid oscillations (AHF), maximum amplitude of pulse oscillations (ACF) were determined. The first component of the active mechanism of regulation of tissue circulation was calculated according to the formula ALF/PM; the second component — according to the formula σ/ALF; the first component of the passive mechanism of modulation of tissue circulation was calculated according to the formula ACF/σ; the second component — according to the formula AHF/σ. In addition, the intravascular resistance ACF/PM · 100 % and the microcirculation efficiency coefficient ALF/(AHF + ACF) were studied. The study was carried out on a Doppler flowmeter Vingmed SD-100 (Sweden). Results and discussion. The obtained results indicate a low level of tissue perfusion, insufficient functioning of tissue blood circulation modulation mechanisms and reduced vasomotor activity of microvessels in the areas of affected skin of patients with lichen planus. It was also established that the modulation of tissue blood circulation was redistributed in the direction of reducing the passive mechanism, that is, in the direction of disturbances of cardiac and respiratory rhythms of fluctuations. Conclusions. In the examined patients with a typical (classical) form of the clinical course of lichen planus, a stagnant­static type of hemodynamics in the dermis was established during the examination by laser Doppler flowmetry in the skin areas affected by a specific papular rash.It has also been proved that in patients with lichen planus, in particular, in skin areas with specific lichenoid lesions, there is a redistribution of modulation of tissue blood circulation towards a decrease in the passive mechanism, that is, towards cardiac and respiratory rhythm disorders of fluctuations.The established disorders of dermal vascularization in the areas of skin lesions of patients with lichen planus expand the understanding of the pathogenesis of this dermatosis and need to be taken into account when developing the tactics of its complex, individualized therapy, which will contribute to increasing the effectiveness of treatment.

Anxiety and Obesity in Children: Anti-oxidative Medications and Hyperbaric Oxigenation Therapy

IntroductionObesity is a grave problem in pediatrics and child psychiatry. It was revealed that in many cases obesity has comorbidity with different mental disorders. Besides a number of endocrine disturbances, immune system deficiency and oxidative stress with free radical oxidation take part in pathogenesis of these phenomena.ObjectivesThe essence of the therapeutic effect of hyperbaric oxygen lies in the fact that under the influence of elevated barometric pressure, oxygen saturation of body fluids increases: blood, interstitial fluid, which deliver oxygen to organs and tissues, increasing oxygen supply to cells by 5-10 times and eliminating hypoxia (oxygen starvation tissues). Hyperbaric oxygen, normalizing blood circulation in tissues and metabolic processes at the cellular level, has a number of effects that favorably affect the patient’s condition: promotes the formation of a new vascular network in areas where it is damaged or insufficient, has anti-edematous, anti-inflammatory and wound healing effects, has an immunocorrective effect , normalizes hormonal status, enhances the action of a number of pharmacological agents. The aim of our research was to study effects of HBO on children suffering from anxiety and obesityas a result of the mental instability? S;eep disturbances and immune instabilityMethodsSessions of hyperbaric oxygenation were carried out at a pressure of 1.6 ATA: the first session lasted 45 minutes, subsequent sessions was 30 minutes. After HBO, each of the patients during the day showed a steady increase in the saturation index, which persisted until the morning of the next day. An analysis of fluctuations in the saturation index during the day showed its decrease in all patients to a minimum value at 8 am and its general dynamic increase from the beginning of hyperbaric oxygenation. Parameters of immune status, including serum concentrations of IgA, IgM and IgG, circulating immune complexes were studied in pediatric patients, aged from 10 to 14 years old, 42 girls and 34 girls. Mapping EEG was used for evaluation of electric brain activity.ResultsIt was found that HBO treatment normalized mental state: patients demonstrated less anxiety and overeating habits, тormalization of sleep, positive dynamics of sleep, reflected in the EEG pattern in the form of alpha waves. Immune reactions were changed: IgA, IgM and IgG, were increased and CIC serum level decreased.ConclusionsThe use of antioxidant therapy in combination with psychopharmacological drugs has long been a well-established method of treatment for a variety of psychopathological conditions. The inclusion of hyperbaric oxygenation in this complex also helps to achieve more distinct results in terms of weight loss in obesity and normalization of the mental state, improved sleep and significant immunocorrection.Disclosure of InterestNone Declared

Literature Review: Pengaruh Kompres Hangat Terhadap Nyeri Dismenorea Pada Remaja

Teenager will experience hormonal changes the body related to the maturity the reproductive organs, namely the first menstrual period is menarche. Warm compresses have effect on reducing dysmenorrhea pain, this is because the warm feeling can reduce muscle spasms, stimulate nerve fibers that close, has vasodilating effect on blood vessels, dilates blood vessels and improves blood circulation in tissues, reduces the effect muscle tension, reduces pain intensity and provides warm and comfortable feeling. To identify the effect warm compresses on dysmenorrhea pain in adolescents. The method used this research is literature review. Using the Google Scholar data base source, the keywords warm compresses, dysmenorrhea pain, teenagers. Maximum time for publishing articles is 10 years (2012-2022). It was found that 3 articles were taken according the inclusion criteria. It was found that the characteristics the selected respondents were among adolescents including the age 15-25 years, the dysmenorrhea pain scale before was mild to severe pain and after warm compresses it became painless to mild pain. Identification dysmenorrhea in adolescents, namely primary dysmenorrhea. The results analysis from three journal articles show that warm compresses have effect on reducing dysmenorrhea pain among adolescents. Conclusion, warm compresses have effect on reducing dysmenorrhea among adolescents.

Підходи до визначення механізмів ергогенної дії нефармакологічних засобів антиоксидантної спрямованості

One of the powerful methodologies of ergogenic nature is the use of vibration loads in the mode of "whole body vibration", which in terms of frequency of oscillations mostly coincides with the frequency of oscillations of the microstructures of the body itself. The purpose of the study was to evaluate the effectiveness of the use of non-pharmacological agents with antioxidant nature of action in vibration loads in athletes. Materials and methods. To assess the effectiveness of vibration loads as a non-pharmacological ergogenic agent, we have chosen vibration loads as one of the most characteristic mechanical effects on the human body. The study of the effectiveness and impact mechanisms of vibration loads on the body of athletes using domestic spiral-vortex simulator involved 24 representatives of cyclic sports. They are qualified rowers in kayaks and canoes. These athletes were divided into equal groups (12 people) by the number of group members – control and main. In the dynamics of research, not only changes under the influence of additional vibration loads of indicators of special physical performance were evaluated, but also numerous homeostatic parameters that reflect the severity of oxidative stress, structural and functional state of cell membranes, the degree of endogenous toxicity, intensity of humoral immunity, and also systemic factors that affect the formation of physical performance – the activity of the factor induced by hypoxia and the main angiogenic factor. Vibration load after the main standard training session was created using a spiral-vortex simulator «PLH-9051» for 30 minutes. The examination of the participants was conducted before starting and at the end of the stage of direct preparation for the competition. Results and discussion. The results of our study have proven that the vibration of the whole body in this mode does not lead to negative changes in the basic standard laboratory parameters of the body. At the same time, it was found that the indicators in the 12-minute test (endurance characteristics) and in the one-minute test (speed characteristics) significantly improved. As for the metabolic changes that are the basis for such rearrangements of the parameters of special physical performance, it is established that there is no additional activation of oxidative stress during vibration training. Vibration loads, firstly, have a positive effect at the subcellular level – the activity of lipid peroxidation reduces and antioxidant protection improves. At the same time, positive changes occur in the activation links of angiogenetic characteristics, which are an indirect reflection of the increase in the number of microvessels and the improvement of tissue blood circulation with the increase of oxygen transfer and plastic and energy substrates. Conclusion. Thus, according to the obtained data, vibration loads in the mode of vibration load of the whole body lasting 30 minutes after standard training load are similar to hypoxic training conditions, but without the occurrence of oxidative stress, and can be used for the same purpose – to improve adaptation mechanisms and increase physical performance at the special preparatory stage of athletes specializing in cyclic sports, and in a more general interpretation – in sports with a predominantly aerobic mechanism of energy supply

The Effect of Slow Stroke Back Massage Cutaneus Stimulation on Pain Intensity Osteoarthritis in The Elderly

Osteoarthritis (OA) also known as degenerative joint disease is the most common in all forms of arthritis and causes pain and disability in the elderly. This disease is characterized by progressive loss of joint cartilage, synovitis (inflammation of the synovium lining the joints), joint pain, stiffness, and loss of joint movement (Lemone, 2018:1679). Skin stimulation that can be done is Slow-Stroke Back Massage. Proper use of skin stimulation: slow-stroke back massage can reduce pain perception and help reduce muscle tension which can reduce pain intensity, but it can also cause dilation of blood vessels and improve blood circulation in tissues. This activity was carried out at the Lubuk Pakam Health Center in January 2021. The target of this community service is 30 elderly people with osteoarthritis. The method used in this community service is providing education or counseling to patients with Osteoarthritis. The media used are Power point presentation (PPT) and LCD for approximately 90 minutes. To measure the success of the education or counseling provided, knowledge measurement before and after education or counseling was carried out using a questionnaire. Data analysis for bivariate calculations in this study used Pair Samples t-test with the provisions of 0.05. Based on the results of statistical tests using paired sample t-test, p value (= 0.000) < (= 0.05) it can be concluded that the hypothesis in this study is accepted,

FDTD Simulation of Magnetic Field Distribution in Normal and Blood Cancer for Treatment

Non-invasive cancer treatment has the potential to eliminate infection and scar formation associated with surgery to minimize side effects. Light stimulation can use for treatment to increase efficiency, reduce treatment costs, eliminate infection, etc. Magnetic fields can improve blood circulation in tissues and stimulate the body’s metabolism. The magnetic field can induce joule heating and expand the blood vessels of cancerous tumors. These blood vessels increase the possibility of excess oxygen to enter the tumor creating obstacles to the survival of oxygen-rich cancers. In this study, we investigate finite difference times domain (FTDT) simulation of magnetic field in normal and blood cancer. The low frequency with range 10-106 is used in this study. The maximum magnetic field for normal blood and CLL1 is 400 nm and 250 nm in 125 cm electrode size. While for 50 nm electrode size, the maximum magnetic field in normal blood and CLL 1 is 400 nm and 300 nm. But there The maximum magnetic field for normal blood and CLL1 is 400 nm and 250 nm in 125 cm electrode size. While for 50 nm electrode size, the maximum magnetic field in normal blood and CLL 1 is 400 nm and 300 nm. But there is no peak for blood cancer in final stage CLL2.

Features of blood`s microcirculation at physical loads

This research deals with the study of blood microcirculation peculiarities.Materials and methods. 72 students of Bogdan Khmelnytsky Melitopol State Pedagogical University, aged 18–19, were examined. The experimental research consisted of the study of blood microcirculation functional state by means of Laser Doppler flowmetry (LDF) method. It helped to evaluate the state of tissue blood-circulation and to detect individual-typological peculiarities of blood microcirculation under the influence of physical activity (before and after exercise).Results. Three types of blood microcirculation were identified by using LDF-metry. The normoemic type of blood microcirculation, characterized by the superposition of oscillatory rhythms and reflected the balance of the mechanisms of regulation of microcirculation. The hyperemic type, characterized by a «monotonous» LDF-gram with a high parameter of microcirculation, which reflects the relative predominance of metabolic mechanisms in the regulation of microcirculation. The hypoemic type, characterized by a «monotonous» LDF-gram with a low parameter of the microcirculation parameter, which reflects the decrease of vasomotor mechanisms in the regulation of microcirculation. According to the LDF-metric data, the examined students under intensive physical activity have a significant increase in microcirculatory status: by 6 % of the microcirculation parameter, by 28 % of the mean square deviation and by 45 % of the initial value of the coefficient of variation.Conclusions. This dynamics of microcirculation shows that under the influence of physical exertion, a person creates significant functional reserves for the redistribution of blood flow and for more perfect intraorgan capillary blood flow. It was found, that in the process of physical activity, morpho-functional rearrangements of the human cardiovascular system occur. This reaction is formed by several components of blood microcirculation: blood flow in the transport direction, regulating blood supply in accordance with the needs of tissues and the exchange component of the histochemical barrier

Clinical Evaluation of the Method of Active Abdominal Drainage in General Peritonitis Rancid

Acute general putrid peritonitis refers to the severe inflammation of the peritoneum. He is constantly accompanied by jendotoksicheskim shock and progressive multiple organ failure. Macro and micro blood circulation in tissues and organs of the abdominal cavity Portal vein system is blocked from the first minutes the development of pathological process and toxins and nedookislennye metabolic products accumulate in them. For their removal requires efferent methods of treatment, one of which suggests the author of this article. Technical and physical techniques against a backdrop of complex drug therapy perpetrated as cleansing and forcible blood vessels promotion portal system. In this way manage to restore homeostasis. For developing this method, he was extradited to USSR patent (No. 1787036, dated March 7, 1991). To confirm the effectiveness of the proposed method of treatment, the author describes the clinical observations.

Application of Chitosan/PVA Nano fiber as a potential wound dressing for streptozotocin-induced diabetic rats

Diabetes mellitus is a worldwide health problem affecting 1–2% of the population of world with noticeable morbidity and mortality. Vascular events such as hypertension, nephropathy, neuropathy and retinopathy are happened in diabetic patients. Decline in tissue blood circulation may causes hypoxia and finally may leads to slow wound healing and amputation. PVA/Chitosan Nano fiber wound dressings have high moisture vapor transmission rate and good antimicrobial activity11Chellamani, K. P., P. Sundaramoorthy, and T. Suresham. Wound dressing made out of poly vinyl alcohol/chitosan nanomembranes, J. Acad. Ind. Res. 1 (2012) 342–347. PCNWD substrate does not have any recognized cytotoxicity effects and has excellent odor absorbing capability. In the present study, Streptozotocin (STZ) is used to induce diabetes in rats, Skin ulcers are produced experimentally in the experimentally induced diabetic and non-diabetic rats. Then PCNWD used as wound dressing for 2 weeks period to evaluate its macroscopic and microscopic effects on wound healing in comparison with untreated diabetic and non-diabetic rats experimental ulcers. The findings of current study indicate significant acceleration in diabetes wound healing on the rats treated by PVA/Chitosan Nano fiber.

Daily dynamic of indicators of girl-students’ blood micro-circulation

Purpose: study daily dynamic of indicators of girl-students’ blood micro-circulation. Material: 340 girls of 17-19 years old age were examined. The method of laser Doppler’s flow metering was used. Results: The state of tissue blood circulation was determined. Character of micro-circulation’s changes under influence of daily bio-rhythms was detected. In first half of day tension of mechanisms of micro-circulation’s regulation takes place. Partially it reduces by 4 p.m. at the account of strengthening of metabolic components of vasomotor rhythm. In evening period there is observed compensatory increasing of breathing and pulse modulations. It is connected with weakening of sympathetic and strengthening of parasympathetic impacts on tissue blood circulation. Also we registered changes in correlation of rhythmic components of tissue blood circulation’s oscillations at the accounts of weakening of vasomotor rhythm. It witnesses about tension of regulatory mechanisms. Conclusions: it is recommended to use the received data as normative indicators of laser Doppler’s flow metering when studying pathological processes.

Значение неинвазивного исследования микроциркуляции в конечности при оценке уровня ампутации у пациентов с критической ишемией (краткий обзор литературы)

The development of modern vascular surgery is impossible without improvement of diagnostic methods of examination. The development of severe disorders of blood circulation in limbs, beyond compensation, ends up executing amputation. In the present review the authors considered one of the current problems of modern vascular surgery - high amputation in patients with critical ischemia of lower extremities, the truncation of the leg. According to the majority authors, the main reason for early purulent - necrotic complications in high amputation is the mistake of determining the level of amputation. This fact is accompanied by a sharp reduction in the duration and quality of life, which entails increasing social burden and increases economic costs of rehabilitation of patients. One of the possible solutions to this problem is to study the safety regulatory mechanisms resistive Department microcirculation (arterioles, precapillary sphincters and metarterioles). This article presents the available arsenal of vascular surgery: methods of diagnostics of the microcirculation. It is proved the critical role of non-invasive methods for measuring microcirculatory disorders in critical limb ischemia (CLI) when the doctors choose the level of amputation. It is a comprehensive assessment of blood circulation in tissues and tissue metabolism allows to giving an objective answer on the degree of ischemic damage to the tissue in occlusive diseases of arteries of lower extremities.

Use of Hypertonic Sodium Chloride Solution at Surgery under Extracorporeal Circulation

The paper analyzes the data available in the references on different aspects of using hypertonic sodium chloride solution during surgery under extracorporeal circulation in cardiosurgical care. The hypertonic solution is shown to lower positive fluid balance in the perioperative period, to increase cardiac output with simultaneously decreased vascular resistance, to improve lung oxygenating function, and to normalize tissue blood circulation and neurological status in patients exposed to artificial perfusion. There is evidence for its effect on the immune system and capillary endothelium. It is suggested that it is necessary to study the effect of the hypertonic solution on the incidence of complications and death rates during surgery under extracorporeal circulation and it is proposed to use the solution under long-term extracorporeal circulation. Key words: hypertonic saline, sodium chloride, extracorporeal circulation.

Carbon Monoxide Inhalation Protects Rat Intestinal Grafts from Ischemia/Reperfusion Injury

Carbon monoxide (CO), a byproduct of heme catalysis by heme oxygenases, has been shown to exert anti-inflammatory effects. This study examines the cytoprotective efficacy of inhaled CO during intestinal cold ischemia/reperfusion injury associated with small intestinal transplantation. Orthotopic syngenic intestinal transplantation was performed in Lewis rats after 6 hours of cold preservation in University of Wisconsin solution. Three groups were examined: normal untreated controls, control intestinal transplant recipients kept in room air, and recipients exposed to CO (250 ppm) for 1 hour before and 24 hours after surgery. In air grafts, mRNA levels for interleukin-6, cyclooxygenase-2, intracellular adhesion molecule (ICAM-1), and inducible nitric oxide synthase rapidly increased after intestinal transplant. Histopathological analysis revealed severe mucosal erosion, villous congestion, and inflammatory infiltrates. CO effectively blocked an early up-regulation of these mediators, showed less severe histopathological changes, and resulted in significantly improved animal survival of 92% from 58% in air-treated controls. CO also significantly reduced mRNA for proapoptotic Bax, while it up-regulated anti-apoptotic Bcl-2. These changes in CO-treated grafts correlated with well-preserved CD31(+) vascular endothelial cells, less frequent apoptosis/necrosis in intestinal epithelial and capillary endothelial cells, and improved graft tissue blood circulation. Protective effects of CO in this study were mediated via soluble guanylyl cyclase, because 1H-(1,2,4)oxadiazole (4,3-alpha) quinoxaline-1-one (soluble guanylyl cyclase inhibitor) completely reversed the beneficial effect conferred by CO. Perioperative CO inhalation at a low concentration resulted in protection against ischemia/reperfusion injury to intestinal grafts with prolonged cold preservation.

201Tl and 99Tcm-human serum albumin for assessment of the effect of hypertensive treatment with angiotensin II infusion on tumour circulation.

The biodistribution of 201Tl and of 99Tcm-human serum albumin (99Tcm-HSA) was observed in tumour-bearing mice to investigate if tissue blood circulation could be evaluated in groups of mice infused with angiotensin II at a rate of 0.5 micrograms kg-1 min-1 (L) or 1 microgram kg-1 min-1 (H). Ten minutes after tracer injection, tumour uptake of 201Tl in the angiotensin II infused group showed a 2.20- and a 3.18-fold increase in the L and H groups, respectively, when compared to a group of mice infused with saline (P = 0.0478 and 0.0029, respectively). The effect of angiotensin II infusion on 201Tl uptake was minimal in normal organs. Decreased normal organ uptake of simultaneously injected 99Tcm-HSA in the L and H groups indicated the contraction of normal organ vessels, while increased tumour uptake of the tracer indicated mechanical dilatation of tumour vessels. We conclude that the effect of angiotensin II or other vasoactive agents can be non-invasively assessed by 201Tl and 99Tcm-HSA scintigraphy.