Blood Cell Counts In Mice Research Articles

Influence of exogenous interferon on the peripheral white blood cell count in mice.

The effect of interferon (IF) injected intraperitoneally on the peripheral white blood-cell (WBC) count in mice was studied. Mouse serum or brain IF produced in vivo in different mouse strains by injecting various viral inducers depressed the lymphocyte count from 3 to 24 h after the injection. The effect was correlated to the antiviral titer of the preparations. The inhibitory factor exhibited physico-chemical properties of IF. Crude IF preparations obtained from mouse cell cultures, human IF and mock preparations devoid of anti-viral activity exerted no lymphocytopenic effect.