The integration of nanotechnology in healthcare has brought about revolutionary advancements, particularly in diagnostics and therapeutics. However, managing the vast and sensitive data generated by these applications poses significant challenges, particularly concerning security, privacy, and regulatory compliance. This study explores the design, development, and optimization of a blockchain-based secure data management system tailored for nanotechnology applications in the United States healthcare sector. The proposed system leverages blockchain's decentralized and immutable ledger technology to enhance data security and privacy, ensure regulatory compliance, and improve overall system performance. Our implementation showed substantial improvements in data security, with an 86.67% reduction in data breaches and an 85% decrease in unauthorized access cases. Additionally, compliance with major data privacy standards like HIPAA, GDPR, and CCPA increased by over 20%. Performance metrics demonstrated robust scalability, maintaining high transaction speeds and manageable latency across various load conditions. Cost analysis revealed significant reductions in data storage, security, and compliance costs, highlighting the economic benefits of adopting blockchain technology in healthcare. Moreover, the system exhibited lower energy consumption compared to traditional data management systems, addressing environmental concerns. Correlation and scatter plot analyses provided insights into the scalability and performance dynamics of the blockchain system. These findings underscore the transformative potential of blockchain technology in addressing the data management challenges of nanotechnology in healthcare. The study concludes with recommendations for adopting blockchain to enhance data security, regulatory compliance, and economic efficiency in the U.S. healthcare sector.