Blockage Of Blood Vessels Research Articles

Prediction of cardiovascular disease using deep learning algorithms to prevent COVID 19

ABSTRACT The leading cause of mortality is due to cardio vascular disease (CVD) globally. CVD is the major cause of death all over the world for the past years because an estimation of 17.5 million people died from CVD in 2012 and premature death from CVD is 37% below the age of 70. In health-care field, the data generated are large, critical, and more complex and multi-dimensional. In the current situation, the medical professionals working in the field of heart disease can predict up to 67% accuracy but the doctors need an accurate prediction of heart disease. The ultimate goal of this study is to early prediction of CVD by enhancing both predictive analysis and probabilistic classification. Deep learning techniques such as CNN and RNN emulate human cognition and learn from training examples to predict future events. As a result, the future prediction of the cardiovascular disease has been found. The prediction of CVD can be used for the prevention of COVID-19 disease using deep learning algorithm. So, this can be employed to detect the early stage of the disease. The importance of the CVD refers to the conditions like narrowed or blocked blood vessels which may lead to some other diseases like heart attack, chest pain or stroke.

The Effect of High Fiber Consumption Patterns on Lowering Cholesterol Levels Low Density Lipoprotein: Literature Review

Background: Hypercholesterolemia can cause blockages in blood vessels and heart. Not infrequently people with hypercholesterolemia will experience myocardial infarction in the heart which leads to death. Changes in lifestyle are characterized by consuming less fiber-containing foods which have an impact on increasing LDL cholesterol levels in the blood. This study aimed to determine the effect of the application of high fiber consumption patterns on the reduction of cholesterol levels. Method: Literature review from the Google Scholar database, Pubmed published from 2010 to 2020, and manually select articles that are relevant to the research statement and use the keywords high fiber consumption patterns and hypercholesterolemia. Results: From the results of the literature review conducted, it was found that there were 10 related articles that met the criteria. Results: The results of the search are obtained by consuming a high-fiber diet (avocado, guava and dragon fruit, carrots and tomatoes, etc.) which produce nutrients and antioxidants such as anthocyanins, flavonoids, lycopene, PUFA, MUFA, niacin, fiber, vitamin C and phytosterols which can help lower LDL cholesterol levels and increase HDL. Conclusion: There is a relationship between the pattern of consumption of high-fiber foods to decrease cholesterol levels. With a high-fiber consumption pattern, it can bind bile acids and then excreted together with feces, this acid can reduce LDL cholesterol levels.

Dhikr Therapy Can Improve Muscle Strength In Non-Hemorrhagic Stroke Patients

Background: Non-hemorrhagic stroke is a disease that occurs due to a blockage in certain brain blood vessels. Therefore, the brain area is not supplied with energy and oxygen so that the brain tissue does not function. The problem that occurs in non-hemorrhagic strokes is the weakness of the limbs and facial muscles. Non-pharmacological therapy for non-hemorrhagic stroke sufferers is dhikr therapy. Dhikr therapy relies on feelings and heart to calm the soul and increase muscle strength. This study aims to determine the effect of dhikr therapy on muscle strength in non-hemorrhagic stroke patients 
 Methods: This study used a quasi-experimental research design with pre-and post-test with control group. Non-probability sampling was used to determine the sample, which consisted of 54 respondents: 27 in the treatment group with ROM therapy, dhikr and 27 in the control group with ROM therapy. Manual Muscle Testing (MMT) Instrument is used to measure muscle strength. The data were analyzed using an independent T-test
 Results: There is an effect of dhikr therapy on muscle strength after implementing the therapy in the intervention and control groups with a p-value of the right upper extremity of 0.000, p-value of the left upper extremity of 0.008, p-value of the right lower extremity of 0.007 and p-value of the left lower extremity of 0.007
 Conclusion: The results of this study indicate that dhikr therapy can improve muscle strength in non-hemorrhagic stroke patients at the Sibela Community Health Center of Surakarta

Neuroprotective effects of Korean White ginseng and Red ginseng in an ischemic stroke mouse model

BackgroundStroke is a neurological disorder characterized by brain tissue damage following a decrease in oxygen supply to brain due to blocked blood vessels. Reportedly, 80% of all stroke cases are classified as cerebral infarction, and the incidence rate of this condition increases with age. Herein, we compared the efficacies of Korean White ginseng (WG) and Korean Red Ginseng (RG) extracts (WGex and RGex, respectively) in an ischemic stroke mouse model and confirmed the underlying mechanisms of action. MethodsMice were orally administered WGex or RGex 1 h before middle cerebral artery occlusion (MCAO), for 2 h; the size of the infarct area was measured 24 h after MCAO induction. Then, the neurological deficit score was evaluated and the efficacies of the two extracts were compared. Finally, their mechanisms of action were confirmed with tissue staining and protein quantification. ResultsIn the MCAO-induced ischemic stroke mouse model, WGex and RGex showed neuroprotective effects in the cortical region, with RGex demonstrating superior efficacy than WGex. Ginsenoside Rg1, a representative indicator substance, was not involved in mediating the effects of WGex and RGex. ConclusionWGex and RGex could alleviate the brain injury caused by ischemia/reperfusion, with RGex showing a more potent effect. At 1,000 mg/kg body weight, only RGex reduced cerebral infarction and edema, and both anti-inflammatory and anti-apoptotic pathways were involved in mediating these effects.

Study of the Blood Flow average for Atherosclerosis using Ultrasound Doppler shift

Atherosclerosis is a condition that affects the walls of arteries repeatedly; blood vessel blockage caused by atherosclerosis is a frequent cause of heart attack and stroke. The use of Doppler change, a recent advancement in ultrasound technology, would improve its function by improving accuracy. Blood flow measurement is crucial because it can aid in the early detection of many diseases. One of these diseases is atherosclerosis, which has been researched using the ultrasound Doppler scattering method to measure blood flow average velocity in the dorsal artery of the foot. The study’s findings revealed that age and diabetes had a greater impact than other factors such as medical history, high blood pressure, and triglycerides.

Effect analysis of kinetic energy progressive exercise in patients with acute myocardial infarction after percutaneous coronary intervention: a randomized trial.

Acute myocardial infarction (AMI) is the most common critical illness clinically. Percutaneous coronary intervention (PCI) can help patients with AMI by reopening their blocked blood vessels and improving clinical symptoms. Clinical practice has confirmed that rehabilitation training after PCI could significantly promote the recovery of patients' heart function, reduce cardiovascular events, and have a positive significance for prognosis. This study aimed to explore the effect of kinetic energy progressive exercise (PEKE) applied to patients with AMI after PCI. From April 2019 to April 2020, a total of 98 patients with AMI after PCI in our hospital were randomly allocated to PEKE group and routine intervention (RI) group. The RI group adopted routine intervention, while the PEKE group introduced PEKE intervention on the basis of the RI group. The incidence of adverse events (AEs), motor function, cardiac function, and quality of life (QoL) before and after intervention were compared between the two groups. Compared with the RI group, the incidence of AEs in the PEKE group was significantly reduced (χ2=4.404, P=0.036). After 6 months of intervention, the maximum exercise load and metabolic equivalent of the PEKE group were greater than those of the RI group (t=7.114, 4.565; P=0.000, 0.000). After 6 months of intervention, the left ventricular ejection fraction (LVEF) of the PEKE group was greater than that of the RI group (t=6.826, P=0.000), and there were no significant differences in left ventricular end-diastolic volume (LVEDV) and left ventricular end-systolic volume (LVESV) compared with the RI group (t=1.253, 1.147; P=0.213, 0.254). After 6 months of intervention, the PEKE group's symptoms, physical function, cognitive function, psychosocial function, and satisfaction scores were greater than those in the RI group (t=5.991, 4.612, 7.165, 5.731, 5.468; P=0.000, 0.000, 0.000, 0.000, 0.000). We applied PEKE was to AMI patients with after PCI, and it was shown to effectively reduce AEs, improve the patients' exercise ability and cardiac function, and improve their QoL. ClinicalTrials.gov Identifier: ChiCTR2100046123.

Hubungan Kerasionalan Peresepan Obat Antihipertensi Dengan Outcome Klinis Pada Pasien Stroke Iskemik Rawat Inap RSUD Dr. Soegiri Lamongan

Ischemic stroke is a disruption of blood supply to the brain caused by the blockage of blood vessels. Hypertension is a comorbid disease in ischemic stroke. Appropriate treatment can affect the success of therapy and the achievement of the desired blood pressure. This study aims to evaluate the rationale for using antihypertensive drugs to achieve clinical outcomes in the form of blood pressure. This study was designed in an observational analytic manner with a cross-sectional approach, retrospective in nature with a purposive sampling method in ischemic stroke patients who received antihypertensive prescriptions in RSUD Dr. Soegiri Lamongan. The sample used was 100 patients. The results showed that the most widely used antihypertensive drugs were CCB with a percentage of 41.8%, ARB with a percentage of 27.6%. The rationale for prescribing was obtained: 100% correct indication, 100% correct patient, 91% correct drug, and 100% correct dose. The results of the Chi-Square test have obtained an expected value of 5, so that it is followed by the Fisher's Test, which obtained a p-value of 0.021 (p 0.05). The conclusion of this study is that patients who received a rational antihypertensive prescription were 91%, for patients who achieved clinical outcomes as much as 86% and there was a relationship between the rationality of prescribing antihypertensive drugs with clinical outcomes in the form of achieving target blood pressure in ischemic stroke patients at RSUD Dr. Soegiri Lamongan.

Photo-responsive hydrogel facilitates nutrition deprivation by an ambidextrous approach for preventing cancer recurrence and metastasis

Postoperative recurrence at the primary site and distant metastasis remains the challenge in treating triple-negative breast cancer due to its unpredictable invasion into adjacent tissues. Although systemic chemotherapy has been extensively adopted to attenuate the recurrence and metastasis, the abundant nutrition supply by blood vessels would promote the rapid proliferation of tumor cells and angiogenesis. Herein, we reported a nutrition deprivation strategy by ambidextrously blocking the residual blood vessels and inhibiting angiogenesis to realize efficient treatment of triple-negative breast cancer. To this end, an injectable hydrogel with photo-responsive property was prepared by using polydopamine crosslinked collagen/silk fibroin composite to deliver thrombin for blocking blood vessels and angiogenesis. In the presence of NIR light, the locked thrombin was released into the blood vessels in the adjacent tissues to promote blood coagulation. In addition, the photothermal effect would reduce the secreting of VEGF for preventing angiogenesis in the adjacent tissues. The in vitro and in vivo results demonstrated that the permanent interruption of nutrient supply by blocking the blood vessels adjacent to the resected tumor and preventing angiogenesis is a promising strategy to prevent the recurrence and metastasis of TNBC.

Deep Learning based Method for Multi-class Classification of Diabetic Retinopathy

Diabetes mellitus is a form of diabetes with secondary microvascular complication leading to renal dysfunction and retinal loss also termed as diabetic retinopathy. Retinopathy is grave form of retinal disease. It is the leading cause of blindness in the world. Blockage of tiny minute retinal blood vessels due to the high blood sugar level is the reason why retinopathy leads to blindness or loss of vision. This study serves the purpose of deep learning-based diagnosis of Diabetic retinopathy using the fundus imaging of the eye. In this study architectures such as VGG 16 and VGG 19 are deployed in order to classify the images into 5 categories. The performance of the two models were compared. The highest accuracy is 77.67% when using the VGG 16 pre-trained model.

Metal chelation attenuates oxidative stress, inflammation, and vertical burn progression in a porcine brass comb burn model

Oxidative stress and inflammation may mediate cellular damage and tissue destruction as the burn wound continues to progress after the abatement of the initial insult. Since iron and calcium ions play key roles in oxidative stress, this study tested whether topical application of a metal chelator proprietary lotion (Livionex Formulation (LF) lotion), that contains disodium EDTA as a metal chelator and methyl sulfonyl methane (MSM) as a permeability enhancer, would prevent progression or reduce burn wound severity in a porcine model.We have reported earlier that in a rat burn model, LF lotion reduces thermal injury progression. Here, we used the porcine brass comb burn model that closely mimics the human condition for contact burns and applied LF lotion every 8 h starting 15 min after the injury. We found that LF lotion reduces the depth of cell death as assessed by TUNEL staining and blood vessel blockage in the treated burn sites and interspaces. The protein expression of pro-inflammatory markers IL-6, TNF-a, and TNFα Converting Enzyme (TACE), and lipid aldehyde production (protein-HNE) was reduced with LF treatment. LF lotion reversed the burn-induced decrease in the aldehyde dehydrogenase (ALDH-1) expression in the burn sites and interspaces. These data show that a topically applied EDTA-containing lotion protects both vertical and horizontal burn progression when applied after thermal injury. Curbing burn wound conversion and halting the progression of second partial burn to third-degree full-thickness burn remains challenging when it comes to burn treatment strategies during the acute phase. Burn wound conversion can be reduced with targeted treatments to attenuate the oxidative and inflammatory response in the immediate aftermath of the injury. Our studies suggest that LF lotion could be such a targeted treatment.

Magnetic mesoporous embolic microspheres in transcatheter arterial chemoembolization for liver cancer

Transcatheter arterial chemoembolization (TACE) is the main treatment for liver cancer. Although many embolic agents have been exploited in TACE, embolic agents combining embolization, drug loading, and imaging properties have not yet been constructed. Herein, we report a new magnetic mesoporous embolic microsphere that can simultaneously be loaded with doxorubicin (Dox), block vessels, and be observed by magnetic resonance imaging (MRI). The microspheres were prepared by decorating magnetic polystyrene/Fe3O4 particles with mesoporous organosilica microparticles (denoted as PS/Fe3O4@MONs). The PS/Fe3O4@MONs were uniformly spherical and large (50 µm), with a high specific surface area, uniform mesopores, and a Dox loading capacity of 460.8 µg mg−1. Dox-loaded PS/Fe3O4@MONs (PS/Fe3O4@MON@Dox) effectively inhibited liver cancer cell growth. A VX2 rabbit liver tumor model was constructed to study the efficacy of TACE with PS/Fe3O4@MON@Dox. In vivo, PS/Fe3O4@MON@Dox could be smoothly delivered through an arterial catheter to achieve chemoembolization. Moreover, PS/Fe3O4@MON@Dox and residual tumor parenchyma could be distinguished on MRI, which is of great significance for evaluating the efficacy of TACE. Histopathology showed that PS/Fe3O4@MON@Dox could be deposited in the tumor vessels, completely blocking the blood supply. Overall, PS/Fe3O4@MON@Dox showed good drug loading, embolization and imaging performance as well as potential for use in TACE. Statement of SignificanceTranscatheter arterial chemoembolization (TACE) is the main treatment for liver cancer. Although many embolic agents have been exploited in TACE, embolic agents combining embolization, drug-loading, and imaging properties have not yet been constructed. In this work, we prepared magnetic mesoporous microspheres as a new embolic agent that can simultaneously load doxorubicin (Dox), block blood vessels and enable magnetic resonance imaging. Overall, this new embolic microsphere-mediated TACE strategy for liver cancer showed good therapeutic effects, and the PS/Fe3O4@MON@Dox embolic microspheres provide a new avenue for improving the efficacy of TACE for liver cancer and postoperative evaluation.

Large red cell-derived membrane particles are major contributors to hypercoagulability in sickle cell disease

Sickle cell disease (SCD) is one of the most common inherited single gene disorders. Polymerisation of sickle hemoglobin results in erythrocytes that are inflexible and adherent, leading to coagulation, vascular and cellular activation and resultant blood vessel blockage. Previous studies have observed elevated numbers of red cell-derived particles (RCDP), also denoted extracellular vesicles, in SCD plasma. Here, imaging flow cytometry was used to quantify all RCDP in SCD plasma. A more heterogenous population of RCDP was observed than previously reported. Significantly, large right side-out red cell macrovesicles (MaV), 7 µm in diameter, were identified. Most RCDP were right side-out but a minor population of inside-out vesicles was also present. Electron micrographs confirmed the heterogenous nature of the RCDP detected. All MaV are decorated with prothrombotic phosphatidylserine (PS) and their removal from plasma lengthened clotting times by more than three-fold. Removal of all right side-out RCDP from SCD patient plasma samples resulted in a seven-fold increase in clotting time. These results indicate that MaV comprise a large area of prothrombotic membrane and are thus major contributors to hypercoagulation in SCD. Consequently, controlled removal of MaV and PS exposed RCDP from plasma could provide a novel therapy for managing this disease.

Potential of fibrinolytic protease enzyme from tissue of sand sea cucumber (Holothuria scabra) as thrombolysis agent

Cardiovascular diseases (CVD) are still the main cause of death in modern society with thrombosis as their most common underlying pathology. The occurrence of thrombosis is characterized by thrombus formation in the circulatory system of the body causing blood clot blockage. Thrombus blocking blood vessels can be destroyed through fibrinolysis by plasmin. Commonly administered fibrinolytic drugs activate plasminogen and convert plasminogen to plasmin which degrades fibrin. However, these agents have limitations such as higher costs, shorter half-lives, allergic reactions and intravenous administration-caused bleeding. Hence, more effective and safer antithrombotic drugs are needed in anti-thrombosis therapy. This paper was intended to assess the ability of Holothuria scabra tissue fibrinolytic proteases as a thrombolytic agent based on literature studies. Summary of recent studies showed that various strong fibrinolytic enzymes could be produced from various animal tissues such as snake and earthworm, yet from sea organism’ tissues are barely reported. In this literature review, the potential of protease enzymes from tissue of H. scabra as thrombolysis agent is summarized and discussed. Among the findings is that H. scabra has the highest protein content among other sea cucumbers in Indonesia, yet the isolation of protease enzymes from H. scabra tissue has not been reported. Hence, there is high possibility in finding novel proteases, which may include serine and metallo-protease known for their thrombolysis activities.

Anesthesia Management in Patient with Placenta Percreta Performed Intra-aortic Ballooning Caesarean Section

<p>Placenta accreta spectrum is one of maternal mortality’s causes which is related with severe obstetric bleeding that requires hysterectomy. The incidence rate of the spectrum placenta increases with increasing caesarean section. Placenta accreta spectrum is also close-related to placenta previa. The aim of this study is to understand perioperative management in patient with placenta percreta performed with intra-aortic ballooning in caesarean section. We are following a case on a 36 year old female patient, multigravida at term pregnant with placenta percreta and history of caesarean section 5 and 2 years ago. The surgeries performed were caesarean section surgery as well as intra-aortic ballooning. Anesthetic technique used was general anesthesia. Operation duration approximately ± 180 minutes, bleeding 1500 cc. After the operation, the patient was admitted to the ICU. The patient going well and discharged from ICU to ward on the second day. After three days in ward, the patient discharged to home. Hemodynamic changes during balloon intra-aortic procedures are of particular concern to anesthetists. This is because the stopping of blood flow to the aorta in this case can cause an increase in blood vessel pressure, where the administration of nitroglycerin at low doses can reduce venous tone resulting in venous vasodilation which will maintain hemodynamic stability during the process of blocking blood vessels with a balloon. From the case we may conclude that anesthesia in pregnant women with placenta accreta spectrum should be carried out with caution and involve a multidisciplinary specialist given its high risk of bleeding. The intra-aortic balloon insertion technique can be an option used to reduce the risk of bleeding in patients with placenta accreta spectrum.</p>

Development of an Optical Method for the Evaluation of Whole Blood Coagulation.

Blood coagulation is a defense mechanism, which is activated in case of blood loss, due to vessel damage, or other injury. Pathological cases arise from malfunctions of the blood coagulation mechanism, and rapid growth of clots results in partially or even fully blocked blood vessel. The aim of this work is to characterize blood coagulation, by analyzing the time-dependent structural properties of whole blood, using an inexpensive design and robust processing approaches. The methods used in this work include brightfield microscopy and image processing techniques, applied on finger-prick blood samples. The blood samples were produced and directly utilized in custom-made glass microchannels. Color images were captured via a microscopy-camera setup for a period of 35 min, utilizing three different magnifications. Statistical information was extracted directly from the color components and the binary conversions of the images. The main advantage in the current work lies on a Boolean classification approach utilized on the binary data, which enabled to identify the interchange between specific structural elements of blood, namely the red blood cells, the plasma and the clotted regions, as a result of the clotting process. Coagulation indices produced included a bulk coagulation index, a plasma-reduction based index and a clot formation index. The results produced with the inexpensive design and the low computational complexity in the current approach, show good agreement with the literature, and a great potential for a robust characterization of blood coagulation.

Intravenous Thrombolysis in Acute Branch Retinal Artery Occlusion Based on the Stroke Green Channel: A Case Report

Retinal artery occlusion is an acute-onset eye disease that seriously impairs vision, and is a critical condition in ophthalmology. The effect of traditional ophthalmology treatment methods are not ideal. It is difficult to recanalize blocked blood vessels early, but thrombolysis can be given within an effective time window to dissolve the thrombus, improve retinal blood perfusion and restore the function of the retinal inner layer cells. Under the protection of the green channel for stroke, we performed intravenous thrombolysis for patients with branch retinal artery obstruction, and achieved satisfactory results, and the patients were cured.

HUBUNGAN PENGETAHUAN DAN SIKAP DENGAN UPAYA PENCEGAHAN STROKE PADA PASIEN HIPERTENSI DI RUANGAN POLI SARAF RSUD KOTA KOTAMOBAGU

Stroke is a cut in blood flow to the brain, generally occurs due to rupture of blood vessels to the brain or blockage of blood vessels so that the supply of nutrients and oxygen to the brain is reduced. Stroke causes physical impairment or disability. The study reports that in the last 20 years there has been an increase in the burden of stroke in several European countries by 1.1 million per year in 2000 to 1.5 million per year in 2025. In most cases of stroke, it shows that stroke occurs from an accumulated pattern. life and habits of daily living a day. Stroke prevention efforts are also influenced by the knowledge and attitudes of stroke sufferers.
 This research uses descriptive analytic method with cross sectional approach. The total population of 30 patients with grade II hypertension was also taken as a total population of 30 patients. Data analysis using Chi Square test.
 Results: There is a relationship between knowledge and efforts to prevent stroke in hypertensive patients, which is the value of P = 0.000 where the p value is less than p (0.05). There is a relationship between attitude and stroke prevention efforts in hypertensive patients with a value of p = 0.000. As a suggestion: the research site is expected to provide input to improve health services, especially hypertensive patients who are at high risk of stroke. For further research, it is hoped that the research will be better so that the patient's knowledge about the relationship between the knowledge of stroke prevention in hypertensive patients in the neurological clinic of Kotamobagu City Hospital is even better. For health workers at the Nerve Police, they should be active in providing health education about the dangers and prevention of strokes.
 Keywords: Knowledge, Attitude, Stroke, Hypertension Patients

The Role of “Medical Social Worker” in Cardiovascular Thoracic Surgery

Cardiovascular system is relating to the circulatory system of human body, which comprises the heart and blood vessels and carries nutrients and oxygen to the tissues of the body and removes carbon dioxide and other wastes from them. It plays an important role in helping the human body to meet the demands of activity, exercise, including maintains body temperature and stress. Captivatingly, by reason of some dysfunctional in body function lead to cardiovascular disease that especially involve narrowed or blocked blood vessels that can make cause to a heart attack, chest pain or stroke too. And Cardiothoracic Vascular surgery is related with surgery of thorax which entails with great complications somehow. Work carried out by trained personnel with the aim of alleviating the conditions of those people in a community suffering from any disease that personnel factually Social worker particularly who engage in medical practice. Supplementary, Medical Social Worker can perform their appreciable role in pre-operative stage, at operative stage, post-operative stage, at managing post-operative outcomes and notwithstanding retraction in pre-position of thoracic surgery of patient who unusually effected from cardiovascular disease. In this paper attempt has been made to analyses role of Social Worker in thoracic surgery. The present paper has been portrayed in two parts, parts one related with general description and part II related with specialized approach.

Geriatric Cardiology and its Relationship of Coronary Heart Disease

Geriatric cardiology is a relatively new field aimed at transforming cardiovascular protection to an aging population by incorporating fundamentals of geriatric medicine into the systemic care of older adults with cardiovascular disease. The clinical demonstration of Coronary heart disease in older patients shows the effect of the disease superimposed on the physiological effects of age. At autopsy, 40% of elderly women and 85% of elderly men have blockage of blood vessels and it cause coronary heart disease. Octogenarians incorporate 10% of the US population but 15% of the hospitalizations for myocardial infraction. Coronary arteriography older substances have substandard disease than the younger

FACTORS AFFECTING HYPERCOLESTEROLEMIA IN LANSIA IN THE WORKING AREA OF PUSKESMAS DAIK 2020

Hypercholesterolemia is one of the causes of metabolic disorders that cause coronary heart disease, blood vessels and diseases related to blockage of blood vessels. WHO data in 2015 states that more than 17 million people worldwide die from coronary heart disease and blood vessels. The results of screening for the elderly in the Daik Community Health Center Work Area in 2019, of the 398 elderly who were examined, there were 283 elderly who had hypercholesterolemia, namely 71.1% of the elderly with cholesterol> 200 mg / dl. One of the factors that affect hypercholesterolemia, among others: Diet and Physical Activity. The purpose of this study was to determine the factors that influence hypercholesterolemia in the elderly in the Daik Community Health Center Work Area in 2020. This research is a quantitative study with a cross sectional design. The study population was 283 elderly people aged> 60 years who had hypercholesterolemia. The sample in this study were 165 people with purposive sampling technique. Data were collected using a Diet questionnaire and a Physical Activity questionnaire. which was carried out on the elderly aged 60-75 years with hypercholesterolemia .. Data analysis for bivariate with chi-square test at degree ? = 0.05. The results showed that the eating habits of the most respondents were eating foods containing cholesterol, the results of statistical tests were obtained by using Chi-Square analysis x2 count 52.5 ? x2` Table 5.991. The most respondents physical activity was light physical activity with the number of Metabolic <600 (MET), the results of the Chi-Square test x2 count 182.94 ? x2` Table 5.991. There is a significant influence between dietary habits and physical activity with hypercholesterolemia in the elderly in the Daik Community Health Center Work Area. Keywords: Elderly, Hypercholesterolemia, Daik Community Health Center