Block Test Research Articles

Non-invasive ultrasonic sensing of internal conditions on a partial full-scale spent nuclear fuel canister mock-up

The safe storage of spent nuclear fuel (SNF) in dry cask storage systems (DCSSs) is critical to the nuclear fuel cycle and the future of nuclear energy. A critical component of DCSSs is the SNF canister. The canister is a sealed stainless-steel structure, which is first vacuum dried and then backfilled with helium. The structural deterioration within a canister can be monitored through its internal gas properties. This monitoring serves as the driving force behind the non-invasive ultrasonic sensing approach in this paper. A major challenge in collecting gas-borne signals using ultrasonic sensing is the impedance mismatch between the stainless-steel canister and the helium gas inside. Only a small fraction of the ultrasonic signal makes its way from the transmitter to the receiver through the gas medium. In this paper, experimental studies on a partial full-scale canister mock-up were carried out to capture the gas-borne signals. Damping materials were applied on the outside, and blocking and unblocking tests were conducted to identify the gas-borne signal. The research results showed that the excitation frequency played an important role in maximizing the gas-borne signals. The gas-borne signal was successfully detected at around the theoretical time-of-flight (TOF) at 225 kHz. A high signal-to-noise ratio (SNR) was achieved in the measurements. Next, acoustic impedance matching (AIM) layers were added, and it was found that the gas signal energy was improved by 160.4% compared with that of no AIM layers. Subsequently, the relative humidity (RH) level and temperature of the gas were varied to simulate abnormal internal conditions of the canister. The non-invasive testing system demonstrated reliability and sensitivity in detecting gas temperature and RH variations. Theoretical calculations demonstrated the potential for detecting low-level xenon and air within an actual SNF canister filled with helium. Last, an active noise cancellation (ANC) method, previously developed by the authors, was verified on the canister mock-up for the first time. The results showed that the SNR of the gas signal was improved by 213.6% compared with that of no ANC.

Development of high-quality and water-resistant PBG through H-PDMS modification: From experiments to molecular dynamics simulation

The effective treatment and high-value application of phosphogypsum (PG) are of critical importance for the sustainable development of this construction material. However, its poor water-resistance property has limited its application in the construction field. In order to expand the application potential of phosphorous-building gypsum (PBG) as a durable material, potassium hydroxide (KOH) and hydroxyl‑terminated polydimethylsiloxane (H-PDMS) were used as the activating agent, and the water-resistant modifying agent in this study, respectively, to develop a high-quality and water-resistant PBG product. In addition, molecular dynamics was used to reveal the modification mechanism of H-PDMS and the water-resistance mechanism of KOH activating PBG. The study results show that H-PDMS can significantly improve the water-resistance performance of PBG test blocks. KOH can increase the surface activity of PBG by introducing -OH radicals, promote the reaction between H-PDMS and PBG, and form a dense hydrophobic layer on PBG, thus effectively improving its water-resistance performance. The number of surface active -OH radicals in PBG, the clustering effect of H-PDMS, and impurities in PBG can all result in different experimental and simulation outcomes. Meanwhile, the electrostatic force is an important factor influencing the adsorption of water droplets on the surface of PBG, and the reaction of H-PDMS with PBG normally occurs between Si-O and S-O. This study has systematically interpreted the working mechanism of water-resistant PBG, presenting an important significance in the utilization of PG resources.

A systematic review of upper extremity outcome measures assessed in randomized controlled trials of post stroke upper extremity rehabilitation over time

ABSTRACT Background The heterogeneity in outcome measures of post stroke rehabilitation trials suggests the need for consensus approach in stroke recovery measurement. To reach this aim, it is important to understand the past and current use of outcome measures in randomized control trials (RCTs) of stroke rehabilitation. Objective To systematically review RCTs of post stroke UE rehabilitation interventions to understand the use of UE outcome measures in research and their changes over time. Methods CINAHL, Embase, PubMed, Scopus and Web of Science were searched from 1960 to 1 April 2021. Studies were eligible for inclusion if they (1) were RCTs or crossovers published in English (2) ≥50% of participants were affected by stroke, 3) included adults ≥ 18 years old, and (4) applied an intervention to the hemiparetic UE as the primary objective of the study. Results 1,276 RCTs met inclusion criteria, and 112 different outcome measures were identified. Outcome measures were classified according to the International Classification of Functioning, Disability and Health (ICF) framework. Outcome measures most frequently assessed body function and structure (n = 1,692), followed by activities (n = 1,572) and participation (n = 162). The most used outcome measures were the Fugl-Meyer Assessment (n = 619), the modified Ashworth Scale (n = 255), Action Research Arm Test (n = 211), Wolf Motor Function Test (n = 184), and Box and Block Test (n = 178). Conclusions Understanding the breadth of outcome measures that have been used over time emphasizes the need for proposed standardization of outcome measures but also the need to adjust and expand consensus recommendations based on past and ongoing research trends.

LNG storage tanks 9% Ni steel weld inspection via phased-coherent TFM and SVD enhancement

ABSTRACT 9% Ni steel is commonly utilised in liquefied natural gas storage tanks due to its strong resistance to corrosion and oxidation. However, the welds in these tanks are prone to serious defects, necessitating thorough non-destructive testing. Unfortunately, when inspecting nickel-based alloy welds using phased array ultrasonic testing (PAUT) technology the ultrasonic waves are scattered and attenuated because of the coarse columnar grains. To address this challenge, this paper introduces a based on SVD enhancement directivity corrected circular coherence factor weighted TFM imaging algorithm (SVD-DC-CCF). Initially, the CCF matrix is corrected by the directivity and energy attenuation compensation factors, then weighted with the TFM pixel point amplitude. Subsequently, the weighted amplitude matrix undergoes singular value decomposition (SVD), followed by the establishment of an enhancement factor to reconstruct the amplitude matrix. The proposed algorithm is evaluated through experiments on three types of defects in a 30.0 mm thick 9% Ni steel T-shaped fillet weld test block. Results demonstrate superior signal-to-noise ratio (SNR) and enhanced image resolution. Compared to TFM results, the SNR increases by 4.97 dB, 4.25 dB, and 4.96 dB, respectively, while the array performance index (API) decreases by 9.80%, 34.39%, and 22.22%, respectively.

Comparative analysis of upper body kinematics in stroke, Parkinson's disease, and healthy subjects: An observational study using IMU-based targeted box and block test

BackgroundThe Box and Block Test (BBT) is an essential and widely used test in rehabilitation for the assessment of gross unilateral manual dexterity. Although it is a valid, simple, and ecological instrument, it does not provide a quantitative measure of the upper limb trajectories during the test. Research questionThe study introduces a new motion-capture-based method (using ecological Inertial Measurement Units - IMUs) to evaluate upper body kinematics while performing a targeted version of BBT (tBBT). MethodsThis observational study compares data from 35 healthy subjects, 35 subjects with Parkinson’s disease, and 35 post-stroke individuals to evaluate upper limb kinematics during tBBT quantitatively. Seven IMUs were placed on the trunk, head, and upper limb of each subject. The joint angles and kinematic scores were calculated and analyzed. Motor task execution time and kinematic scores were statistically correlated with clinical assessment measures. Kruskal-Wallis between groups test and Dunn-Bonferroni post-hoc were used. ResultsThe statistics revealed significant differences (p<0.05) among the three groups. The analyzed joint angles highlight various compensatory strategies in neurological subjects, such as using the trunk to complete a motor task instead of the shoulder and using the wrist instead of the elbow, along with differences in movement fluidity (DimensionLess-Jerk, p<0.05). A positive correlation was found between kinematics and the Fugl-Meyer Assessment-Upper Limb (r=0.7344; p<0.01), and a negative correlation between kinematics and the Unified Parkinson's Disease Rating Scale (r=-0.5286; p<0.01). SignificanceThe quantitative assessments of joint kinematics correlated to clinical assessments could guarantee a new method of assessment of the upper limb in subjects with motor deficits. This would allow to capture new insight into the characteristics of the subject’s disability, with implications for the choice of a personalized rehabilitation treatment focused on the motor recovery of the upper limb.

Feasibility of a home-based home videogaming intervention with a family-centered approach for children with cerebral palsy: a randomized multiple baseline single-case experimental design

BackgroundWorldwide, children with cerebral palsy (CP) living in underserved communities face barriers to accessing motor therapy services. This study assessed the implementation and effectiveness of an 8-week, upper limb (UL) home-based intervention with a movement-tracking videogame (Bootle Blast) in Costa Rican children with CP.MethodsChildren established a weekly playtime goal and two UL activities of daily living (ADLs) that they would like to improve on. A multiple-baseline, single-case experimental design, was used with the Performance Quality Rating Scale (PQRS) as the repeated measure to track changes in performance of the selected ADLs between the baseline (usual care) and intervention (Bootle Blast) phases. The Canadian Occupational Performance Measure (COPM), the Box and Blocks Test (BBT) and the Children’s Hand-Use Experience Questionnaire (CHEQ) were collected before and after the intervention. Technical barriers were documented during weekly video calls with a monitoring therapist. Treatment effect size, slope changes and percentage of non-overlapping data were identified for the PQRS. Descriptive statistics summarized results for the BBT, CHEQ, videogame logs (e.g., playtime) and technical barriers.ResultsFifteen children participated and 13 completed the intervention. Both participants who dropped out did so after completing baseline assessments, but before experiencing Bootle Blast. Children’s mean active playtime (i.e., mini-games targeting the UL) across the 8-weeks was 377 min, while mean total time spent engaging with Bootle Blast (active + passive play time [e.g., time navigating menus, reviewing rewards]) was 728 min. In total, eight technical issues (from five children) were reported, and all but three were resolved within 48 h. Partial effectiveness was associated with the intervention. Specifically, 85% of participants improved on the PQRS and 69% achieved clinically important improvements ≥ 2 points in performance on the COPM. Children improved by 1.8 blocks on average on the BBT, while on the CHEQ, five children had a clinically important increase of 10% of the total number of UL activities performed with both hands.ConclusionBootle Blast is a feasible and effective option to facilitate access and engage children with cerebral palsy in UL home rehabilitation.Trial registration Trial registration number: NCT05403567.

Unilateral vs. bilateral DLPFC rTMS: comparative effects on depression, visual-spatial memory, inhibitory control and cognitive flexibility in major depressive disorder.

Exciting left DLPFC activity with high frequency and inhibiting right DLPFC with low frequency repetitive transcranial magnetic stimulation (rTMS) has shown antidepressant effects in major depressive disorder (MDD) and executive functions. However, few studies have directly compared unilateral and bilateral protocols. Forty-seven individuals with treatment-resistant MDD underwent 10 sessions of rTMS over left DLPFC (20 Hz), bilateral DLPFC (left 20 Hz, right 1 Hz), or sham stimulation. Outcomes were depression (Beck Depression Inventory-II), visual-spatial memory (Corsi Block Test), response inhibition (Go/No-Go task), and cognitive flexibility (Wisconsin Card Sorting Test) assessed before and after treatment. Both unilateral and bilateral rTMS significantly reduced depression levels versus sham controls based on BDI-II scores. While bilateral stimulation did not improve Corsi Test performance, unilateral protocol enhanced visual-spatial memory. On the Go/No-Go task, accuracy was higher in both active stimulation groups compared to sham, with no response time differences. Neither unilateral nor bilateral rTMS had significant effects on cognitive flexibility per the WCST. Despite comparable antidepressant effects, unilateral stimulation had some cognitive advantages over bilateral rTMS, potentially due to greater left dorsolateral prefrontal cortex excitation. Further research on parameter optimization is warranted.

PROPIEDADES DINÁMICAS DE IMPACTO DE COMPUESTOS DE LODOS DE PAPEL DOPADOS CON OXICLORURO DE MAGNESIO

To address the heavy pollution caused by paper sludge, this study investigates a novel approach by incorporating paper sludge into magnesium oxychloride cement to develop a new type of concrete composite material. To achieve waste utilisation, cost savings and pollution reduction, the impact dynamics properties of the concrete specimens were conducted using an electromagnetically driven Hopkinson pressure bar, while a high-speed camera recorded the specimen destruction process, stress-strain curve, destruction morphology, deformation field, and evolution of energy consumption. Results show that as the paper sludge doping increases, the peak stress of the stress-strain curve and the energy consumption gradually increase. Increasing the voltage leads to a gradual rise in peak stress and energy consumption of the specimen. During the impact test, the transverse fissures gradually are developed in the test block, and as the impact stress increases, the fissures are widened until the specimen eventually being fractured. Moreover, the higher impact voltage and paper sludge content result in the increased specimen displacement and strain. It is expected that nearly 50% of paper sludge will be recycled every year by this method, which will save 10%-20% of raw materials. The conclusions obtained in this study provide a reference for the engineering application of the paper sludge concrete composites. Keywords: Paper sludge, Magnesium oxychloride, Digital image correlation, Energy consumption, Impact dynamic properties.

Phased Array Ultrasonic Inspection of Composite Fuselage Panel

Abstract The composite fuselage panel is a crucial component in large civil aircraft, necessitating higher detection rates and efficiency. Phased array ultrasonic testing can enhance the efficiency and defect detection rate; however, it is essential to consider the structural characteristics of the fuselage to ensure reliable identification of design defects. Based on the material properties, structural features, and defect detection requirements of composite fuselage panels, a test block reflecting their characteristics was designed and fabricated with various prefabricated defects. Ultrasonic phased array method was employed for a series of testing parameter optimization experiments and defect detectability analysis. The detected flaws were quantitatively analyzed and compared with those obtained using conventional ultrasonic automatic scanning techniques to validate the effectiveness of the developed ultrasonic phased array method. The feasibility of utilizing phased array ultrasonics for nondestructive evaluation of wide-body airliner composite fuselage panels is confirmed.

The Influence and Mechanism of Curing Methods and Curing Age on the Mechanical Properties of Yellow River Sand Engineered Cementitious Composites.

This study investigates the potential use of Yellow River sand (YRS) sourced from the lower reaches of the Yellow River in China as a sustainable and cost-effective substitute for quartz sand in Engineered Cementitious Composites (ECC). With an annual accumulation of approximately 400 million tons in this region, YRS presents a substantial resource. ECC specimens with 100% YRS replacement with quartz sand were subjected to various curing methods: natural, steam, standard, and sprinkler. Extensive mechanical testing including flexural, compressive, uniaxial tensile, and four-point flexural tests was conducted. Additionally, Scanning Electron Microscope (SEM) and Mercury Intrusion Porosimetry (MIP) analyses investigated microscopic mechanisms influencing macroscopic mechanical properties. Finally, the mechanical properties of the YRS-ECC test block after 14 days of standard curing and the traditional sand ECC test block were compared and analyzed. The results indicate that ECC specimens with 100% YRS substitution under natural curing show an optimal ultimate tensile strain of more than 4%, providing the best resistance to the reduction in ultimate flexural load and deflection due to aging. Steam curing enhances flexural and compressive strength, achieving an ultimate flexural load of 5 kN and a maximum deflection of 4.42 mm at 90 days. SEM analysis revealed lower C-S-H gel density under natural curing and higher under steam curing, enhancing fiber pull-out in steam-cured specimens. The MIP tests demonstrated that natural curing had the highest porosity (32.86%) and average pore size (51.69 nm), whereas steam curing resulted in the smallest average pore size, with 44% of pores under 50 nm. Compared with traditional sand, it is found that the ultimate bending load and deflection of YRS-ECC are 5.7% and 9.4% higher than those of traditional sand ECC, respectively, and its ultimate tensile strength and strain are also improved. These findings highlight YRS as a sustainable alternative to natural sand in ECC, with natural curing proving the most effective for superior mechanical performance, including tensile strain, crack resistance, and durability.

Modeling fluid flow in heterogeneous porous media with physics-informed neural networks: Weighting strategies for the mixed pressure head-velocity formulation

Physics-informed neural networks (PINNs) are receiving increased attention in modeling flow in porous media because they can surpass purely data-driven approaches. However, in heterogeneous domains, PINNs often face convergence challenges due to discontinuities in rock properties. A promising alternative is the mixed formulation of PINNs, which utilizes pressure head and velocity fields as primary variables. This formulation introduces a multi-term loss function whose terms must be carefully balanced to ensure effective convergence during training. The main goal of this work is to identify the most suitable weighting technique to overcome convergence issues and enhance the applicability of the mixed formulation of PINNs for modeling flow in heterogeneous porous media. Thus, we implement and adapt different global and local weighting techniques and evaluate their performance through multiple test scenarios, involving stochastic and block heterogeneity. The results reveal that the most appropriate weighting strategy is the max-average technique. In the case of stochastic heterogeneity, this technique allows for improving the convergence of the training algorithm. In the case of discontinuous heterogeneity, the max-average method is the only strategy that achieved convergence, highlighting its robustness. The results also show that under high heterogeneity, using an appropriate weighting technique becomes imperative because baseline PINN failed to converge. Implementing an optimal weighting strategy can improve convergence and yield accurate solutions with fewer learnable parameters, thereby enhancing overall model performance.

Realizing computer vision rehabilitation assessment tests & evaluation applications for mobile devices

Upper extremity impairments are a common consequence of stroke, necessitating thorough rehabilitation monitoring and kinematic assessments to facilitate motor recovery. The Box and Block Test (BBT) and Sollerman Hand Function Test (SHFT) are two widely utilized and recommended tools for objectively measuring upper limb dexterity and evaluating fine motor skill rehabilitation in patients. However, these tests rely on specific equipment and therapist attendance, making the process time-consuming and clinic-dependent. This paper introduces a computer vision-based hand rehabilitation assessment suite specifically designed for mobile devices, such as smartphones and tablets, which serves as a virtual alternative to traditional methods while also incorporating an interactive exergame. Our application faithfully integrates the original tests’ guidelines and procedures into an engaging computer vision experience, utilizing advanced technologies like MediaPipe Hands for precise hand and finger tracking. This innovative solution obviates the need for additional computer peripherals such as smart gloves or VR headsets, as well as physical equipment like wooden boxes and blocks, relying solely on the built-in camera of everyday mobile devices. In addition, we address several technical challenges encountered in our approach and outline future directions for score normalization and feature expansion, ensuring the continued improvement and efficacy of our hand rehabilitation assessment suite.

Brain-Hand Function Relationships Based on Level of Grasp Function in Chronic Left-Hemisphere Stroke

Background and Objective The biomarkers of hand function may differ based on level of motor impairment after stroke. The objective of this study was to determine the relationship between resting state functional connectivity (RsFC) and unimanual contralesional hand function after stroke and whether brain-behavior relationships differ based on level of grasp function. Methods Sixty-two individuals with chronic, left-hemisphere stroke were separated into three functional levels based on Box and Blocks Test performance with the contralesional hand: Low (moved 0 blocks), Moderate (moved >0% but <90% of blocks relative to the ipsilesional hand), and High (moved ≥90% of blocks relative to the ipsilesional hand). Results RsFC in the ipsilesional and interhemispheric motor networks was reduced in the Low group compared to the Moderate and High groups. While interhemispheric RsFC correlated with hand function (grip strength and Stroke Impact Scale Hand) across the sample, contralesional RsFC correlated with hand function in the Low group and no measures of connectivity correlated with hand function in the Moderate and High groups. Linear regression modeling found that contralesional RsFC significantly predicted hand function in the Low group, while no measure correlated with hand function in the High group. Corticospinal tract integrity was the only predictor of hand function for the Moderate group and in an analysis across the entire sample. Conclusions Differences in brain-hand function relationships based on level of motor impairment may have implications for predictive models of treatment response and the development of intervention protocols aimed at improving hand function after stroke.

Psychometric properties of the modified reaching performance scale in persons with multiple sclerosis

BackgroundA valid and reliable assessment tool to describe the quality of the movement pattern of reaching can provide valuable insights into motor performance deficits in persons with MS (pwMS). The Reaching Performance Scale, developed for stroke, is a promising scale to assess movement patterns in pwMS. However, psychometric properties of the scale are lacking in pwMS. ObjectivesFirstly, to investigate the content validity of the modified Reaching Performance Scale for application in patients with MS (mRPS). Secondly, to investigate the psychometric properties (within- and between-session reliability and concurrent validity) of the mRPS for pwMS. MethodsForty-five pwMS (mean EDSS 6.6 pt, IQR 6–7.5) executed the mRPS that rates the quality of movement patterns and compensations during reach to grasp tasks. The content validity was determined by an expert panel based on observations of subjects performing the RPS. The reliability was based on five repetitions within one day, and between two days. For the concurrent validity, outcome measures at two levels of the International Classification of Functioning were correlated with the mRPS: Body Structure and Function level: Fugl-Meyer Assessment of the Upper Limb (FMA-UL), maximal isometric hand grip strength (HGS; Activity level: Action Research Arm Test (ARAT), Box and Blocks Test (BBT), Nine Hole Peg Test (NHPT) and Trunk Impairment Scale 2.0 (TIS 2.0) as well as perceived performance by the Manual Ability Measure-36 (MAM-36). ResultsScale modifications were made only on the ratings of the trunk displacement subscale. The mRPS had excellent agreement scores for within-session reliability (range of Kappa between 0.85 and 0.98) and moderate-to-excellent agreement scores for between-session reliability (K: 0.66–1.00). Regarding validity, the mRPS was highly correlated with the ARAT (rho=0.74, p < 0.001), followed by moderate correlations with trunk performance (TIS 2.0, rho= 0.61, p < 0.001), hand function (BBT: rho=0.64, p < 0.001; NHPT: rho=-0.61, p < 0.001) and perceived performance (MAM36 rho= 0.53, p < 0.001). ConclusionThe mRPS is a reliable measurement tool to describe the movement pattern quality and motor compensations used during reaching in pwMS. Concerning concurrent validity, the mRPS is partially related to other measures of upper limb and trunk performance.

Is a Plantarflexed First Ray the Primary Deformity In Children With Cavovarus Feet Secondary to Charcot-Marie-Tooth Disease? A Pedobarographic Analysis.

Charcot-Marie-Tooth disease (CMT) is a common cause of cavovarus foot deformity in children. This deformity is often quoted as being forefoot driven, with a primary deformity of first ray plantarflexion driving the hindfoot into varus by virtue of the tripod effect of the foot, which was hypothesized by Coleman and is commonly assessed clinically using his eponymous block test. The primary goal of this study was to objectively investigate this hypothesis using dynamic pedobarography. A review of the gait lab archives at a large tertiary referral center was carried out to identify children with CMT who had foot photos and dynamic pedobarographic data. Two orthopaedic surgeons then determined the weight-bearing hindfoot alignment of these children using clinical photography. The order of contact during gait of the first metatarsal relative to the fifth metatarsal was then obtained from the dynamic pedobarographic data. One hundred eighteen feet from 60 children with CMT met the study inclusion criteria. Sixty-eight varus feet were compared with 50 nonvarus feet. First ray contact occurred before fifth ray contact in only 39.7% of the varus feet compared with 34.0% of the nonvarus feet, which did not meet statistical significance (P=0.526). In this cohort, dynamic pedobarography did not consistently demonstrate the first metatarsal contact occurring before the fifth metatarsal contact in children with varus feet secondary to CMT. While nearly 40% of the feet did make initial contact on the first ray, 60% of the feet landed in varus before the first ray made contact, leading us to believe that the foot is prepositioned in varus. This may be in part due to the progressive muscle imbalance and secondary deformity that has occurred. Surgical management of these children should take this.

Sparse TFM imaging of different-scale phased array based on the DWSO algorithm

ABSTRACT Using sparse matrix for total focusing method (TFM) imaging can improve computational efficiency in non-destructive testing (NDT). In sparse matrix design, binary particle swarm optimisation (BPSO) and genetic algorithm (GA) often fall into local optimal solution, and the computational efficiency decreases significantly with the expansion of array scale. In this paper, a discrete war strategy optimisation (DWSO) is proposed to realise sparse array ultrasonic imaging. This method uses equidistant scatter mapping to real-number encode the array position and limit the search range. Then, the fitness function is constructed with low side lobe peak and narrow main lobe width to obtain the optimal array element distribution. Experiments on standard test block demonstrate the DWSO algorithm has a narrower main lobe width and lower side lobe peaks than BPSO and GA. The imaging time of the sparse array constructed by this algorithm is reduced by more than 65% compared with the full array. As array scale grows, the running time variation of the proposed method is reduced by 73.2% and 77.3% compared with GA and BPSO, which has good adaptability and provides theoretical support for real-time defect detection.

Differential Trial-Type Effects in an Implicit Relational Assessment Procedure: Extending the DAARRE Model

The differential arbitrarily applicable relational responding effects (DAARRE) model explains two effects commonly observed with the implicit relational assessment procedure (IRAP): the single trial-type dominance effect (STTDE) and the dissonant-target trial-type effect (DTTTE). We sought to explore variables that modulate these effects. Forty-two participants who completed an IRAP met the practice criteria (median latency ≤ 2,000 ms and accuracy ≥ 80% correct) and thus proceeded to six test blocks of trials. The IRAP had four trial-types: trial-type 1: happy-face—happy-word; trial-type 2: happy-face—fear-word; trial-type 3: fear-face—happy-word; trial-type 4: fear-face—fear-word. Participants were randomly assigned to start with a consistent (respond True, False, False, True, respectively, to the four trial-types) or inconsistent (opposite responding) block. Difference (DIRAP) scores were calculated (inconsistent minus consistent latencies). A significantly larger DIRAP score was observed in trial-type 2 relative to trial-type 3 (a DTTTE), but only for participants who started with the inconsistent block. A “happiness superiority” STTDE (i.e., larger DIRAP score on trial-type 1 relative to trial-type 4) was observed, but only for participants who failed to maintain the criteria at the trial-type level (in any of the trial-types). Overall, the findings highlight the importance of distinguishing between the functional versus relational properties of the stimuli presented within an IRAP. The modulation of the DTTTE is interpreted in terms of functional coherence between the target and response option in inconsistent blocks. A novel data-analytic algorithm is presented to identify performance criteria violations at the trial-type level. The findings suggest that a greater focus is required in relational frame theory on the impact of the functional properties of stimuli on relational framing.

Effectiveness of mixed reality-based rehabilitation on hands and fingers by individual finger-movement tracking in patients with stroke

BackgroundMixed reality (MR) is helpful in hand training for patients with stroke, allowing them to fully submerge in a virtual space while interacting with real objects. The recognition of individual finger movements is required for MR rehabilitation. This study aimed to assess the effectiveness of updated MR-board 2, adding finger training for patients with stroke.MethodsTwenty-one participants with hemiplegic stroke (10 with left hemiplegia and 11 with right hemiplegia; nine female patients; 56.7 ± 14.2 years of age; and onset of stroke 32.7 ± 34.8 months) participated in this study. MR-board 2 comprised a board plate, a depth camera, plastic-shaped objects, a monitor, a palm-worn camera, and seven gamified training programs. All participants performed 20 self-training sessions involving 30-min training using MR-board 2. The outcome measurements for upper extremity function were the Fugl–Meyer assessment (FMA) upper extremity score, repeated number of finger flexion and extension (Repeat-FE), the thumb opposition test (TOT), Box and Block Test score (BBT), Wolf Motor Function Test score (WMFT), and Stroke Impact Scale (SIS). One-way repeated measures analysis of variance and the post hoc test were applied for the measurements. MR-board 2 recorded the fingers’ active range of motion (AROM) and Dunnett’s test was used for pairwise comparisons.ResultsExcept for the FMA-proximal score (p = 0.617) and TOT (p = 0.005), other FMA scores, BBT score, Repeat-FE, WMFT score, and SIS stroke recovery improved significantly (p < 0.001) during MR-board 2 training and were maintained until follow-up. All AROM values of the finger joints changed significantly during training (p < 0.001).ConclusionsMR-board 2 self-training, which includes natural interactions between humans and computers using a tangible user interface and real-time tracking of the fingers, improved upper limb function across impairment, activity, and participation. MR-board 2 could be used as a self-training tool for patients with stroke, improving their quality of life.Trial registration number: This study was registered with the Clinical Research Information Service (CRIS: KCT0004167).

Absence of BOLD adaptation in chronic fatigue syndrome revealed by task functional MRI.

Neurological symptoms are central to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), yet its underlying neurophysiological mechanisms remain elusive. We examined a neglected aspect of task-based functional MRI, focusing on how blood oxygenation level-dependent (BOLD) signals alter during cognitive tasks in ME/CFS. This prospective observational study utilised MRI scans on ME/CFS participants and healthy controls (HCs) with sedentary lifestyles (ACTRN12622001095752). Participants completed two blocks of a Symbol Digit Modalities Test, with 30 trials per block split into two sets. The fMRI signal changes between blocks and sets were compared within and between groups. Thirty-four ME/CFS participants (38 years ± 10; 27 women) and 34 HCs (38 ± 10; 27 women), were evaluated. In the second task block, ME/CFS participants exhibited increased activation in the right postcentral gyrus, contrasting with decreased activation in multiple regions in HCs. These results were further confirmed by significantly higher bilateral dynamic changes (2nd vs 1st set) in the motor, sensory and cognitive cortex in ME/CFS compared to HCs and significant correlations between those changes in the left primary motor cortex with fatigue severities. BOLD adaptation, potentially improving energy economy, was absent in ME/CFS, which may provide an underlying neurophysiological process in ME/CFS.

Effects of multisensory stimulation on infants' learning of object pattern and trajectory.

This study investigated whether infants encode better the features of a briefly occluded object if its movements are specified simultaneously by vision and audition than if they are not (data collected: 2017-2019). Experiment 1 showed that 10-month-old infants (N = 39, 22 females, White-English) notice changes in the visual pattern on the object irrespective of the stimulation received (spatiotemporally congruent audio-visual stimulation, incongruent stimulation, or visual-only; = .53). Experiment 2 (N = 72, 36 female) found similar results in 6-month-olds (Test Block 1, = .13), but not 4-month-olds. Experiment 3 replicated this finding with another group of 6-month-olds (N = 42, 21 females) and showed that congruent stimulation enables infants to detect changes in object trajectory (d = 0.56) in addition to object pattern (d = 1.15), whereas incongruent stimulation hinders performance.