Powder Blends Research Articles

High-Pressure Torsion: A Path to Refractory High-Entropy Alloys from Elemental Powders

For the first time, the refractory high-entropy alloys with equiatomic compositions, HfNbTaTiZr and HfNbTiZr, were synthesized directly from a blend of elemental powders through ten revolutions of high-pressure torsion (HPT) at room temperature. This method has demonstrated its effectiveness and simplicity not only in producing solid bulk materials but also in manufacturing refractory high-entropy alloys (RHEAs). Unlike the melting route, which typically results in predominantly single BCC phase alloys, both systems formed new three-phase alloys. These phases were defined as the Zr-based hcp1 phase, the α-Ti-based hcp2 phase, and the Nb-based bcc phase. The volume fraction of the phases was dependent on the accumulated plastic strain. The thermal stability of the phases was studied by annealing samples at 500 °C for one hour, which resulted in the formation of a mixed structure consisting of the new two hexagonal and cubic phases.

Development of Functional Dairy Spread

Aims: The study aimed to develop functional dairy spread that is spreadable at refrigeration temperature and low in fat content. Study Design: Development of functional dairy spread and its analysis. Place and Duration of Study: Department of Dairy Technology, Dairy Science College, Hebbal, Bengaluru, Karnataka Veterinary, Animal and Fisheries Sciences University, Bidar, Karnataka, India. Between June 2023 and April 2024. Methodology: Ingredients for the functional dairy spread were optimized through sensory analysis by a panel using a 9-point hedonic scale. The optimized spread was then analysed for its techno-functional attributes and microbiological quality. Results: The optimized dairy spread contained skim milk powder (14%), whey protein concentrate (4%), and salt (1%), with cream, flaxseed oil, sunflower oil, carboxymethyl cellulose, and glycerol monostearate as constant ingredients. The spice blend of ginger, garlic, coriander, and white pepper powder was optimized at 2%. The optimized functional dairy spread had 30.20% fat, 7.46% protein, and 53.2% moisture, with total solids at 47.6% and ash at 2.57%. Acidity was 0.42% LA, viscosity was 123 cP, and the hardness index was 0.47 mm. Water activity was 0.932, spreadability was 1.6 cm/hr, and colour measured at L* 87.32, a* -1.65, b* 16.05. Coliforms, yeast and molds, staphylococci, and lipolytic counts were all nil. Conclusion: The developed product exhibited excellent spreadability at refrigeration temperature and had a low fat content while being functional spread.

Advanced Hierarchical Biomorphous Silicon Carbide Monoliths

Porous silicon carbide (SiC) has attracted considerable attention in the field of cellular ceramics for a variety of applications such as catalyst supports, filters, or in the biomedical field due to its excellent structural properties, mechanical strength, and chemical stability. However, SiC has certain limitations due to high‐temperature profiles and costly manufacturing methods. Therefore, it is investigated that porous biomorphic silicon carbide monoliths using a powder blend of paper‐derived carbon fibers, phenolic resin, and silicon, resulting in comparatively low sintering temperatures (T = 1300 to 1550 °C) and good mechanical strength. This near‐net‐shape process uses low‐cost raw materials and enables the production of silicon carbides with high open porosity (P = 51.48% to 68.28%) and low shrinkage. The influence of different amounts of carbon sources (Cfibers and Cresin) on the mechanical (4‐point bending) and thermal properties (laser flash method) is investigated. In addition, to improve the pressure gradients, macrochannels with multiple layers of sacrificial polymer lattices are incorporated, resulting in hierarchical structures with high permeability. Thus, this advanced biomimetic approach offers great potential for structured cellular ceramics with tailored properties for biomedical, catalyst support, or nuclear fuel cladding materials.

Improvement of a pharmaceutical powder mixing process in a tote blender via DEM simulations

An industrial-scale pharmaceutical powder blending process was studied via discrete element method (DEM) simulations. A DEM model of two active pharmaceutical ingredient (API) components and a combined excipient component was calibrated by matching the simulated response in a dynamic angle of repose tester to the experimentally observed response. A simulation of the 25-minute bin blending process predicted inhomogeneous API distributions along the rotation axis of the blending container. These concentration differences were confirmed experimentally in a production-scale mixing trial using high-performance liquid chromatography analysis of samples from various locations in the bin. Several strategies to improve the blend homogeneity were then studied using DEM simulations. Reversing the direction of rotation of the blender every minute was found to negligibly improve the blending performance. Introducing a baffle into the lid at a 45° angle to the rotation axis sped up the axial mixing and resulted in a better final blend uniformity. Alternatively, rotating the blending container 90° around the vertical axis five minutes prior to the process end was predicted to reduce axial segregation tendencies.

FORMULATION AND STABILITY EVALUATION OF ANTI-OBESITY NUTRACEUITCAL BLEND OF WHITE KIDNEY BEAN EXTRACT (PHASEOLUS VULGARIS L.), PROPOLIS ETHANOLIC EXTRACT AND CRPIC3

Objective: This study aimed to formulate and evaluate the stability profile of an anti-obesity nutraceutical combination in different dosage forms. Methods: Active and inactive ingredients were formulated into pharmaceutical dosage forms. The quality parameters of the dosage forms were determined, followed by accelerated stability testing (40±2 °C and 75±5% Relative Humidity (RH)) for 180 d was completed to evaluate their physical, chemical and microbiological attributes throughout the storage period. Results: Pre-formulation parameters of the powder blend of active and inactive ingredients for each dosage form showed a satisfactory flowability with Hausner's ratio falling between 1.16 and 1.18, average angle of repose between 22.29° and 22.90° and acceptable compressibility with Carr’s index below 25%. Tablets assessments were acceptable with a mean friability value of 0.21±0.03%, hardness of 4.12±0.09 kg/cm2. The average disintegration time of 5 min 10 sec for tablets and 4 min and 30 sec for capsules. The accelerated stability study revealed that tablet dosage forms are stable for longer period that can reach up to 180 d (24 mo real-time), while sachets and capsules are stable for a period of 135 d (18 mo real-time). Conclusion: The anti-obesity blend of White Kidney Bean Extract (WKBE), Propolis Ethanolic Extract (PEE) and CrPic3 can be successfully formulated in acceptable and convenient dosage forms that can be stable for 18-24 mo.

In Situ Generation of TiCN Ni‐Based Coatings by Laser Cladding and Study of Their Structure and Properties

The influence of the ratio of TiN powder, graphite powder, and Ni60 powder on the phase composition, microstructure, microhardness, and wear properties of the TiCN Ni‐based coating on H13 steel is investigated. The findings indicate that varying proportions of TiN powder, C powder, and Ni60 powder have a minimal impact on the coating's phase composition. The diffraction peak intensity of TiC0.3N0.7 increases with the addition of (C + TiN) in the blended powder, while the crystallinity of TiC0.3N0.7 in the Ni‐based coating with a 30% (C + TiN) mass fraction decreases. The grain structure of the 20% Ni‐based coating is fine and uniform, while the microstructure of the 30% Ni‐based coating is characterized by a large polymerization phase‐containing Ti elements, with the TiCN‐reinforced phase exhibiting irregular grain morphology. The microhardness HV0.5 of the coating with a 20% (C + TiN) mass fraction ranges from 725 to 772, with an average hardness of 747.8 HV0.5, which is 3.4 times the hardness of the substrate material and 1.3 times the hardness of the Ni‐based coating. As the mass fraction of (C + TiN) in the hybrid powder increases, the friction loss mass of the coating tends to decrease and then increase. The average wear of the Ni‐based coating with a 20% (C + TiN) mass fraction is ≈22.4% of that of the substrate and 50% of that of the Ni‐based coating, demonstrating excellent wear resistance. The wear mechanism is primarily characterized by brittle spalling and abrasive wear.

Mechanical properties of hafnium tantalum carbides via field assisted sintering technology for hypersonic vehicles

Ultra-high temperature ceramics (UHTCs) are refractory transition-metal carbides, nitrides, and borides with the highest melting temperatures known materials, making them prime candidates for applications in aerospace and hypersonic vehicles. Of the UHTCs, tantalum carbide (TaC) and hafnium carbide (HfC) feature the highest melting temperatures. We investigated the binderless consolidation of HfC/TaC powder blends using Field Assisted Sintering Technology (FAST). Powders consisting of 90/10, 50/50, and 10/90 vol% HfC:TaC were sintered to high densities (>94 %). Bulk and nanomechanical, chemical, and microstructural characterization revealed substantially greater strength, hardness, and stiffness for ternary alloys. Mechanical properties correlated with physiochemical analysis indicated trace oxygen phases, solid-solution strengthening, and nonstoichiometric carbon were the key mechanisms driving the peak property enhancement of the 50 vol% solid-solution sample, despite lower densities. This study provides insight into optimizing the compositional design of HfC-TaC alloys by balancing influences from solid solution strengthening and the thermodynamic effects of oxygen/carbon stoichiometry.

Effect of powder and process parameters on in-situ alloying of nitinol during laser powder bed fusion

Powder characteristics such as flow energy, bulk density, compressibility, morphology, particle size distribution (PSD) and laser energy absorbtivity have a significant impact on the Laser Bed Powder Fusion (L-PBF) process. The impact of powder characteristics on in-situ nickel-titanium alloy formation within the L-PBF process is not well understood. In this work, the characteristics of nickel, titanium and two elemental blends of nickel-titanium powder were compared with those of a pre-alloyed nitinol powder. L-PBF solidification tracks were generated using selected powders and characterised for resulting track dimensions and chemical homogeneity. This study demonstrates that the melt homogenisation time and the size of titanium particles relative to nickel particles are critical factors for successful in-situ alloying of nitinol within the L-PBF process. The variation in elemental composition within solidification track cross sections, as measured by EDX point spectra, was found to increase significantly for laser scanning speeds of 400 mm/s and above. Furthermore, the elemental composition inhomogeneity with increasing laser scan speed was found to be significantly more pronounced for a nickel-titanium powder blend of spherical particles with average titanium particle size of 48 μm compared to an otherwise similar blend with an average titanium particle size of 32 μm. There was no significant difference recorded between solidification track widths of in-situ alloyed blends compared to pre-alloyed blends, indicating that optimal hatch spacing for in-situ alloying is likely to be similar to that required for pre-alloyed powders.

The Impact of Goode Health LLC Superfood Chocolate Blend Beverage on Peripheral Macro and Microvascular Function

Cardiovascular disease (CVD) is the leading cause of death in the US and world-wide. The are many risk factors associated with elevated risk for and prevalence of CVD; however, it is well documented that reduced macro and microvascular function/health is a major contributing factor. The mechanisms are multifactorial however, reduced vasodilatory reactivity, secondary to elevated oxidative stress and/or inflammation contribute to elevated disease risk. Diets and/or interventions high in antioxidants, polyphenols, and/or anti-inflammatory properties reduce CVD and metabolic disease risk. Furthermore, this is mediated in part through improvements in vascular function. This study tested the hypothesis that 2-weeks of increased daily consumption of a beverage high in antioxidants, polyphenols, and anti-inflammatory properties would improve well-validated indices of peripheral macro and microvascular function in a cohort of Hispanic individuals. METHODS: Six Hispanic individuals (4 males; age: 42±14 yr.; BMI 32±7 kg/m2) participated. All measures were assessed before (pre) and following (post) 14-days of increased daily consumption of the Goode Health LLC Superfood Moroccan Chocolate Blend. During the intervention participants added the chocolate blend powder mix (~28 g) to 8 oz water twice daily. This beverage is high in healthy ingredients including plant-based proteins, prebiotic fiber, antioxidant polyphenols, and anti-inflammatory properties. Peripheral macro and microvascular function/health were assessed pre- and post-intervention as vasodilation in the brachial artery (flow mediated vasodilation; %FMD) and reactive hyperemia (peak mean forearm blood velocity (FBVmean)) in the forearm vasculature respectively following 5-min of forearm ischemia induced by suprasystolic cuff occlusion. RESULTS: Peripheral macrovascular function assessed as %FMD tended to be augmented following Goode Health LLC beverage consumption (Pre: 4.2±2.2 % vs. Post: 5.8±1.6 %, P=0.08). Whereas peripheral microvascular function assessed as peak FBVmean was augmented following the intervention (Pre: 70±17 cm·s−1 vs. Post: 78±20 cm·s−1, P=0.04) CONCLUSION: These preliminary data indicate a positive effect of Goode Health LLC Superfood Moroccan Chocolate Blend consumption on indices of peripheral macro and microvascular function/health. Future studies will continue to expand upon these findings in a larger cohort. Goode Health LLC. This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

High entropy (HfTiZrVNb)B2 ceramic particulate reinforced Al matrix composites: Synthesis, mechanical, microstructural and thermal characterization

This study aims to introduce a novel type of particulate reinforced Al matrix composite. High entropy (HfTiZrVNb)B2 ceramic particulate reinforced Al matrix composites were produced via a combined process of different powder metallurgy methods. Firstly, boride compounds (HfB2, TiB2, ZrB2, VB2, NbB2) were synthesized in the laboratory scale using the related metal oxide, boron oxide, and magnesium by mechanochemical synthesis (MCS) and leaching processes under optimum conditions. Secondly, the synthesized and purified boride powders were mixed in equimolar ratios using a planetary ball mill for 72 h, and they were sintered at 2000 °C under 30 MPa via spark plasma sintering (SPS). Thirdly, equimolar high entropy (HfTiZrVNb)B2 bulks were crushed, converted into powder forms, and added into Al powders at different amounts as 1, 2, 5, 10, and 15 wt %. Lastly, these powder blends were mechanically alloyed in a vibratory ball mill for 6 h, cold pressed and pressureless sintered at 630 °C for 2 h. For characterization techniques, X-ray diffractometry (XRD), thermal analysis, scanning electron microscopy/energy dispersive spectrometry (SEM/EDS), density measurements using pycnometer and Archimedes' methods, microhardness and dry sliding wear tests were conducted on the sintered composites. The highest hardness (∼1.5 GPa) and the lowest wear rate (∼0.0012 mm3/Nm) were obtained in the Al-15 wt % (HfTiZrVNb)B2 sample.

Unveiling the impact of heat treatment on powder-metallurgy α+β titanium alloy for achieving a superior strength-ductility combination

The present study investigated the effects of heat treatment (solid solution and aging treatments) on the microstructure and mechanical properties of a hot-rolled α+β Ti–3Al–5Mo–4.5V (TC16) produced through blended elemental powder metallurgy (BEPM) process using master alloy hydrogenation (MAH) approach. After solid solution treatment, metastable martensite α'' phase and athermal ω phase were formed. Aging treatment facilitated decomposition of metastable phases and precipitation of αs particles. Dispersion strengthening, resulting from the formation of a significant amount of α/β interfaces between fine secondary αs particles and β matrix, played a decisive role in enhancing the strength of the TC16 alloy. However, elevated aging temperatures promoted the coarsening of αs particles, leading to a reduction in the strengthening effect. A systematic investigation of the effects of the solid solution and aging treatments enabled the evolution of a bimodal microstructure with the precipitation of fine αs particles, contributing to an outstanding combination of strength and ductility. The ultimate tensile strength reached 1424.6 MPa with an elongation at break of 7.7%, while the hardness reached 380.2HV.

Exploration of an atomic‐scale boron additive in SiAlON ceramics

AbstractSiAlON ceramics are of interest for high‐risk applications such as biomedical implants and combustion engine turbines. This work is part of a larger study aimed at leveraging atomic‐ or molecular‐scale additives to control the densification, microstructures, and ultimate structural properties of SiAlONs. Here, we investigate the effects of boron in silicon nitride‐based ceramics. The present work demonstrates a possible chemical method for controlling the microstructural development of SiAlONs by incorporating boric acid (H3BO3) into the starting powder blend. Raman spectroscopy and 11B solid‐state magic angle spinning nuclear magnetic resonance cooperatively indicate that after sintering, boron exists in threefold coordination with nitrogen in the turbostratic boron nitride (t‐BN) structure. The results of this work indicate that the incorporation of boron and generation of t‐BN bonding in the SiAlON system result in a narrower grain size distribution, a suppression of second phases such as yttrium aluminosilicates, and ultimately, increased flexure strength. A separate fractographic study showed that SiAlONs fabricated with 3 wt% boric acid exhibited fracture origins such as subtle surface flaws or cracks, while lower dopant levels and undoped SiAlONs typically failed from flaws such as inclusions or large grains. It is argued that the modification of the intergranular glass chemistry and resulting generation of t‐BN reduces atomic diffusion through the grain boundary phase and inhibits the crystallization of second phases as well as exaggerated grain growth that often characterizes the development of β′‐SiAlON.

Powder bed fusion–laser beam (PBF-LB) three-dimensional (3D) printing: Influence of laser hatching distance on the properties of zolpidem tartrate tablets

Laser sintering, known as powder bed fusion–laser beam (PBF-LB), offers promising potential for the fabrication of patient-specific drugs. The aim of this study was to provide an insight into the PBF-LB process with regard to the process parameters, in particular the laser hatching distance, and its influence on the properties of zolpidem tartrate (ZT) tablets. PHARMACOAT® 603 was used as the polymer, while Candurin® Gold Sheen and AEROSIL® 200 were added to facilitate 3D printing. The particle size distribution of the powder blend showed that the layer height should be set to 100 µm, while the laser hatching distance was varied in five different steps (50, 100, 150, 200 and 250 µm), keeping the temperature and laser scanning speed constant. Increasing the laser hatching distance and decreasing the laser energy input led to a decrease in the colour intensity, mass, density and hardness of the ZT tablets, while the disintegration and dissolution rate were faster due to the more fragile bonds between the particles. The laser hatching distance also influenced the ZT dosage, indicating the importance of this process parameter in the production of presonalized drugs. The absence of drug-polymer interactions and the amorphization of the ZT were confirmed.

Ballistic performance of titanium-based layered composites made using blended elemental powder metallurgy and hot isostatic pressing

Metal matrix composites tiles based on Ti–6Al–4V (Ti64) alloy, reinforced with 10, 20, and 40 (vol%) of either TiC or TiB particles were made using press-and-sinter blended elemental powder metallurgy (BEPM) and then bonded together into 3-layer laminated plates using hot isostatic pressing (HIP). The laminates were ballistically tested and demonstrated superior performance. The microstructure and properties of the laminates were analyzed to determine the effect of the BEPM and HIP processing on the ballistic properties of the layered plates. The effect of porosity in sintered composites on further diffusion bonding of the plates during HIP is analyzed to understand the bonding features at the interfaces between different adjacent layers in the laminate. Exceptional ballistic performance of fabricated structures was explained by a significant reduction in the residual porosity of the BEPM products by their additional processing using HIP, which provides an unprecedented increase in the hardness of the layered composites. It is argued that the combination of the used two technologies, BEPM and HIP is principally complimentary for the materials in question with the abilities to solve the essential problems of each used individually.

Manufacturing process transfer to a 30 kg/h continuous direct compression line with real-time composition monitoring

Transferring an existing marketed pharmaceutical product from batch to continuous manufacturing (CM) without changes in regulatory registration is a challenging task in the pharmaceutical industry. Continuous manufacturing can provide an increased production rate and better equipment utilisation while retaining key quality attributes of the final product. Continuous manufacturing necessitates the monitoring of critical quality attributes in real time by appropriate process analytical tools such as near infra-red (NIR) probes. The present work reports a successful transfer of an existing drug product from batch to continuous manufacturing process without changing the formulation. A key step was continuous powder blending, whose design and operating parameters including weir type, agitation rate, dynamic hold-up and residence time were systematically investigated with respect to process repeatability. A NIR-based multivariate data model for in-line composition monitoring has been developed and validated against an existing quality control method for measuring tablet content uniformity. A continuous manufacturing long-run with a throughput of 30 kg/h (approx. 128,000 tablets per hour), uninterrupted for 320 min, has been performed to test and validate the multivariate data model as well as the batch to continuous process transfer. The final disintegration and dissolution properties of tablets manufactured by the continuous process were found to be equivalent to those manufactured by the original batch process.

A correction method for mitigating absorbance discrepancies between near-infrared spectrometers through the incorporation of blended carbon-titanium dioxide powder

In near-infrared spectroscopy analysis, ensuring the accurate transfer of models between different instruments relies on maintaining the accuracy of instrument wavelengths and absorbance. To mitigate absorbance drift at different wavelength points, this paper proposes a near-infrared spectroscopy point-by-point quadratic polynomial correction method based on carbon-titanium dioxide powder samples. The method establishes a quadratic polynomial relationship model for the absorbance of each wavelength point between the main instrument and slave instruments. The study utilized two S450 grating-based diffuse reflection near-infrared spectroscopy instruments, with one serving as the main instrument and the other as the slave instrument. The point-by-point quadratic polynomial was employed to correct wheat spectra collected by the slave instruments, and a crude protein content prediction model for wheat was established, comparing it with linear regression correction. After correction, the average Euclidean distance of wheat spectra decreased by 66.71%, from 0.0937 to 0.0321, and the average peak-valley Euclidean distance decreased by 72.28%, from 0.0203 to 0.0056. The standard deviation of the predicted results decreased by 90.69%, from 1.4372 to 0.1338. The correction effect of the method combined with traditional preprocessing methods was superior to using preprocessing methods alone. Overall, the near-infrared spectroscopy point-by-point quadratic polynomial correction method based on carbon-titanium dioxide powder samples significantly reduces spectral differences between different instruments, enhances spectral consistency, and diminishes prediction errors, achieving improved model sharing between instruments.

Refractory High‐Entropy Alloys Produced from Elemental Powders by Severe Plastic Deformation

A comparative investigation of two fundamentally different approaches for the synthesis, microstructure evolution, and mechanical properties of the refractory high‐entropy alloys (RHEA) HfNbTaTiZr and HfNbTiZr is performed. The two methods comprises conventional arc (button) melting and a powder route based on mechanical alloying and consolidation via severe plastic deformation. In particular, blended elemental powder is pre‐compacted and subjected to one or four passes of equal channel angular pressing (ECAP) at 500 °C and then 10 revolutions of high pressure torsion (HPT) at room temperature to an effective strain between 4 and 40. Some samples are then annealed at 500 °C for 1 h to investigate the thermal stability of the phases. The four ECAP passes at 500 °C do not result in the formation of the body‐centered cubic (BCC) phase typical for the program RHEAs despite the presence of interfacial zones between particles and defect‐driven diffusion. Nevertheless, a single ECAP pass is sufficient to create a solid bulk sample for subsequent HPT. After 10 HPT revolutions, in contrast to melting route resulting in a single BCC phase alloy, both alloys form new phases comprising a Nb‐rich BCC phase and a ZrHf‐rich HCP phase in both alloys.

Reactive deposition of CYSZ coatings using PS-PVD technology

CYSZ (CeO2-Y2O3-ZrO2) coatings were prepared via PS-PVD (plasma spray physical vapor deposition) using untreated YSZ and CeO2 blend powders instead of commercially CYSZ powders. 8YSZ was mixed with different proportions of CeO2 (10, 20and 30 wt%). CYSZ agglomerated composite powders were then produced via spray drying and CYSZ coatings were deposited through PS-PVD spraying. Microstructures of composite powders and coatings were observed using SEM and EDS, and characterization of powders and coatings were evaluated via XRD, laser particle size measurement and XPS. Results showed agglomerated composite powders possessed high percentages of particles with optimum size and were suitable for subsequent PS-PVD process. The coatings prepared with reactive deposition had a typical columnar structure as current coating method. The coatings exhibited uniform distribution of all elements and consisted mainly of the t-ZrO2 phase. Crystal structure and properties of coatings were identical to coating deposited via solid phase reactive powder.

Binder Jetting 3D Printing of Binary Cement-Siliceous Sand Mixture.

Three-dimensional printing allows accurate geometries to be obtained across a wide range of applications and it is now also moving into the architecture and construction industry. In the present work, a unique binary mix composed of ordinary Portland cement (OPC) and quick-setting cement (QSC) was combined with silica sand aggregate in different proportions for a customized binder jetting 3D printing (BJ3DP) process. Specimens were printed using the blended dry powders and deionized water to determine the impact of the processing variables on the properties of the realized specimens. The results show that the properties are influenced by the binary mix proportions and the layer thickness. The investigation found significant improvement in mechanical performance on increasing the proportion of OPC and optimal conditions were identified with proportions of 35 wt% OPC and 5 wt% QSC. Notable enhancements were also observed as the layer thickness was reduced.

African Breadfruit Seed Oil as Lipid Phase of Self-Emulsifying Drug Delivery System for Improved Gastrointestinal Fluid Solubility of Ibuprofen: Design and Evaluation

Introduction: Rain forest vegetations all over the world produce large quantity of economically important seed oils which, in most developing countries are utilized only as food condiments but hardly employed in pharmaceutical formulations.
 Objectives: The purpose of this work was to formulate ibuprofen-loaded self-emulsifying drug delivery system for the enhancement of the gastrointestinal fluid solubility of this poorly water soluble drug.
 Methods: The breadfruit seed oil was extracted by the soxhlet extraction technique and characterized for various physicochemical properties including acid, iodine, peroxide, saponification values and organoleptic properties. The super saturation solubility process, water titration studies and pseudo ternary phase diagrams were used to select and quantify the components of the emulsion systems. The liquid self-emulsifying drug delivery systems were converted to solid forms by adsorption onto a blend of miceocrystalline cellulose and Aerosil-200 powders. The resulting wet mass was dried and processed for encapsulation.
 Results: The percentage yield of the oil from the extraction process was 20.68 % while the acid, iodine, and saponification values were, 4.12 ± 1.24, 21.91 ± 0.88, and 302.45 ± 1.22 respectively. The ibuprofen exhibited higher solubility in the hydrolysed oil than in the crude form. Fourier transform infrared analysis did not reveal existence of component incompatibility. The optimized liquid and solid emulsions exhibited standard characteristics that were compatible to previous literature reports. The formulations also exhibited superior drug release properties over two control samples.
 Conclusion: It was concluded that Breadfruit seed oil has the potential to function as the lipid component of ibuprofen-loaded self-emulsifying drug delivery system formulated to enhance the aqueous solubility of the drug.