This study aimed to formulate the lidocaine-pressure sensitive adhesive (PSA) patches by melt blending technique using STR-5L block rubber as the main polymer, hydroxyethyl cellulose (HEC) as a tackifier, and paraffinic oil as a softener. STR-5L with 80 Mooney viscosity was masticated for 15 min using two rolls mill machines, and then HEC, paraffinic oil and lidocaine were added, respectively. Lidocaine-PSA patches were constructed after 75 min of mixing and rolled out with a gap of 0.1 mm. Their physicochemical properties, in vitro drug release and permeation, and stability were evaluated. Lidocaine base (LB) and lidocaine hydrochloride salt (LH) were used as the models of hydrophobic and hydrophilic drugs, respectively. The results were found that STR-5L block rubber with HEC and paraffinic oil blends could be used as a PSA matrix for both lidocaine base and salt delivery. Moreover, either LB or LH powder could be mixed during the PSA production process. Lidocaine-PSA patches exhibited higher hydrophilic properties when compared with the plain rubber patch due to the hydrophilic property of HEC. LB showed the molecular dispersion in the PSA patch but LH showed the crystalline character in the PSA patch when observed by differential scanning calorimeter and X-ray diffractometer. The drug release of both LB and LH from PSA patches were not significantly different. However, the LB permeation through pig skins was better than LH's one due to its hydrophobic characteristic. The most suitable condition to keep lidocaine-PSA patches in this study was at 4 °C of storage temperature.