Powder Blends Research Articles

Process Optimization for Development of Extruded Snack from Brown Rice-Amaranth-Moringa Seed Powder Blend

The study was aimed at utilizing brown rice, germinated amaranth and moringa seed powder in the development of nutritious extruded product. The extruded product was optimized by employing Response Surface Methodology using Central Composite Rotatable Design (CCRD). The experiment consists of three independent variables each having five different levels. The process variables were selected as feed moisture content (8-16%), blend ratio of brown rice flour: germinated amaranth flour: defatted moringa seed powder (50:45:5, 50:40:10, 50:35:15, 50:30:20 and 50:25:25) and barrel temperature (100-140ºC). Optimization was done on the basis of product responses i.e. bulk density, expansion ratio and hardness. The values of bulk density, expansion ratio and hardness of extruded products ranged between 0.06 to 0.35 g/cm2, 2.30 to 3.34 and 497.48 to 1425.17 g, respectively. The optimum values of extrusion conditions obtained through numerical optimization were blend ratio (50:30:20), feed moisture content (12%) and barrel temperature (1300C). The corresponding predicted values for bulk density, expansion ratio and hardness was 0.0964 g/cm3, 3.33 and 617.16 g, respectively with desirability 0.912. Whereas the corresponding experimental values for bulk density, expansion ratio and hardness were 0.0939 g/cm3, 3.35 and 635.56 g, respectively. Thus, it is concluded that the brown rice, germinated amaranth and defatted moringa seed has potential to be incorporated in the development of nutritious extruded snacks.

Deposition and Characterization of Fluoropolymer–Ceramic (ECTFE/Al2O3) Coatings via Atmospheric Plasma Spraying

Thermal spray techniques allow coatings to be deposited from a wide range of materials with controlled thicknesses, from micrometres to millimetres. For this reason, thermal spraying can optimize performance for diverse applications across industries, ensuring strong adhesion and the durability of coated surfaces. In this work, composite ethylene chlorotrifluoroethylene/ceramic (ECTFE/Al2O3) coatings with different ceramic ratios were deposited by plasma spraying. Four coatings were produced by spraying blended powders consisting of pure ECTFE and ECTFE with 5%, 10%, and 15 wt.% Al2O3. The effect of varying the ceramic ratio on the coatings’ microstructure and properties was investigated. Morphology and particle size distributions were determined for the raw powders. The microstructural examination of the coatings showed proportional increases in Al2O3 content. An improvement in adhesion was achieved with ceramic in the coatings from 5 wt.% Al2O3. Enhanced friction coefficients were obtained with ceramic, except for 15 wt.% Al2O3. Taber abrasion tests showed a minimal influence on ceramic content.

HIGH VOLUME BRICK POWDER CONCRETE SYNERGISTIC WITH METAKAOLIN: PHYSICOMECHANICAL PROPERTIES AND DRYING SHRINKAGE

Currently, sustainability of the construction and building industry taken a priority. This study investigates the feasibility of using a high volume (up to 50%) of blended waste brick powder (BP) and metakaolin (MK) as ordinary Portland cement (OPC) replacements. The binder of the control mixture was a blend of 50% OPC and 50% BP, while the other two mixes were prepared by substituting 10% and 20% of BP with MK. The characteristics of fresh concrete were assessed depending on measuring the mixture temperature, the fresh density, and the workability. The bulk density, and the mechanical properties were investigated and tested at 7 and 28 days. In the line of durability parameters, the void content and drying shrinkage up to 90 days of all mixtures were evaluated. The findings have demonstrated that the control mixture achieved high workability (slump =180 mm), structural compressive strength (34 MPa) at 28 days, low void content (<3%), and acceptable shrinkage strain. The workability of the mixes containing 10%MK:40%BP and 20%MK:30%BP has slightly decreased, while the mechanical properties were increased and the drying shrinkage were declined. However, the inclusion of This study highlighted an ecological technique toward waste management of construction materials and confirmed the possibility of including a high volume of BP as a cementitious material to synthesize more sustainable concrete.

Potential of Encapsulated Bovine Colostrum in Powder-Based Formulations for Facial Clay, Peel-Off Gel, and Sleeping Gel Masks

Bovine colostrum is a bioactive compound with potential in cosmetic applications but has a limited shelf life. This study aimed to develop an effective encapsulation system for bovine colostrum using the complex coacervation method and incorporate it into powder formulations for facial masks. The research explored various gelatin-to-gum Arabic ratios to optimize the physical and chemical stability, encapsulation efficiency, and loading capacity of the encapsulated bovine colostrum (EBC). The EBC was further incorporated into powder formulations for clay masks, peel-off gel masks, and sleeping gel masks. The optimal gelatin-to-gum Arabic ratio was found to be 2:1, yielding the highest entrapment efficiency (66.6 ± 3.3% w/w) and loading capacity (67.6 ± 3.4% w/w) of bovine colostrum. For clay masks, the most effective powder blend incorporating EBC enhanced the moisture content, water solubility, and hygroscopicity, without affecting the drying time (9.7 ± 0.6 min). Additionally, peel-off gel masks incorporating EBC significantly reduced water activity and improved moisture content and hygroscopicity, while the drying time decreased from 44.3 ± 0.6 to 25.0 ± 1.7 min. For sleeping gel masks, the formulation with EBC increased water activity, while other parameters remained stable. In conclusion, the EBC with enhanced stability was effectively integrated into various powders for facial mask formulations.

Real-time monitoring of small changes in powder blends and ejected tablets in a low-dose formulation with 1 %w/w of active pharmaceutical ingredient using Raman and near-infrared spatially resolved spectroscopy within a tablet press.

This study used Raman and near-infrared (NIR) spectroscopy to monitor small real-time changes in powder blends and tablets in low-dose pharmaceutical formulations. The research aims to enhance process analytical technology (PAT) in pharmaceutical manufacturing, ensuring high-quality and uniform products with applications to produce drugs with narrow therapeutic indices (NTI). The study utilizes Raman and NIR spatially resolved spectroscopy (SRS) techniques to monitor a moderate cohesive material's active pharmaceutical ingredient (API) concentrations during manufacturing. The sampling locations were a bin blender for the batch blending procedure where the powder heterogeneity plays a significant role in product homogeneity, a feed frame of a tablet press where powder blend dynamics is critical to final product quality, and the outlet port of the tablet press where tablets immediately after ejection can be monitored in real-time. The study used semifine acetaminophen (APAP) as the API. Results indicated that Raman and NIR SRS could detect small API concentration changes as low as 0.50%w/w, demonstrating their sensitivity and utility in real-time monitoring. The findings support the feasibility of these techniques in ensuring tight process control and highlight the performance of reducing waste and optimizing manufacturing processes in line with quality by design principles. The results highlight the importance of residence time distribution (RTD) in understanding the flow of the materials and powder behavior within the tablet press feed frame. RTD analyses showed that both Raman and NIR SRS techniques could effectively track concentration changes and ensure uniformity in the powder blends and tablets with signal-to-noise ratios higher than 3, demonstrating the sensitivity of the methods to small API changes. The %RSD during a steady state of 250s (corresponding to 1.04kg of material at 15kg/h) for the step changes presented values of 6.74% at 0.50%w/w, 5.39% at 1.00%w/w, and 2.99% at 1.50%w/w for Raman predictions in powder blends within the feed frame and 15.46% at 0.50%w/w, 9.64% at 1.00%w/w, and 5.68% at 1.50%w/w for NIR SRS predictions of tablets ejected at the outlet port of the tablet press. In conclusion, this research demonstrates the potential of advanced spectroscopic techniques and data analysis in pharmaceutical manufacturing. By enabling precise real-time monitoring and control, these techniques contribute to higher-quality drug products, particularly NTI drugs, aligning with modern regulatory expectations and advancing pharmaceutical production technology.

Selective laser sintering for printing bilayer tablets.

In this study Selective Laser Sintering (SLS) was used to produce bilayer tablets containing rosuvastatin and acetylsalicylic acid. Initially, monolithic tablets of each drug were manufactured using different laser intensities in order to identify their impact on the tablet's dissolution, friability and hardness. After the optimization, the final bilayer tablet was fabricated using a new method, that allowed the printing using different powder blends. For that, a 3D-printed casing was employed to maintain the compartments of the tablet in the correct position during the printing process. The results demonstrated that the increased laser intensities led to denser inner cores, enhanced hardness, decreased friability, and slower drug release. Moreover, the new method was able to produce bilayer tablets completely aligned, showing a minor impact on dissolution when the two compartments were printed together in a single tablet. The work demonstrated the feasibility of using SLS in the production of multi-material drug delivery systems.

Exploring the impact of the ball milling process on the homogenous blending of polyamide 6-AZ61 magnesium powders

Exploring the impact of the ball milling process on the homogenous blending of polyamide 6-AZ61 magnesium powders

A new approach to overcome cytotoxic effects of Cu by delivering dual therapeutic ions (Sr, Cu)

The incorporation of trace elements such as strontium (Sr) and copper (Cu) in the composition of mesoporous bioactive glass (MBG) is widely known to enhance its biological functionality for bone tissue regeneration METHODS: Two MBG powders with the composition 80SiO2-11CaO-5P2O5-xCuO/SrO, one doped with 4 mol.% of CuO, the second with 4 mol.% of SrO were blended in the weight ratios of Cu-MBG: Sr-MBG; 100:0, 70: 30, 50: 50, 30: 70 and 0:100 aiming at minimizing Cu to minimize the cytotoxicity of Cu while preserving its antimicrobial activity. The synergistic effects of Sr and Cu ions on bioactivity, cytotoxicity, and antimicrobial activity were studied. Transmission electron microscopy (TEM) examination of Cu-MBG and Sr-MBG showed fringes related to the development of a mesoporous structure. The specific surface area values of the Cu-MBG and Sr-MBG powders were 287 and 349 m2/g, respectively. A characteristic compact layer consisting of particles with platelet-like morphology commonly associated with HAp crystals was confirmed after 7 days soaking in simulated body fluid (SBF). Mouse preosteoblast cells (MC3T3-E1) exhibited higher cell viability when exposed to a 1 % w/v eluate from blended Cu-MBG powders compared to pure Cu-MBG. Notably, the Cu-MBG: Sr-MBG ratio of 30:70 exhibited cell viability of around 85 % at this concentration. A higher cell viability (above 100 %) towards MC3T3-E1 cells was observed for all powders when tested with the 0.1 % w/v eluate. With progressive increase in the amount of Cu-MBG in the blended system the bacterial inhibitory effects were more pronounced. The Cu ions released from Cu-MBG generate hydroxyl ions and increase the pH leading to disruption of the cellular membrane of microbes, resulting in enhanced antimicrobial activity. This newly developed blended system composed of Cu and Sr doped MBGs is expected to be more effective as bioactive filler in comparison to single ion doped MBGs for bone tissue engineering applications.

Using density changes to monitor blending with magnesium stearate by terahertz time-domain spectroscopy.

Magnesium stearate (MgSt) is among the most common excipients and the most common lubricant in solid oral products. It is primarily added to tablet formulations to ease ejection during tablet compression. While commonly present in low concentrations, the addition of MgSt substantially affects the final tablet properties. Its impact is further not only concentration dependent but also varies with exposure of the formulation to shear, which worst-case results in over-lubrication. The presented study investigated the applicability of terahertz time-domain spectroscopy (THz-TDS) to monitor the shear-induced blend densification of microcrystalline cellulose blended with MgSt over a range of concentrations (0.3, 0.7, and 1.0%). The effect of shear was investigated by variation of blending times (5 - 20min) in a diffusion blender. THz-TDS measurements of the powder blends were acquired in transmission by measuring directly through the mixing container. The refractive index at terahertz frequencies was found to be sufficiently sensitive to resolve the densification of the blend with increased blending times. Thus, THz-TDS blend density measurements can be used as a surrogate parameter to evaluate the total shear exposure of a blend. Considerations regarding implementation are discussed. In the context the approach was integrated with the well-described THz-TDS-based tablet porosity analysis into a unified model to monitor and predict the tensile strength. Including the THz-TDS measurement on the blend allowed for a more accurate description of the tensile strength, reducing the root mean squared error by over 40% (0.33MPa). The possibility of monitoring the density changes of a blend non-invasively makes THz-TDS a promising process analytical technology approach for controlling the total shear impact on lubricated blends and tablet quality.

Formulation and evaluation of herbal floating tablets

Herbal tablets are oral dosage form that float in stomach and remain there for long period of time. They are designed to improve the bioavailability of drugs and deliver them locally to the stomach. Floating tablets can offer several advantages, including sustained drug delivery and site- specific drug. This review explains about the advantages, disadvantages, applications, general formulation factors. General excipients used, methods of manufacturing, Evaluation parameters were described briefly. Brief note on pre- compressional studies of powder blend, preparation of floating tablets and post compression studies of tablets were mentioned.

FORMULATION AND OPTIMIZATION OF GASTRO-RETENTIVE FLOATING TABLETS OF ENALAPRIL MALEATE AND LOSARTAN FOR ENHANCED BIOAVAILABILITY AND THERAPEUTIC EFFICACY

The objective of this study was to formulate and optimize gastro-retentive floating tablets of Enalapril Maleate and Losartan to enhance their bioavailability and therapeutic efficacy. These drugs, commonly used in the management of hypertension and heart failure, suffer from limited solubility and rapid gastric emptying, which reduce their effectiveness. Gastro-retentive floating tablets were developed using hydroxypropyl methylcellulose (HPMC K4M) and guar gum as release-controlling agents, with sodium bicarbonate and citric acid as effervescent agents to ensure buoyancy. Twenty formulations were prepared using the direct compression method and evaluated for critical parameters, including hardness, friability, swelling index, floating lag time, total floating time, and in-vitro drug release.Preformulation studies confirmed the compatibility of the drugs with excipients, with no chemical interactions detected using FTIR spectroscopy. The micrometric properties of the powder blends demonstrated excellent flowability and compressibility, ensuring suitability for tablet manufacturing. All formulations showed acceptable weight variation, hardness, and friability. The floating lag time ranged from 4.3 to 5.1 minutes, and total floating times exceeded 8 hours for all batches. Drug content ranged from 96.79% to 99.57%, reflecting uniformity and accuracy in dosing.In-vitro dissolution studies revealed sustained release profiles, with optimized formulations achieving over 90% cumulative drug release within 12 hours. Batch F7 demonstrated the best overall performance, with a high swelling index, minimal floating lag time, prolonged floating duration, and consistent drug release. These findings indicate that gastro-retentive floating tablets of Enalapril Maleate and Losartan can effectively address challenges associated with poor bioavailability and rapid gastric emptying, offering a promising approach for improved therapeutic outcomes and patient compliance.

Hard magnetic SmCo5-Sn nanocomposites produced by high-pressure torsion

Hard magnetic SmCo5-Sn nanocomposites produced by high-pressure torsion

Small- to Large-Scale Electron Beam Powder Bed Fusion of Functionally Graded Steels

The ability to control process parameters over time and build space in electron beam powder bed fusion (PBF-EB) opens up unprecedented opportunities to tailor the process and use materials of a different nature in the same build. The present investigation explored the various methods used to adapt the PBF-EB process for the production of functionally graded materials (FGMs). In this way, two pre-alloyed powders—a stainless steel (SS) powder and a highly alloyed cold work tool steel (TS) powder—were combined during processing in an S20 Arcam machine. Feasibility experiments were first carried out in a downscaled build setup, in which a single powder container was installed on top of the rake system. In the container, one powder was placed on top of the other (SS/TS) so that the gradient materials were produced as the powders were spread and intermixed during the build. The process was later scaled up to an industrial machine setup, where a similar approach was implemented using two configurations of powder disposal: SS/SS + TS/TS and TS/TS + SS/SS. Each configuration had an intermediate layer of powder blend. The FGMs obtained were characterized in terms of their microstructure and local and macromechanical properties. For the microstructural analysis, optical microscopy, scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDX) were performed on the polished cross-sections. This provided evidence of gradual microstructural and compositional transitions in the samples, with a shift from SS to TS and vice versa. Nanoindentation experiments confirmed that there was a consequent gradient in the hardness, stiffness, and wear ratio from the softer and ductile SS to the harder and stiff TS. Scratch experiments revealed gradual evolution in the sliding wear behavior of the printed materials. A “progressive spring” and a “hardness-tailored punching tool” were fabricated as demonstrators. The results obtained demonstrate the great potential to gradually tailor the composition, microstructure, mechanical properties, and wear resistance by combining different powders, and they suggest that any PBF-EB system can be repurposed to build gradient materials without hardware modification. Potential applications include the tooling industry, where hard and wear-resistant materials are needed for the surfaces of tools, with tougher and more ductile materials used in the cores of tools.

Физико-химические свойства арахисовой пасты с добавлением кокосовой муки и сухого молока

Peanut butter is a popular, versatile food spread globally known for its nutritional value and unique flavor. As consumer preferences evolve, there is an increasing demand for fortified products. Coconut flour and milk powder are potential fortification agents due to their nutritional benefits and compatibility with various food matrices. We explored the effects of incorporating coconut flour and milk powder into peanut butter, analyzing its nutritional composition and sensory qualities. Various combinations (0, 5, 10, and 15% w/w) of coconut flour, milk powder, and their mixture were introduced into peanut butter followed by a thorough physicochemical and sensory analysis. The results showed notable changes in both physical and chemical attributes. Coconut flour and its combination with milk powder increased the moisture content in peanut butter, while milk powder had the opposite effect. The protein content peaked in the peanut butter with 15% coconut flour, while the fat content diminished with higher concentrations of coconut flour and milk powder. Carbohydrate levels in the supplemented samples surpassed those of the control and commercial peanut butters. All the variants exhibited a pseudoplastic flow behavior, with coconut flour and milk powder concentrations affecting viscosity. The textural analysis revealed differences in oil separation, spreadability, and firmness, with 15% coconut flour yielding the highest firmness and oil separation. Noteworthy color changes were evident, particularly with the inclusion of 15% milk powder. Sensory assessments favored the peanut butter with a 15% blend of coconut flour and milk powder, while the color preference leaned towards the 15% milk powder variant. The consumers preferred the peanut butter fortified with a 15% blend of coconut flour and milk powder. Our research can help food manufacturers create healthier, more appealing products that cater to evolving consumer preferences and dietary requirements.

Development and Evaluation of Bilayer Tablets of Bimodal release of Bisoprolol Fumarate

Bisoprolol is a type of antihypertensive drug (β-blocker). It is a poorly water-soluble and highly permeable drug that belongs to class II biopharmaceutical classification. This investigation represents the formulation development of bisoprolol to immediate and sustained the drug release. In immediate release different types of polymers like Sodium Starch Glycolate, Crospovidone and Lactose were used in this study. In sustained release different types of polymers like HPMC, Guar Gum and Magnesium Stearate were used in this study. Eight different formulations were developed by using different excipients at various ratios. The powder blend was evaluated for bulk density, tapped density, flow property whereas tablets were evaluated for thickness, hardness, weight variation, compressibility index, uniformity of content, disintegration time, and drug release profile. The present study concluded that bilayer tablets of Bisoprolol Fumarate as an alternative to the conventional dosage form.

Fortification of pasta with upcycled bread and plant-based powder blends

Food waste remains a significant global challenge for sustainability, leading to the concept of a circular economy. To support this concept, the objective of this study was to develop value-added pasta from unsold wholemeal bread and low glycemic index (GI) bread and to incorporate mixed plant powders (Polygonum minus + Amaranthus tricolor, Polygonum minus + Apium graveolens and Polygonum minus + Breynia androgyna) that could provide additional nutritional and health benefits. The in vitro antioxidant potential, cooking quality, texture and sensory properties of fortified wholemeal bread pasta and low-GI bread pasta samples were evaluated and compared. The results revealed that the incorporation of bread and plant powders substantially increased the antioxidant capacity of cooked samples enriched with low-GI pasta, up to 77.2% in DPPH and 0.40 mg/g AAE in terms of ABTS radical scavenging activity, 0.31 mg/g AAE in terms of FRAP reducing ability, 0.27 mg/g GAE in total phenolic content, 0.75 mg/g QE in total flavonoid content and 0.27 mg/g QE in total flavonol content, in comparison with the control pasta. The inclusion of bread and plant powder also altered the textural properties of fortified pasta. In particular, low-GI bread pasta fortified with plant powders presented increased chewiness (2.91–3.31 g mm) and springiness (0.84–0.89 mm) values compared with those of the control pasta, although their cooking and sensory properties were not significantly influenced. These results indicate that the development and fortification of pasta through the upcycling of breads and mixed plant powders is a valuable approach for producing sustainable bread pasta with potential health-promoting effects.

Unveiling the Potential of Civil Briquette Furnace Slag as a Silico–Aluminon Additive in Alkali-Activated Materials

Civil briquette furnace slag (FS), as a type of industrial solid waste, is not currently being recycled as a resource by the building materials industry. This study focuses on the potential of FS in the formulation of alkali-activated materials (AAMs) compared with calcium carbide slag (CS). This study encompasses three distinct AAM systems: alkali-activated fly ash alone (AAFA), fly ash–slag powder blends (AAFB), and slag powder alone (AABS). Electrical conductivity, fluidity, drying shrinkage, and flexural and compressive strengths were also assessed. Advanced characterization techniques, including SEM-EDS, XRD, FTIR, and TG-DSC, were utilized to examine the morphology, mineralogy, and reaction products. Despite the chemical similarity between FS and CS, FS exhibits limited active chemical components (SiO2, Al2O3, CaO, and MgO) and primarily functions as a physical filler, and thus lacks the chemical binding properties of CS. FS has a positive effect on the long-term compressive strength of the AABS system but not on the AAFA and AAFB systems. The NaOH-activated SP mortar sample with 20% FS reaches a compressive strength of 29.8 MPa at 360 days. The binding strength in AAMs incorporating FS is predominantly attributed to the gel formation within the alkali-activated matrix. This research offers valuable insights into the strategic use and substitution of CS, FS, and other silico–aluminon additives within the context of AAMs development.

Formulation and evaluation of sustained release matrix tablet of ketoprofen

The aim of the study was the formulation of the sustained release matrix tablet of Ketoprofen. The sustained release tablet was prepared by wet-granulation method. The tablets were formulated using hydrophilic polymer HPMC K4M and xanthan gum. Preformulation compatibility studies indicate that there is no interaction between the excipient and the drug. Total seven batches were prepared and powder blends before compression was subjected for evaluation of flow properties. All the parameter was found to be within the limit showing good flow property. After compression, the entire tablet batch was evaluated for thickness, hardness, friability, weight variation, drug content uniformity, swelling index, In-vitro release pattern. The thickness of tablet indicates that die fill was uniform in all the formulation and the formulation possessed sufficient hardness & friability indicating a good mechanical strength of the development formulation. The weight of the all the formulation were found to be with in pharmacopeial limit. The In-Vitro dissolution profile of all the formulation of Ketoprofen was controlled over an extended period of time. The optimized formulation of F7 containing combination of HPMC K4M and xanthan gum was consider as the best formulation with respect to its sustained in vitro drug release for 12 hrs, total sustained release time & improved bioavailability. The developed formulation was found to be stable during the stability studies of 3 month indicating good stability of the tablets.

Processing TiC nanoparticle reinforced aluminum matrix composites in PBF-LB: Powder blending approach, particle sintering, precipitation and grain refinement

Processing TiC nanoparticle reinforced aluminum matrix composites in PBF-LB: Powder blending approach, particle sintering, precipitation and grain refinement

Melt Alloying of Two-Dimensional Hybrid Perovskites: Composition-Dependence of Thermal and Optical Properties.

Melt alloying, the process of melting a physical powder blend to create a homogeneous alloy, is widely used in materials processing. By carefully selecting the materials and their proportions, the physical properties of the resulting alloy can be precisely controlled. In this study, we investigate the possibility of utilizing melt alloying principles for meltable two-dimensional hybrid organic-inorganic perovskites (2D-HOIPs). We blend and melt mixtures of two selected 2D-HOIPs: the glass-forming (S-NEA)2PbBr4 (S-NEA = (S)-(-)-1-(1-naphthyl)ethylammonium) and the liquid-forming (1-MHA)2PbI4 (1-MHA = 1-methylhexylammonium). Upon melting and cooling, 1-MHA-poor blends (X1-MHA ≤ 50% mol, where X1-MHA corresponds to the relative molar concentration of (1-MHA)2PbI4 in the blend) form a hybrid glass, while 1-MHA-rich blends (X1-MHA ≥ 70% mol) crystallize. The melting temperature of all blends, as well as the glass transition temperature of the glass-forming blends, change according to blend composition. In all cases, melting produces a homogeneous structure, either glassy or crystalline, which remains such after the glassy samples are recrystallized upon a second heat treatment. This method enables band gap tuning of the blends, given that it varies with composition and crystallinity. Overall, this work demonstrates the applicability of classical melt processing to binary-component functional hybrid systems, and paves the way to solvent-free perovskite-based device fabrication.