Guidelines of blast resistant design for AASHTO girder bridges have not taken up much importance on researches. As the transportation infrastructure mainly bridges are highly vulnerable for bomb attack, they must be designed to resist it. The analysis and design of bridges subjected to blast load requires a detailed understanding of blast propagation and its dynamic effects on various structural elements. The response of bridge components subjected to blast load is carried out using Abaqus explicit finite element software. The bridge is modeled on the basis of AASHTO-LRFD bridge design specification for highway bridges. Blast load has been introduced on different critical location of the bridge to understand their effects on various structural elements and extent of damage. A thorough parametric study varying standoff distance and TNT mass is done to understand their importance in developing a blast resistant design for AASHTO Girder Bridge. The study concludes that the value of maximum displacement decreases with the increase in standoff distance.