Exposure of building infrastructures to accidental or intentional blasts is an extreme load condition that may cause irreparable damage leading to the collapse of buildings. Columns being principal elements are the most important for the stability and safety of the buildings under accidental explosions and subversive blast events and therefore attract the attention of structural engineers and researchers. Some recent examples are the Beirut seaport explosion (August 2020), the explosion at an ammunition warehouse in Ryazan City of Russia (October 2020), the gas explosion in China’s Hubei Province (June 2021), a blast at a chemical factory on the outskirts of Bangkok (July 2021), and the explosion on a container ship docked at Dubai’s Jebel Ali Port (July 2021). In the crises like ongoing conflict between Russia and Ukraine, the enhanced response of the principal components of a structure may save the life of the building users by limiting severe damage to the structure. In this study, three experimentally tested 3000-mm-long normal strength concrete columns, 300mm x 300mm, provided with (i) conventional reinforcement, (ii) seismic reinforcements over top and bottom confining regions (600 mm), and (iii) seismic reinforcement over confining and mid-height regions, carrying an axial working load of 950 kN available in the literature, are modeled in the ABAQUS 2020 code and are subjected to 82 kg TNT close-range explosive load at a scaled distance 1.0 m/kg1/3using the software’s explicit module. In addition to this, one column with seismic reinforcement over its entire length has been considered and modeled. The concrete damage plasticity model is explored for nonlinear elastic and inelastic behaviors, degradation of stiffness, and loading rate effect on concrete. Following the validation of the numerical models, the seismic reinforcements of the columns have been replaced by the cross-diagonal reinforcements between the conventional stirrups with the same axial load. Blast performance of the columns with the seismic reinforcements and with replaced diagonal reinforcements is critically examined and discussed. The results show that the application of cross-diagonal reinforcements as a replacement for the seismic reinforcements enhances the blast resistance of the reinforced concrete column significantly by reducing the damage and displacement.