Article1 May 1953THE USE OF ACTH AND CORTISONE IN THE TREATMENT AND IN THE DIFFERENTIAL DIAGNOSIS OF MALIGNANT EXOPHTHALMOS: A PRELIMINARY REPORTLAURANCE W. KINSELL, M.D., F.A.C.P., JOHN W. PARTRIDGE, M.D., NADINE FOREMAN, M.D.LAURANCE W. KINSELL, M.D., F.A.C.P.Search for more papers by this author, JOHN W. PARTRIDGE, M.D.Search for more papers by this author, NADINE FOREMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-38-5-913 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe present report comprises the findings in nine patients who have been studied during the past two years, all of whom presented the complaint of exophthalmos of severe or moderately severe degree, in association with obvious or probable thyroid dysfunction.CLINICAL OBSERVATIONSPatient G. T. was referred through the kindness of Dr. Gale Whiting and Dr. Owen Dickson. Three months prior to admission she had had a thyroidectomy for a toxic goiter in association with exophthalmos of moderate degree. Following surgery the exophthalmos became progressively worse and, despite the administration of desiccated thyroid, reached a magnitude sufficient to endanger both...Bibliography1. Naffziger HC: Progressive exophthalmos following thyroidectomy; its pathology and treatment, Ann. Surg. 94: 582, 1932. CrossrefGoogle Scholar2. HillReissForshamThorn SRRSPHGW (a) : The effect of adrenocorticotrophin and cortisone on thyroid function: thyroid-adrenocortical interrelationships, J. Clin. Endocrinol. 10: 1375, 1950. (b) Wolfson, W. Q., Beierwaltes, W. H., Robinson, W. D., Duff, I. F., Jones, J. R., Knerpp, C. T., Siemienski, J. S., and Eya, M.: Corticogenic hypothyroidism: its incidence, clinical significance and management during prolonged treatment with ACTH or cortisone, Proceedings Second Clinical ACTH Conference, Vol. 2, J. R. Mote, Editor, 1951, The Blakiston Company, Philadelphia. CrossrefGoogle Scholar3. KinsellPartridgeBolingMargen LWJWLS: Dietary modification of the metabolic and clinical effects of ACTH and cortisone, Ann. Int. Med. 37: 921, 1952. LinkGoogle Scholar4. François J (a) : Estrogen therapy in Graves' disease, Bull. Soc. beige d'opht. 97: 194, 1951. (b) Smelser, G. K., and Ozanics, V.: Relation of steroid hormones to the development of experimental exophthalmos, Am. J. Ophth. 34: 87, 1951. Google Scholar5. Salassa RM (a) : Effects of cortisone and ACTH in certain endocrine conditions, Proc. Staff Meet., Mayo Clin. 25: 497, 1950. (b) Woods, A. C.: Present status of ACTH and cortisone in clinical ophthalmology, Am. J. Ophth. 34: 945, 1951. (c) Fitzgerald, J. R., Bellows, J. G., Donegan, J. M., Gamble, R. C., Krause, A. C., Mann, W. A., Pearlman, M. D., and Zekman, T. N.: Early clinical results of ACTH and cortisone treatment of ocular disease, Arch. Ophth. 45: 320, 1951. (d) Chandler, G. N., and Hertfall, S. J.: Cortisone and ACTH in exophthalmic ophthalmoplegia, Lancet 1: 847, 1952. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Oakland, California*Received for publication March 3, 1953.This material was presented in part at the Graduate Assembly, sponsored jointly by the Alameda Contra Costa County Medical Association and the Institute for Metabolic Research, February 5, 1953.From the Institute for Metabolic Research, Highland Alameda County Hospital, Oakland, California.†Schering Research Fellow in Endocrinology, 1950-52.Grateful acknowledgment is made to the Armour Laboratories for supplies of ACTHAR Gel, to Merck & Company for supplies of Cortone and Hydrocortone used in some of these studies, and to the Schering Corporation for ethinyl estradiol (Estinyl), and testosterone propionate (Oreton). Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNetwork Meta-Analysis of Different Intravenous Glucocorticoid Regimes for the Treatment of Graves’ OrbitopathyEndocrine ophthalmopathy: pharmacogenetic markers of efficiency of glucocorticoid therapyRetrospective Analysis of Patients With Graves Orbitopathy Treated By Pulses Of Methylprednisolone, With a Focus on Adverse EventsShort and long-term effects of high-dose intravenous methylprednisolone pulse therapy on thyroid-associated ophthalmopathyCommon Immunosuppressive Monotherapy for Graves’ Ophthalmopathy: A Meta-AnalysisMeta-analysis of methylprednisolone pulse therapy for Graves' ophthalmopathyHyperthyroidism, Exophthalmos, and Goiter: Historical Notes on the OrbitopathyGraves’ DiseaseMedical Treatment for Thyroid-Associated OphthalmopathyDie Strahlentherapie gutartiger Erkrankungen innersekretorischer DrüsenDie Strahlentherapie gutartiger Erkrankungen innersekretorischer DrüsenThe General Appearance (Habitus)Adrenal steroid therapy of severe infiltrative ophthalmopathy of Graves' diseaseTREATMENT OF THYROID OPHTHALMOPATHY WITH CORTICOID ANALOGUESLOCALIZED PRETIBIAL MYXEDEMA: REPORT OF TWO CASES TREATED WITH HYDROCORTISONE BY LOCAL INJECTION*RICHARD W. DYKE, M.D., F.A.C.P., CLAYTON E. WOOD, M.D., SOPHOCLES D. MARTY, M.D.EXOPHTHALMOS OF GRAVES' DISEASE: A SUMMARY OF THE PRESENT STATUS OF THERAPY*E. PERRY MCCULLAGH, M.D., F.A.C.P., MARVIN CLAMEN, M.D., W. JAMES GARDNER, M.D., ROSCOE J. KENNEDY, M.D., GEORGE LOCKHART III, M.D.ALKALINE PHOSPHATASE IN THE WHITE CELLSADRENOCORTICAL STEROIDS IN MALIGNANT EXOPHTHALMOSThe Thyro-Hypophysial Syndrome.The Thyro-Hypophysial Syndrome.Krankheiten der SchilddrüsePhysiology of the Adrenal CortexCORTISONE IN EXOPHTHALMOS 1 May 1953Volume 38, Issue 5Page: 913-917KeywordsAdrenocorticotropic hormoneEstradiolFallsGraduate medical educationHyperthyroidismPropionatesSurgeryTestosteroneThyroidThyroidectomy ePublished: 1 December 2008 Issue Published: 1 May 1953 Copyright & PermissionsCopyright, 1953, by The American College of PhysiciansPDF downloadLoading ...
Read full abstract
Oct 1, 1954
William Montagna 
Open Access