Bladder Metastasis Research Articles

Renal cell carcinoma with metachronous metastasis to the contralateral adrenal gland and urinary bladder: A case report

The adrenal gland and urinary bladder are rare localizations of metastases of renal cell carcinoma (RCC). In the present study, a case of metastasis to the contralateral adrenal gland and urinary bladder of clear cell-type RCC (ccRCC) in the left kidney is reported in a male who had undergone left radical nephrectomy at 55 years of age. Computed tomography (CT) revealed a mass in the right adrenal gland 5 years following surgery, and type-B ultrasound demonstrated a 1.0-cm solid space-occupying lesion in the right wall of the bladder. Consequently, laparoscopic right adrenalectomy and transurethral resection of the bladder tumor were performed. Furthermore, based on histopathological examination and immunohistochemical staining, the patient was pathologically diagnosed with contralateral adrenal gland and urinary bladder metastasis of ccRCC. CT performed at the 1-year follow-up detected multiple solid space-occupying lesions in the right kidney. Therefore, the patient was treated with sunitinib targeted therapy. To date, the patient is generally in good condition, without evident drug side effects or complaints of discomfort.

Abstract 5095: 1,25D3 inhibits migration and invasion through miR-101-3p in human bladder cancer cells

Abstract Bladder cancer is the fourth most common cancer diagnosed and eighth leading cause of cancer death in men. Metastasis is the primary reason for mortality. The 5-year survival rates for localized and metastatic bladder cancers are 94% and 6%, respectively. Therefore, more effective strategies to prevent and inhibit bladder cancer invasion and metastasis are needed to prolong survival. Epidemiological and experimental studies support a role for 1,25(OH) 2D3 (1,25D3) in cancer prevention and treatment. More recently, 1,25D3 has also been reported to inhibit tumor cell invasion and metastasis in several model systems. To study the anti-tumor effect of 1,25D3 in bladder cancer, we selected four human bladder cell lines including T24, 253J, 253J-BV and TCC-SUP cells. 253J-BV is a metastatic line generated from 253J cells through a series of orthotopic inoculation. Vitamin D receptor was expressed and induced by 1,25D3 in all four cell lines. However, treatment with 1,25D3 did not significantly affect the proliferation of the bladder cancer cell lines. To investigate the impact of 1,25D3 on bladder cancer cell migration and invasion, the cells were treated with control EtOH or 1,25D3 in the wound healing assay or chamber-based migration or invasion assays. 1,25D3 suppressed migration and invasion of 253J-BV and TCC-SUP cells but neither 253J nor T24 cells. MiRNAs play critical regulatory roles in cancer cell migration and invasion. We selected 253J and 253J-BV cells for further investigation of the role of miRNAs in 1,25D3 regulation of migration and invasion. Our previous PCR panel studies showed that 1,25D3 differentially regulated miRNA expression profiles in 253J and 253J-BV cells. From the markedly regulated miRNAs, we chose miR-101-3p and miR-126-3p to examine their potential contribution to the inhibition of migration and invasion by 1,25D3. 1,25D3 induced the expression of miR-101-3p and reduced miR-126-3p expression in 253J-BV cells but not 253J cells. To investigate the role of the two miRNAs, we employed pre-miR and miRNA inhibitors. Transfection with miR-101-3p inhibitor vector suppressed migration and invasion in 253J-BV cells. In addition, miR-101-3p inhibitor rescued 1,25D3-induced inhibition of migration and invasion in 253J-BV cells. On the other hand, pre-miR-101-3p transfection followed by 1,25D3 treatment resulted in further reduction of migration and invasion in 253J-BV cells. However, transfection with miR-126-3p inhibitor or pre-miR-126-3p did not alter 1,25D3-inhibition of migration and invasion in 253J-BV cells. These results indicate that 1,25D3 suppresses migration and invasion through the induction of miR-101-3p in human bladder cancer 253J-BV cells. Citation Format: Yingyu Ma, Wei Luo, Rachel Pratt, Donald L. Trump, Candace S. Johnson. 1,25D3 inhibits migration and invasion through miR-101-3p in human bladder cancer cells. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 5095. doi:10.1158/1538-7445.AM2015-5095

10 Bladder metastasis from renal cell carcinoma: Retrospective analysis of 65 reported cases

10 Bladder metastasis from renal cell carcinoma: Retrospective analysis of 65 reported cases

Bladder metastasis from renal cell carcinoma: retrospective analysis of 65 reported cases

This study was carried out to clarify the presentation, treatment options, and prognosis of renal cell carcinoma (RCC) metastasis to the bladder in which we do not yet have a comprehensive understanding. A systematic Medline, Web of Science, Embase, Google, and Ichushi Web search was performed to identify articles describing RCC metastasis to the bladder. The final cohort included 65 patients. The majority (75%) experienced gross hematuria at the point of diagnosis of RCC. RCC metastasis to the bladder occurred both synchronously (23%) and metachronously (77%), and the median time for metachronous bladder metastasis following the diagnosis of RCC was 33 months. Of the 58 patients whose metastatic data were available, 36 (62%) had metastasis to the bladder only, while 22 (38%) had additional sites of metastasis. On pathology, clear cell carcinoma was the most common histology (92%) and all bladder tumors were consistent with RCC metastasis; the median tumor size was 2.1 cm, and two-thirds of cases were superficial (non-muscle invasive) disease. The 2-year cancer-specific survival rate in patients with solitary bladder metastasis was 71.1%, which was significantly higher than in patients with additional distant metastasis (25.8%, p = 0.007). Regarding the interval after the diagnosis of primary RCC, the 2-year cancer-specific survival rate in patients who experienced bladder metastasis after more than a 1 year follow-up was 58.4%, compared to 34.6% in their counterparts (p = 0.063). A curative resection may provide a good possibility of long-term survival, particularly in those with a solitary bladder metastasis and/or a long interval after nephrectomy.

Vulvar melanoma with urethral invasion and bladder metastases - a case report and review of the literature.

Vulvar melanoma is an aggressive neoplasm with a poor prognosis. Approximately 25% to 50% of patients survive 5 years [1]. This malignancy is prone to late metastasis, so 5-year survival does not equal cure. The management of recurrent disease continues to be experimental and individualized [2].

Metastasis of Gastric Signet-Ring Cell Carcinoma to the Urinary Bladder: A Case Report and Review of the Literature.

Although signet-ring cell (SRC) adenocarcinoma is commonly seen in the stomach, it is a very rarely seen histologic entity in the bladder. It is difficult to distinguish primary SRC adenocarcinoma of the bladder from bladder metastasis of SRC carcinoma of the stomach only based on histological findings. In such cases, clinical findings and immunohistochemical studies may be helpful. We present here a 48-year-old male patient presenting with hematuria and abdominal pain. Computerised tomography of the patient revealed a gastric mass, peritoneal involvement, and thickening of the bladder wall, and histopathological analysis revealed SRC adenocarcinoma in both of the endoscopic biopsies taken from the stomach and bladder. Immunohistochemical analyses confirmed the diagnosis of SRC adenocarcinoma of the bladder secondary to gastric cancer.

Metastatic renal cell carcinoma to the urinary bladder: a report of 11 cases.

Metastatic renal cell carcinoma (RCC) to the urinary bladder is rarely seen. Herein, we report the histologic subtypes, immunohistochemical characteristics, and prognosis of 11 patients with metastatic RCC to the urinary bladder. The mean age at the time of diagnosis of metastatic RCC to the bladder was 66 years (range, 58 to 79 y). There were 9 male and 2 female patients. Four patients presented with hematuria, 2 with urinary retention/obstruction, and 1 with bladder calculi. Four patients were asymptomatic and presented for surveillance cystoscopy, wherein they were found to have bladder masses. Nine patients had prior histories of RCC. The remaining 2 patients presented with metastatic clear cell RCC to the bladder and were subsequently found to have renal masses. The average time between nephrectomy and metastasis to the bladder was 20.7 months (range, 0 to 87 mo). Of the 10 patients with radical/partial nephrectomy, 7 cases were clear cell (2 with sarcomatoid features), 2 papillary, and 1 chromophobe with histologic fidelity between the primary and metastasis. Of cases with available data, the primaries' ISUP nucleolar grades were 2 (n=2), 3 (n=4), and 4 for the 2 cases with sarcomatoid features. In 8 cases, the bladder RCC undermined overlying urothelium with extensive urothelial denudation, and in 3 cases the RCC was free floating without attachment to the urothelium. The 1 chromophobe RCC metastasized with pagetoid spread to a preexisting urothelial papilloma. PAX8 immunohistochemistry was used to confirm the diagnosis in 2 cases. Three patients have no evidence of disease (7, 9, and 13 mo). Two are alive with disease after chemotherapy (30, 37 mo). Six patients are dead of disease with multiorgan metastases; 4 are dead after therapy (5, 8, 25, 28 mo), and two died without radiation or chemotherapy at 10 and 71 months. Metastatic RCC to the urinary bladder is uncommon, with most cases clear cell RCC. In some cases, evidence supports "drop metastases" as the mechanism of spread and patients have relatively long survival. However, in other cases spread to the bladder is in the setting of metastases to other sites, and these patients tended to die relatively shortly after their bladder metastases.

Non-papillary bladder metastasis from pancreatic adenocarcinoma

Non-papillary bladder metastasis from pancreatic adenocarcinoma

Analysis of the treatment and prognosis for gestational trophoblastic neoplasia patients with urinary system and adrenal glands metastasis

To analyze the treatment and prognosis of patients with gestational trophoblastic neoplasia with urinary system and adrenal glands metastasis. The treatment and prognoses of 32 patients with gestational trophoblastic neoplasia with urinary system and adrenal glands metastasis from Dec. 1990 to Dec. 2010 at Peking Union Medical College Hospital, Chinese Academy of Medical Sciences were respectively reviewed. Treatment methods: all 32 patients received 9 courses(in average) of a multi- drug chemotherapy in our hospital (range 1-24 coures). Among them, 3 patients with bladder metastasis received intravesical chemotherapy of fluorouracil. 9 patients received surgical treatments in other hospital and 15 patients received surgical treatments while undergoing chemotherapy in our hospital. Treatment results: after the treatments, of the 32 patients, 21 (66%) patients achieved complete remission, 3(9%) exhibited partial remission and 8 (25%) progressed. Seven patients with renal metastasis achieved complete remission. Two patients with adrenal glands metastasis achieved complete remission. Nine patients with urinary bladder metastasis achieved complete remission. Seven patients with ureters metastasis achieved complete remission. Two (10% ) of 21 patients with complete remission relapsed. Multidrug and multiroute chemotherapy is the main strategy for patients with gestational trophoblastic neoplasia with urinary system and adrenal glands metastasis. The prognoses of patients with renal or adrenal glands metastasis are much worse than those in patients with bladder and ureters metastasis because of concomitant multiogran metastasis. Adequate attention should be given to patients with renal or adrenal glands metastasis. Individual treatment, assisted by surgery when necessary, may be carried out for these patients to achieve a better outcome.

La vessie : un site rare de métastase de cancer du sein

Bladder metastasis of breast origin are rare. Lobular carcinoma is the most frequent histological subtype of the primary tumor. This secondary location can be the only one or can be associated with other locations. The prognosis is poor. The period between primary breast tumor and the development of bladder metastasis is variable. Herein is reported the case of a 68-year-old woman presenting with irritative disorders. Urological examination was performed and made the diagnosis. When having a history of breast cancer, the occurrence of urinary symptoms require radiographics and a cystoscopy.

Expression and clinical significance of Twist, E-cadherin and N-cadherin in bladder carcinoma by tissue microarray

Objective To investigate the expression of Twist,E-cadherin and N-cadherin in bladder urothelial carcinoma and evaluate their relationships with tumor.Methods From January 1998 to June 2007,the expression of Twist,E-cadherin and N-cadherin protein were detected in 180 bladder urothelial carcinoma tissue specimens in paraffin blocks and 60 normal bladder tissue specimens by tissue microarray and immunohistochemistry.Results Compared with normal hladder tissues,the expression of Twist and N-cadherin was up-regulated in bladder carcinoma tissues and the positive percentage was 63.9％ and 47.8％ respectively.The percentage of high E-cadherin expression in bladder carcinoma tissues was only 27.8％,which was significantly lower than that in normal bladder tissues.The expression of Twist was significantly related with age,tumor number,vessel invasion,distant metastasis and lymph node metastasis (P＜0.05).The expression of E-cadherin was significantly related with distant metastasis and lymph node metastasis (P＜ 0.05).The expression of N-cadherin was significantly related with distant metastasis and lymphnode metastasis (P＜0.05).There was significant positive correlation between Twist and E-cadherin expression (P＜ 0.05).There was significant positive correlation between Twist anl N-cadherin expression (P＜0.05).There was negative correlation between E-cadherin and N-cadherin expression.All the 180 bladder carcinoma patients were followed up after the surgery,and the mean follow-up time was (35.2±9.1) months.The 5-year survival rates of patients with low and high Twist expressions were 67.7％ and 46.1％ respectively,and there was significant difference between the two groups (P＜0.05).The multivariate analysis indicated that the Twist expression was an independent prognostic factor of bladder carcinoma.Conclusions The high expression of Twist,E-cadherin and N-cadherin are involved in the processes of invasion and metastasis of bladder urothelial carcinoma.The Twist expression was one of the independent prognostic factors of bladder urothelial carcinoma. Key words: Twist protein; E-cadherin protein; N-cadherin protein; Bladder urothelial carcinoma; Tissue microarray

Down-regulating ribonuclease inhibitor enhances metastasis of bladder cancer cells through regulating epithelial–mesenchymal transition and ILK signaling pathway

Accumulating evidences implicate that ribonuclease inhibitor (RI) plays a suppressing role in cancer development. However, the mechanisms underlying antitumor of RI remain largely unknown. Epithelial–mesenchymal transition (EMT) is regarded as a key event in tumor progression. The reports have demonstrated that EMT was implicated in metastasis of bladder cancer. Therefore, we suppose that RI might involve regulating EMT of bladder cancer. Here bladder cancer T24 cells were transfected with pGensil-1-siRNA-RI vectors. HE staining, living cell observation, Phalloidine-FITC staining of microfilament, cell adhesion, scratch migration, and Matrigel invasion were examined respectively. RI expression and colocalization with ILK were detected using confocal microscope. Proteins associated with EMT were determined with Western blotting and immunohistochemistry in vivo and in vitro. Effects of RI expression on tumor growth, metastasis and EMT related proteins in BALB/C nude mouse and clinical human bladder cancer specimens were valued with histological, immunohistochemical and immunofluorescent examination respectively. We demonstrated that down-regulating RI increased cell proliferation, migration and invasion, changed cell morphology and adhesion, and rearranged cytoskeleton by inducing EMT and ILK signaling pathway in bladder cancer cells. In addition, we showed that down-regulating RI promoted tumorigenesis and metastasis of bladder cancer in vivo. Finally, we found that bladder cancer with invasive capability had higher Vimentin, Snail, Slug and Twist as well as lower E-cadherin and RI expression in clinical human specimens. Our results suggest that RI could play a novel role in inhibiting metastasis of bladder through regulating EMT and ILK signaling pathway.

English

AIMS & OBJECTIVES: To find out prevalence of gallbladder mass among the patients of gallbladder pathology & define morphological feature of gall bladder masses using real time gray scale ultrasonography and color Doppler flow imaging & power Doppler imaging to find out prevalence of gall stones among the patients of gall bladder mass. MATERIAL AND METHOD: 10424 patients were evaluated for gall bladder pathology with grey scale ultrasonography in between 1.10.12 to 30.09.2013 in Radiodiagnosis department of G.R.M.C. RESULT: 54 patients out of 10424 i.e. 0.5% were found to have gall bladder mass lesion. Among these 79.5% (43) of patients had gall bladder carcinoma, 9.3% (5) had gall bladder polyp, 87.4% (4) had mucocele of gall bladder 1.9% (1) had porcelain gall bladder and 1.9% (1) had gall bladder metastasis. The youngest patient in our study was 12 years old male presented with mucocele. Oldest patient in our study was 68 years old female presented with gallbladder carcinoma.7% of overall gall bladder mass lesion were encountered in females showing clear female preponderance. Gall Stone embedded in 70% of gall bladder mass. CONCLUSION: J.A. group of hospital and G.R. Medical College, Gwalior serve a good proportion of population of M.P. and adjoining area of U.P. and Rajasthan which is endemic for gall bladder pathology. The present study concludes that ultrasonography is a powerful readily available and cost effective tool in the diagnosis of gall bladder pathology.

Une métastase vésicale révélant une linite gastrique : à propos d’un cas et revue de la littérature

Secondary tumors of the bladder are rare, they represent less than 2% of all bladder neoplasms [1]. Most reported cases conform to autopsy series [2].Frequent primitives are the colon, prostate, rectum and cervix. In such cases, the bladder is affected by direct extension, in particular in advanced stage with peritoneal scattering. The vesical metastases of the gastric cancers are secondary to hematogenous spread of tumor cells. Brought back in the literature by some sporadic cases, there were seven cases of adenocarcinoma with cells signet ring [1]. We report the eighth case of bladder metastasis of gastric linitis which has the distinction to be revealing.

Bladder metastasis from lung adenocarcinoma: a difficult differential diagnosis with primary bladder adenocarcinoma

BackgroundBladder metastases from lung adenocarcinoma are extremely rare; in the seven previously reported cases, the finding of an intact epithelium overlying the bladder tumour was considered suggestive of a secondary lesion. We describe the first case of bladder metastasis from lung adenocarcinoma whereby endoscopic appearance was strongly consistent with primary bladder cancer, thus complicating the differential diagnosis with primary bladder adenocarcinoma.Case reportA 65-year-old woman with a 13-year history of clean intermittent catheterization was diagnosed with a right lung adenocarcinoma metastatic to mediastinal and right supraclavicular nodes, as well as to the left lung, and treated with six cycles of cisplatin/pemetrexed, followed by six cycles of pemetrexed only. The 18-month follow-up computed tomography revealed several solid lesions of the bladder wall and she was scheduled for transurethral resection of bladder tumours. Endoscopic appearance was strongly consistent with primary bladder cancer but a thorough pathologic evaluation allowed the diagnosis of bladder metastasis from lung adenocarcinoma.ConclusionsDifferentiating primary bladder adenocarcinoma from metastatic adenocarcinoma lesions can be difficult. An endoscopic appearance consistent with primary bladder cancer further complicates the differential diagnosis, which heavily relies on pathologic evaluation and specific immunohistochemical staining.

Asymptomatic Bladder Metastasis from Breast Cancer

Introduction. Breast cancer is the most common nondermatologic cancer in women. Common metastatic sites include lymph nodes, lung, liver, and bone. Metastases to the bladder are extremely rare, with all reported cases presenting with urinary symptoms. Case Report. Herein, we report the first case of completely asymptomatic bladder metastasis from breast cancer, occasionally revealed, 98 months after the initial diagnosis of lobular breast carcinoma, by a follow-up computed tomography scanning showing thickening of left bladder wall and grade II left hydronephrosis. A positive staining for estrogen and progesterone receptors was confirmed by immunohistochemistry. Discussion. The reported case confirms that bladder metastases from breast cancer tend to occur late after the diagnosis of the primary tumor and, for the first time, points out they can be asymptomatic. Conclusion. Such data support the need for careful follow-up and early intervention whenever such clinical situation is suspected.

A Case of Recurrent Breast Cancer with Solitary Metastasis to the Urinary Bladder

Elderly patients with breast cancer often present with symptomatic, locoregionally advanced rather than screening-detected disease, thereby increasing the risk of metastatic recurrence during their remaining life time. Typical sites of metastases include lungs, bones, liver, and brain. Here we present a patient who developed a solitary urinary bladder metastasis five years after primary diagnosis of stage T4 N0 estrogen receptor-positive lobular carcinoma, while on continued adjuvant endocrine treatment (91 years of age). Anemia and increased serum creatinine resulting from hydronephrosis led to diagnosis of metastatic disease, which was confirmed by transurethral resection. The patient responded clinically to palliative radiotherapy and a different type of endocrine therapy. One year after diagnosis of metastatic disease, she died without signs of cancer progression.

Hematuria from My Stomach? A Case of Metastatic Gastric Cancer with Bladder Metastasis

Hematuria from My Stomach? A Case of Metastatic Gastric Cancer with Bladder Metastasis

One case of renal clear cell carcinoma with solitary urinary bladder metastasis and its literature review

Objective To explore the clinical features,possible transfer mechanisms,and treatment options of renal cell carcinoma with urinary bladder metastasis.Methods The detail of the clinical information of a renal cell carcinoma case with bladder metastasis was reported and the related literatures were reviewed.Result Urinary bladder metastasis of renal cell carcinoma is very rare.The metastasis occurring only in urinary bladder is rarer.Most of the bladder metastasises involve with other organs' metastasis.Conclusions Urinary bladder metastasis of renal cell carcinoma may be hematogenous,lymphatic,and intraluminal seeding as potential mechanism of metastasis.Renal cell carcinoma metastasis occurring only in urinary bladder should be treated with a surgery. Key words: Kidney neoplasm; Neoplasm metastasis; Urinary bladder metastasis.

Occurrence of bladder metastasis 10 years after surgical removal of a primary gastric cancer: a case report and review of the literature

IntroductionSecondary bladder neoplasms are uncommon and they represent only 2% of all malignant bladder tumors.Case presentationThe authors present a case of a 59-year-old Caucasian man with a primary gastric adenocarcinoma that had been surgically removed 10 years before he developed bladder metastasis. He presented with low abdominal pain after 10 years without any symptoms. Cystoscopy and an abdominal computed tomography scan showed a bladder tumor. A transurethral resection of the bladder tumor was performed. A histological examination revealed an adenocarcinoma, which turned out to be a metastasis of the primary gastric tumor. One year later, abdominal surgery revealed peritoneal metastases.ConclusionThis is the first known case in Europe where bladder metastasis occurred 10 years after surgical removal of a primary gastric neoplasm. There are only four cases in the literature where metastases of the peritoneum developed 11 years after surgical removal of a primary gastric tumor.