This study was performed to detect the dispersal of Escherichia coli and Salmonella enterica as well as reveal its antibiogram and spread of ESBL genes in the isolates from retail beef and chicken meat. Eighty-two beef and chicken meat samples have been picked up from butcher's stores and restaurants in Cairo and Giza, Egypt. Escherichia coli were isolated from 15% of examined beef and chicken meat samples, which was 52%, 41%, 12% and 1% from raw beef, raw chicken beef ready for consumption and chicken ready for consumption samples respectively. However, Salmonella enterica was detected from 1% from chicken meat samples ready for consumption only which constitute 5% from different meat samples. Escherichia coli isolates were insensitive to Clindamycin and Rifampin 100% each and showed high resistance to Ciprofloxacin, 78.9%. While Salmonella enterica isolate was unsusceptible to Ceftazidime, Cefepime, Cefotaxime, Clindamycin, Ciprofloxacin and Rifampin. All Escherichia coli isolates as well as, salmonella enterica isolate were phenotypically ESBL positive. All of Escherichia coli isolates contained blaTEM gene while blaSHV gene was detected in 85% and 60% in members of Escherichia coli recovered from raw and ready for consumption meat respectively. blaTEM and blaSHV both genes were detected in Salmonella enterica isolate. While BlaCTX gene did not detect in any of the Escherichia coli and salmonella enterica isolates.