ABSTRACT Introduction: Internal Family Systems (IFS) Therapy has grown in popularity over the last several decades, demonstrating promising utility, especially in the treatment of mood disorders. However, IFS researchers have yet to explore its relevance specifically for Black populations in the United States. Objective: The present study investigated relationships between self-leadership, racial identity attitudes, race related stress, and mental health outcomes. Specifically, this study examined self-leadership as a potential mediator in the relationship between Black racial identity attitudes and the experience of race-related stress and mental health outcomes Methods: Participants (N = 79) were Black-identifying undergraduate students who completed self-report inventories. Mediation analyses were conducted using SPSS. Results: Self-leadership significantly predicted less severe negative mental health outcomes. Additionally, self-leadership fully mediated the relationship between the pre-encounter attitude of self-hatred and mental health outcomes, and self-leadership partially mediated the relationship between multiculturalist inclusive attitudes and stress due to institutional racism. Conclusion: Findings point to the potential utility of a major component of IFS, self-leadership, for future Black clinical populations.