Huge promises, enormous risks, minor safety precautions– that's the thumbnail version of the controversial recent history of nanotechnology, the science of using truly teeny bits of matter (1 nanometer = one-billionth of a meter) to make potentially miraculous new stuff. Someday, perhaps within this decade, carbon “nanotubes” sized one-thousandth the width of a human hair may clean polluted water and cancer could be cured using gold-plated “nanobul-lets” that would heat up and kill tumors. Yet along the way, workers and consumers who handle or inhale volatile nanoparticles may suffer health damage, which wouldn't become clear until the products are in wide use. Nanotech production, most of which is done through chemical synthesis (though some scientists zap particles with lasers), remains without specific regulations to ensure worker safety or shield the environment. Critics say that safety research funding, even including some major recent budget boosts, is as scanty as public understanding of the potential problems. “Nano-technology is, by everyone's definition, the biggest technological revolution the world has ever seen, but society is mostly still in the dark about it”, says Patrick Mooney, who spearheads the international opposition as director of the Action Group on Erosion, Technology and Concentration (ETC), based in Ottawa, Canada. Hopes and concerns about nanotechnology all stem from the same simple rule: substances change the way they behave when broken down into really tiny bits, in some cases acquiring surprising new powers: some get stronger, some turn different colors, and some even explode. Given all the unknowns, the ETC has called for a moratorium on new production, pending new regulations, and is seeking United Nations involvement in future oversight. ETC's call for caution is one of many; Swiss Re, the world's second largest re-insurance company (insuring insurance firms), and the UK's Royal Society and Royal Academy of Engineering have all warned of the need for more safety research. Experiments on animals have shown that once in the body, nanoparticles can travel to the brain. Other research suggests that nanoparticles may damage inhabitant organisms if released in soils and groundwater. While the fantastical fear of “gray goo”, originated by author K Eric Drexler to envision how self-replicating nanorobots might wreak havoc on the Earth, has been widely dismissed, a new nano-threat is “green goo”, suggesting out-of-control engineered teeny life forms. “We take green goo very seriously”, says Drexler. The US government isn't going that far, but over the past few years, it has substantially increased spending to investigate specific safety issues, in what is quickly shaping up to be a historical departure from the usual ways of dealing with emerging technology. According to a representative of the US Office of Science and Technology Policy, who asked to remain anonymous, so far the US federal agencies have dedicated approximately $40 million to specific safety research in FY2006, including spending by the Environmental Protection Agency, the National Science Foundation, the National Institute for Occupational Safety and Health, and the National Institutes of Health. While this money and attention is a major step forward, Mooney and other critics say it is insufficient considering that the US government plans to spend $1 billion on nanotech research projects in FY2006 and that the National Science Foundation predicts that nanotechnology could grow into a $1 trillion industry by 2015. The emerging landscape is reminiscent of the 1990s' biotech boom, when scientists raced to patent inventions and start their own companies. Critics say the huge potential profitability of nanotech innovations may dissuade researchers from focusing sufficient attention on the dark side of the new technology. “There has been no consensus about safety”, says Mooney, “so you'll see workers in private companies in Texas with bare hands and faces, while wearing surgical masks and gloves in France, and space suits in Africa”. Kristen Kulinowski, director of the federally funded Center for Biological and Environmental Nanotechnology at Rice University (Houston, TX), says she's encouraged by the trend towards more spending on safety research, though she emphasizes the danger of making “the same mistake we made with asbestos, PCBs, and DDT”, where products got into the mainstream before the discovery of risks that were so serious they had to be pulled off the market, by which time the damage had been done. Mooney goes further: “There has to be a broader social debate”, he says, noting that the British government has sponsored “juries”, in which lay citizens work with scientists and government officials to pose questions about where the new science is heading. “We need to get society not just to talk but to figure out what the priorities are”, he says. “If that isn't done, there'll be an explosion as changes start to come in.” Katherine Ellison
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