SummaryIn this paper, a 256 × 256 CMOS image sensor is introduced in which the pixel signals are read and converted into digital data in a completely differential mode. This technique helps to obtain pixel signals with higher linearity and accuracy compared with conventional methods. Improving the linearity and accuracy of the image sensor has a direct impact on increasing the quality of the generated images. The simulation results of the proposed pixel readout circuit show that the THD, SINAD, SNR, and SFDR are 0.45%, 47 dB, 66 dB, and 46 dB, respectively. The voltage gain of the proposed readout circuit is about 1, causing it to read the photodetector signals more accurately than the conventional methods. A full differential single‐slope ADC with a working frequency of 50 Mhz has the task of converting the pixel signal to 10 bits of digital data. The total power consumption of a column of sensors is about 80 μW. All the circuits are designed and implemented using 0.18‐μm CMOS technology in Virtuoso and simulated by the SPECTRE.