Bisphenol A (BPA) as a trace contaminant has been reported, due to widespread use in the plastics industry. This study applied the 35 kHz ultrasound (US) to activate four different common oxidants (H2O2, HSO5−, S2O82−, and IO4−) for BPA degradation. With increasing initial concentration of oxidants, the degradation rate of BPA increased. The synergy index confirmed that a synergistic relationship between US and oxidants. This study also examined the impact of pH and temperature. The results showed that the kinetic constants of US, US-H2O2, US-HSO5- and US-IO4−decreased when the pH increased from 6 to 11. The optimal pH for US-S2O82− was 8. Notably, increasing temperature decreased the performance of US, US-H2O2, and US-IO4- systems, while it could increase the degradation of BPA in US-S2O82− and US-HSO5-. The activation energy for BPA decomposition using the US-IO4- system was the lowest, at 0.453nullkJnullmol−1, and the synergy index was the highest at 2.22. Additionally, the ΔG# value was found to be 2.11 + 0.29T when the temperature ranged from 25 °C to 45 °C. The main oxidation contribution is achieved by hydroxyl radicals in scavenger test. The mechanism of activation of US-oxidant is heat and electron transfer. In the case of the US-IO4- system, the economic analysis yielded 271 kwh m−3, which was approximately 2.4 times lower than that of the US process.