Gay, lesbians and bisexual young people are at increased risk for mental disorder including depression, suicide attempts and suicide ideation. To present a female patient who admitted to psychiatry outpatient clinic with depressive symptoms developing upon decision of her girlfriend to marry. A 38 years old unmarried woman, living with an opressive family refered to outpatient clinic with depressive mood, sensitiveness, loss of interest, general fatigue, forgetfulness, insomnia, irritability, decrease in self-esteem lasting for about 1.5 month. She came to clinic with a woman younger than her. She stated that she had many friends but she was different and special for her. She revealed that the depressive symptoms occured upon decision of her girlfriend to marry. Her girlfriend would move to another city in 5-6 month. She said that she could not cope with her seperation, although she assumed herself as rigid and strong person. Her girlfriend also mentioned the relationship with the patient. She was diagnosed as major depression. Patient was prescribed 20 mgday citaloprame with supportive psychotherapy. Despite paucity of data on depression among lezbian, this group is generally thought to be at greater risk for depression than are heterosexual women. In addition to shared risk factors with heteresexual women, lezbians have additional unique risk factors. Furthermore, this case report reveals some cultural factors can be particularly important for a lezbian's psychological well-being.