Anatomy: Roux-Y hepaticojejunostomy: liver transplant (live donor, N 8; cadaveric, N 3), cholecystectomy injury revision (N 9), other (N 7). Technical Success: 94% in OA-ERCP vs. 73% in PTBD (p 0.27). Median months to resolve AS: 2 (0-9.5) in OA-ERCP vs. 7.5 (3-34) in PTBD (p 0.03). Number of subsequent procedures in OA-ERCP vs. PTBD group were 28 (median 1, range 0-10) vs. 104 (median 5, range 2-43)(p 0.002). OA-ERCP group had 42 (median 2, range 1-11) total interventions: dilation and/or cautery (N 22), dilation/ cautery/stent (N 3), subsequent PTBD (N 18). PTBD group had 111 (median 6, range 3-44) total interventions: int/ext drain placement(N 11), balloon dilation/ drain exchange(N 27), drain exchanges only (N 60), drain removals (N 11), and subsequent ERCP to traverse AS (N 2). Complications: OA-ERCP perforation (N 2; non-operative) and bleeding (N 1); PTC cholangitis(N 2), fistula (N 1), and bacteremia/sepsis (N 2)(19% vs. 46%, p 0.21). Median postprocedural hospitalization days in OA-ERCP 0 (0-1) vs. 2 (1-51)in PTBD (p 0.0002). Follow-up for median 11 months (1-42) in 25/27 (92.6%) patients. Clinical improvement in OA-ERCP vs. PTBD group was 86% vs 60%, respectively (p 0.19). None of the ERCP and 9.1% in PTBD group required surgical intervention (p 0.48). Conclusions: 1)OA-ERCP is associated with fewer procedures and post-procedural hospitalization days to achieve success rates similar to PTBD. 2) Clinical improvement is seen in the majority of patients with documented anastomotic strictures treated by OA-ERCP or PTBD. 3) In expert hands, OA-ERCP for treating AS may be the preferred choice due to the need for fewer procedures and a shorter duration of treatment to achieve AS resolution.
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