Bipolar Morphology Research Articles

Feeding post-core collapse supernova explosion jets with an inflated main sequence companion

ABSTRACT We simulate the response of a main sequence star to the explosion of a stripped-envelope (type Ib or Ic) core-collapse supernova (CCSN) when the main sequence star orbits the core at a distance of $10 \, \mathrm{R}_\odot$ or $20 \, \mathrm{R}_\odot$ at explosion. We use the stellar evolution code mesa to follow the response of main sequence stars of masses $3 \, \mathrm{M}_\odot$ and $7\, \mathrm{M}_\odot$ to energy deposition and mass removal. The collision of the CCSN ejecta with the main sequence star deposits energy and inflate the main sequence star. If the binary system stays bound after the CCSN explosion, the inflated main sequence star might engulf the newly born neutron star (NS). We assume that the NS accretes mass through an accretion disc and launches jets. The jets remove mass from the inflated main sequence star and collide with the CCSN ejecta. Although this scenario is rare, it adds up to other rare scenarios to further support the notion that many stripped envelope CCSNe are powered by late jets. The late jets can power these CCSNe-I for a long time and might power bumps in their light curve. The jets might also shape the inner ejecta to a bipolar morphology. Our results further support suggestions that there are several ways to feed an NS (or a black hole) to launch the late jets in superluminous supernovae.

Unexplored outflows in nearby low luminosity AGNs

Context. Multi-phase outflows play a central role in galaxy evolution shaping the properties of galaxies. Understanding outflows and their effects in low luminosity active galactic nuclei (AGNs), such as low ionisation nuclear emission line regions (LINERs), is essential. LINERs bridge the gap between normal and active galaxies, being the most numerous AGN population in the local Universe. Aims. Our goal is to analyse the kinematics and ionisation mechanisms of the multi-phase gas of NGC 1052, the prototypical LINER, in order to detect and map the ionised and neutral phases of the putative outflow. Methods. We obtained Very Large Telescope MUSE and Gran Telescopio Canarias MEGARA optical integral field spectroscopy data for NGC 1052. In addition to stellar kinematics maps, by modelling spectral lines with multiple Gaussian components, we obtained flux, kinematic, and excitation maps of both ionised and neutral gas. Results. The stars are distributed in a dynamically hot disc (V/σ ∼ 1.2), with a centrally peaked velocity dispersion map (σc = 201 ± 10 km s−1) and large observed velocity amplitudes (ΔV = 167 ± 19 km s−1). The ionised gas, probed by the primary component is detected up to ∼30″ (∼3.3 kpc) mostly in the polar direction with blue and red velocities (∣V∣ < 250 km s−1). The velocity dispersion map shows a notable enhancement (σ > 90 km s−1) crossing the galaxy along the major axis of rotation in the central 10″. The secondary component has a bipolar morphology, velocity dispersion larger than 150 km s−1, and velocities up to 660 km s−1. A third component is detected with MUSE (and barely with MEGARA), but it is not spatially resolved. The broad-line region (BLR) component (used to model the broad Hα emission only) has a full width at half maximum of 2427 ± 332 and 2350 ± 470 km s−1 for MUSE and MEGARA data, respectively. The maps of the NaD absorption indicate optically thick neutral gas with complex kinematics. The velocity field is consistent with a slow rotating disc (ΔV = 77 ± 12 km s−1), but the velocity dispersion map is off-centred without any counterpart in the (centrally peaked) flux map. Conclusions. We found evidence of an ionised gas outflow (secondary component) with a mass of 1.6 ± 0.6 × 105 M⊙, and mass rate of 0.4 ± 0.2 M⊙ yr−1. The outflow is propagating in a cocoon of gas with enhanced turbulence and might be triggering the onset of kiloparsec-scale buoyant bubbles (polar emission), both probed by the primary component. Taking into account the energy and kinetic power of the outflow (1.3 ± 0.9 × 1053 erg and 8.8 ± 3.5 × 1040 erg s−1, respectively) as well as its alignment with both the jet and the cocoon, and that the gas is collisionally ionised (due to gas compression), we consider that the most likely power source of the outflow is the jet, although some contribution from the AGN is possible. The hints of the presence of a neutral gas outflow are weak.

The Planetary Nebula in the 500 Myr Old Open Cluster M37

We report confirmation of a large, evolved, bipolar planetary nebula and its blue, white dwarf central star as a member of the ∼500 Myr old Galactic open star cluster M37 (NGC 2099). This is only the third known example of a planetary nebula in a Galactic open cluster and was found via our ongoing program of identifying and studying planetary nebulae—open cluster associations. High confidence in the association comes from the consistent radial velocities and proper motions for the confirmed central star and cluster stars from Gaia, reddening agreement, and location of the planetary nebula well within the tidal cluster boundary. Interestingly, all three Galactic examples have bipolar morphology and likely Type-I chemistry, both characteristics of higher mass progenitors. In this case the progenitor star mass is in the midrange of ∼2.8 M ☉. It provides a valuable, additional point on the key stellar initial-to-final mass relation independent of cluster white dwarf estimates and also falls in a gap in the poorly sampled mass region. This planetary nebula also appears to have the largest kinematical age ever determined and implies increased visibility lifetimes when they are located in clusters.

Study of 2021 outburst of the recurrent nova RS Ophiuchi: Photoionization and morphokinematic modelling

ABSTRACT We present the evolution of the optical spectra of the 2021 outburst of RS Ophiuchi (RS Oph) over about a month after the outburst. The spectral evolution is similar to the previous outbursts. Early spectra show prominent P Cygni profiles of hydrogen Balmer, Fe ii, and He i lines. The emission lines were very broad during the initial days, which later became narrower and sharper as the nova evolved. This is interpreted as the expanding shocked material into the winds of the red giant companion. We find that the nova ejecta expanded freely for ∼4 d, and afterwards, the shock velocity decreased monotonically with time as v ∝ t−0.6. The physical and chemical parameters associated with the system are derived using the photoionization code cloudy. The best-fitting cloudy model shows the presence of a hot central white dwarf source with a roughly constant luminosity of ∼1.00 × 1037 erg s−1. The best-fitting photoionization models yield absolute abundance values by number, relative to solar of He/H ∼1.4–1.9, N/H = 70–95, O/H = 0.60–2.60, and Fe/H ∼1.0–1.9 for the ejecta during the first month after the outburst. Nitrogen is found to be heavily overabundant in the ejecta. The ejected hydrogen shell mass of the system is estimated to be in the range of $3.54 - 3.83 \times 10^{-6}\, {\rm M}_{\odot }$. The 3D morphokinematic modelling shows a bipolar morphology and an inclination angle of i = 30° for the RS Oph binary system.

Design of ECM Functionalized Polycaprolactone Aligned Nanofibers for Peripheral Nerve Tissue Engineering

PurposePeripheral nerve injury (PNI) and its regeneration continue to remain a significant medical burden worldwide. The current treatment strategies used to treat PNI are often associated with multiple complications and yet do not achieve complete motor and sensory functions. Recently, synthetic biodegradable nerve conduits have become one the most commonly used conduits to repair small gaps in nerve injury. But they have not shown better results than nerve grafts possibly because of the lack of biological microenvironment required for axonal growth. Schwann cells play a very crucial role in peripheral nerve regeneration where activated SCs produce multiple neurotrophic factors that help in remyelination and immune modulation during nerve repair. Studies have shown that nanofibrous scaffolds have better bioactivity and more closely mimic the native structure of the extracellular matrix. Therefore, the present study was focused on designing a nanofibrous scaffold that would cover the roles of both structural support for the cells that can provide a microenvironment with biological cues for nerve growth and regeneration.MethodsDecellularized Schwann cell ECM were spin-coated on polycaprolactone random and aligned nanofibrous scaffolds and their compatibility was evaluated using Schwann cells.ResultsSchwann cells displayed growth in the direction of the aligned PCL nanofibers and ACM treated exhibited appropriate bipolar morphology indicating that these modified fibers could provide directional cues making them highly suitable for neuronal cell growth.ConclusionOur results indicate that the fabricated aligned SC-ACM treated PCL scaffolds would be a potential biomaterial to treat peripheral nerve injuries and promote regeneration.Graphical

Carbon Abundances in Compact Galactic Planetary Nebulae: An Ultraviolet Spectroscopic Study with the Space Telescope Imaging Spectrograph (STIS)

We surveyed a sample of compact Galactic planetary nebulae (PNe) with the Space Telescope Imaging Spectrograph on the Hubble Space Telescope (HST) to determine their gas-phase carbon abundances. Carbon abundances in PNe constrain the nature of their asymptotic giant branch (AGB) progenitors, as well as cosmic recycling. We measured the carbon abundances, or the limits thereof, of 11 compact Galactic PNe, notably increasing the sample of Galactic PNe whose carbon abundance based on HST ultraviolet spectra is available. The dust content of most targets has been studied elsewhere from Spitzer spectroscopy; given the compact nature of the nebulae, both UV and IR spectra can be directly compared to study gas- and dust-phase carbon. We found that carbon-poor (C/O < 1) compact Galactic PNe have an oxygen-rich dust type, while their carbon-enhanced counterparts (C/O > 1) have carbon-rich dust, confirming the correlation between gas- and dust-phase carbon content that was known for Magellanic Cloud PNe. Based on models of expected final yields from AGB evolution, we interpret the majority of the carbon-poor PNe in this study as the progeny of ∼1.1–1.2 M ⊙ stars that experienced some extra mixing on the red giant branch. They went through the AGB but did not go through the carbon star phase. Most PNe in this group have a bipolar morphology, possibly due to the presence of a subsolar companion. The carbon-enhanced PNe in our sample could be the progeny of stars in the ∼1.5–2.5 M ⊙ range, depending on their original metallicity.

In vivo electrophysiological study of the targeting of 5-HT3 receptor-expressing cortical interneurons by the multimodal antidepressant, vortioxetine.

The antidepressant vortioxetine has high affinity for the ionotropic 5‐HT3 receptor (5‐HT3R) as well as other targets including the 5‐HT transporter. The procognitive effects of vortioxetine have been linked to altered excitatory:inhibitory balance in cortex. Thus, vortioxetine purportedly inhibits cortical 5‐HT3R‐expressing interneurons (5‐HT3R‐INs) to disinhibit excitatory pyramidal neurons. The current study determined for the first time the effect of vortioxetine on the in vivo firing of putative 5‐HT3R‐INs whilst simultaneously recording pyramidal neuron activity using cortical slow‐wave oscillations as a readout. Extracellular single unit and local field potential recordings were made in superficial layers of the prefrontal cortex of urethane‐anaesthetised rats. 5‐HT3R‐INs were identified by a short‐latency excitation evoked by electrical stimulation of the dorsal raphe nucleus (DRN). Juxtacellular‐labelling found such neurons had the morphological and immunohistochemical properties of 5‐HT3R‐INs: basket cell or bipolar cell morphology, expression of 5‐HT3R‐IN markers and parvalbumin‐immunonegative. Vortioxetine inhibited the short‐latency DRN‐evoked excitation of 5‐HT3R‐INs and simultaneously decreased cortical slow wave oscillations, indicative of pyramidal neuron activation. Likewise, the 5‐HT3R antagonist ondansetron inhibited the short‐latency DRN‐evoked excitation of 5‐HT3R‐INs. However unlike vortioxetine, ondansetron did not decrease cortical slow‐wave oscillations, suggesting a dissociation between this effect and inhibition of 5‐HT3R‐INs. The 5‐HT reuptake inhibitor escitalopram had no consistent effect on any electrophysiological parameter measured. Overall, the current findings suggest that vortioxetine simultaneously inhibits (DRN‐evoked) 5‐HT3R‐INs and excites pyramidal neurons, thereby changing the excitatory:inhibitory balance in cortex. However, under the current experimental conditions, these two effects were dissociable with only the former likely involving a 5‐HT3R‐mediated mechanism.

An XMM-Newton EPIC X-Ray View of the Symbiotic Star R Aquarii

Abstract We present the analysis of archival XMM-Newton European Photon Imaging Camera (EPIC) X-ray observations of the symbiotic star R Aquarii. We used the Extended Source Analysis Software package to disclose diffuse soft X-ray emission extending up to 2.′2 (≈0.27 pc) from this binary system. The depth of these XMM-Newton EPIC observations reveals in unprecedented detail the spatial distribution of this diffuse emission, with a bipolar morphology spatially correlated with the optical nebula. The extended X-ray emission shares the same dominant soft X-ray-emitting temperature as the clumps in the jet-like feature resolved by Chandra in the vicinity of the binary system. The harder component in the jet might suggest that the gas cools down; however, the possible presence of nonthermal emission produced by the presence of a magnetic field collimating the mass ejection cannot be discarded. We propose that the ongoing precessing jet creates bipolar cavities filled with X-ray-emitting hot gas that feeds the more extended X-ray bubble as they get disrupted. These EPIC observations demonstrate that the jet feedback mechanism produced by an accreting disk around an evolved, low-mass star can blow hot bubbles, similar to those produced by jets arising from the nuclei of active galaxies.

Role of Macrophages and Mast Cells as Key Players in the Maintenance of Gastrointestinal Smooth Muscle Homeostasis and Disease.

The gut contains the largest macrophage pool in the body, with populations of macrophages residing in the mucosa and muscularis propria of the gastrointestinal (GI) tract. Muscularis macrophages (MMs), which are located within the muscularis propria, interact with cells essential for GI function, such as interstitial cells of Cajal, enteric neurons, smooth muscle cells, enteric glia, and fibroblast-like cells, suggesting that these immune cells contribute to several aspects of GI function. This review focuses on the latest insights on the factors contributing to MM heterogeneity and the functional interaction of MMs with other cell types essential for GI function. This review integrates the latest findings on macrophages in other organs with increasing knowledge of MMs to better understand their role in a healthy and diseased gut. We describe the factors that contribute to (muscularis macrophage) MM heterogeneity, and the nature of MM interactions with cells regulating GI function. Finally, we also describe the increasing evidence suggesting a critical role of another immune cell type, the mast cell, in normal and diseased GI physiology.

Novel Mg-0.5Ca-xMn Biodegradable Alloys Intended for Orthopedic Application: An In Vitro and In Vivo Study.

Mg-based biodegradable materials, used for medical applications, have been extensively studied in the past decades. The in vitro cytocompatibility study showed that the proliferation and viability (as assessed by quantitative MTT-assay—3-(4,5-dimethyltiazol-2-yl)-2,5-diphenyl tetrazolium bromide) were not negatively affected with time by the addition of Mn as an alloying element. In this sense, it should be put forward that the studied alloys don’t have a cytotoxic effect according to the standard ISO 10993-5, i.e., the level of the cells’ viability (cultured with the studied experimental alloys) attained both after 1 day and 5 days was over 82% (i.e., 82, 43–89, 65%). Furthermore, the fibroblastic cells showed variable morphology (evidenced by fluorescence microscopy) related to the alloy sample’s proximity (i.e., related to the variation on the Ca, Mg, and Mn ionic concentration as a result of alloy degradation). It should be mentioned that the cells presented a polygonal morphology with large cytoplasmic processes in the vicinity of the alloy’s samples, and a bipolar morphology in the remote region of the wells. Moreover, the in vitro results seem to indicate that only 0.5% Mn is sufficient to improve the chemical stability, and thus the cytocompatibility; from this point of view, it could provide some flexibility in choosing the right alloy for a specific medical application, depending on the specific parameters of each alloy, such as its mechanical properties and corrosion resistance. In order to assess the in vivo compatibility of each concentration of alloy, the pieces were implanted in four rats, in two distinct body regions, i.e., the lumbar and thigh. The body’s reaction was followed over time, 60 days, both by general clinical examinations considering macroscopic changes, and by laboratory examinations, which revealed macroscopic and microscopic changes using X-rays, CT(Computed Tomography), histology exams and SEM (Scanning Electron Microscopy). In both anatomical regions, for each of the tested alloys, deformations were observed, i.e., a local reaction of different intensities, starting the day after surgery. The release of hydrogen gas that forms during Mg alloy degradation occurred immediately after implantation in all five of the groups examined, which did not affect the normal functionality of the tissues surrounding the implants. Imaging examinations (radiological and CT) revealed the presence of the alloy and the volume of hydrogen gas in the lumbar and femoral region in varying amounts. The biodegradable alloys in the Mg-Ca-Mn system have great potential to be used in orthopedic applications.

Morphology, physiology and synaptic connectivity of local interneurons in the mouse somatosensory thalamus.

The thalamic reticular nucleus (TRN) neurons, projecting across the external medullary lamina, have long been considered to be the only significant source of inhibition of the somatosensory ventral posterior (VP) nuclei of the thalamus. Here we report for the first time effective local inhibition and disinhibition in the VP. Inhibitory interneurons were found in GAD67–GFP‐expressing mice and studied using in vitro multiple patch clamp. Inhibitory interneurons have expansive bipolar or tripolar morphologies, reach across most of the VP nucleus and display low threshold bursting behaviour. They form triadic and non‐triadic synaptic connections onto thalamocortical relay neurons and other interneurons, mediating feedforward inhibition and disinhibition. Synaptic inputs arrive before those expected from the TRN neurons, suggesting that local inhibition plays an early and significant role in the functioning of the somatosensory thalamus. Key points The physiology and structure of local interneurons in the mouse somatosensory thalamus is described for the first time.Inhibitory interneurons have extensive dendritic arborization providing significant local dendro‐dendritic inhibition in the somatosensory thalamus.Triadic and non‐triadic synaptic connectivity onto thalamic relay neurons and other interneurons provides both local feedforward inhibition and disinhibition.Interneurons of the somatosensory thalamus provide inhibition before the thalamic reticular nucleus, suggesting they play an important role in sensory perception.

Significance of electrical activity in the right superior pulmonary vein post-isolation and relationship to superior vena cava potentials.

After antral pulmonary vein isolation (PVI), electrical potentials may persist deep in the right superior pulmonary vein (RSPV). Whether these potentials signify true pulmonary vein potential (PVP) (implying inadequate RSPV isolation) or are far-field potentials (FFP) from the superior vena cava (SVC) is unclear. Here, we attempt to assess the incidence of persistent potentials in RSPV post-isolation and methods to differentiate PVP from FFP. Following PVI, we mapped the RSPV and the SVC with simultaneously placed catheters. We recorded the incidence of SVC potentials, RSPV potentials, and distance between the 2 structures. When RSPV potentials were present, we assessed (1) relationship to SVC potentials, (2) RSPV-SVC distance, and (3) responses on pacing from either site. Among 43 consecutive post-PVI patients, 39 (91%) patients had SVC electrical activity but only 10 had persistent RSPV potentials. Of these, 2/10 had true PVP, and 8 were FFP from SVC. Bipolar electrogram morphology did not differentiate PVP from FFP, but low-amplitude (5mA) SVC pacing was an effective maneuver. However, high-amplitude (≥ 10mA) pacing from SVC and/or RSPV could result in far-field capture of the other site even when RSPV was devoid of electrical activity. Average RSPV-SVC distance was 15.9mm. Persistent RSPV potentials occur rarely post-PVI despite the close proximity to electrically active SVC. When present, true PVP can be differentiated from FFP by low-amplitude pacing from SVC. Bipolar EGM morphology and high-amplitude pacing are unreliable at differentiating these potentials.

Evidence for PKD2L1-positive neurons distant from the central canal in the ventromedial spinal cord and medulla of the adult mouse.

Neurons in contact with the cerebrospinal fluid (CSF) are found around the medullo-spinal central canal (CC) in adult mice. These neurons (CSF-cNs), located within or below the ependymal cell layer, known as the stem cell niche, present a characteristic morphology with a dendrite projecting to the CC and ending with a protrusion. They are GABAergic, present an intermediate neuronal maturity and selectively express PKD2L1, a member of the transient receptor potential channel superfamily with sensory properties. Using immunohistological and electrophysiological recording techniques in mice, we characterize the properties of a new population of PKD2L1 positive cells that is distant from the CC in a zone enriched with astrocytes and ependymal fibers of the ventro-medial spinal cord and medulla. They appear around embryonic day 16 and their number increases up to early postnatal days. With development and the reorganization of the CC region, they progressively become more distant from the CC, suggesting some migratory capabilities. These neurons share functional and phenotypical properties with CSF-cNs but appear subdivided in two groups. One group, present along the midline, has a bipolar morphology and extends a long dendrite along ependymal fibers and towards the CC. The second group, localized in more ventro-lateral regions, has a multipolar morphology and no apparent projection to the CC. Altogether, we describe a novel population of PKD2L1+ neurons distant from the CC but with properties similar to CSF-cNs that might serve to sense modification in the composition of either CSF or interstitial liquid, a function that will need to be confirmed.

Primary culture of adult cortical neurons from reptile Gekko japonicus.

Adult neurons of several reptiles still retain the ability of axonal regeneration in contrast to the low intrinsic regenerative capacity of those in the central nervous system (CNS) in mammals. This feature of the reptilian neurons has provided a perfect model for elucidating the regenerative mechanism lost in the mammalian counterparts. However, little information is available on the primary culture method of adult reptilian neurons, which greatly limits their valuable applications. In the present study, we introduced a simple and easy method for the isolation, culture, and identification of neurons from the cerebral cortex using the adult geckos. The cultured cells were further identified by immunofluorescence using antibodies against neuron-specific markers β-Ⅲ-tubulin and NeuN. The cortical neurons from adult gecko displayed spindle-shaped, bipolar, or multipolar morphology with a plump soma. This primary culture method for adult reptilian neurons will be beneficial for comparative studies of neuronal biology in various vertebrates.

Chemotactic TEG3 Cells' Guiding Platforms Based on PLA Fibers Functionalized With the SDF-1α/CXCL12 Chemokine for Neural Regeneration Therapy.

(Following spinal cord injury, olfactory ensheathing cell (OEC) transplantation is a promising therapeutic approach in promoting functional improvement. Some studies report that the migratory properties of OECs are compromised by inhibitory molecules and potentiated by chemical concentration differences. Here we compare the attachment, morphology, and directionality of an OEC-derived cell line, TEG3 cells, seeded on functionalized nanoscale meshes of Poly(l/dl-lactic acid; PLA) nanofibers. The size of the nanofibers has a strong effect on TEG3 cell adhesion and migration, with the PLA nanofibers having a 950 nm diameter being the ones that show the best results. TEG3 cells are capable of adopting a bipolar morphology on 950 nm fiber surfaces, as well as a highly dynamic behavior in migratory terms. Finally, we observe that functionalized nanofibers, with a chemical concentration increment of SDF-1α/CXCL12, strongly enhance the migratory characteristics of TEG3 cells over inhibitory substrates.

Single-cell morphological characterization of CRH neurons throughout the whole mouse brain

BackgroundCorticotropin-releasing hormone (CRH) is an important neuromodulator that is widely distributed in the brain and plays a key role in mediating stress responses and autonomic functions. While the distribution pattern of fluorescently labeled CRH-expressing neurons has been studied in different transgenic mouse lines, a full appreciation of the broad diversity of this population and local neural connectivity can only come from integration of single-cell morphological information as a defining feature. However, the morphologies of single CRH neurons and the local circuits formed by these neurons have not been acquired at brain-wide and dendritic-scale levels.ResultsWe screened the EYFP-expressing CRH-IRES-Cre;Ai32 mouse line to reveal the morphologies of individual CRH neurons throughout the whole mouse brain by using a fluorescence micro-optical sectioning tomography (fMOST) system. Diverse dendritic morphologies and projection fibers of CRH neurons were found in various brain regions. Follow-up reconstructions showed that hypothalamic CRH neurons had the smallest somatic volumes and simplest dendritic branches and that CRH neurons in several brain regions shared a common bipolar morphology. Further investigations of local CRH neurons in the medial prefrontal cortex unveiled somatic depth-dependent morphologies of CRH neurons that exhibited three types of mutual connections: basal dendrites (upper layer) with apical dendrites (layer 3); dendritic-somatic connections (in layer 2/3); and dendritic-dendritic connections (in layer 4). Moreover, hypothalamic CRH neurons were classified into two types according to their somatic locations and characteristics of dendritic varicosities. Rostral-projecting CRH neurons in the anterior parvicellular area had fewer and smaller dendritic varicosities, whereas CRH neurons in the periventricular area had more and larger varicosities that were present within dendrites projecting to the third ventricle. Arborization-dependent dendritic spines of CRH neurons were detected, among which the most sophisticated types were found in the amygdala and the simplest types were found in the hypothalamus.ConclusionsBy using the CRH-IRES-Cre;Ai32 mouse line and fMOST imaging, we obtained region-specific morphological distributions of CRH neurons at the dendrite level in the whole mouse brain. Taken together, our findings provide comprehensive brain-wide morphological information of stress-related CRH neurons and may facilitate further studies of the CRH neuronal system.

Modeling Light Curves of Bipolar Core Collapse Supernovae from the Equatorial Plane

Abstract We use the two-components bipolar toy model of core collapse supernova (CCSN) ejecta to fit the rapid decline from maximum luminosity in the light curve of the type IIb CCSN SN 2018gk (ASASSN-18am). In this toy model we use a template light curve from a different CCSN that is similar to SN 2018gk, but that has no rapid drop in its light curve. The bipolar morphology that we model with a polar ejecta and an equatorial ejecta increases the maximum luminosity and causes a steeper decline for an equatorial observer, relative to a similar spherical explosion. The total energy and mass of our toy model for SN 2018gk are E SN = 5 × 10 51 erg and M SN = 2.7 M ⊙ . This explosion energy is more than what a neutrino driven explosion mechanism can supply, implying that jets exploded SN 2018gk. These energetic jets likely shaped the ejecta to a bipolar morphology, as our toy model requires. We crudely estimate that f ≈ 2%–5% of all CCSNe show this behavior, most being hydrogen deficient (stripped-envelope) CCSNe, as we observe them from the equatorial plane. We estimate the overall fraction of CCSNe that have a pronounced bipolar morphology to be f bip ≈ 5%–15% of all CCSNe.

Ariadne's Thread in the Developing Cerebral Cortex: Mechanisms Enabling the Guiding Role of the Radial Glia Basal Process during Neuron Migration.

Radial neuron migration in the developing cerebral cortex is a complex journey, starting in the germinal zones and ending in the cortical plate. In mice, migratory distances can reach several hundreds of microns, or millimeters in humans. Along the migratory path, radially migrating neurons slither through cellularly dense and complex territories before they reach their final destination in the cortical plate. This task is facilitated by radial glia, the neural stem cells of the developing cortex. Indeed, radial glia have a unique bipolar morphology, enabling them to serve as guides for neuronal migration. The key guiding structure of radial glia is the basal process, which traverses the entire thickness of the developing cortex. Neurons recognize the basal process as their guide and maintain physical interactions with this structure until the end of migration. Thus, the radial glia basal process plays a key role during radial migration. In this review, we highlight the pathways enabling neuron-basal process interactions during migration, as well as the known mechanisms regulating the morphology of the radial glia basal process. Throughout, we describe how dysregulation of these interactions and of basal process morphology can have profound effects on cortical development, and therefore lead to neurodevelopmental diseases.

Radio light curves and imaging of the helium nova V445 Puppis reveal seven years of synchrotron emission

ABSTRACT V445 Puppis is the only helium nova observed to date; its eruption in late 2000 showed high velocities up to 8500 km s−1, and a remarkable bipolar morphology cinched by an equatorial dust disc. Here we present multifrequency radio observations of V445 Pup obtained with the Very Large Array (VLA) spanning 1.5–43.3 GHz, and between 2001 January and 2008 March (days ∼89–2700 after eruption). The radio light curve is dominated by synchrotron emission over these 7 yr, and shows four distinct radio flares. Resolved radio images obtained in the VLA’s A configuration show that the synchrotron emission hugs the equatorial disc, and comparisons to near-IR images of the nova clearly demonstrate that it is the densest ejecta – not the fastest ejecta – that are the sites of the synchrotron emission in V445 Pup. The data are consistent with a model where the synchrotron emission is produced by a wind from the white dwarf impacting the dense equatorial disc, resulting in shocks and particle acceleration. The individual synchrotron flares may be associated with density enhancements in the equatorial disc and/or velocity variations in the wind from the white dwarf. This overall scenario is similar to a common picture of shock production in hydrogen-rich classical novae, but V445 Pup is remarkable in that these shocks persist for almost a decade, much longer than the weeks or months for which shocks are typically observed in classical novae.

Impact of Micro-, Mini- and Multi-Electrode Mapping on Ventricular Substrate Characterisation.

Accurate substrate characterisation may improve the evolving understanding and treatment of cardiac arrhythmias. During substrate-based ablation techniques, wide practice variations exist with mapping via dedicated multi-electrode catheter or conventional ablation catheters. Recently, newer ablation catheter technology with embedded mapping electrodes have been introduced. This article focuses on the general misconceptions of voltage mapping and more specific differences in unipolar and bipolar signal morphology, field of view, signal-to-noise ratio, mapping capabilities (density and resolution), catheter-specific voltage thresholds and impact of micro-, mini- and multi-electrodes for substrate mapping. Efficiency and cost-effectiveness of different catheter types are discussed. Increasing sampling density with smaller electrodes allows for higher resolution with a greater likelihood to record near-field electrical information. These advances may help to further improve our mechanistic understanding of the correlation between substrate and ventricular tachycardia, as well as macro-reentry arrhythmia in humans.