Studies on the inhibition effectiveness of the initial degree of inoculation of the Salmonella microorganism were carried out. In this paper, the irradiation efficiency of model systems with electron beams with beam energy of 6.5 and 10 MeV was studied. The investigations were carried out at UELV-10-10-C-70 accelerator at Frumkin Institute of Physical Chemistry and Electrochemistry of Russian Academy of Sciences (IPCE RAS) with an average beam power of 6.5 MeV and at radiation-technological center with an electron accelerator UELR-10-10-40 at A.I. Burnazyan Federal Medical Biophysical Centre of Federal Medical Biological Agency with an average electron energy of 10 MeV. The conducted researches on studying and revealing the dependence of inhibition of pathogenic microflora, irradiation with different intensity, on the structure (density) of the studied samples, which model liquid and solid nutrient media. The study used a strain Salmonella enterica subsp. Enterica serovar Typhimurium. The results of the effective inhibition of the initial degree of contamination for the two plants were obtained. Studies have shown that the effectiveness of inhibition of Salmonella culture can vary depending on the characteristics of electron beams. For example, when samples were irradiated with electrons with energy of 6.5 and 10 MeV at doses from 3 to 7 kGy, various results of the inhibition effectiveness of Salmonella culture on media with different work were obtained. When processing samples with studied strains of cultures in the dose range from 4 to 5 kGy, there is an increase in the growth of microorganisms for all processing conditions. In the remaining studied ranges their inhibition are observed. It is important to take into account not only the effectiveness of the oppression of microflora on specific products, but also the efficiency of the installation for a specific sample.