Biomedical Sciences Research Articles

Advancing doctoral student professional development through a strengths-based cohort program

Purpose Strengths-based professional development has been associated with positive outcomes in academia and in the organizational workplace. Students pursuing their doctoral degrees in the biomedical sciences in the US are often on graduate assistantships, where they experience an academic component to their training integrated with an employee-like existence. The individual who serves as their academic and research advisor is often their supervisor, who pays their stipend. The traditional training structure poses unique challenges and may be accompanied by stress, burnout and imposter phenomenon. The purpose of this study is to utilize a strengths-based approach to equip students with essential personal and professional skills that build self-awareness and self-confidence further preparing them for their future in the scientific workforce. Design/methodology/approach The authors developed and implemented a novel strengths-based professional development cohort program for doctoral students in the biomedical sciences at a research-intensive (R1) institution. The program was designed to create a supportive and inclusive space for participants (n = 18) to explore their identity as a student and scientists and to develop and leverage their talents for more effective and strategic use. Program outcomes were evaluated through a mixed methods case study design using a post-program Likert-based survey (n = 10 participants) and participant interviews (n = 13). Explanatory sequential design was used in the interpretation of the findings. Findings The results show that the program had a positive impact on students’ perceptions of themselves as scientists, as well as on their self-efficacy, self-confidence and interpersonal interactions in the research setting. Practical implications This strengths-based professional development program demonstrates immense potential as a model to equip students with self-awareness and a new foundation of essential skills needed to supplement their technical and scientific training for their future careers in the team-based workplace. Originality/value This study demonstrates how professional development programming can complement scientific training by equipping students with self-awareness and other lifelong skills to navigate feelings of imposter phenomenon and interpersonal relationships in the team-based workplace.

Interdisciplinary teaching squares enhance reflection and collegiality: A collaborative pedagogical approach

AimTo explore the experiences of interdisciplinary Higher Educational Academics within Nursing, Midwifery, Pharmacy and Biomedical Science in the use of teaching squares as a formative, collaborative pedagogical tool to promote reflection. BackgroundOne approach to enhancing academic teaching practice involves the provision of feedback to individual academics. This approach can be challenging for the reviewer, hence other less intimidating approaches are popular. One such approach is the teaching square. In this approach typically 4 other teaching staff are involved in observing their peers’ teaching methods (synchronous or asynchronous) and then engaging in a cycle of personal reflection. Reflection on teaching practices of their peers can provide opportunity to improve their own teaching. Typically teaching squares involve participants from the same academic discipline, however, in this study participants from related yet different disciplines were purposely connected and the benefits of this approach assessed. DesignA qualitative descriptive design was used to explore the participants’ experiences of undertaking interdisciplinary teaching squares through online questionnaires and focus group feedback opportunities. MethodsThis study was undertaken between August 2022 to June 2023 at an Australian university. Sixteen academic staff members from Nursing, Midwifery, Pharmacy & Pharmaceutical science and Biological science expressed an interest in the project. Five participants elected not to continue citing time pressures and 11 staff members participated in the project. Participation involved completing the teaching square experience and a subsequent focus group that were held to explore their experiences of undertaking a teaching square. The demographic survey data were presented and the focus group interviews were recorded, transcribed and analysed thematically. ResultsTriangulation of the findings resulted in the identification of four main themes: Teaching squares for professional networks; Perceptions of Safety; Stepping in and out of a reflective cycle; and Time Constraints vs. Time Value. ConclusionsThe study aimed to explore the effectiveness of teaching squares in encouraging academic reflection on teaching and fostering a collaborative teaching culture within interdisciplinary higher education academics. An unexpected finding was the value and promotion of interdisciplinarity professional relationships and networks. The findings from this research project offer valuable insights into the benefits of adopting teaching squares in health education and contributes to evidence-based pedagogical practices.

Machine learning assisted sorting of active microswimmers.

Active matter systems, being in a non-equilibrium state, exhibit complex behaviors, such as self-organization, giving rise to emergent phenomena. There are many examples of active particles with biological origins, including bacteria and spermatozoa, or with artificial origins, such as self-propelled swimmers and Janus particles. The ability to manipulate active particles is vital for their effective application, e.g., separating motile spermatozoa from nonmotile and dead ones, to increase fertilization chance. In this study, we proposed a mechanism-an apparatus-to sort and demix active particles based on their motility values (Péclet number). Initially, using Brownian simulations, we demonstrated the feasibility of sorting self-propelled particles. Following this, we employed machine learning methods, supplemented with data from comprehensive simulations that we conducted for this study, to model the complex behavior of active particles. This enabled us to sort them based on their Péclet number. Finally, we evaluated the performance of the developed models and showed their effectiveness in demixing and sorting the active particles. Our findings can find applications in various fields, including physics, biology, and biomedical science, where the sorting and manipulation of active particles play a pivotal role.

Altmetric coverage of health research in Ireland 2017-2023: a protocol for a cross-sectional analysis.

Scientific publications have been growing exponentially, contributing to an oversaturated information environment. Quantifying a research output's impact and reach cannot be solely measured by traditional metrics like citation counts as these have a lag time and are largely focused on an academic audience. There is increasing recognition to consider 'alternative metrics' or altmetrics to measure more immediate and broader impacts of research. Better understanding of altmetrics can help researchers better navigate evolving information environments and changing appetites for different types of research. Our study aims to: 1) analyse the amount and medium of Altmetric coverage of health research produced by Irish organisations (2017 - 2023), identifying changes over time and 2) investigate differences in the amount of coverage between clinical areas (e.g., nutrition vs. neurology). Using Altmetric institutional access, we will gather data on research outputs published 1 January 2017 through 31 December 2023 from active Irish organisations with Research Organisation Registry (ROR) IDs. Outputs will be deduplicated and stratified by their Australian and New Zealand Standard Research Classification relating to ≥1 field of health research: Biological Sciences, Biomedical and Clinical Sciences, Chemical Sciences, Health Sciences, and Psychology. We will clean data using R and perform descriptive analyses, establishing counts and frequencies of coverage by clinical area and medium (e.g., traditional news, X, etc.); data will be plotted on a yearly and quarterly basis where appropriate. Improved understanding of one's information environment can help researchers better navigate their local landscapes and identify pathways for more effective communication to the public. All R code will be made available open-source, allowing researchers to adapt it to evaluate their local landscapes.

An unconditionally stable numerical scheme for solving nonlinear Fisher equation

Abstract In this study, novel numerical methods are presented for solving nonlinear Fisher equations. These equations have a wide range of applications in various scientific and engineering fields, particularly in the biomedical sciences for determining the size of brain tumors. The challenges posed by the nonlinearity of the equations are effectively addressed through the development of numerical techniques. The nonlinearity is tackled using a combination of the method of lines and backward differentiation formulas of varied orders. This method is unconditionally stable, and its accuracy is evaluated using error norms. The methods are successfully validated against test problems with known solutions, demonstrating their superiority through comparative analyses with existing methodologies in the literature.

Mechanism of Pressure-Modulated Self-Trapped Exciton Emission in Cs2TeCl6 Double Perovskite.

Pressure-modulated self-trapped exciton (STE) emission mechanism in all-inorganic lead-free metal halide double perovskites characterized by large Stokes-shifted broadband emission, has attracted much attention across various fields such as optics, optoelectronics, and biomedical sciences. Here, by employing the all-inorganic lead-free metal halide double perovskite Cs2TeCl6 as a paradigm, the authors elucidate that the performance of STE emission can be modulated by pressure, attributable to the pressure-induced evolution of the electronic state (ES). Two ES transitions happen at pressures of 1.6 and 5.8GPa, sequentially. The electronic behaviors of Cs2TeCl6 can be jointly modulated by both pressure and ES transitions. When the pressure reaches 1.6GPa, the Huang-Rhys factor S, indicative of the strength of electron-phonon coupling, attains an optimum value of ≈12.0, correlating with the pressure-induced photoluminescence (PL) intensity of Cs2TeCl6 is 4.8-fold that of its PL intensity under ambient pressure. Through analyzing the pressure-dependent STE dynamic behavioral changes, the authors have revealed the microphysical mechanism underlying the pressure-modulated enhancement and quenching of STE emission in Cs2TeCl6.

Abstract P314: A Community Outreach Program Focused on Hypertension Awareness Reaches 600+ People in Rural Georgia and Works to Build the Next Generation of Biomedical Scientists

The U.S. national average for the prevalence of hypertension in women aged 35-44 is 10.8%. In southeastern states including Georgia, Mississippi, and South Carolina, the prevalence of hypertension in women of this same age group is 13.5%, 17.8%, and 15.5%, respectively. The increase is mostly observed in Black women from non-metro areas. Thus, a need exists to improve awareness of cardiovascular risk in these communities and to support scientific research to improve the understanding of how sex contributes to differences in cardiovascular risk factors like hypertension. Rural Obese At Risk (ROAR) establishes a Specialized Center of Research Excellence on Sex Differences (SCORE) homed at Augusta University, spanning three Southeast universities. The overall goal is to establish ROAR as a national resource and recognized leader in cardiovascular disease in females, and to change perceptions and awareness surrounding cardiovascular risk in women across the Southeast, particularly in high-risk groups. One objective of ROAR Augusta is to establish a community outreach pipeline of trained scientists to increase awareness of sex as a biological variable (SABV), promote optimal cardiovascular healthcare for men and women, and empower the community to self-monitor and identify barriers to improving access to healthcare through the Community Engagement Core (CEC). The CEC aims to develop meaningful relationships among the research, medical, and lay communities promoting the increase of awareness of the importance of blood pressure control in women through community outreach, a Qualitative Needs Assessment, design and dissemination of unique illustrative educational materials related to cardiovascular disease in women, and the launch of a Blood Pressure Checks for Women campaign. In six months (December 2023 – May 2024), ROAR participated in 10 community events providing blood pressure checks and educational materials and reaching more than 600 people in 6 counties; awarded one pre-doctoral career enhancement mini-sabbatical; awarded three early career SABV pilot grants; hosted a SABV symposium reaching 120 biomedical scientists; and hosted a SABV seminar and workshop reaching 142 biomedical scientists. In conclusion, the ROAR CEC is well on its way to positively impacting hypertension perceptions and awareness in women across the Southeast.

Investigation of the interaction mechanism and enzyme activity of trypsin with cerium oxide nanoparticles

In this study, the interaction mechanism and native conformational variation of trypsin (Try) affected by CeO2 nanoparticles (NPs) were systematically studied via various spectroscopic methods. The results of fluorescence spectroscopy revealed that CeO2 NPs markedly quenched the endogenous fluorescence of Try via the mechanism of static quenching. The main forces that contributed to the binding of Try and CeO2 NPs were van der Waals forces, hydrogen bonds, and electrostatic forces, as observed by the binding constants and significant thermodynamic characteristics of the two substances. The incorporation of CeO2 NPs lead to a slight change in the structure of Try, as shown by synchronized fluorescence spectroscopy, three-dimensional fluorescence spectroscopy and circular dichroism (CD) spectroscopy. Moreover, the enzyme activity of Try decreased with the addition of CeO2 NPs. This study is highly important for fully evaluating the use of CeO2 NPs in biomedical sciences and is helpful for clarifying the mechanism between Try and CeO2 NPs at the molecular level.

A tutorial on optical photothermal infrared (O-PTIR) microscopy.

This tutorial reviews the rapidly growing field of optical photothermal infrared (O-PTIR) spectroscopy and chemical imaging. O-PTIR is an infrared super-resolution measurement technique where a shorter wavelength visible probe is used to measure and map infrared (IR) absorption with spatial resolution up to 30× better than conventional techniques such as Fourier transform infrared and direct IR laser imaging systems. This article reviews key limitations of conventional IR instruments, the O-PTIR technology breakthroughs, and their origins that have overcome the prior limitations. This article also discusses recent developments in expanding multi-modal O-PTIR approaches that enable complementary Raman spectroscopy and fluorescence microscopy imaging, including wide-field O-PTIR imaging with fluorescence-based detection of IR absorption. Various practical subjects are covered, including sample preparation techniques, optimal measurement configurations, use of IR tags/labels and techniques for data analysis, and visualization. Key O-PTIR applications are reviewed in many areas, including biological and biomedical sciences, environmental and microplastics research, (bio)pharmaceuticals, materials science, cultural heritage, forensics, photonics, and failure analysis.

Students' approaches to developing scientific communication skills.

Science communication is a core skill for undergraduate science students to acquire in preparation for their future careers, but studies show that this skill is underdeveloped in science graduates. The aim of this study was to discover the resources and approaches undergraduate students use to effectively develop their science communication skills and how the use of these methods relates to academic performance on a communication task. Undergraduate students undertaking a second-year biomedical science course (n = 490) were asked which approaches and resources they used to aid the development of their science communication skills, and the frequency of their responses was correlated against their laboratory report mark, using multiple regression and relative weights analysis. Students' (n = 453) use of Communication Learning in Practice for Scientists (CLIPS; an open-access interactive website on science communication), resources provided by the university, interactions with university teaching staff, and engagement with the scientific literature significantly predicted the laboratory report mark. Students enrolled in a blended format or in remote online learning only, and in different programs, performed comparably in the written report and used similar approaches and resources, other than remote students reporting more use of other online resources and students in blended learning engaging more with university resources. Together, these findings provide insight into which strategies are most helpful for undergraduate students to engage with to improve their scientific communication skills. The findings highlight that the provision of well-designed interactive communication resources, guided assessment resources, and opportunities to engage with teaching staff can assist in the development of science communication skills.NEW & NOTEWORTHY This study identifies the approaches and resources that undergraduate science students use to develop their science communication skills. It reveals which of these approaches and resources predict improved academic performance in a written science communication assessment task. The findings point to the importance of explicit guidance, and engagement with teaching staff, in advancing the development of science communication skills.

Sir Harold Ridley as the Pioneer of Intraocular Lenses: His Inspiration Drawn From World War II Pilots.

This article underscores the monumental contributions of Sir Harold Ridley to the development of intraocular lenses (IOLs), which have revolutionized cataract surgery. Sir Harold Ridley, a British ophthalmologist and medical scientist, drew inspiration from the injuries of World War II pilots to pioneer the first successful IOL implantation in 1949 at St. Thomas's Hospital. The lens, made from Perspex CQ, marked the inception of modern cataract surgery. Despite facing considerable skepticism and resistance from the medical community throughout the 1950s and 60s, Ridley's perseverance led to the gradual acceptance of IOLs by the 1970s. Today, Ridley is rightfully recognized as the "father of the intraocular lens," with his groundbreaking work having profoundly impacted the field of ophthalmology and improved the quality of life for millions globally.

Forced Migration, Deterrence, and Solutions to the Non-Natural Disaster of Migrant Deaths Along the US-Mexico Border and Beyond

Executive Summary The International Organization of Migration has characterized the US-Mexico border as the world’s deadliest land migration route. By August 2024, a minimum of 5,405 persons had died or gone missing along this border since 2014, with record high numbers since 2021. Migrant deaths occur despite decades of: US Border Patrol search and rescue initiatives; public education campaigns targeting potential migrants on the dangers of irregular migration; dozens of academic publications and reports highlighting the root causes of these deaths; efforts by consular officials, local communities, and humanitarian agencies to locate, identify, and repatriate human remains; and desperate attempts by families to learn the fate of their missing loved ones. This paper introduces a special edition of the Journal on Migration and Human Security (JMHS), which draws on original research and the expertise of medical examiners, forensic anthropologists, social scientists, and humanitarian organizations to examine this persistent human tragedy. Many of the authors investigate migrant deaths in their professional capacities. They identify the dead, return remains to family members, and champion reforms to prevent deaths and better account for the dead and missing. This JMHS special edition represents a collaboration between the University of Arizona’s Binational Migration Institute, the Center for Migration Studies of New York (CMSNY), and the Working Group on Mapping Migrant Deaths along the US Southwest Border. The Working Group includes scholars and practitioners from California, Arizona, New Mexico, Texas, and New York who have met monthly since October of 2021. The special edition examines in granular detail the causes of migrant deaths, US border enforcement strategies and tactics, migrant death statistics, and the resource and capacity challenges faced by US counties along and leading from the US-Mexico border in investigating these deaths. The US Department of Homeland Security (DHS) and many public officials attribute the deaths to the predations of human smugglers, the victims’ ignorance or assumption of risk, and the harsh “natural” conditions to which migrants finally succumb. This special issue also documents the underlying non-natural causes of this enduring tragedy, and offers both overarching and more targeted solutions to preventing and minimizing migrant deaths. The issue builds upon and extends seminal research on migrant deaths first featured in CMSNY publications more than two decades ago. Section I introduces the issue of migrant deaths by posing the question: Why should we care? Section II describes the genesis of “prevention through deterrence”—a border enforcement theory and strategy—and its evolution through subsequent Customs and Border Protection (CBP) and US Border Patrol strategic plans. It describes the immense enforcement infrastructure built around this idea by successive administrations and Congresses, and it explains why it has failed to stem irregular migration and how it has contributed to migrant deaths. Section III reviews the main causes of migrant deaths—forced migration, the combined effects of prevention through deterrence and border enforcement tactics, the denial of access to asylum, the border wall, the “naturalization” of migrant deaths, and the dominant vision of the border as a site of danger and exclusion. Section IV reviews the legislative standards for identifying, investigating, and reporting on migrant decedents. It also details the deficiencies of Border Patrol and county-level sources of data on deaths, and it outlines ways to strengthen data collection. Section V discusses the burdens placed on communities along and leading from the border in investigating deaths and their need for greater resources and capacity to address this problem. Section VI outlines the anomalies and challenges related to the Border Patrol’s migrant rescue program. Section VII describes international legal standards to guide the investigation of migrant deaths and two model programs. Section VIII sets forth policy recommendations to prevent migrant deaths and to honor and account for the dead.

Design and implementation of an asynchronous online course-based undergraduate research experience (CURE) in computational genomics.

As genomics technologies advance, there is a growing demand for computational biologists trained for genomics analysis but instructors face significant hurdles in providing formal training in computer programming, statistics, and genomics to biology students. Fully online learners represent a significant and growing community that can contribute to meet this need, but they are frequently excluded from valuable research opportunities which mostly do not offer the flexibility they need. To address these opportunity gaps, we developed an asynchronous course-based undergraduate research experience (CURE) for computational genomics specifically for fully online biology students. We generated custom learning materials and leveraged remotely accessible computational tools to address 2 novel research questions over 2 iterations of the genomics CURE, one testing bioinformatics approaches and one mining cancer genomics data. Here, we present how the instructional team distributed analysis needed to address these questions between students over a 7.5-week CURE and provided concurrent training in biology and statistics, computer programming, and professional development. Scores from identical learning assessments administered before and after completion of each CURE showed significant learning gains across biology and coding course objectives. Open-response progress reports were submitted weekly and identified self-reported adaptive coping strategies for challenges encountered throughout the course. Progress reports identified problems that could be resolved through collaboration with instructors and peers via messaging platforms and virtual meetings. We implemented asynchronous communication using the Slack messaging platform and an asynchronous journal club where students discussed relevant publications using the Perusall social annotation platform. The online genomics CURE resulted in unanticipated positive outcomes, including students voluntarily discussing plans to continue research after the course. These outcomes underscore the effectiveness of this genomics CURE for scientific training, recruitment and student-mentor relationships, and student successes. Asynchronous genomics CUREs can contribute to a more skilled, diverse, and inclusive workforce for the advancement of biomedical science.

Carbon dots in biomedicine: From synthesis to application

Many studies have examined the properties and possible uses of carbon dots (CDs), a novel class of zero-dimensional carbon nanomaterials. Many notable features are present in them, such as robust colloidal stability, easy surface functionalization and bioconjugation, robust biocompatibility in vivo and in vitro settings, resistance to photobleaching, an environmentally benign synthesis process, and a comparatively low production cost. These characteristics make carbon dots an attractive option for a variety of possible biomedical uses. This work provides a thorough review of the most recent developments in the biomedical sciences, covering the physicochemical characteristics, synthesis techniques, and uses of carbon dots in biosensing, bioimaging, and disease treatment. It is based on a thorough examination of the relevant literature and experimental results. According to the study findings that are now accessible, carbon dots have a lot of potential applications in the biomedical industry. These properties make carbon dots suitable for use in bioimaging, biosensing, and disease treatment. Nevertheless, there are still some challenging issues that require further investigation and analysis. It is anticipated that further research and exploration will result in carbon dots making a significant contribution to human health in the future, and that the ongoing innovation and development of carbon dot technology will result in a significant transformation of the biomedical field.

Fastening the Future: Surgical Zip Ties for Enhanced Wound Closure and Patient Well-Being

Surgical zip tie skin closures are emerging as a revolutionary approach in wound management, promising significant advancements in patient safety and surgical success. Current research emphasizes the efficacy of zip tie closures in promoting wound healing, reducing the risk of dehiscence, and enhancing cosmetic outcomes across various surgical procedures. Compared to traditional suturing techniques, zip tie closures offer secure wound approximation, minimize tension on wound edges, and contribute to faster recovery times with lower incidences of infection and scarring. Case studies and clinical trials demonstrate the effectiveness of these closures, emphasizing their role in improving surgical outcomes. Future investigations should focus on optimizing zip tie design and material properties to ensure compatibility with different skin types and surgical sites. Innovations in biodegradable and antimicrobial materials could further enhance the utility and applications of zip ties. The potential for using zip tie closures in minimally invasive and robotic-assisted surgeries offers precision and ease of use in complex procedures. Multidisciplinary collaboration between surgeons, engineers, and biomaterial scientists is essential for refining zip tie closure systems, conducting clinical trials, and establishing standardized protocols for integration into routine surgical practice. Addressing challenges related to material biocompatibility, mechanical strength, and user ergonomics will be essential for navigating challenges and limitations. Ultimately, the adoption of surgical zip tie skin closures has the potential to revolutionize wound management and improve patient care, setting new standards in surgical care through innovation and evidence-based practice.

Statistical applications in the biomedical sciences: A review

This study covers applications areas of statistics in biological science. The integration of statistical methods into the biological sciences has revolutionized data analysis, enhancing the accuracy of data analysis and interpretation. This review aims to provide a comprehensive overview of the key statistical techniques used in biomedical research, highlighting their applications, advantages, and limitations. We conducted a systematic literature search across major databases, we focused on studies that have employed descriptive statistics, inferential statistics, regression analysis, multivariate analysis, survival analysis, Bayesian statistics, and machine learning methods in biomedical sciences. Our findings reveal that statistical methods are indispensable in various areas, including genomics, proteomics, epidemiology, ecology, clinical trials, and pharmacology. Each section of this review details the specific applications of these methods, supported by relevant case studies that illustrate their practical implementation and impact. This review underscores the indispensable role of statistics in biological research, providing actionable insights and recommendations for researchers aiming to leverage statistical tools to drive scientific discovery.

De Novo Design and Characterization of Amphiphilic Peptides with Basic Side Chains for Tailored Interfacial Chemistries.

Lysine-leucine (LK) peptides have been used as model systems and platforms for 2D material design for decades. LK peptides are amphiphilic sequences designed to bind and fold at hydrophobic surfaces through hydrophobic leucine side chains and hydrophilic lysine side chains extending into the aqueous subphase. The hydrophobic periodicity of the sequence dictates the secondary structure at the interface. This robust design makes them ideal candidates for controlling interfacial chemistry. This study presents the de novo design and characterization of two novel peptides: LRα14 and LHα14, which substitute lysine with arginine and histidine, respectively, in the helical LKα14 sequence. This modification is intended to expand the LK peptide platform to a new basic interfacial chemistry. We explore the stability of the new LRα14 and LHα14 designs with respect to changes in pH and salt concentration in bulk solution and at the interface using circular dichroism (UV-CD) and vibrational sum-frequency generation spectroscopy, respectively. Notably, the structural stability of the peptides remains unaffected across a wide range of pH and ionic strength values. At the same time, the variation of side-chain chemistry leads to a wide spectrum of interfacial water structures. By extension of the LK platform to include arginine and histidine, this study broadens the toolbox for designing tailored interfacial chemistries with applications in material and biomedical sciences.

How fast do scholarly papers get read by various user groups? A longitudinal and cross‐disciplinary analysis of the evolution of Mendeley readership

AbstractTo provide a dynamic perspective on the evolution of Mendeley readership, this study conducts an 8‐year longitudinal analysis of approximately 3.4 million scholarly papers published in 2015. Mendeley readership data were collected annually from 2016 to 2023 for the sampled papers to analyze the temporal accumulation patterns of readership following publication. The results indicate that Mendeley readership exhibits a speed advantage compared to citations and a prevalence advantage compared to Twitter mentions, demonstrating both initial prevalence and sustained growth on a yearly basis. However, the patterns of accumulation vary across disciplines, with papers in Biomedical and Health Sciences showing the fastest accrual of extensive Mendeley readership data. Leveraging demographic data provided by Mendeley, this study further investigates how different user groups—categorized by academic status, disciplinary affiliation, and geographic location—engage with papers across various disciplines. The findings highlight Mendeley readership as a rapid and substantial altmetric, yet they also emphasize the need to interpret the nature of the attention captured by Mendeley readership with caution, considering its potential biases introduced by the varying engagement levels of different user groups across disciplines.

TIBBIYOTDA DEONTOLOGIYA VA BIOETIKANING DOLZARB MUAMMOLARI

The development of modern medicine directly depends on the synthesis of achievements in both fundamental and applied natural sciences. Medicine not only studies the human being but also extends beyond natural sciences, which not only allows but also includes the integration of ethical factors into explanatory research. In the late 20th century, the incorporation of the bioethical component into medical and biological knowledge became particularly relevant due to the rapid development and implementation of new biomedical technologies. The realities of biomedical science and practice, such as resuscitation, transplantation, genetic engineering, and artificial fertilization, make social and ethical issues pertinent not only to the professional medical community but also to society as a whole. Among these are the determination of the social and moral justification of resuscitation procedures, the recognition of socio-ethical restrictions on methods of artificial fertilization, including in vitro reproduction and cloning; the determination of the social and moral acceptability of genetic diagnosis and prognosis, etc. In this article, the author discusses the current issues of deontology and bioethics.

Advancements in Sericulture: Innovations and Biomedical Applications of Silk and Its Derivatives

Silk, particularly from the Bombyx mori species, has been found to possess unique properties that make it exceptionally suitable for biomedical applications. Sericulture, traditionally known for silk production, has found significant applications in the biomedical field. This article explores the use of silk and its derivatives in various biomedical applications, including tissue engineering, drug delivery systems, wound healing, and medical sutures. The biocompatibility, biodegradability and mechanical properties of silk make it an ideal material for numerous medical applications. This article discusses the advancements in utilizing sericulture products in biomedical sciences, highlighting the potential and the challenges of these applications.