Biomedical Experts Research Articles

Boosting circadian autophagy by means of intermittent time-restricted feeding: a novel anti-ageing strategy?

OAE Publishing Inc. is an international scholarly publisher specializing in peer-reviewed academic journals. To promote academic exchange and knowledge sharing, OAE provides an outstanding academic platform for biomedical experts and scholars all over the world.

Optimization of tamoxifen-induced gene regulation in cardiovascular research.

OAE Publishing Inc. is an international scholarly publisher specializing in peer-reviewed academic journals. To promote academic exchange and knowledge sharing, OAE provides an outstanding academic platform for biomedical experts and scholars all over the world.

New insights into the dynamics of age-related clonal hematopoiesis

OAE Publishing Inc. is an international scholarly publisher specializing in peer-reviewed academic journals. To promote academic exchange and knowledge sharing, OAE provides an outstanding academic platform for biomedical experts and scholars all over the world.

The importance of "when" in calorie restriction-induced lifespan extension.

OAE Publishing Inc. is an international scholarly publisher specializing in peer-reviewed academic journals. To promote academic exchange and knowledge sharing, OAE provides an outstanding academic platform for biomedical experts and scholars all over the world.

Physical exercise in older patients with heart failure

OAE Publishing Inc. is an international scholarly publisher specializing in peer-reviewed academic journals. To promote academic exchange and knowledge sharing, OAE provides an outstanding academic platform for biomedical experts and scholars all over the world.

Deficient Lmna in fibroblasts: an emerging role of non-cardiomyocytes in DCM.

OAE Publishing Inc. is an international scholarly publisher specializing in peer-reviewed academic journals. To promote academic exchange and knowledge sharing, OAE provides an outstanding academic platform for biomedical experts and scholars all over the world.

The use of targeted LNP/mRNA technology to generate functional, transient CAR T cells and treat cardiac injury in vivo

OAE Publishing Inc. is an international scholarly publisher specializing in peer-reviewed academic journals. To promote academic exchange and knowledge sharing, OAE provides an outstanding academic platform for biomedical experts and scholars all over the world.

Small molecules that enhance mitophagy to delay aging and neurodegeneration.

OAE Publishing Inc. is an international scholarly publisher specializing in peer-reviewed academic journals. To promote academic exchange and knowledge sharing, OAE provides an outstanding academic platform for biomedical experts and scholars all over the world.

Pursuing the physician-scientist path to satisfy research curiosity and passion for patient care

OAE Publishing Inc. is an international scholarly publisher specializing in peer-reviewed academic journals. To promote academic exchange and knowledge sharing, OAE provides an outstanding academic platform for biomedical experts and scholars all over the world.

SGLT2 inhibitors in patients with HFpEF: how old is too old?

OAE Publishing Inc. is an international scholarly publisher specializing in peer-reviewed academic journals. To promote academic exchange and knowledge sharing, OAE provides an outstanding academic platform for biomedical experts and scholars all over the world.

Space mission: where failure is not an option

OAE Publishing Inc. is an international scholarly publisher specializing in peer-reviewed academic journals. To promote academic exchange and knowledge sharing, OAE provides an outstanding academic platform for biomedical experts and scholars all over the world.

Fasting confers stress resistance to skeletal muscle stem cells through non-metabolic actions of β- hydroxybutyrate: implications in cardioprotection and aging

OAE Publishing Inc. is an international scholarly publisher specializing in peer-reviewed academic journals. To promote academic exchange and knowledge sharing, OAE provides an outstanding academic platform for biomedical experts and scholars all over the world.

Communicative competence of a cardiologist: ethical and psychological analysis

The article problematizes the issue behind the standard categories of psychosocial factors, informing a patient about disease, prognosis, treatment methods, etc. The issue of a doctor’s role in interaction with a patient. Although psychological research methods are actively used in cardiology practice, and their results are quite transparent and demonstrate the specifics of patients experiencing the disease, affective states, soping skills, there are still questions about a physician not as a biomedical expert, but as a helping specialist. And although deontological imperatives require quite clear personal qualities from a doctor, the very realization of these qualities should be based on psychological approaches and culturalpsychological categories. As such, the way a doctor interacts with a patient can be described in terms of virtue ethics, which is an integral category that describes personal characteristics. Such characteristics, being implemented directly in clinical communication, could become a universal “recipe” for meaningful cooperation.

Social systems matter: Precision medicine, public health, and the medical model

Drawing on data from semi-structured interviews conducted in Singapore, Canada, and the United States, this paper shows that biomedical experts are deeply concerned about the shortcomings of the biomedical model of health. Precision public health, when anchored in genomics, can be considered a twenty-first century version of the medical model of health, which originated from nineteenth century germ theory. First, concerns regarding the adoption of genetic testing to identify disease susceptibility, and limitations of genome-based disease prevention exist. This includes limited evidence of the utility of screening measures in reducing mortality, lack of reimbursement for genetic screening, negative implications of genetic screening, and limitations of race/ethnicity-based genetic screening. Second, there are also concerns regarding the treatment of diseases, particularly the management of the costs of treatment and genetic testing in the context of national public health systems. Ultimately, it was found that healthcare-related inequities can be reduced in a universal, publicly funded, single-payer healthcare setting. These findings provide strong evidence supporting the social model of health by highlighting the key role of social systems and non-clinical interventions in precision public health to improve health outcomes for all.

ECOA-5. Integrative 3D spatial characterization of genomic and epigenomic intratumoral heterogeneity in glioblastoma

Treatment failure in glioblastoma is often attributed to intratumoral heterogeneity (ITH), which fosters tumor evolution and selection of therapy-resistant clones. While genomic alterations are known contributors to ITH, emerging studies highlight functional roles for epigenomic ITH which integrates differentiation status, stochastic events, and microenvironmental inputs. Here, we have established a novel platform for integrative characterization of genomic and epigenomic ITH of glioblastoma in three-dimensional (3-D) space. In collaboration with neurosurgeons and biomedical imaging experts, we utilize 3-D surgical neuro-navigation to safely acquire ~10 tumor samples per patient representing maximal anatomical diversity. We conduct whole-exome sequencing, RNA sequencing, and assay for transposase-accessible chromatin using sequencing (ATAC-Seq) on each sample. The spatial location of each sample is mapped by its 3-D coordinates, allowing 360-degree visualization of genomic and epigenomic ITH for each patient. We demonstrate this approach on 8 patients with primary IDH-WT glioblastoma (83 spatially mapped samples), providing unprecedented insight into their spatial organization at the genomic and epigenomic levels. We link genetically defined tumor subclones to patterns of open chromatin and gene regulation, revealing underlying transcription factor binding at active promoters and enhancers. We also identify ITH in whole-genome doubling and focal oncogene amplification events in multiple patients, which we then link with epigenomic ITH. Further, to study microenvironmental inputs and their contribution to epigenomic ITH, we conduct deconvolution of RNA sequencing and ATAC-Seq data by analyzing feature co-variation. We resolve the 3-D spatial organization of immune, neural, and other nontumor cell types present in glioblastoma, characterizing their functional states and interactions with tumor cells. This work provides the most comprehensive spatial characterization of genomic and epigenomic ITH to date in glioblastoma. As a resource for further investigation, we have developed an interactive data sharing platform – The 3D Glioma Atlas – that enables 360-degree visualization of both genomic and epigenomic ITH.

Day-to-day discovery of preprint\u2013publication links

Preprints promote the open and fast communication of non-peer reviewed work. Once a preprint is published in a peer-reviewed venue, the preprint server updates its web page: a prominent hyperlink leading to the newly published work is added. Linking preprints to publications is of utmost importance as it provides readers with the latest version of a now certified work. Yet leading preprint servers fail to identify all existing preprint–publication links. This limitation calls for a more thorough approach to this critical information retrieval task: overlooking published evidence translates into partial and even inaccurate systematic reviews on health-related issues, for instance. We designed an algorithm leveraging the Crossref public and free source of bibliographic metadata to comb the literature for preprint–publication links. We tested it on a reference preprint set identified and curated for a living systematic review on interventions for preventing and treating COVID-19 performed by international collaboration: the COVID-NMA initiative (covid-nma.com). The reference set comprised 343 preprints, 121 of which appeared as a publication in a peer-reviewed journal. While the preprint servers identified 39.7% of the preprint–publication links, our linker identified 90.9% of the expected links with no clues taken from the preprint servers. The accuracy of the proposed linker is 91.5% on this reference set, with 90.9% sensitivity and 91.9% specificity. This is a 16.26% increase in accuracy compared to that of preprint servers. We release this software as supplementary material to foster its integration into preprint servers’ workflows and enhance a daily preprint–publication chase that is useful to all readers, including systematic reviewers. This preprint–publication linker currently provides day-to-day updates to the biomedical experts of the COVID-NMA initiative.

My Body, My Cells: Rhetoric and the Molecularization of the Human

ABSTRACT In September 2016, the US Food and Drug Administration held a public hearing inviting comments on the regulation of human cells, tissues, and cellular and tissue-based products. This essay uses Nikolas Rose’s concept of molecularization to show the rhetorical conflicts that emerged between lay public arguments and biomedical experts’ claims about the limits of personal autonomy, ownership, and the definition of cells and tissues as products. By analyzing how public actors negotiate the regulation of human tissues, I argue that a rhetorical account of molecularization shows how and for whom bodies are commodified and physically distributed. Through this rhetorical account of molecularization, I move between the molecular level of the body (the micro) and the situatedness of human bodies (the macro) to rethink the ways bodies are defined, even at the level of the cell.

Polypharmacy side-effect prediction with enhanced interpretability based on graph feature attention network.

Polypharmacy side effects should be carefully considered for new drug development. However, considering all the complex drug-drug interactions that cause polypharmacy side effects is challenging. Recently, graph neural network (GNN) models have handled these complex interactions successfully and shown great predictive performance. Nevertheless, the GNN models have difficulty providing intelligible factors of the prediction for biomedical and pharmaceutical domain experts. A novel approach, graph feature attention network (GFAN), is presented for interpretable prediction of polypharmacy side effects by emphasizing target genes differently. To artificially simulate polypharmacy situations, where two different drugs are taken together, we formulated a node classification problem by using the concept of line graph in graph theory. Experiments with benchmark datasets validated interpretability of the GFAN and demonstrated competitive performance with the graph attention network in a previous work. And the specific cases in the polypharmacy side-effect prediction experiments showed that the GFAN model is capable of very sensitively extracting the target genes for each side-effect prediction. https://github.com/SunjooBang/Polypharmacy-side-effect-prediction.

Neurological connections and endogenous biochemistry - potentially useful in electronic-nose diagnostics for coronavirus diseases

OAE Publishing Inc. is an international scholarly publisher specializing in peer-reviewed academic journals. To promote academic exchange and knowledge sharing, OAE provides an outstanding academic platform for biomedical experts and scholars all over the world.

Caloric restriction reverses aging: one cell at a time

OAE Publishing Inc. is an international scholarly publisher specializing in peer-reviewed academic journals. To promote academic exchange and knowledge sharing, OAE provides an outstanding academic platform for biomedical experts and scholars all over the world.