Biomedical Enhancement Research Articles

Growth hormone, enhancement and the pharmaceuticalisation of short stature

This paper takes the biological drug human Growth Hormone (hGH) as a case study to investigate processes of pharmaceuticalisation and medicalisation in configuring childhood short stature as a site for pharmaceutical intervention. Human growth hormone is considered to have legitimate applications in treating childhood growth hormone deficiency and short stature associated with other recognised conditions. It is also regarded by bioethicists and others as a form of human biomedical enhancement when applied to children with idiopathic or ‘normal’ short stature. The purpose of this study is not to evaluate whether treatment of idiopathic short stature is enhancement or not, but to evaluate how some applications of hGH in treating short stature have come to be accepted and stabilised as legitimate ‘therapies’ while others remain contested as ‘enhancements’. A comparative, historical approach is employed, drawing on approaches from medical sociology and Science and Technology Studies (STS) to set out a socio-technical history of hGH in the US and UK. Through this history the relative influence and interplay of drivers of pharmaceuticalisation, including industry marketing and networks of drug distribution, and processes of medicalisation will be employed to address this question and simultaneously query the value of enhancement as a sociological concept.

Noise-Enhanced Information Systems

Noise, traditionally defined as an unwanted signal or disturbance, has been shown to play an important constructive role in many information processing systems and algorithms. This noise enhancement has been observed and employed in many physical, biological, and engineered systems. Indeed stochastic facilitation (SF) has been found critical for certain biological information functions such as detection of weak, subthreshold stimuli or suprathreshold signals through both experimental verification and analytical model simulations. In this paper, we present a systematic noise-enhanced information processing framework to analyze and optimize the performance of engineered systems. System performance is evaluated not only in terms of signal-to-noise ratio but also in terms of other more relevant metrics such as probability of error for signal detection or mean square error for parameter estimation. As an important new instance of SF, we also discuss the constructive effect of noise in associative memory recall. Potential enhancement of image processing systems via the addition of noise is discussed with important applications in biomedical image enhancement, image denoising, and classification.

Love Troubles: Human Attachment and Biomedical Enhancements

AbstractIn fascinating recent work, Julian Savulescu and his various co‐authors argue that human love is one of the things we can improve upon using biomedical enhancements. Is that so? This article first notes that Savulescu and his co‐authors mainly treat love as a means to various other goods. Love, however, is widely regarded as an intrinsic good. To investigate whether enhancements can produce the distinctive intrinsic good of love, this article does three things. Drawing on Philip Pettit's recent discussion of ‘robustly demanding goods’, it asks what exactly we intrinsically desire in seeking love; it considers four possible outcomes involving attachment‐enhancements and attachments; and it considers two different pieces of news we might receive about our lovers' attachment to us (that it is, or that it is not, sustained with the help of enhancement‐technologies). Enhancement‐sustained attachment, it is concluded, is less desirable than the intrinsic good of love.

Biomedical enhancement and the pursuit of mastery and perfection: a critique of the views of Michael Sandel

This article is a comprehensive critical analysis of the objections of Michael Sandel to the possibilities of human enhancement as foreseen by recent developments in new (particularly genetic) biotechnologies. It is shown that enhancement has always been a feature of human development. The nature and possibilities of these new technologies are briefly discussed, followed by an explanation of Sandel's views. In critical response to Sandel, the author raises three arguments that are discussed in detail, followed by a conclusion that contains wrap-up arguments. The three main arguments relate, first, to Sandel's rejection of enhancement tout court, second to the (in)consistency of his argument about the ‘gifted’ nature of reality, and third to the problems raised by his idea that the striving for mastery is the main problem with enhancement. On the basis of an extensive analysis, the author finds Sandel's position untenable. It is shown that Sandel espouses the ‘simple conservative argument’ (Buchanan). The author concludes that science and technology are not value free, and that the critical evaluation of enhancements cannot lead to an overall judgment, but has to progress in a piecemeal manner. The author also concludes that the notion of ‘human nature’ cannot be regarded as a moral desideratum.

An Empirically Informed Critique of Habermas’ Argument from Human Nature

In a near-future world of bionics and biotechnology, the main ethical and political issue will be the definition of who we are. Could biomedical enhancements transform us to such an extent that we would be other than human? Habermas argues that any genetic enhancement intervention that could potentially alter 'human nature' should be morally prohibited since it alters the child's nature or the very essence that makes the child who he is. This practice also commits the child to a specific life project or, in any case, it puts specific restrictions on his freedom to choose a life of his own. Ultimately, genetic enhancement jeopardizes the very foundations of moral equality. I contend that Habermas' argument is based either on a series of presuppositions that imply a gross misunderstanding of evolution or the relevant factual information concerning the action we are about to morally assess is not empirically supported. Hence, the argument from human nature is based on a series of false or problematic assumptions, and, as such, it fails to play the normative role intended by Habermas.

Enhancement and Civic Virtue.

Opponents of biomedical enhancement frequently adopt what Allen Buchanan has called the Personal Goods Assumption. On this assumption, the benefits of biomedical enhancement will accrue primarily to those individuals who undergo enhancements, not to wider society. Buchanan has argued that biomedical enhancements might in fact have substantial social benefits by increasing productivity. We outline another way in which enhancements might benefit wider society: by augmenting civic virtue and thus improving the functioning of our political communities. We thus directly confront critics of biomedical enhancement who argue that it will lead to a loss of social cohesion and a breakdown in political life.

Genetyczne udoskonalanie a moralna doskonałość

Idea udoskonalania moralnego jest jednym z nowych zagadnień dyskutowanych przez zwolenników i przeciwników ulepszania ludzkiej kondycji. W niniejszym artykule chcę odpowiedzieć na pytanie, czy możliwe jest wypracowanie kompromisowego stanowiska, godzącego pewną wersję projektu udoskonalania moralnego człowieka z tradycyjną wizją ludzkiego rozwoju jako indywidualnego i autonomicznego dążenia do moralnej doskonałości. Rozpocznę od przedstawienia sposobu, w jaki w dyskusji nad udoskonalaniem ludzkiej kondycji pojawiła się kategoria udoskonalania moralnego. Następnie zaprezentuję transhumanistyczne założenia i argumenty za biomedycznym udoskonalaniem człowieka w wymiarze moralnym. W części trzeciej przeanalizuję cztery problemy związane z zagadnieniem moralnej doskonałości: problem prawa do niedoskonałości, uzasadnienia poświęcenia, moralnej oceny cech podmiotu oraz racji doskonalenia moralnego.

Organic Interfaces; or, How Human Beings Augment Their Digital Devices

Organic Interfaces; or, How Human Beings Augment Their Digital Devices

Biomedical Enhancements as Justice

Biomedical enhancements, the applications of medical technology to make better those who are neither ill nor deficient, have made great strides in the past few decades. Using Amartya Sen's capability approach as my framework, I argue in this article that far from being simply permissible, we have a prima facie moral obligation to use these new developments for the end goal of promoting social justice. In terms of both range and magnitude, the use of biomedical enhancements will mark a radical advance in how we compensate the most disadvantaged members of society.

Normal Human Variation: Refocussing the Enhancement Debate

This article draws attention to several common mistakes in thinking about biomedical enhancement, mistakes that are made even by some supporters of enhancement. We illustrate these mistakes by examining objections that John Harris has recently raised against the use of pharmacological interventions to directly modulate moral decision-making. We then apply these lessons to other influential figures in the debate about enhancement. One upshot of our argument is that many considerations presented as powerful objections to enhancement are really strong considerations in favour of biomedical enhancement, just in a different direction. Another upshot is that it is unfortunate that much of the current debate focuses on interventions that will radically transform normal human capacities. Such interventions are unlikely to be available in the near future, and may not even be feasible. But our argument shows that the enhancement project can still have a radical impact on human life even if biomedical enhancement operated entirely within the normal human range.

Enhancing Children against Unhealthy Behaviors-An Ethical and Policy Assessment of Using a Nicotine Vaccine.

Health behaviors such as tobacco use contribute significantly to poor health. It is widely recognized that efforts to prevent poor health outcomes should begin in early childhood. Biomedical enhancements, such as a nicotine vaccine, are now emerging and have potential to be used for primary prevention of common diseases. In anticipation of such enhancements, it is important that we begin to consider the ethical and policy appropriateness of their use with children. The main ethical concerns raised by enhancing children relate to their impact on children's well-being and autonomy. These concerns are significant, however they do not appear to apply in the case of the nicotine vaccine; indeed the vaccine could even further these goals for children. Nevertheless, concerns about broadly applying this enhancement may be more challenging. The vaccine may be less cost-effective than alternative public efforts to prevent tobacco use, utilizing it could distract from addressing the foundational causes of smoking and it might not be publically acceptable. Empirical research about these concerns is needed to ascertain their likelihood and impact as well as how they could be minimized. This research could help determine whether behavior-related enhancements hold promise for improving children's health.

You cannot have your normal functioning cake and eat it too

Does biomedical enhancement challenge justice in health care? This paper argues that health care justice based on the concept of normal functioning is inadequate if enhancements are widespread. Two different...

Negated bio-events: analysis and identification.

BackgroundNegation occurs frequently in scientific literature, especially in biomedical literature. It has previously been reported that around 13% of sentences found in biomedical research articles contain negation. Historically, the main motivation for identifying negated events has been to ensure their exclusion from lists of extracted interactions. However, recently, there has been a growing interest in negative results, which has resulted in negation detection being identified as a key challenge in biomedical relation extraction. In this article, we focus on the problem of identifying negated bio-events, given gold standard event annotations.ResultsWe have conducted a detailed analysis of three open access bio-event corpora containing negation information (i.e., GENIA Event, BioInfer and BioNLP’09 ST), and have identified the main types of negated bio-events. We have analysed the key aspects of a machine learning solution to the problem of detecting negated events, including selection of negation cues, feature engineering and the choice of learning algorithm. Combining the best solutions for each aspect of the problem, we propose a novel framework for the identification of negated bio-events. We have evaluated our system on each of the three open access corpora mentioned above. The performance of the system significantly surpasses the best results previously reported on the BioNLP’09 ST corpus, and achieves even better results on the GENIA Event and BioInfer corpora, both of which contain more varied and complex events.ConclusionsRecently, in the field of biomedical text mining, the development and enhancement of event-based systems has received significant interest. The ability to identify negated events is a key performance element for these systems. We have conducted the first detailed study on the analysis and identification of negated bio-events. Our proposed framework can be integrated with state-of-the-art event extraction systems. The resulting systems will be able to extract bio-events with attached polarities from textual documents, which can serve as the foundation for more elaborate systems that are able to detect mutually contradicting bio-events.

Allen Buchanan, Beyond Humanity: the Ethics of Biomedical Enhancement

Allen Buchanan, Beyond Humanity: the Ethics of Biomedical Enhancement

Evolution, Genetic Engineering, and Human Enhancement

There are many ways that biological theory can inform ethical discussions of genetic engineering and biomedical enhancement. In this essay, we highlight some of these potential contributions, and along the way provide a synthetic overview of the papers that comprise this special issue. We begin by comparing and contrasting genetic engineering with programs of selective breeding that led to the domestication of plants and animals, and we consider how genetic engineering differs from other contemporary biotechnologies such as embryo selection. We go on to consider the implications of genetic engineering for human nature, human evolution, and persistence of the human species. Finally, we question whether genetic interventions warrant the extraordinary ethical scrutiny they are often given, and we show how the misleading “genetic blueprint” metaphor has imposed a faulty structure on the enhancement debate. We conclude by considering the nature of biological development and the sobering limits it places on what genetic engineering can reasonably hope to achieve

Human Nature and Respect for the Evolutionarily Given: a Comment on Lewens

Any serious ethical discussion of the enhancement of human nature must begin with a reasonably accurate picture of the causal-historical structure of the living world. In this Comment, I show that even biologically sophisticated ethical discussions of the biomedical enhancement of species and speciel natures are susceptible to the kind of essentialistic thinking that Lewens cautions against. Furthermore, I argue that the same evolutionary and developmental considerations that compel Lewens to reject more plausible conceptions of human nature pose equally serious problems for some prominent critiques of biomedical enhancement that presuppose the existence of a “given” biological potential that can be distorted by agentic cultural influences.

Sexual dimorphism and human enhancement

Robert Sparrow argues that because of women's longer life expectancy philosophers who advocate the genetic modification of human beings to enhance welfare rather than merely supply therapy are committed to...

Genetic Enhancement in Sport: Just Another Form of Doping?

Patented genetic technologies such as the ACTN3 genetic test are adding a new dimension to the types of performance enhancement available to elite athletes. Organized sports organizations and governments are seeking to prevent athletes' use of biomedical enhancements. This paper discusses how these interdiction efforts will affect the use and availability of genetic technologies that can enhance athletic performance. The paper provides a working definition of enhancement, and in light of that definition and the concerns of the sports community, reviews genetic enhancement as a result of varied technologies, including, genetic testing to identify innate athletic ability, performance-enhancing drugs developed with genetic science and technology, pharmacogenetics, enhancement through reproductive technologies, somatic gene transfer, and germ line gene transfer.

Beyond Humanity? The Ethics of Biomedical Enhancement – By Allen Buchanan

BioethicsVolume 26, Issue 7 p. 391-392 Beyond Humanity? The Ethics of Biomedical Enhancement – By Allen Buchanan JONNY ANOMALY, JONNY ANOMALY Duke/UNCSearch for more papers by this author JONNY ANOMALY, JONNY ANOMALY Duke/UNCSearch for more papers by this author First published: 25 July 2012 https://doi.org/10.1111/j.1467-8519.2012.01964.xCitations: 1 Prof. Jonny Anomaly, Philosophy Department, Caldwell Hall CB 3125; 240, East Cameron; Chapel Hill, NC 27599. Email: jonathan.anomaly@duke.edu Conflict of interest statement: No conflicts declared Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article.Citing Literature Volume26, Issue7Special Issue: The role of solidarity in bioethicsSeptember 2012Pages 391-392 RelatedInformation

Natural Selection, Childrearing, and the Ethics of Marriage (and Divorce): Building a Case for the Neuroenhancement of Human Relationships

We argue that the fragility of contemporary marriages—and the corresponding high rates of divorce—can be explained (in large part) by a three-part mismatch: between our relationship values, our evolved psychobiological natures, and our modern social, physical, and technological environment. “Love drugs” could help address this mismatch by boosting our psychobiologies while keeping our values and our environment intact. While individual couples should be free to use pharmacological interventions to sustain and improve their romantic connection, we suggest that they may have an obligation to do so as well, in certain cases. Specifically, we argue that couples with offspring may have a special responsibility to enhance their relationships for the sake of their children. We outline an evolutionarily informed research program for identifying promising biomedical enhancements of love and commitment.