Biomarkers In Breast Cancer Survivors Research Articles

Impact of Physical Rehabilitation on Bone Biomarkers in Non-Metastatic Breast Cancer Women: A Systematic Review and Meta-Analysis.

Rehabilitation might improve bone health in breast cancer (BC) patients, but the effects on bone biomarkers are still debated. Thus, this meta-analysis of randomized controlled trials (RCTs) aims at characterizing the impact of rehabilitation on bone health biomarkers in BC survivors. On 2 May 2022, PubMed, Scopus, Web of Science, Cochrane, and PEDro were systematically searched for RCTs assessing bone biomarker modifications induced by physical exercise in BC survivors. The quality assessment was performed with the Jadad scale and the Cochrane risk-of-bias tool for randomized trials (RoBv.2). Trial registration number: CRD42022329766. Ten studies were included for a total of 873 patients. The meta-analysis showed overall significant mean difference percentage decrease in collagen type 1 cross-linked N-telopeptide (NTX) serum level [ES: -11.65 (-21.13, -2.17), p = 0.02)] and an increase in bone-specific alkaline phosphatase (BSAP) levels [ES: +6.09 (1.56, 10.62). According to the Jadad scale, eight RCTs were considered high-quality studies. Four studies showed a low overall risk of bias, according to RoBv.2. The significant effects of rehabilitation on bone biomarkers suggested a possible implication for a precision medicine approach targeting bone remodeling. Future research might clarify the role of bone biomarkers monitoring in rehabilitation management of cancer treatment induced bone-loss.

Mindfulness is associated with improved psychological well-being but no change in stress biomarkers in breast cancer survivors with depression: a single group clinical pilot study

BackgroundThe aim of this clinical single group pilot study was to assess mental well-being, psychological symptoms, and a set of stress biomarkers among breast cancer survivors with high depressive symptoms undergoing the Mindfulness-Based Stress Reduction (MBSR) program.MethodsParticipants included 23 curatively treated breast cancer survivors from the Helsinki University Central Hospital with clinically significant symptoms of depression (Beck Depression Inventory > 13, and assessed by a psychiatrist), at 1-year post-operative follow-up. Mental wellbeing and psychological symptoms were assessed with self-reported questionnaires (Resilience Scale, Self-Compassion Scale, Five Facet Mindfulness Questionnaire, World Health Organization Quality of Life-questionnaire, Perceived Stress Scale, Beck Depression Inventory, Beck Anxiety Inventory, Insomnia Severity Index); in addition, stress response was assessed with biomarkers (cortisol, adrenocorticotropine, and high-sensitivity-CRP from blood; 24 h-cortisol from urine). All measures were addressed at baseline, mid-program (4 weeks after baseline) and at the completion of the 8-week MBSR program. Engagement to the independent mindfulness home practice was collected with a diary.ResultsFrom baseline to the completion of the 8-week MBSR program, we observed significant increases in resilience (d = 0.60, p = 0.005), and quality of life (d = 0.92, p = 0.002), and significant reductions in symptoms of depression (d = − 1.17, p < 0.0001), anxiety (d = − 0.87, p < 0.0001), insomnia (d = − 0.58, p = 0.006), and marginally significant reduction in perceived stress (d = − 0.40, p = 0.09). We found no changes in self-compassion or mindfulness skills, nor in the stress biomarkers during or at the completion of the program. There was no association between the engagement time to the independent mindfulness practice and any of the outcomes.ConclusionsAttending the MBSR program was associated with increased wellbeing and reduced psychological symptoms in breast cancer survivors with clinically significant symptoms of depression. However, these favorably experienced changes did not transfer to the level of stress biomarkers during the 8-week program. Lack of association between the engagement in the mindfulness home practice and change in outcomes suggests that in the studied range of practice time, other qualities of MBSR despite the amount of independent practice may have a more important role for the improved wellbeing.Trial registration ISRCTN12326308 at 16/02/2021, retrospectively registered.

Adhesion Molecules ICAM-1 and PECAM-1 as Potential Biomarkers of Central Nervous System Damage in Women Breast Cancer Survivors.

Breast cancer (BC) is the most common tumor in women worldwide with high mortality rates. Surgical methods followed by radio–chemotherapy are used to treat these tumors. Such treatment can lead to various side effects, including neurological complications. The development of a reliable biomarker to predict the onset of CNS complications could improve clinical outcomes. In the current study, ICAM-1 and PECAM-1 serum levels were measured as potential biomarkers in 45 female patients in a long-term follow-up period after breast cancer treatment, and compared to 25 age-matched female healthy volunteers. Serum levels of both biomarkers, ICAM-1 and PECAM-1 were significantly higher in patients after breast cancer treatment and could be associated with cognitive dysfunction, depression, and vestibulocerebellar ataxia. In conclusion, our results provide a first hint that elevated serum levels of ICAM-1 and PECAM-1 could serve as early predictive biomarkers in breast cancer survivors that might help to improve the management of these patients.

Effects of meditation compared to music listening on biomarkers in breast cancer survivors with cognitive complaints: secondary outcomes of a pilot randomized control trial

ContextWe previously reported positive behavioral effects of both daily mantra meditation and classical music listening interventions in breast cancer survivors with cancer related cognitive complaints. ObjectiveThe objective of this pilot study was to compare the effects of the meditation intervention to a music listening intervention on biomarkers of inflammation and cellular aging (secondary outcomes) in breast cancer survivors. DesignRandomized control trial, baseline data collection (time 1), post intervention data collection (time 2) SettingCommunity-based, Central Texas Participants25 breast cancer survivors (BCS) who were 3 months to 6 years post chemotherapy completion and reported cognitive changes. Intervention(s)Kirtan Kriya meditation (KK) or classical music listening (ML), 8 weeks, 12 min a day Main OutcomeTelomerase activity [TA], c-reactive protein [CRP], soluble IL-2 receptor alpha [sIL-2Rα], soluble IL-4 receptor [sIL-4R], soluble IL-6 receptor [sIL-6R], soluble tumor necrosis factor receptor II [sTNF-RII], VEGF receptor 2 [sVEGF-R2], and VEGF receptor 3 [sVEGF-R3] ResultsRepeated measures analysis of variance models were analyzed from time 1 to time 2 by group for each biomarker. A pattern of greater telomerase activity across time in both groups (F (1,15) = 3.98, p = .06, ω2 = 0.04); significant decreases in sIL-4R across time for both groups (F (1,22) = 6.28, p = .02, ω2 = .003); group*time effect was nominally different but not statistically different for sIL-4R (F(1,22) = 3.82, p = .06, ω2 = .001); and a pattern for a group*time effect with ML group showing higher levels of sVEGF-R3 at time 2 (F (1,20) = 2.59, p = .12, ω2 = .009). No significant effects were found for CRP, sIL-2Rα, sIL-6R, sTNF-RII, or sVEGF-R2.

Impact of a randomized weight loss trial on breast tissue markers in breast cancer survivors.

e12501 Background: Weight loss interventions are effective approaches to reduce body weight and alter serum biomarkers in breast cancer survivors, however the impact on breast tissue biomarkers is unknown. The Lifestyle, Exercise and Nutrition (LEAN) study was a randomized trial designed to test the effect of a weight loss intervention on body composition and breast tissue and serum biomarkers. Methods: Fifity-one women with a BMI ³ 25.0 kg/m2 diagnosed with breast cancer, who had completed chemotherapy and/or radiation therapy were randomized to weight loss intervention or usual care. Breast tissue biopsies from the unaffected breast, fasting serum samples, and body composition were measured at baseline and 6-months. Ki67, insulin receptor (IR), CD68 and CD163 were measured by Automated Quantitative Analysis (AQUA) method. Mean baseline to 6-month changes were compared using ANCOVA adjusting for baseline values. Results: Pre- and post-intervention biopsies were conducted in 49 and 42 women respectively, with both pre- and post- epithelial tissue available from 25 women; epithelial tissue was unavailable in the remaining 66 women. Women were 56.8 ± 8.9 years old, diagnosed 3.3 + 3.8 years prior, primarily Stage I breast cancer (54%), with a BMI of 32.8 ± 6.0 kg/m2. At baseline, breast tissue levels of IR were inversely associated with both percent body fat (r = -0.47, p = .03) and serum insulin levels (r = -0.45, p = .04); serum insulin levels were inversely associated with CD68 (r = -0.47, p = .03). Significant between-group biomarker changes are presented in Table 1. At month 6, loss in percent body fat was associated with increased IR (r = -0.42, p = .05). Increased CD68 breast tissue expression was associated with reductions in serum levels of CRP (r = -0.49, p=0.02). There was no significant effect of the intervention on IR expression or Ki67 (p&gt;0.10). Conclusions: Breast tissue biopsies are feasible to collect in a clinical research setting among breast cancer survivors. A 6-month weight loss intervention led to decreased levels of CD163 in breast tissue and serum levels of leptin, and increased serum levels of adiponectin among breast cancer survivors. At baseline and month 6, changes in breast tissue biomarkers were favorably associated with serum biomarkers and body composition. Future confirmation is required to confirm the added benefit of tissue biomarkers beyond serum as an endpoint for lifestyle interventions among breast cancer survivors. Clinical trial information: NCT02110641. [Table: see text]

Associations between religious and spiritual variables and neuroimmune activity in survivors of breast cancer: a feasibility study.

Chronic stress is associated with neuroimmune inflammation and adverse outcomes in breast cancer survivors. Some breast cancer survivors rely on religious and spiritual (R/S) variables to manage stress after breast cancer treatment. A spiritually based psychoneuroimmunological (PNI) model of health suggests that R/S variables influence neuroimmune activity; however, these associations are not well-established. A pilot study was conducted to assess the feasibility of studying associations between R/S variables and neuroimmune biomarkers in breast cancer survivors. Salivary alpha-amylase (sAA) and interleukin-6 (IL-6) were sampled among women previously treated for breast cancer. The primary aim was to assess feasibility and acceptability of the sampling protocol. A secondary aim explored associations between sAA, IL-6, R/S variables, and health outcomes. Forty-one women completed the study. Biomarker sampling yielded 246 acceptable specimens used for analysis. SAA was detectable in 96% of specimens and IL-6 was detectable in 44% of specimens. The R/S variables with the strongest associations to sAA were spiritual self-rank (rs = .39; p < .05) and forgiveness (rs = .40; p < .05). The R/S variable with the strongest association to salivary IL-6 was positive congregational support (rs = .42; p < .05). Feasibility and acceptability of the sampling protocol were confirmed. Reference ranges for sAA and IL-6 for female breast cancer survivors are presented. Results suggest that spiritual beliefs and religious practices are associated with neuroimmune activity, adding credence to a spiritually based PNI model of health. Findings lay the foundations for future R/S-based interventions to promote health and well-being in breast cancer survivors.

Effects of Diet and Exercise-Induced Weight Loss on Biomarkers of Inflammation in Breast Cancer Survivors: A Systematic Review and Meta-analysis.

Adiponectin, leptin, and pro- and anti-inflammatory cytokines are implicated in breast cancer risk and recurrence. Weight loss, via the dynamic interplay of energy balance through exercise and/or caloric restriction, decreases risk of breast cancer recurrence. We investigated the effects of lifestyle modifications (exercise only, or combined caloric restriction and exercise) on adipokines, IL2, IL6, IL8, IL10, C-reactive protein (CRP), and TNFα biomarkers in breast cancer survivors. Searches were completed in June and July of 2019 to identify randomized controlled trials that met inclusion criteria. Weighted mean difference was calculated using random- or fixed-effects models based on the heterogeneity of the studies. 2501 records were identified, with 30 ultimately meeting inclusion criteria of the systematic review; 21 studies provided data suitable for meta-analysis. We observed leptin levels were significantly reduced in the exercise-only group compared with sedentary control [WMD -5.66; 95% confidence interval (CI), -11.0 to -0.33; P = 0.04]. Leptin may be a primary mediator of exercise-induced improvements in breast cancer recurrence. This is the first review and meta-analysis to examine combined exercise and caloric restriction programs in breast cancer survivors. Future studies should further examine combined programs and their efficacy for altering leptin.

Abstract C122: Ethnicity as a moderator of the effects of aerobic and resistance exercise on metabolic syndrome in breast cancer survivors

Abstract Background and Purpose: Metabolic syndrome (MSY) is associated with increased risk of cardiovascular disease, type 2 diabetes, and recurrence in breast cancer survivors (BCS). MSY is 1.5 times more common in Hispanic compared to non-Hispanic women. Hispanic women in the United States are more likely to be obese and physically inactive than matched non-Hispanic counterparts, raising risk for developing MSY. Exercise mitigates MSY in BCS; however, few studies have focused on minorities. The purpose of this secondary analysis was to examine ethnicity as a moderator of the effects of a 16-week combined aerobic and resistance clinical exercise intervention on MSY and related biomarkers in BCS. Experimental Design: Sedentary, overweight or obese (BMI&amp;gt;25.0 kg/m2) BCS (Stage I-III; n=100) were randomized to exercise (n=50) or usual care (n=50). The exercise intervention promoted supervised, progressive moderate-vigorous (65-85% heart rate maximum) aerobic and resistance exercise thrice weekly for 16 weeks. Aerobic exercise included cycling, walking, or jogging at 65-85% maximum heart rate. Resistance exercise was performed in circuit-fashion with 3 sets of 10-15 repetitions including upper and lower body exercises at 65-70% 1-repetition maximum. MSY variables (blood pressure, waist circumference, triglycerides, glucose, and high-density lipoprotein-cholesterol) and related biomarkers (insulin, insulin resistance HOMA-IR, C-reactive protein [CRP]) were measured at baseline and post-intervention (4 months). Differences in mean changes for outcomes by ethnicity were evaluated using linear mixed-models to assess effect modification. Summary of Results: Fifty-seven Hispanic BCS and 43 non-Hispanic BCS with an average age of 53.5±10.4 years and BMI of 33.5±5.5 kg/m2 were included. Hispanic BCS were younger, of greater adiposity, had higher-stage cancers, and had worse metabolic profiles at baseline compared to non-Hispanic BCS (p&amp;lt;0.001). Ethnicity was found to moderate the effects of exercise training on triglycerides (mean difference, -36.4; 95% confidence interval (95% CI), -62.1-18.3; p=0.04) and glucose (mean difference, -8.6; 95% CI, -18.7-3.1; p=0.05) with Hispanic BCS exhibiting larger improvements than non-Hispanic BCS. Ethnicity moderated the effect of exercise on insulin (P for interaction=0.09), HOMA-IR (P for interaction=0.06), and CRP (P for interaction=0.05). Conclusions: Hispanic, as compared to non-Hispanic, BCS have poorer metabolic profiles, but may achieve better outcomes from exercise. To our knowledge, this is the first study to explore racial/ethnic disparities in MSY between Hispanic and non-Hispanic BCS and document differential response to exercise. Clinical exercise interventions may attenuate ethnic health disparities in BCS. Future trials should aim for diversity. Citation Format: Christina M. Dieli-Conwright, Frank C. Sweeney, Kerry S. Courneya, Debu Tripathy, Nathalie Sami, Kyuwan Lee, Thomas A. Buchanan, Darcy Spicer, Leslie Bernstein, Joanne E. Mortimer, Wendy Demark-Wahnefried. Ethnicity as a moderator of the effects of aerobic and resistance exercise on metabolic syndrome in breast cancer survivors [abstract]. In: Proceedings of the Eleventh AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2018 Nov 2-5; New Orleans, LA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl):Abstract nr C122.

Using Isotemporal Analyses to Examine the Relationships Between Daytime Activities and Cancer Recurrence Biomarkers in Breast Cancer Survivors.

For breast cancer survivors, moderate to vigorous physical activity (MVPA) is associated with improved survival. Less is known about the interrelationships of daytime activities (sedentary behavior [SB], light-intensity physical activity, and MVPA) and associations with survivors' health outcomes. This study will use isotemporal substitution to explore reallocations of time spent in daytime activities and associations with cancer recurrence biomarkers. Breast cancer survivors (N = 333; mean age 63y) wore accelerometers and provided fasting blood samples. Linear regression models estimated the associations between daytime activities and cancer recurrence biomarkers. Isotemporal substitution models estimated cross-sectional associations with biomarkers when time was reallocated from of one activity to another. Models were adjusted for wear time, demographics, lifestyle factors, and medical conditions. MVPA was significantly associated with lower insulin, C-reactive protein, homeostatic model assessment of insulin resistance, and glucose, and higher sex hormone-binding globulin (all P < .05). Light-intensity physical activity and SB were associated with insulin and homeostatic model assessment of insulin resistance (both P < .05). Reallocating 18 minutes of SB to MVPA resulted in significant beneficial associations with insulin (-9.3%), homeostatic model assessment of insulin resistance (-10.8%), glucose (-1.7%), and sex hormone-binding globulin (7.7%). There were no significant associations when 79 minutes of SB were shifted to light-intensity physical activity. Results illuminate the possible benefits for breast cancer survivors of replacing time spent in SB with MVPA.

Depresio- eta antsietate-sintomen eta hanturaren arteko erlazioa bularreko minbizia gainditutako emakumeetan

Bularreko minbizia gainditutako emakumeen antsietate- eta depresio-prebalentzia biztanleria orokorrarena baino handiagoa da. Nahasmendu horien eta minbiziaren arteko fisiopatologian zenbait faktore berdin aurki daitezke: hantura, zitokinak eta kortisola. Ikerketa honen helburua bularreko minbizia gainditutako emakumeetan depresio- eta antsietate-sintomen eta hantura-adierazleen arteko erlazioa aztertzea da. Kortisol-maila handiagoak aurkitu ditugu antsietate- eta depresio-sintomak dituzten emakumeetan. Gainera, TNF-α maila altuak aurkitu ditugu depresioa duten emakumeetan.

Abstract 5271: Exercise intervention alleviates inflammation-related biomarkers in breast cancer survivors

Abstract Purpose: In this pilot study we assessed the feasibility of breast cancer survivors exercising at Curves facilities, and examined stress-related biomarkers to explain the association between exercise and reduction in cancer associated co-morbidities. Methods: 50 sedentary, estrogen-positive, postmenopausal breast cancer survivors were recruited from the City of Hope, of whom 50% were randomized into a 16-week Curves exercise intervention. Adherence to the exercise/control regimen was followed through the 16 weeks. Body measurements and blood samples were taken at each time point. Samples were analyzed using genome-wide RNA sequencing and inflammation measured using a 13 Plex Immunology Multiplex Assay and a C-reactive protein assay. Results: Although insignificant variation in weight loss was observed between the two groups after 16 weeks, the exercise group did show a reduction in 12 of the 14 measurable inflammation markers compared to the control group. The average fold change after 16 weeks showed that women in the exercise group had a 40% and 25% reduction in the proinflammatory markers CRP and IL-6, respectively, when compared to the control group. Additionally, a greater number of women in the exercise group showed an overall decrease in proinflammatory markers including IL-6, CRP, TNF-α and IL-8 when compared to the control group; 80% of the women in the exercise group showed reduced levels of IL-8 at 16 weeks compared to control group where only 36.4% of women had any reduction in IL-8 levels. Interestingly, irrespective of the exercise intervention, analyses based on their exposure to radiation therapy (RT), showed that women who underwent RT exhibited increased levels of all 14 inflammation markers at 16-weeks while women who had not been given RT showed a slight decrease in 13 of the 14 inflammation markers. The gene expression profiling results for the exercise group showed 435 differentially expressed (DE) genes post-intervention, when compared to the gene expression at baseline (p=0.05). Several of these DE genes are involved with inflammatory response, interleukin and interferon signaling pathways. Interestingly, the difference at baseline between the breast cancer survivors from this study and a group of women without a history of cancer from a parallel exercise study by our team showed a drastic variation, with a total of 2,543 DE genes (p=0.05), with most of the DE genes associated with catabolic cellular processes. Conclusion: Our results indicate that moderate levels of exercise, even without weight loss, could potentially be useful in alleviating inflammation and stress-related biomarkers in breast cancer survivors. The expression-level variation at baseline between women with and without a history of breast cancer could be attributed to the oncogenic and chemotherapy-related stress in the breast cancer survivors. Further gene set enrichment analysis is needed for all groups. Citation Format: Aditi Vyas, Yuan Chun Ding, Sarah Flores, Megan Johnson, Gabrielle Riazi, Joanne Mortimer, Susan Neuhausen, Jessica Clague Dehart. Exercise intervention alleviates inflammation-related biomarkers in breast cancer survivors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 5271.

Ultrasensitive Quantification of Inflammatory Biomarkers in Breast Cancer Survivors

Abstract Background Inflammatory changes in breast cancer survivors, have been linked to symptoms including sleep disturbance and fatigue. While inflammation is well-studied, limitations in detection of inflammatory proteins in human serum may obscure scientific understanding; traditional methodologies (e.g. enzyme-linked immunosorbent assay (ELISA)) often cannot detect beyond the picomolar level). Purpose This study describes new methodologies for evaluating biomarkers by comparing IL-6- levels in the serum of breast cancer survivors previously obtained in the parent study using the BioPlex200 System (Luminex®) to those obtained in this study using the SMCxPRO (MilliporeSigma). Methods The principles outlined in the Declaration of Helsinki and U.S. Government regulations (45 CFR Part 46; 56 FR 28003) were followed. Following Institutional Review Board (IRB) approval and informed consent, survivors of treated Stage I–III breast cancer (6 to 10 years prior) were recruited into the parent study. Serum and self-reported measurements of sleep and fatigue (e.g. Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale, Patient-Reported Outcomes Measurement Information System Fatigue scale) were collected at a single time point. A bead-based assay system was then used to perform single molecule counting and these results were compared to those previously obtained using conventional methods. Results Inflammatory changes are detectable using both systems, but the SMCxPRO assay has a lower limit of quantification. Femtomolar-level sensitivity may result in identification of meaningful associations that could not be determined otherwise. Future research efforts to replicate and expand upon these findings are needed.

Sedentary Behaviors and Biomarkers Among Breast Cancer Survivors.

Sedentary behavior is associated with increased risk of poor outcomes in breast cancer survivors, but underlying mechanisms are not well understood. This pilot study explored associations between different aspects of sedentary behaviors (sitting, prolonged sitting, sit-to-stand transitions, and standing) and breast cancer risk-related biomarkers in breast cancer survivors (n = 30). Sedentary behavior variables were objectively measured with thigh-worn activPALs. Breast cancer risk-related biomarkers assessed were C-reactive protein (CRP), insulin, and homeostatic model assessment of insulin resistance (HOMA-IR) and were measured in fasting plasma samples. Linear regression models were used to investigate associations between sedentary behavior variables and biomarkers (log CRP, insulin, and HOMA-IR). Sit-to-stand transitions were significantly associated with insulin resistance biomarkers (P < .05). Specifically, each 10 additional sit-to-stand transitions per day was associated with a lower fasting insulin concentration (β = -5.52; 95% CI, -9.79 to -1.24) and a lower HOMA-IR value (β = -0.22; 95% CI, -0.42 to -0.03). Sit-to-stand transitions were not significantly associated with CRP concentration (P = .08). Total sitting time, long sitting bouts, and standing time were not significantly associated with CRP, insulin, or HOMA-IR (P > .05). Sit-to-stand transitions may be an intervention target for reducing insulin resistance in breast cancer survivors, which may have favorable downstream effects on cancer prognosis.

The Effects of Dietary Nutrition Education on Weight and Health Biomarkers in Breast Cancer Survivors.

Weight gain after breast cancer diagnosis portends a poorer prognosis, and the majority of sufferers appear to gain weight. Metabolic syndrome is a common co-condition with breast cancer. The Mediterranean diet has been used to reduce excess weight, metabolic syndrome, and to improve the inflammatory profile, and therefore may offer the breast cancer survivor specific benefits over and above the currently recommended nutrition guidelines to eat a low fat, healthy diet. The aim of this randomised controlled trial was to investigate whether a Mediterranean (MD) or low-fat diet (LF) reduce weight and general health in survivors of stage 1–3 breast cancer through a six-month, six-session education package to support dietary change. A control dietary arm received no intervention. Outcome measures for weight, body mass index (BMI), waist circumference, blood lipids, blood glucose, dietary adherence, 3-day food diary, and PREDIMED questionnaire and quality of life were assessed. Both dietary intervention arms, on average, lost weight over the course of the intervention, with significant (p < 0.05) decreases seen in BMI and waist circumference measurements. The control arm gained weight and significantly (p < 0.05) increased BMI and waist circumference measurements overall (1.10 ± 3.03 kg, 0.40 ± 1.65 kg/m2, and 1.94 ± 2.94 cm respectively). Positive trends in blood biomarkers were observed for the intervention arms. Dietary adherence was sufficient. Nutritional education and group support appears to exert beneficial effects on health in breast cancer survivors, of lesser importance is the type of diet that forms the basis of the education.

No. 5 Effects of Exercise Interventions on Pro-Inflammatory Biomarkers in Breast Cancer Survivors

No. 5 Effects of Exercise Interventions on Pro-Inflammatory Biomarkers in Breast Cancer Survivors

Effects of exercise on cancer-related biomarkers in breast cancer survivors: An updated systematic review and meta-analysis of randomized controlled trials.

e20691 Background: Physical activity and exercise has been identified as a curative intervention to improve physical and mental health, and even cancer prognosis, in breast cancer survivors. Though...

Effect of exercise on weight, body fat, and serum inflammatory biomarkers in breast cancer survivors with aromatase inhibitor arthralgias: The hormones and physical exercise (HOPE) study.

9536 Background: We recently reported that exercise reduced AI-associated arthralgias. This analysis examined potential mechanisms mediating the effect on exercise on arthralgia, specifically weigh...

Exercise to improve obesity-related biomarkers in breast cancer survivors

Exercise to improve obesity-related biomarkers in breast cancer survivors

Feasibility of a Lifestyle Intervention on Body Weight and Serum Biomarkers in Breast Cancer Survivors with Overweight and Obesity

Physical inactivity and being overweight or obese are lifestyle factors that put breast cancer survivors at a higher risk for a cancer recurrence and/or development of other chronic diseases. Despite this, there is limited research that has identified effective lifestyle interventions aimed specifically at weight loss in breast cancer survivors. This pilot study is a single-arm experimental pre–post test design, conducted from November 2009 to July 2010, that tested the efficacy of a 24-week group-based lifestyle intervention modeled on the Diabetes Prevention Program in early stage breast cancer survivors (N=14). The intervention included 16 diet sessions led by a registered dietitian and 150 min/wk of moderate-to-vigorous exercise. Study outcome measures were completed at baseline, 24, and 36 weeks (nonintervention follow-up). The primary outcome was change in body weight, and secondary outcomes were change in body composition, aerobic fitness, dietary intake, and blood biomarkers. Overall, participants were postmenopausal women aged 54.6±8.3 years with obesity (body mass index 30.1±3.6), and had completed adjuvant cancer treatment 2 years prior. Results showed an average weight loss of 3.8±5.0 kg and a decrease in body mass index, percent body fat, and waist and hip circumferences at 24 weeks and an additional mean weight loss of 0.8±1.2 kg at 36 weeks. In exploratory analysis, participants who lost >7% body weight were older and attended a greater percentage of diet and supervised exercise sessions. There were no significant changes in any of the blood biomarkers at 24 and 36 weeks; however, the results provide a measure of expected effect size for future research studies. This pilot study demonstrated the efficacy of a lifestyle intervention based on the Diabetes Prevention Program in early stage breast cancer survivors and represents an innovative clinical intervention for dietetics practitioners to address the unmet need for programs.

Health-related quality of life and biomarkers in breast cancer survivors participating in tai chi chuan

Breast cancer survivors experience diminished health-related quality of life (HRQOL). We report on the influence of tai chi chuan exercise (TCC) on HRQOL and explore associations between changes in HRQOL and biomarkers. Breast cancer survivors (N = 21) were randomly assigned to TCC or standard support therapy (SST) for 12weeks (three times/week; 60min/session). Interleukin-6, interleukin-8 (IL-8), insulin-like growth factor-1 (IGF-1), insulin-like growth factor-binding protein (IBFBP)-1, IGFBP-3, glucose, insulin, and cortisol were measured pre- and postintervention. Overall HRQOL and subdomains were assessed at preintervention (T1), midintervention (T2) and postintervention (T3) and biomarkers at T1 and T3. The TCC group improved in total HRQOL (T1-T2:CS = 8.54, P = 0.045), physical functioning (T1-T2:CS = 1.89, P = 0.030), physical role limitations (T1-T2 CS = 1.55, P = 0.023), social functioning (T1-T3:CS = 1.50, P = 0.020), and general mental health (T1-T2:CS = 2.67, P = 0.014; T1-T3:CS = 2.44, P = 0.019). The SST improved in social functioning (T1-T2:CS = 0.64, P = 0.043) and vitality (T1-T2:CS = 0.90, P = 0.01). There were relationships between changes in IGF-1 and overall HRQOL (r = -0.56; P < 0.05), physical role limitation (r = -0.68; P < 0.05), and social functioning (r = -0.56; P < 0.05). IGFBP-1 changes were associated with physical role limitations changes (r = 0.60; P < 0.05). IGFBP-3 changes were associated with physical functioning changes (r = 0.46; P ≤ 0.05). Cortisol changes were associated with changes in physical role limitations (r = 0.74; P < 0.05) and health perceptions (r = 0.46; P < 0.05). Glucose changes were associated with emotional role limitation changes (r = -0.70; P < 0.001). IL-8 changes were associated with emotional role limitation changes (r = 0.59; P < 0.05). TCC may improve HRQOL by regulating inflammatory responses and other biomarkers associated with side effects from cancer and its treatments. TCC may be an intervention capable of improving HRQOL in breast cancer survivors.