91Centre for Integrated Systems Biology of Ageing and Nutrition, Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle uponTyne, United Kingdom, 2School of Computing Science, Newcastle University, Newcastle upon Tyne, United Kingdom, 3QB3 Institute, University of California, Berkeley,California, United States of America, 4Harvard School of Public Health, Department of Biostatistics, Boston, Massachusetts, United States of America, 5Department ofComputer Science, Free University Berlin, Berlin, Germany, 6Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin,Germany, 7Biotec, TU Dresden, Dresden, Germany, 8International Society for Computational Biology, La Jolla, California, United States of America, 9Computational andStructural Biology Unit, EMBL, Heidelberg, Germany